The DOI matches its Crossref record; 55 of the 55 references it cites were found in a registry or an index.
IL-7 is critical for homeostatic proliferation and survival of naïve T cells
Open accessAbstract
In T cell-deficient conditions, naïve T cells undergo spontaneous “homeostatic” proliferation in response to contact with self-MHC/peptide ligands. With the aid of an in vitro system, we show here that homeostatic proliferation is also cytokine-dependent. The cytokines IL-4, IL-7, and IL-15 enhanced homeostatic proliferation of naïve T cells in vitro. Of these cytokines, only IL-7 was found to be critical; thus, naïve T cells underwent homeostatic proliferation in IL-4−and IL-15−hosts but proliferated minimally in IL-7−hosts. In addition to homeostatic proliferation, the prolonged survival of naïve T cells requires IL-7. Thus, naïve T cells disappeared gradually over a 1-month period upon adoptive transfer into IL-7−hosts. These findings indicate that naïve T cells depend on IL-7 for survival and homeostatic proliferation.
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Cites
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Cited by
Bendall, S. C., Simonds, E. F., Qiu, P., Amir, E.-A. D., Krutzik, P. O., Finck, R., Bruggner, R. V., Melamed, R., Trejo, A., Ornatsky, O. I., et al. (2011) · Science · doi:10.1126/science.1198704 · Cited by 2,279
Effector and memory T-cell differentiation: implications for vaccine development
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Kaech, S. M., Tan, J. T., Wherry, E. J., Konieczny, B. T., Surh, C. D., & Ahmed, R. (2003) · Nature Immunology · doi:10.1038/ni1009 · Cited by 1,830
Self-citationMetabolic Regulation of T Lymphocytes
MacIver, N. J., Michalek, R. D., & Rathmell, J. C. (2013) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032712-095956 · Cited by 1,244
Immunoregulatory mechanisms of mesenchymal stem and stromal cells in inflammatory diseases
Shi, Y., Wang, Y., Li, Q., Liu, K., Hou, J., Shao, C., & Wang, Y. (2018) · Nature Reviews Nephrology · doi:10.1038/s41581-018-0023-5 · Cited by 1,223
Metadata
- Authors
- Tan, J. T., Dudl, E., LeRoy, E., Murray, R., Sprent, J., Weinberg, K. I., & Surh, C. D.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2001-07-10
- Volume
- 98
- Issue
- 15
- Pages
- 8732-8737
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1992031335
- Cited by
- 965
- References
- 55
- FWCI
- 13.65
- Type
- journal article
- Language
- en
- Open access
- green
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- Tan, J. T., Dudl, E., LeRoy, E., Murray, R., Sprent, J., Weinberg, K. I., & Surh, C. D. (2001). IL-7 is critical for homeostatic proliferation and survival of naïve T cells. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.161126098
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