Subsets of Human Dendritic Cell Precursors Express Different Toll-like Receptors and Respond to Different Microbial Antigens
Open accessAbstract
Toll-like receptors (TLRs) are ancient microbial pattern recognition receptors highly conserved from Drosophila to humans. To investigate if subsets of human dendritic cell precursors (pre-DC), including monocytes (pre-DC1), plasmacytoid DC precursors (pre-DC2), and CD11c+ immature DCs (imDCs) are developed to recognize different microbes or microbial antigens, we studied their TLR expression and responses to microbial antigens. We demonstrate that whereas monocytes preferentially express TLR 1, 2, 4, 5, and 8, plasmacytoid pre-DC strongly express TLR 7 and 9. In accordance with these TLR expression profiles, monocytes respond to the known microbial ligands for TLR2 (peptidoglycan [PGN], lipoteichoic acid) and TLR4 (lipopolysaccharide), by producing tumor necrosis factor (TNF)-α and interleukin (IL)-6. In contrast, plasmacytoid pre-DCs only respond to the microbial TLR9-ligand, CpG-ODNs (oligodeoxynucleotides [ODNs] containing unmethylated CpG motifs), by producing IFN-α. CD11c+ imDCs preferentially express TLR 1, 2, and 3 and respond to TLR 2-ligand PGN by producing large amounts of TNF-α, and to viral double-stranded RNA-like molecule poly I:C, by producing IFN-α and IL-12. The expression of distinct sets of TLRs and the corresponding difference in reactivity to microbial molecules among subsets of pre-DCs and imDCs support the concept that they have developed through distinct evolutionary pathways to recognize different microbial antigens.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Cytokines produced by the epithelium or by migrating inflammatory cells upon viral infection may affect cell-to-cell contact through interaction with TJs and desmosomes and thus disrupt the continuity of the epithelial barrier.
“In addition, cytokines produced by the epithelium or by migrating inflammatory cells upon viral infection may affect cell-to-cell contact through interaction with TJs and desmosomes and thus disrupt the continuity of the epithelial barrier (135).”
From The airway epithelium: soldier in the fight against respiratory viruses (2011) · cites this paper as [135]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction
Chomczynski, P., & Sacchi, N. (1987) · Analytical Biochemistry · doi:10.1006/abio.1987.9999 · Cited by 65,240 · see citing works
Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
Chomczyński, P., & Sacchi, N. (1987) · Analytical Biochemistry · doi:10.1016/0003-2697(87)90021-2 · Cited by 47,092 · see citing works
Dendritic cells and the control of immunity
Banchereau, J., & Steinman, R. M. (1998) · Nature · doi:10.1038/32588 · Cited by 14,244 · see citing works
A Toll-like receptor recognizes bacterial DNA
Hemmi, H., Takeuchi, O., Kawai, T., Kaisho, T., Sato, S., Sanjo, H., Matsumoto, M., Hoshino, K., Wagner, H., Takeda, K., et al. (2000) · Nature · doi:10.1038/35047123 · Cited by 6,491 · see citing works
Takeuchi, O., Hoshino, K., Kawai, T., Sanjo, H., Takada, H., Ogawa, T., Takeda, K., & Akira, S. (1999) · Immunity · doi:10.1016/s1074-7613(00)80119-3 · Cited by 3,680 · see citing works
Toll-like receptors in the induction of the innate immune response
Aderem, A. A., & Ulevitch, R. J. (2000) · Nature · doi:10.1038/35021228 · Cited by 3,047 · see citing works
The Nature of the Principal Type 1 Interferon-Producing Cells in Human Blood
Siegal, F. P., Kadowaki, N., Shodell, M., Fitzgerald-Bocarsly, P. A., Shah, K., Ho, S., Antonenko, S., & Liu, Y.-J. (1999) · Science · doi:10.1126/science.284.5421.1835 · Cited by 2,293 · see citing works
Self-citationOzinsky, A., Underhill, D. M., Fontenot, J. D., Hajjar, A. M., Smith, K. D., Wilson, C. B., Schroeder, L. A., & Aderem, A. A. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.250476497 · Cited by 2,086 · see citing works
Reciprocal Control of T Helper Cell and Dendritic Cell Differentiation
Rissoan, M., Soumelis, V., Kadowaki, N., Grouard, G., Brière, F., Malefyt, R. D. W., & Liu, Y.-J. (1999) · Science · doi:10.1126/science.283.5405.1183 · Cited by 1,835 · see citing works
Self-citationCella, M., Jarrossay, D., Facchetti, F., Alebardi, O., Nakajima, H., Lanzavecchia, A., & Colonna, M. (1999) · Nature Medicine · doi:10.1038/11360 · Cited by 1,734 · see citing works
Peptidoglycan- and Lipoteichoic Acid-induced Cell Activation Is Mediated by Toll-like Receptor 2
Schwandner, R., Dziarski, R., Wesche, H., Rothe, M., & Kirschning, C. J. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.25.17406 · Cited by 1,704 · see citing works
Innate immune recognition: mechanisms and pathways
Medzhitov, R., & Janeway, C. (2000) · Immunological Reviews · doi:10.1034/j.1600-065x.2000.917309.x · Cited by 1,589 · see citing works
Grouard, G., Rissoan, M., Filgueira, L., Durand, I., Banchereau, J., & Liu, Y.-J. (1997) · The Journal of Experimental Medicine · doi:10.1084/jem.185.6.1101 · Cited by 1,187 · see citing works
Self-citationRecognition of Stress-Induced MHC Molecules by Intestinal Epithelial γδ T Cells
