The DOI matches its Crossref record; 235 of the 235 references it cites were found in a registry or an index.
Comorbidity of insomnia and depression
Abstract
During the last decade, several studies have shown that insomnia, rather than a symptom of depression, could be a medical condition on its own, showing high comorbidity with depression. Epidemiological research indicates that insomnia could lead to depression and/or that common causalities underlie the two disorders. Neurobiological and sleep EEG studies suggest that a heightened level of arousal may play a common role in both conditions and that signs of REM sleep disinhibition may appear in individuals prone to depression. The effects of antidepressant drugs on non-REM and REM sleep are discussed in relation to their use in insomnia comorbid with depression. Empirical treatment approaches are behavioral management of sleep combined with prescription of a sedative antidepressant alone, co-prescription of two antidepressants, or of an antidepressant with a hypnotic drug.
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“The strong association of depressive and insomnia symptoms is consistent with evidence supporting their high level of comorbidity [35, 62–65].”
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“Chronic insomnia has been associated with a number of negative health outcomes, including obesity and metabolic dysregulation [3,4], hypertension and increased risk of myocardial infarction [5,6], increased susceptibility to infections [7], and depression [8].”
BackgroundInsomnia and Daytime Sleepiness Are Risk Factors for Depressive Symptoms in the Elderly
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Metadata
- Authors
- Staner, L.
- Affiliations
- Centre hospitalier de Rouffach (FR)
- Corresponding author
- Staner, Luc
- Venue
- Sleep Medicine Reviews
- Publisher
- Elsevier BV
- Published
- 2010-02
- Volume
- 14
- Issue
- 1
- Pages
- 35-46
- ISSN
- 1087-0792 (ISSN-L)
- OpenAlex
- W2046148869
- Cited by
- 481
- References
- 235
- Citations by year
- 2026: 19 · 2025: 45 · 2024: 35 · 2023: 41 · 2022: 33 · 2021: 34 · 2020: 29 · 2019: 35 · 2018: 24 · 2017: 33 · 2016: 32 · 2015: 33 · 2014: 15 · 2013: 26 · 2012: 25
- FWCI
- 2.24
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Sleep Medicine Reviews (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Keywords
- insomnia, depression, comorbidities, sleep arousal, antidepressants, hypnotics, sleep EEG, neurobiology of depression
- MeSH terms
- Behavior Therapy, Combined Modality Therapy, Depressive Disorder, Electroencephalography, Humans, Hypnotics and Sedatives, Sleep Initiation and Maintenance Disorders, Sleep, REM, Comorbidity
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