The DOI matches its Crossref record; 103 of the 103 references it cites were found in a registry or an index.
IL-7 signaling and CD127 receptor regulation in the control of T cell homeostasis
Open accessAbstract
Summary After their development in the thymus, mature T cells are maintained in the periphery by two sets of survival signals, namely TCR signals from contact with self-peptide/MHC ligands and the cytokine receptor signals from binding IL-7 and IL-15. These signals cooperate to maximize the utility of finite resources to support a diverse pool of mature T cells. It is becoming increasingly clear that multiple mechanisms exist to regulate expression of IL-7R at the transcriptional and post-translational levels. The interplay between TCR signals and IL-7R signals are also important in regulation of IL-7R expression. This review will focus on regulation of T cell homeostasis by IL-7R signaling, with an emphasis on the cross talk between signals from TCR and IL-7R.
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“During viral infection, the memory-precursor effector cells (MPEC; CD127hi KLRG1lo) regain CD127 expression, as opposed to the short-lived effector cells (SLEC; CD127lo KLRG1hi) [75], thereby making CD127 a marker for memory precursor CD8 T cells.”
BackgroundSelf-citationA function for interleukin 2 in Foxp3-expressing regulatory T cells
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Interleukin-7 mediates the homeostasis of naïve and memory CD8 T cells in vivo
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Early lymphocyte expansion is severely impaired in interleukin 7 receptor-deficient mice.
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Homeostasis of Naive and Memory T Cells
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Self-citationNew insights into the regulation of T cells by γc family cytokines
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IL-7 is critical for homeostatic proliferation and survival of naïve T cells
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Self-citationImpaired B and T Cell Antigen Receptor Signaling in p110δ PI 3-Kinase Mutant Mice
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Fibroblastic reticular cells in lymph nodes regulate the homeostasis of naive T cells
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Cited by
Hirayama, A. V., Gauthier, J., Hay, K. A., Voutsinas, J. M., Wu, Q., Gooley, T., Li, D., Cherian, S., Chen, X., Pender, B. S., et al. (2019) · Blood · doi:10.1182/blood-2018-11-887067 · Cited by 355
Epithelial–immune cell interplay in primary Sjögren syndrome salivary gland pathogenesis
Verstappen, G. M., Pringle, S., Bootsma, H., & Kroese, F. G. M. (2021) · Nature Reviews Rheumatology · doi:10.1038/s41584-021-00605-2 · Cited by 298
Deletion of Nemo-like Kinase in T Cells Reduces Single-Positive CD8+ Thymocyte Population
Daams, R., Sime, W., Leandersson, K., Sitnicka, E., & Massoumi, R. (2020) · The Journal of Immunology · doi:10.4049/jimmunol.2000109 · Cited by 7
Metadata
- Authors
- Carrette, F., & Surh, C. D.
- Venue
- Seminars in Immunology
- Publisher
- Elsevier BV
- Published
- 2012-06
- Volume
- 24
- Issue
- 3
- Pages
- 209-217
- ISSN
- 1044-5323 (ISSN-L)
- OpenAlex
- W2002641565
- Cited by
- 254
- References
- 103
- FWCI
- 5.55
- Type
- journal article
- Language
- en
- Open access
- green
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