Groh, V., Steinle, A., Bauer, S., & Spies, T. A. (1998) · Science · doi:10.1126/science.279.5357.1737 · Cited by 1,142 · see citing works
Kinetics of dendritic cell activation: impact on priming of TH1, TH2 and nonpolarized T cells
Langenkamp, A., Messi, M., Lanzavecchia, A., & Sallusto, F. (2000) · Nature Immunology · doi:10.1038/79758 · Cited by 1,140 · see citing works
Dendritic cell regulation of TH1-TH2 development
Moser, M., & MURPHY, K. M. M. (2000) · Nature Immunology · doi:10.1038/79734 · Cited by 1,106 · see citing works
Distinct dendritic cell subsets differentially regulate the class of immune response in vivo
Pulendran, B., Smith, J. L., Caspary, G., Brasel, K., Pettit, D., Maraskovsky, E., & Maliszewski, C. R. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.3.1036 · Cited by 993 · see citing works
Maldonado-López, R., Smedt, T. D., Michel, P., Godfroid, J., Pajak, B., Heirman, C., Thielemans, K., Léo, O., Urbain, J., & Moser, M. (1999) · The Journal of Experimental Medicine · doi:10.1084/jem.189.3.587 · Cited by 979 · see citing works
T-cell priming by type-1and type-2 polarized dendritic cells: the concept of a third signal
Kaliński, P., Hilkens, C. M. U., Wierenga, E. A., & Kapsenberg, M. L. (1999) · Immunology Today · doi:10.1016/s0167-5699(99)01547-9 · Cited by 933 · see citing works
Natural Interferon α/β–Producing Cells Link Innate and Adaptive Immunity
Kadowaki, N., Antonenko, S. V., Lau, J. Y., & Liu, Y.-J. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.192.2.219 · Cited by 847 · see citing works
Self-citationPlasmacytoid dendritic cells activated by influenza virus and CD40L drive a potent TH1 polarization
Cella, M., Facchetti, F., Lanzavecchia, A., & Colonna, M. (2000) · Nature Immunology · doi:10.1038/79747 · Cited by 790 · see citing works
Stimulation of Human γδ T Cells by Nonpeptidic Mycobacterial Ligands
Constant, P., Davodeau, F., Peyrat, M., Poquet, Y., Puzo, G., Bonneville, M., & Fournié, J. (1994) · Science · doi:10.1126/science.8146660 · Cited by 710 · see citing works
Ardavı́n, C., Wu, L., Li, C., & Shortman, K. (1993) · Nature · doi:10.1038/362761a0 · Cited by 657 · see citing works
Regulation of Toll-Like Receptors in Human Monocytes and Dendritic Cells
Visintin, A., Mazzoni, A., Spitzer, J. H., Wyllie, D. H., Dower, S., & Segal, D. M. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.1.249 · Cited by 611 · see citing works
Mechanism and Function of a Newly Identified CpG DNA Motif in Human Primary B Cells
Hartmann, G., & Krieg, A. M. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.164.2.944 · Cited by 605 · see citing works
Dendritic Cells Discriminate between Yeasts and Hyphae of the Fungus Candida albicans
d’Ostiani, C. F., Sero, G. D., Bacci, A., Montagnoli, C., Spreca, A., Mencacci, A., Ricciardi‐Castagnoli, P., & Romani, L. R. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.191.10.1661 · Cited by 492 · see citing works
Dendritic-cell function in Toll-like receptor- and MyD88-knockout mice
Kaisho, T., & Akira, S. (2001) · Trends in Immunology · doi:10.1016/s1471-4906(00)01811-1 · Cited by 369 · see citing works
Microbial Lipopeptides Stimulate Dendritic Cell Maturation Via Toll-Like Receptor 2
Hertz, C. J., Kiertscher, S. M., Godowski, P. J., Bouis, D. A., Norgard, M. V., Roth, M. D., & Modlin, R. L. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.4.2444 · Cited by 357 · see citing works
Whelan, M., Harnett, M. M., Houston, K. M., Patel, V., Harnett, W., & Rigley, K. P. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.164.12.6453 · Cited by 324 · see citing works
Spits, H., Couwenberg, F., Bakker, A. Q., Weijer, K. C., & Uíttenbogaart, C. H. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.192.12.1775 · Cited by 321 · see citing works
Bacterial CpG-DNA Triggers Activation and Maturation of Human CD11c−, CD123+ Dendritic Cells
Bauer, M., Redecke, V., Ellwart, J. W., Scherer, B., Kremer, J.-P., Wagner, H., & Lipford, G. B. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.8.5000 · Cited by 292 · see citing works
Lehner, M. D., Morath, S., Michelsen, K. S., Schumann, R. R., & Härtung, T. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.8.5161 · Cited by 284 · see citing works
Thoma-Uszynski, S., Kiertscher, S. M., Ochoa, M. T., Bouis, D. A., Norgard, M. V., Miyake, K., Godowski, P. J., Roth, M. D., & Modlin, R. L. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.165.7.3804 · Cited by 238 · see citing works
Dziarski, R., Wang, Q., Miyake, K., Kirschning, C. J., & Gupta, D. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.3.1938 · Cited by 212 · see citing works
Bendriss‐Vermare, N., Barthélémy, C., Durand, I., Bruand, C., Dezutter‐Dambuyant, C., Moulian, N., Berrih‐Aknin, S., Caux, C., Trinchieri, G., & Brière, F. (2001) · Journal of Clinical Investigation · doi:10.1172/jci11734 · Cited by 198 · see citing works
Wagner, H. (2001) · Immunity · doi:10.1016/s1074-7613(01)00144-3 · Cited by 181 · see citing works
CD1-restricted T-cell responses and microbial infection
Park, S.-H., & Bendelac, A. S. (2000) · Nature · doi:10.1038/35021233 · Cited by 124 · see citing works
CD19+ pro-B cells can give rise to dendritic cells in vitro.
