The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Signal transduction pathways mediated by the interaction of CpG DNA with Toll-like receptor 9
Open accessAbstract
Synthetic oligodeoxynucleotides (ODN) expressing non-methylated "CpG motifs" patterned after those present in bacterial DNA have characteristic immunomodulatory effects. CpG DNA is recognized as a pathogen-associated molecular pattern, and triggers a rapid innate immune response. CpG ODN are being harnessed for a variety of therapeutic uses, including as immune adjuvants, for cancer therapy, as anti-allergens, and as immunoprotective agents. The signal transduction pathway mediated by the engagement of CpG DNA with Toll-like receptor 9 (TLR9) is shared with other members of the TLR family. Recent studies demonstrate that formation and maturation of CpG DNA-containing endosomes are regulated by phosphatidylinositol 3 kinases and the Ras-associated GTP-binding protein, Rab5, which are essential for the initiation of TLR9-mediated signaling.
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Cites
A Toll-like receptor recognizes bacterial DNA
Hemmi, H., Takeuchi, O., Kawai, T., Kaisho, T., Sato, S., Sanjo, H., Matsumoto, M., Hoshino, K., Wagner, H., Takeda, K., et al. (2000) · Nature · doi:10.1038/35047123 · Cited by 6,491 · cited 2×
“Northern blot analysis of various tissues including heart, brain, spleen, lung, liver, skeletal muscle, kidney, and testis indicated that murine TLR9 (mTLR9) transcripts were most abundantly expressed in spleen [11].”
BackgroundCpG motifs in bacterial DNA trigger direct B-cell activation
Krieg, A. M., Yi, A.-K., Matson, S., Waldschmidt, T. J., Bishop, G. A., Teasdale, R., Koretzky, G. A., & Klinman, D. M. (1995) · Nature · doi:10.1038/374546a0 · Cited by 3,508
Self-citationKadowaki, N., Ho, S., Antonenko, S., de Waal Malefyt, R., Kastelein, R. A., Bazan, F., & Liu, Y.-J. (2001) · The Journal of Experimental Medicine · doi:10.1084/jem.194.6.863 · Cited by 1,964
Mechanism and Function of a Newly Identified CpG DNA Motif in Human Primary B Cells
Hartmann, G., & Krieg, A. M. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.164.2.944 · Cited by 605
Cited by
COMPARTMENTALIZED RAS/MAPK SIGNALING
Mor, A., & Philips, M. R. (2006) · Annual Review of Immunology · doi:10.1146/annurev.immunol.24.021605.090723 · Cited by 398
Activation of NK Cells by an Endocytosed Receptor for Soluble HLA-G
Rajagopalan, S., Bryceson, Y. T., Kuppusamy, S. P., Geraghty, D. E., Meer, A. V. D., Joosten, I., & Long, E. O. (2005) · PLoS Biology · doi:10.1371/journal.pbio.0040009 · Cited by 353
Biomaterials for Nanoparticle Vaccine Delivery Systems
Sahdev, P., Ochyl, L. J., & Moon, J. J. (2014) · Pharmaceutical Research · doi:10.1007/s11095-014-1419-y · Cited by 310
Burns, C. C., Campagnoli, R., Shaw, J., Vincent, A., Jorba, J., & Kew, O. (2009) · Journal of Virology · doi:10.1128/jvi.00508-09 · Cited by 170
Metadata
- Authors
- Takeshita, F., Gursel, I., Ishii, K. J., Suzuki, K., Gursel, M., & Klinman, D. M.
- Venue
- Seminars in Immunology
- Publisher
- Elsevier BV
- Published
- 2004-02
- Volume
- 16
- Issue
- 1
- Pages
- 17-22
- ISSN
- 1044-5323 (ISSN-L)
- OpenAlex
- W2082143240
- Cited by
- 189
- References
- 4
- FWCI
- 5.78
- Type
- journal article
- Language
- en
- Open access
- green
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- Takeshita, F., Gursel, I., Ishii, K. J., Suzuki, K., Gursel, M., & Klinman, D. M. (2004). Signal transduction pathways mediated by the interaction of CpG DNA with Toll-like receptor 9. Seminars in Immunology. https://doi.org/10.1016/j.smim.2003.10.009
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
