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Cited by 68Restless Legs Syndrome ResearchParkinson's Disease Mechanisms and TreatmentsSleep and Wakefulness Research

Circadian rhythm of CSF monoamines and hypocretin-1 in restless legs syndrome and Parkinson's disease

Poceta, J. Steven, Parsons, Loren, Engelland, Scott, Kripke, Daniel F.·2009·Sleep Medicine
DOI 10.1016/j.sleep.2007.11.002
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Abstract

The symptoms of restless legs syndrome (RLS) have a circadian pattern and central nervous system dopamine has been implicated in the pathogenesis of the condition. We sought to characterize circadian variation in dopamine and related compounds in human cerebro-spinal fluid (CSF). CSF was continuously withdrawn for 22 h from an implanted lumbar intradural catheter and sampled from three patients with RLS, three patients with Parkinson's disease (PD) and three healthy volunteers. Patients had moderate disease severity and took no medications. We assayed CSF dopamine (DA), homovanillic acid (HVA), dihydroxy-phenylacetic acid (DOPAC) and 5-hydroxyindole acetic acid (5-HIAA) from samples every 30 min by reversed-phase HPLC coupled with electrochemical detection. We also measured CSF levels of hypocretin-1 every hour by RIA. The procedure was well-tolerated. One patient ended the study early due to lumbar radicular pain and was not included in the analysis. There were no changes in CSF cell counts or protein levels from the first to the last samples. There was no difference in any of the compounds between groups, so we fit 24-h cosines to examine if the entire group had significant phase consistency. There was a peak for dopamine at 10 a.m. (p<0.025) and for HVA at 2 p.m. (p<0.01), but no evidence of a significant 24-h rhythm for DOPAC, 5-HIAA, the HVA/5-HIAA ratio, or hypocretin-1. These results demonstrate a circadian rhythm for CSF dopamine and HVA concentrations in humans, with higher levels in the daytime than at nighttime. This circadian variation could underlie the symptoms of RLS and sleep-related variation in motor function in PD.

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  • The amplitude of the circadian rhythm of dopamine appears to be highest in the morning around 10am, and that of homovanillic acid in the afternoon around 2pm.

    “For example, the amplitude of the circadian rhythm of dopamine appears to be highest in the morning around 10am, and that of homovanillic acid in the afternoon, around 2pm (Poceta et al., 2009).”

    From Circadian dysregulation in Parkinson's disease (2017) · cites this paper as Poceta et al., 2009

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Authors
Poceta, J. S., Parsons, L., Engelland, S., & Kripke, D. F.
Affiliations
Scripps Research Institute (US)
Corresponding author
Poceta, J. Steven
ORCID
Kripke, Daniel F.
Venue
Sleep Medicine
Publisher
Elsevier BV
Published
2009-01
Volume
10
Issue
1
Pages
129-133
ISSN
1389-9457 (ISSN-L)
DOI
10.1016/j.sleep.2007.11.002
OpenAlex
W2147880948
Cited by
68
References
27
Citations by year
2026: 1 · 2025: 2 · 2024: 2 · 2023: 7 · 2022: 1 · 2021: 1 · 2020: 3 · 2019: 4 · 2018: 2 · 2017: 3 · 2016: 4 · 2015: 4 · 2014: 3 · 2013: 5 · 2012: 6
FWCI
4.95
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Sleep Medicine (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health
  • National Institute on Alcohol Abuse and Alcoholism (R01AA014619)
  • National Institute on Drug Abuse (R21DA019962)
Topics
  • Health Sciences › Medicine › Epidemiology › Restless Legs Syndrome Research
  • Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
Keywords
restless legs syndrome, Parkinson's disease, circadian rhythm, cerebrospinal fluid, dopamine, homovanillic acid, dihydroxyphenylacetic acid, 5-hydroxyindoleacetic acid, orexin-A, monoamines
MeSH terms
Orexins, Aged, Chromatography, High Pressure Liquid, Circadian Rhythm, Dopamine, Feasibility Studies, Female, Homovanillic Acid, Humans, Hydroxyindoleacetic Acid, Male, Middle Aged, Neuropeptides, Parkinson Disease, Pilot Projects, Restless Legs Syndrome, 3,4-Dihydroxyphenylacetic Acid, Biogenic Monoamines, Intracellular Signaling Peptides and Proteins

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