Björck, P., & Kincade, P. W. (1998) · PubMed · Cited by 95 · see citing works
Yamamoto, T., Yamamoto, S., Kataoka, T., Komuro, K., Kohase, M., & Tokunaga, T. (1994) · Japanese Journal of Cancer Research · doi:10.1111/j.1349-7006.1994.tb02947.x · Cited by 85 · see citing works
Cutting Edge: CD19+ Pro-B Cells Can Give Rise to Dendritic Cells In Vitro
Björck, P., & Kincade, P. W. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.161.11.5795 · Cited by 83 · see citing works
T Cell Activation and Polarization by DC1 and DC2
Liu, Y. J., Kadowaki, N., Rissoan, M., & Soumelis, V. (2000) · Current topics in microbiology and immunology · doi:10.1007/978-3-642-57276-0_19 · Cited by 60 · see citing works
Self-citationModlin, R. L. (2000) · Nature · doi:10.1038/35047207 · Cited by 59 · see citing works
Phenotype of B cells responding to the thymus-independent type-2 antigen polyvinyl pyrrolidinone
Whitmore, A. C., Haughton, G., & Arnold, L. W. (1996) · International Immunology · doi:10.1093/intimm/8.4.533 · Cited by 23 · see citing works
Yoshimura, A., Lien, E., Ingalls, R., Tuomanen, E., Dziarski, R., & Golenbock, D. (1999) · Journal of Immunology · doi:10.4049/jimmunol.163.1.1 · Cited by 2 · see citing works
Flagged first, then by citations
1 of the 45 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Takeda, K., Kaisho, T., & Akira, S. (2003) · Annual Review of Immunology · doi:10.1146/annurev.immunol.21.120601.141126 · Cited by 6,143 · see citing works
Toll-like receptor control of the adaptive immune responses
Iwasaki, A., & Medzhitov, R. M. (2004) · Nature Immunology · doi:10.1038/ni1112 · Cited by 4,166 · see citing works
Interleukin-12 and the regulation of innate resistance and adaptive immunity
Trinchieri, G. (2003) · Nature reviews. Immunology · doi:10.1038/nri1001 · Cited by 3,933 · see citing works
Photodynamic therapy and anti-tumour immunity
Castaño, A. P., Mróz, P., & Hamblin, M. R. (2006) · Nature reviews. Cancer · doi:10.1038/nrc1894 · Cited by 2,685 · see citing works
CpG Motifs in Bacterial DNA and Their Immune Effects
Krieg, A. Μ. (2002) · Annual Review of Immunology · doi:10.1146/annurev.immunol.20.100301.064842 · Cited by 2,570 · see citing works
Small anti-viral compounds activate immune cells via the TLR7 MyD88–dependent signaling pathway
Hemmi, H., Kaisho, T., Takeuchi, O., Sato, S., Sanjo, H., Hoshino, K., Horiuchi, T., Tomizawa, H., Takeda, K., & Akira, S. (2002) · Nature Immunology · doi:10.1038/ni758 · Cited by 2,517 · see citing works
Mouse and human dendritic cell subtypes
Shortman, K., & Liu, Y.-J. (2002) · Nature reviews. Immunology · doi:10.1038/nri746 · Cited by 2,289 · see citing works
Self-citationVaccine Adjuvants: Putting Innate Immunity to Work
Coffman, R. L., Sher, A., & Seder, R. A. (2010) · Immunity · doi:10.1016/j.immuni.2010.10.002 · Cited by 1,927 · see citing works
Plasmacytoid dendritic cells sense self-DNA coupled with antimicrobial peptide
Lande, R., Gregorio, J., Facchinetti, V., Chatterjee, B., Wang, Y.-H., Homey, B., Cao, W., Wang, Y.-H., Su, B., Nestle, F. O., et al. (2007) · Nature · doi:10.1038/nature06116 · Cited by 1,910 · see citing works
Self-citationThe role of myeloid cells in the promotion of tumour angiogenesis
Murdoch, C., Muthana, M., Coffelt, S. B., & Lewis, C. E. (2008) · Nature Reviews Cancer · doi:10.1038/nrc2444 · Cited by 1,642 · see citing works
Collaborative Induction of Inflammatory Responses by Dectin-1 and Toll-like Receptor 2
Gantner, B. N., Simmons, R. M., Canavera, S. J., Akira, S., & Underhill, D. M. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20021787 · Cited by 1,644 · see citing works
IPC: Professional Type 1 Interferon-Producing Cells and Plasmacytoid Dendritic Cell Precursors
Liu, Y.-J. (2004) · Annual Review of Immunology · doi:10.1146/annurev.immunol.23.021704.115633 · Cited by 1,618 · see citing works
Self-citationT-cell quality in memory and protection: implications for vaccine design
Seder, R. A., Darrah, P. A., & Roederer, M. (2008) · Nature reviews. Immunology · doi:10.1038/nri2274 · Cited by 1,541 · see citing works
Inflammatory and immune pathways in the pathogenesis of periodontal disease
