Highly diversified innate receptor systems and new forms of animal immunity
Abstract
Detailed understanding of animal immunity derives almost entirely from investigations of vertebrates, with a smaller, but significant, contribution from studies in fruit flies. This limited phylogenetic scope has artificially polarized the larger view of animal immunity toward the complex adaptive immune systems of vertebrates on the one hand and systems driven by relatively small, stable families of innate receptors of insects on the other. In the past few years analyses of a series of invertebrate deuterostome genome sequences, including those from echinoderms and cephalochordates, sharply modify this view. These findings have far-reaching implications for characterizing the potential range of animal immunity and for inferring the evolutionary pathway that led to vertebrate immune systems.
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The immune cells of sea urchins, lampreys, and amniotes use entirely different receptor proteins, but their deployment is controlled by homologous regulatory states in all three cases.
“For example, the immune cells of sea urchins, lampreys, and amniotes use entirely different receptor proteins, but their deployment is controlled by homologous regulatory states in all three cases (18 -20).”
From Transphyletic conservation of developmental regulatory state in animal evolution (2011) · cites this paper as [20]
Cites
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Evolution of Gene Regulatory Networks Controlling Body Plan Development
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Transphyletic conservation of developmental regulatory state in animal evolution
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Buckley, K. M., Ho, E. C. H., Hibino, T., Schrankel, C. S., Schuh, N. W., Wang, G., & Rast, J. P. (2017) · eLife · doi:10.7554/elife.23481 · Cited by 77 · see citing works
- Authors
- Messier-Solek, C., Buckley, K. M., & Rast, J. P.
- Affiliations
- Sunnybrook Health Science Centre (CA)
- Corresponding author
- Rast, Jonathan P.
- Venue
- Seminars in Immunology
- Publisher
- Elsevier BV
- Published
- 2010-02
- Volume
- 22
- Issue
- 1
- Pages
- 39-47
- ISSN
- 1044-5323 (ISSN-L)
- OpenAlex
- W2036334370
- Cited by
- 87
- References
- 5
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 3 · 2023: 2 · 2022: 2 · 2021: 15 · 2020: 2 · 2018: 3 · 2017: 5 · 2016: 3 · 2015: 4 · 2014: 10 · 2013: 7 · 2012: 14
- FWCI
- 0.73
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Seminars in Immunology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Canadian Institutes of Health Research (MOP74667)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Invertebrate Immune Response Mechanisms
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Keywords
- innate immunity, invertebrate immunity, deuterostomes, Echinodermata, cephalochordates, immune system evolution, genome analysis, animal immunity
- MeSH terms
- Animals, Humans, Immunity, Innate, Phylogeny, Receptors, Immunologic, Evolution, Molecular, Adaptive Immunity
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