Cited by 481Sleep and related disordersSleep and Wakefulness ResearchAnxiety, Depression, Psychometrics, Treatment, Cognitive Processes

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Comorbidity of insomnia and depression

Staner, Luc·2010·Sleep Medicine Reviews

DOI 10.1016/j.smrv.2009.09.003

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Abstract

During the last decade, several studies have shown that insomnia, rather than a symptom of depression, could be a medical condition on its own, showing high comorbidity with depression. Epidemiological research indicates that insomnia could lead to depression and/or that common causalities underlie the two disorders. Neurobiological and sleep EEG studies suggest that a heightened level of arousal may play a common role in both conditions and that signs of REM sleep disinhibition may appear in individuals prone to depression. The effects of antidepressant drugs on non-REM and REM sleep are discussed in relation to their use in insomnia comorbid with depression. Empirical treatment approaches are behavioral management of sleep combined with prescription of a sedative antidepressant alone, co-prescription of two antidepressants, or of an antidepressant with a hypnotic drug.

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Background
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See all 481

Authors: Staner, L.
Affiliations: Centre hospitalier de Rouffach (FR)
Corresponding author: Staner, Luc
Venue: Sleep Medicine Reviews
Publisher: Elsevier BV
Published: 2010-02
Volume: 14
Issue: 1
Pages: 35-46
ISSN: 1087-0792 (ISSN-L)
DOI: 10.1016/j.smrv.2009.09.003
OpenAlex: W2046148869
Cited by: 481
References: 235
Citations by year: 2026: 19 · 2025: 45 · 2024: 35 · 2023: 41 · 2022: 33 · 2021: 34 · 2020: 29 · 2019: 35 · 2018: 24 · 2017: 33 · 2016: 32 · 2015: 33 · 2014: 15 · 2013: 26 · 2012: 25
FWCI: 2.24
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Sleep Medicine Reviews (publishedVersion)
PubMed (publishedVersion)
Topics: Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
Keywords: insomnia, depression, comorbidities, sleep arousal, antidepressants, hypnotics, sleep EEG, neurobiology of depression
MeSH terms: Behavior Therapy, Combined Modality Therapy, Depressive Disorder, Electroencephalography, Humans, Hypnotics and Sedatives, Sleep Initiation and Maintenance Disorders, Sleep, REM, Comorbidity

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