Cekici, A., Kantarci, A., Hasturk, H., & Van Dyke, T. E. (2014) · Periodontology 2000 · doi:10.1111/prd.12002 · Cited by 1,415 · see citing works
Dendritic-cell control of pathogen-driven T-cell polarization
Kapsenberg, M. L. (2003) · Nature reviews. Immunology · doi:10.1038/nri1246 · Cited by 1,440 · see citing works
Key roles of adjuvants in modern vaccines
Reed, S. G., Orr, M. T., & Fox, C. B. (2013) · Nature Medicine · doi:10.1038/nm.3409 · Cited by 1,435 · see citing works
TLR9 signals after translocating from the ER to CpG DNA in the lysosome
Latz, E., Schoenemeyer, A., Visintin, A., Fitzgerald, K. A., Monks, B. G., Knetter, C. F., Lien, E., Nilsen, N. J., Espevik, T., & Golenbock, D. T. (2004) · Nature Immunology · doi:10.1038/ni1028 · Cited by 1,355 · see citing works
Human CD14dim Monocytes Patrol and Sense Nucleic Acids and Viruses via TLR7 and TLR8 Receptors
Cros, J. F., Cagnard, N., Woollard, K. J., Patey, N., Zhang, S., Sénéchal, B., Puel, A., Biswas, S. K., Moshous, D., Pïcard, C., et al. (2010) · Immunity · doi:10.1016/j.immuni.2010.08.012 · Cited by 1,251 · see citing works
Sequence-dependent stimulation of the mammalian innate immune response by synthetic siRNA
Judge, A. D., Sood, V., Shaw, J. R., Fang, D., McClintock, K., & MacLachlan, I. (2005) · Nature Biotechnology · doi:10.1038/nbt1081 · Cited by 1,250 · see citing works
Oshiumi, H., Matsumoto, M., Funami, K., Akazawa, T., & Seya, T. (2003) · Nature Immunology · doi:10.1038/ni886 · Cited by 1,208 · see citing works
Dendritic cells as therapeutic vaccines against cancer
Banchereau, J., & Palucka, A. K. (2005) · Nature reviews. Immunology · doi:10.1038/nri1592 · Cited by 1,195 · see citing works
TNF/iNOS-Producing Dendritic Cells Mediate Innate Immune Defense against Bacterial Infection
Serbina, N. V., Salazar‐Mather, T. P., Biron, C. A., Kuziel, W. A., & Pamer, E. G. (2003) · Immunity · doi:10.1016/s1074-7613(03)00171-7 · Cited by 1,174 · see citing works
Avoiding horror autotoxicus: The importance of dendritic cells in peripheral T cell tolerance
Steinman, R., & Nussenzweig, M. (2002) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.231606698 · Cited by 1,278 · see citing works
Napolitani, G., Rinaldi, A., Bertoni, F., Sallusto, F., & Lanzavecchia, A. (2005) · Nature Immunology · doi:10.1038/ni1223 · Cited by 1,156 · see citing works
Plasmacytoid dendritic cells: sensing nucleic acids in viral infection and autoimmune diseases
Gilliet, M., Cao, W., & Liu, Y.-J. (2008) · Nature Reviews Immunology · doi:10.1038/nri2358 · Cited by 1,190 · see citing works
Self-citationPlasmacytoid predendritic cells initiate psoriasis through interferon-α production
Nestle, F. O., Conrad, C., Tun-Kyi, A., Homey, B., Gombert, M., Boyman, O., Burg, G., Liu, Y.-J., & Gilliet, M. F. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20050500 · Cited by 1,126 · see citing works
Self-citationToll-like receptors in systemic autoimmune disease
Marshak-Rothstein, A. (2006) · Nature Reviews Immunology · doi:10.1038/nri1957 · Cited by 1,116 · see citing works
Mycobacteria Target DC-SIGN to Suppress Dendritic Cell Function
Geijtenbeek, T. B. H., van Vliet, S. J., Koppel, E. A., Sánchez‐Hernández, M., Vandenbroucke‐Grauls, C. M. J. E., Appelmelk, B. J., & van Kooyk, Y. (2002) · The Journal of Experimental Medicine · doi:10.1084/jem.20021229 · Cited by 1,058 · see citing works
mRNA is an endogenous ligand for toll-like receptor 3
Karikó, K., Ni, H., Capodici, J., Lamphier, M., & Weissman, D. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m310175200 · Cited by 1,062 · see citing works
Jongbloed, S. L., Kassianos, A. J., McDonald, K. J., Clark, G. J., Ju, X., Angel, C. E., Chen, C. J., Dunbar, P. R., Wadley, R. B., Jeet, V., et al. (2010) · The Journal of Experimental Medicine · doi:10.1084/jem.20092140 · Cited by 1,019 · see citing works
Mouse type I IFN-producing cells are immature APCs with plasmacytoid morphology
Asselin‐Paturel, C., Boonstra, A., Dalod, M., Durand, I., Yessaad, N., Dezutter‐Dambuyant, C., Vicari, A. P., O’Garra, A., Biron, C. A., Brière, F., et al. (2001) · Nature Immunology · doi:10.1038/ni736 · Cited by 1,021 · see citing works
Immunotherapeutic uses of CpG oligodeoxynucleotides
Klinman, D. M. (2004) · Nature reviews. Immunology · doi:10.1038/nri1329 · Cited by 1,007 · see citing works
Toll-Like Receptor Signaling and Its Role in Cell-Mediated Immunity
Duan, T., Du, Y., Xing, C., Wang, H. Y., & Wang, R. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.812774 · Cited by 990 · see citing works
DC-SIGN: escape mechanism for pathogens
van Kooyk, Y., & Geijtenbeek, T. B. H. (2003) · Nature reviews. Immunology · doi:10.1038/nri1182 · Cited by 930 · see citing works
Microbiota: a key orchestrator of cancer therapy
Roy, S., & Trinchieri, G. (2017) · Nature Reviews Cancer · doi:10.1038/nrc.2017.13 · Cited by 883 · see citing works
Tolerogenic dendritic cells and the quest for transplant tolerance
Morelli, A. E., & Thomson, A. W. (2007) · Nature reviews. Immunology · doi:10.1038/nri2132 · Cited by 898 · see citing works
Bode, C., Zhao, G., Steinhagen, F., Kinjo, T., & Klinman, D. M. (2011) · Expert Review of Vaccines · doi:10.1586/erv.10.174 · Cited by 895 · see citing works
Human lupus autoantibody–DNA complexes activate DCs through cooperation of CD32 and TLR9
Means, T. K., Latz, E., Hayashi, F., Murali, M. R., Golenbock, D. T., & Luster, A. D. (2005) · Journal of Clinical Investigation · doi:10.1172/jci23025 · Cited by 849 · see citing works
Toll-like receptors in the pathogenesis of human disease
Cook, D. N., Pisetsky, D. S., & Schwartz, D. A. (2004) · Nature Immunology · doi:10.1038/ni1116 · Cited by 827 · see citing works
Impact of Protein Kinase PKR in Cell Biology: from Antiviral to Antiproliferative Action
García, M. A., Gil, J., Ventoso, I., Guerra, S., Domingo, E., Rivas, C., & Esteban, M. (2006) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00027-06 · Cited by 818 · see citing works
Immune surveillance in the skin: mechanisms and clinical consequences
Kupper, T. S., & Fuhlbrigge, R. C. (2004) · Nature reviews. Immunology · doi:10.1038/nri1310 · Cited by 805 · see citing works
Paludan, S. R., & Bowie, A. (2013) · Immunity · doi:10.1016/j.immuni.2013.05.004 · Cited by 764 · see citing works
Self-RNA–antimicrobial peptide complexes activate human dendritic cells through TLR7 and TLR8
Ganguly, D., Chamilos, G., Lande, R., Gregorio, J. D., Meller, S., Facchinetti, V., Homey, B., Barrat, F. J., Żal, T., & Gilliet, M. F. (2009) · The Journal of Experimental Medicine · doi:10.1084/jem.20090480 · Cited by 742 · see citing works
Toll-Like Receptors in Antiviral Innate Immunity
Lester, S. N., & Li, K. (2013) · Journal of Molecular Biology · doi:10.1016/j.jmb.2013.11.024 · Cited by 736 · see citing works
Cross‐presentation, dendritic cell subsets, and the generation of immunity to cellular antigens
Heath, W. R., Belz, G., Behrens, G., Smith, C. M., Forehan, S., Parish, I., Davey, G. M., Wilson, N., Carbone, F., & Villadangos, J. (2004) · Immunological Reviews · doi:10.1111/j.0105-2896.2004.00142.x · Cited by 834 · see citing works
Krug, A., French, A. R., Barchet, W., Fischer, J. A. A., Dzionek, A., Pingel, J. T., Orihuela, M. M., Akira, S., Yokoyama, W. M., & Colonna, M. (2004) · Immunity · doi:10.1016/j.immuni.2004.06.007 · Cited by 727 · see citing works
Subcellular Localization of Toll-Like Receptor 3 in Human Dendritic Cells
Matsumoto, M., Funami, K., Tanabe, M., Oshiumi, H., Shingai, M., Seto, Y., Yamamoto, A., & Seya, T. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.171.6.3154 · Cited by 708 · see citing works
Krug, A., Luker, G. D., Barchet, W., Leib, D. A., Akira, S., & Colonna, M. (2003) · Blood · doi:10.1182/blood-2003-08-2674 · Cited by 696 · see citing works
Synthetic TLR Agonists Reveal Functional Differences between Human TLR7 and TLR8
Gorden, K. B., Gorski, K. S., Gibson, S. J., Kedl, R. M., Kieper, W. C., Qiu, X., Tomai, M. A., Alkan, Ş. Ş., & Vasilakos, J. P. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.3.1259 · Cited by 690 · see citing works
TLR3: Interferon induction by double-stranded RNA including poly(I:C)☆
MATSUMOTO, M., & Seya, T. (2008) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2007.11.005 · Cited by 690 · see citing works
Beignon, A. (2005) · Journal of Clinical Investigation · doi:10.1172/jci26032 · Cited by 674 · see citing works
Bernasconi, N. L., Onai, N., & Lanzavecchia, A. (2003) · Blood · doi:10.1182/blood-2002-11-3569 · Cited by 664 · see citing works
The airway epithelium: soldier in the fight against respiratory viruses
Vareille, M., Kieninger, E., Edwards, M. R., & Regamey, N. (2011) · Clinical Microbiology Reviews · doi:10.1128/cmr.00014-10 · Cited by 655 · see citing works
The CD8+ Dendritic Cell Subset Selectively Endocytoses Dying Cells in Culture and In Vivo
Iyoda, T., Shimoyama, S., Liu, K., Omatsu, Y., Akiyama, Y., Maeda, Y., Takahara, K., Steinman, R. M., & Inaba, K. (2002) · The Journal of Experimental Medicine · doi:10.1084/jem.20020161 · Cited by 647 · see citing works
Ito, T., Yang, M., Wang, Y.-H., Lande, R., Gregorio, J. D., Perng, O. A., Qin, X.-F. F., Liu, Y.-J., & Gilliet, M. (2007) · Journal of Experimental Medicine · doi:10.1084/jem.20061660 · Cited by 686 · see citing works
Self-citationLotze, M. T., Zeh, H. J., Rubartelli, A., Sparvero, L. J., Amoscato, A. A., Washburn, N. R., DeVera, M., Liang, X., Tör, M., & Billiar, T. R. (2007) · Immunological Reviews · doi:10.1111/j.1600-065x.2007.00579.x · Cited by 634 · see citing works
Speiser, D. E., Líénard, D., Rufer, N., Rubio‐Godoy, V., Rimoldi, D., Lejeune, F. J., Krieg, A. Μ., Cerottini, J., & Romero, P. J. (2005) · Journal of Clinical Investigation · doi:10.1172/jci23373 · Cited by 637 · see citing works
Moseman, E. A., Liang, X., Dawson, A. J., Panoskaltsis‐Mortari, A., Krieg, A. Μ., Liu, Y., Blazar, B. R., & Chen, W. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.173.7.4433 · Cited by 636 · see citing works
Self-citationBalázs, M., Martin, F., Zhou, T., & Kearney, J. F. (2002) · Immunity · doi:10.1016/s1074-7613(02)00389-8 · Cited by 624 · see citing works
A Novel Host-Parasite Lipid Cross-talk
van der Kleij, D., Latz, E., Brouwers, J. F. H. M., Kruize, Y. C. M., Schmitz, M., Kurt-Jones, E. A., Espevik, T., de Jong, E. C., Kapsenberg, M. L., Golenbock, D. T., et al. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m206941200 · Cited by 587 · see citing works
Nucleic acid recognition by the innate immune system
Barbalat, R., Ewald, S. E., Mouchess, M. L., & Barton, G. M. (2011) · Annual Review of Immunology · doi:10.1146/annurev-immunol-031210-101340 · Cited by 577 · see citing works
Akira, S. (2003) · Current Opinion in Immunology · doi:10.1016/s0952-7915(02)00013-4 · Cited by 585 · see citing works
Role of Toll-Like Receptors in Pathogen Recognition
Janssens, S., & Beyaert, R. (2003) · Clinical Microbiology Reviews · doi:10.1128/cmr.16.4.637-646.2003 · Cited by 575 · see citing works
Dendritic cells and cytokines in human inflammatory and autoimmune diseases
Blanco, P., Palucka, K., Pascual, V., & Banchereau, J. (2008) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2007.10.004 · Cited by 569 · see citing works
Characteristics of Intestinal Dendritic Cells in Inflammatory Bowel Diseases
Hart, A. L., Al-Hassi, H. O., Rigby, R. J., Bell, S., Emmanuel, A. V., Knight, S. C., Kamm, M. A., & Stagg, A. J. (2005) · Gastroenterology · doi:10.1053/j.gastro.2005.05.013 · Cited by 562 · see citing works
Modulation of human dendritic cell phenotype and function by probiotic bacteria
Hart, A. L., Lammers, K., Brigidi, P., Vitali, B., Rizzello, F., Gionchetti, P., Campieri, M., Kamm, M. A., Knight, S. C., & Stagg, A. J. (2004) · Gut · doi:10.1136/gut.2003.037325 · Cited by 555 · see citing works
Close encounters of different kinds: Dendritic cells and NK cells take centre stage
Degli‐Esposti, M. A., & Smyth, M. J. (2005) · Nature reviews. Immunology · doi:10.1038/nri1549 · Cited by 549 · see citing works
Edwards, A. D., Diebold, S. S., Slack, E. M. C., Tomizawa, H., Hemmi, H., Kaisho, T., Akira, S., & Sousa, C. R. E. (2003) · European Journal of Immunology · doi:10.1002/eji.200323797 · Cited by 550 · see citing works
Boonstra, A., Asselin‐Paturel, C., Gilliet, M. F., Crain, C., Trinchieri, G., Liu, Y.-J., & O’Garra, A. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20021908 · Cited by 549 · see citing works
Self-citationAntigen-presentation properties of plasmacytoid dendritic cells.
Villadangos, J., & Young, L. J. (2008) · Immunity · doi:10.1016/j.immuni.2008.09.002 · Cited by 577 · see citing works
Gilliet, M. F., Boonstra, A., Paturel, C., Antonenko, S. V., Xu, X.-L., Trinchieri, G., O’Garra, A., & Liu, Y. (2002) · The Journal of Experimental Medicine · doi:10.1084/jem.20020045 · Cited by 524 · see citing works
Self-citationUccellini, M. B., Broughton, C., Mackay, F., Akira, S., Marshak‐Rothstein, A., & Rifkin, I. R. (2004) · The Journal of Experimental Medicine · doi:10.1084/jem.20031942 · Cited by 519 · see citing works
Vollmer, J., Tluk, S., Schmitz, C., Hamm, S., Jurk, M., Forsbach, A., Akira, S., Kelly, K. M., Reeves, W. H., Bauer, S., et al. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20051696 · Cited by 515 · see citing works
An immune clock of human pregnancy
Aghaeepour, N., Ganio, E. A., McIlwain, D. R., Tsai, A. S., Tingle, M. S., Gassen, S. V., Gaudilliere, D. K., Baca, Q. J., McNeil, L. S., Okada, R. L., et al. (2017) · Science Immunology · doi:10.1126/sciimmunol.aan2946 · Cited by 515 · see citing works
Self- and nonself-recognition by C-type lectins on dendritic cells
Geijtenbeek, T. B. H., van Vliet, S. J., Engering, A., 't Hart, B. A., & van Kooyk, Y. (2004) · Annual Review of Immunology · doi:10.1146/annurev.immunol.22.012703.104558 · Cited by 503 · see citing works
Toll-like receptors as adjuvant receptors
Kaisho, T., & Akira, S. (2002) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/s0167-4889(01)00182-3 · Cited by 493 · see citing works
Coccia, E. M., Severa, M., Giacomini, E., Monneron, D., Remoli, M. E., Julkunen, I., Cella, M., Lande, R., & Uzé, G. (2004) · European Journal of Immunology · doi:10.1002/eji.200324610 · Cited by 489 · see citing works
Human Keratinocytes Express Functional Toll-Like Receptor 3, 4, 5, and 9
Lebre, M. C., van der Aar, A. M. G., van Baarsen, L. G. M., van Capel, T. M. M., Schuitemaker, J. H. N., Kapsenberg, M. L., & de Jong, E. C. (2006) · Journal of Investigative Dermatology · doi:10.1038/sj.jid.5700530 · Cited by 485 · see citing works
(2003) · PubMed · Cited by 477 · see citing works
Lindsay, J. O. (2006) · Gut · doi:10.1136/gut.2005.074971 · Cited by 471 · see citing works
Chemokine up-regulation in SARS-coronavirus–infected, monocyte-derived human dendritic cells
Law, H., Cheung, C. Y., Ng, H. Y., Sia, S. F., Chan, Y. O., Luk, W., Nicholls, J. M., Peiris, M. J. S., & Lau, Y. (2005) · Blood · doi:10.1182/blood-2004-10-4166 · Cited by 467 · see citing works
Ito, T., Amakawa, R., Kaisho, T., Hemmi, H., Tajima, K., Uehira, K., Ozaki, Y., Tomizawa, H., Akira, S., & Fukuhara, S. (2002) · The Journal of Experimental Medicine · doi:10.1084/jem.20020207 · Cited by 464 · see citing works
Barbalat, R., Lau, L., Locksley, R. M., & Barton, G. M. (2009) · Nature Immunology · doi:10.1038/ni.1792 · Cited by 453 · see citing works
The microglial "activation" continuum: from innate to adaptive responses
Town, T., Nikolic, V., & Tan, J. (2005) · Journal of Neuroinflammation · doi:10.1186/1742-2094-2-24 · Cited by 456 · see citing works
Induction and Regulation of IFNs During Viral Infections
Malmgaard, L. (2004) · Journal of Interferon & Cytokine Research · doi:10.1089/1079990041689665 · Cited by 455 · see citing works
Chen, W., Liang, X., Peterson, A. J., Munn, D. H., & Blazar, B. R. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.8.5396 · Cited by 453 · see citing works
Sivori, S., Falco, M., Chiesa, M. D., Carlomagno, S., Vitale, M., Moretta, L., & Moretta, A. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0403744101 · Cited by 451 · see citing works
Robbins, M., Judge, A. D., & MacLachlan, I. (2009) · Oligonucleotides · doi:10.1089/oli.2009.0180 · Cited by 453 · see citing works
Toll-Like Receptor Signaling Inhibits Hepatitis B Virus Replication In Vivo
Isogawa, M., Robek, M. D., Furuichi, Y., & Chisari, F. V. (2005) · Journal of Virology · doi:10.1128/jvi.79.11.7269-7272.2005 · Cited by 443 · see citing works
TLR-Activated B Cells Suppress T Cell-Mediated Autoimmunity
Lampropoulou, V., Hoehlig, K., Roch, T., Neves, P., Gómez, E. C., Sweenie, C. H., Hao, Y., Freitas, A. A., Steinhoff, U., Anderton, S. M., et al. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.7.4763 · Cited by 436 · see citing works
“Similarly, distinct DC subsets express different repertoires of TLR (66, 67).”
BackgroundHasan, U. A., Chaffois, C., Gaillard, C., Saulnier, V., Merck, E., Tancredi, S., Guiet, C., Brière, F., Vlach, J., Lebecque, S., et al. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.5.2942 · Cited by 435 · see citing works
Dendritic cell subsets in health and disease
Ueno, H., Klechevsky, E., Morita, R., Aspord, C., Cao, T., Matsui, T., Pucchio, T. D., Connolly, J., Fay, J. W., Pascual, V., et al. (2007) · Immunological Reviews · doi:10.1111/j.1600-065x.2007.00551.x · Cited by 431 · see citing works
RIG-I and Other RNA Sensors in Antiviral Immunity
Chow, K. T., Gale, M., & Loo, Y. (2018) · Annual Review of Immunology · doi:10.1146/annurev-immunol-042617-053309 · Cited by 429 · see citing works
Penna, G., Roncari, A., Amuchastegui, S., Daniel, K. C., Berti, E., Colonna, M., & Adorini, L. (2005) · Blood · doi:10.1182/blood-2005-05-2044 · Cited by 412 · see citing works
Means, T. K., Hayashi, F., Smith, K. D., Aderem, A. A., & Luster, A. D. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.170.10.5165 · Cited by 411 · see citing works
FRANCHIMONT, D. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1321.009 · Cited by 408 · see citing works
The interferon regulatory factor, IRF5, is a central mediator of toll-like receptor 7 signaling
Schoenemeyer, A., Barnes, B. J., Mancl, M. E., Latz, E., Goutagny, N., Pitha, P. M., Fitzgerald, K. A., & Golenbock, D. T. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m412584200 · Cited by 411 · see citing works
Gilliet, M. F., Conrad, C., Geiges, M. L., Cozzio, A., Thürlimann, W., Burg, G., Nestle, F. O., & Dummer, R. (2004) · Archives of Dermatology · doi:10.1001/archderm.140.12.1490 · Cited by 406 · see citing works
X-linked recessive TLR7 deficiency in ~1% of men under 60 years old with life-threatening COVID-19
Asano, T., Boisson, B., Onodi, F., Matuozzo, D., Moncada‐Vélez, M., Renkilaraj, M. R. L. M., Zhang, P., Meertens, L., Bolze, A., Materna, M., et al. (2021) · Science Immunology · doi:10.1126/sciimmunol.abl4348 · Cited by 406 · see citing works
TLR activation triggers the rapid differentiation of monocytes into macrophages and dendritic cells
Krutzik, S. R., Tan, B. H., Li, H., Ochoa, M. T., Liu, P. T., Sharfstein, S. E., Graeber, T. G., Sieling, P. A., Liu, Y.-J., Rea, T. H., et al. (2005) · Nature Medicine · doi:10.1038/nm1246 · Cited by 404 · see citing works
Self-citation
- Authors
- Kadowaki, N., Ho, S., Antonenko, S., de Waal Malefyt, R., Kastelein, R. A., Bazan, F., & Liu, Y.-J.
- Affiliations
- aDNAX Research Institute of Molecular and Cellular Biology, Palo Alto, CA 94304
- Venue
- The Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 2001-09-17
- Volume
- 194
- Issue
- 6
- Pages
- 863-870
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- PMC
- PMC2195968
- OpenAlex
- W2104904748
- Cited by
- 1,964
- References
- 45
- Citations by year
- 2026: 10 · 2025: 12 · 2024: 16 · 2023: 16 · 2022: 27 · 2021: 37 · 2020: 39 · 2019: 38 · 2018: 28 · 2017: 62 · 2016: 52 · 2015: 56 · 2014: 86 · 2013: 90 · 2012: 95
- FWCI
- 40.14
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The Journal of Experimental Medicine (publishedVersion)
- PubMed Central (publishedVersion, cc-by-nc-sa)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
- Keywords
- Toll-like receptors, dendritic cell precursors, plasmacytoid dendritic cells, monocytes, TLR2, TLR4, TLR7, TLR9, peptidoglycan, lipoteichoic acid, lipopolysaccharide, CpG oligodeoxynucleotides, poly(I:C), TNF-α, interleukin-6, interferon-alpha, IL-12, dendritic cell development
- MeSH terms
- Dendritic Cells, Hematopoietic Stem Cells, Humans, Lipopolysaccharides, Membrane Glycoproteins, Monocytes, Oligodeoxyribonucleotides, Receptors, Cell Surface, Staphylococcus aureus, Biomarkers, Gene Expression, Cytokines, Drosophila Proteins, Toll-Like Receptors, Toll-Like Receptor 1, Toll-Like Receptor 2, Toll-Like Receptor 4, Toll-Like Receptor 7, Toll-Like Receptor 9
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review