The DOI matches its Crossref record; 224 of the 230 references it cites were found in a registry or an index.
REM sleep dysregulation in depression: State of the art
Abstract
Disturbances of sleep are typical for most depressed patients and belong to the core symptoms of the disorder. Since the 1960s polysomnographic sleep research has demonstrated that besides disturbances of sleep continuity, depression is associated with altered sleep architecture, i.e., a decrease in slow wave sleep (SWS) production and disturbed rapid eye movement (REM) sleep regulation. Shortened REM latency (i.e., the interval between sleep onset and the occurrence of the first REM period), increased REM sleep duration and increased REM density (i.e., the frequency of rapid eye movements per REM period) have been considered as biological markers of depression which might predict relapse and recurrence. High risk studies including healthy relatives of patients with depression demonstrate that REM sleep alterations may precede the clinical expression of depression and may thus be useful in identifying subjects at high risk for the illness. Several models have been developed to explain REM sleep abnormalities in depression, like the cholinergic-aminergic imbalance model or chronobiologically inspired theories, which are reviewed in this overview. Moreover, REM sleep alterations have been recently considered not only as biological "scars" but as true endophenotypes of depression. This review discusses the genetic, neurochemical and neurobiological factors that have been implicated to play a role in the complex relationships between REM sleep and depression. We hypothesize on the one hand that REM sleep dysregulation in depression may be linked to a genetic predisposition/vulnerability to develop the illness; on the other hand it is conceivable that REM sleep disinhibition in itself is a part of a maladaptive stress reaction with increased allostatic load. We also discuss whether the REM sleep changes in depression may contribute themselves to the development of central symptoms of depression such as cognitive distortions including negative self-esteem and the overnight consolidation of negatively toned emotional memories.
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In the citing paper
“Actually, the role of REM sleep in the mood regulation is somehow controversial since several studies found that this stage has a depressant effect (Palagini et al., 2013).”
From The Functional Role of Dreaming in Emotional Processes (2019) · cites this paper as Palagini et al., 2013
In the citing paper
“Depressed subjects also show reductions in slow wave (stage 3/4) sleep, increases in rapid eye movement (REM) sleep, including a shorter latency to REM initiation, a protraction of the REM sleep period, and increases in REM density (Palagini et al., 2013; Riemann et al., 2001; Tsuno et al., 2005).”
From The role of inflammation in core features of depression: Insights from paradigms using exogenously-induced inflammation. (2018) · cites this paper as Palagini et al., 2013
In the citing paper
“Depressed subjects also show reductions in slow wave (stage 3/4) sleep, increases in rapid eye movement (REM) sleep, including a shorter latency to REM initiation, a protraction of the REM sleep period, and increases in REM density (Palagini et al., 2013; Riemann et al., 2001; Tsuno et al., 2005).”
From The role of inflammation in core features of depression: Insights from paradigms using exogenously-induced inflammation. (2018) · cites this paper as Palagini et al., 2013
In the citing paper
“Depressed subjects also show reductions in slow wave (stage 3/4) sleep, increases in rapid eye movement (REM) sleep, including a shorter latency to REM initiation, a protraction of the REM sleep period, and increases in REM density (Palagini et al., 2013; Riemann et al., 2001; Tsuno et al., 2005).”
From The role of inflammation in core features of depression: Insights from paradigms using exogenously-induced inflammation. (2018) · cites this paper as Palagini et al., 2013
In the citing paper
“Depressed subjects also show reductions in slow wave (stage 3/4) sleep, increases in rapid eye movement (REM) sleep, including a shorter latency to REM initiation, a protraction of the REM sleep period, and increases in REM density (Palagini et al., 2013; Riemann et al., 2001; Tsuno et al., 2005).”
From The role of inflammation in core features of depression: Insights from paradigms using exogenously-induced inflammation. (2018) · cites this paper as Palagini et al., 2013
In the citing paper
“Depressed subjects also show reductions in slow wave (stage 3/4) sleep, increases in rapid eye movement (REM) sleep, including a shorter latency to REM initiation, a protraction of the REM sleep period, and increases in REM density (Palagini et al., 2013; Riemann et al., 2001; Tsuno et al., 2005).”
From The role of inflammation in core features of depression: Insights from paradigms using exogenously-induced inflammation. (2018) · cites this paper as Palagini et al., 2013
In the citing paper
“However, exogenously-induced inflammation using both endotoxin and IFN-α also led to a suppression of REM sleep (Mullington et al., 2000; Raison et al., 2010), which is the opposite of changes observed in depressed patients (Palagini et al., 2013; Riemann et al., 2001; Tsuno et al., 2005).”
From The role of inflammation in core features of depression: Insights from paradigms using exogenously-induced inflammation. (2018) · cites this paper as Palagini et al., 2013
In the citing paper
“and remediate one of the sleep problems influenced by inflammation (Palagini et al., 2013; Riemann et al., 2001)”
From The role of inflammation in core features of depression: Insights from paradigms using exogenously-induced inflammation. (2018) · cites this paper as Palagini et al., 2013
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Prodepressive effect induced by microinjections of MCH into the dorsal raphe
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“It has also been shown that MCH microinjected within the DRN increased, for at least 6 h, the time spent in REM sleep (Lagos et al., 2009), a behavioral disturbance observed in depressive patients (Palagini et al., 2013).”
InfluentialModulation of the Muscle Activity During Sleep in Cervical Dystonia
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“…of reuptake inhibitor antidepressants suppress REM sleep (increase REM sleep latency time and decrease REM sleep time), which is thought to be an important component of their therapeutic effect (Wilson and Argyropoulos, 2005; Palagini et al., 2013; Wichniak et al., 2017; Riemann et al., 2020).”
Liguori, C., Ferini‐Strambi, L., Izzi, F., Mari, L., Manfredi, N., D’Elia, A., Mercuri, N. B., & Placidi, F. (2018) · British Journal of Clinical Pharmacology · doi:10.1111/bcp.13772 · Cited by 29
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Chronobiology of Mood Disorders: The Role of the Biological Clock in Depression and Bipolar Disorder
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The truncated TrkB receptor influences mammalian sleep
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“, shorter bouts of total sleep and wake), similar to the reduced sleep continuity reported in major depressive disorders (40).”
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Relevance of deprivation studies in understanding rapid eye movement sleep
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“137 As it is difficult to experimentally induce the disorders and study their molecular mechanism of action, we often depend on animal and cellular models to understand the mechanism of action(s).”
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“We did not find differences in REM latency between MDD and other groups, which has been previously described in the literature [46, 47], which may affect the generalizability of findings.”
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“On the other hand, elevated NA in the brain ameliorates depressive symptoms (Moret and Briley, 2011; Palagini et al., 2013).”
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“A probable explanation for the high REM-latency compared to healthy controls is the fact, that most antidepressants increase REM-latency by up to 200% [52].”
BackgroundResultWhat can animal models tell us about depressive disorders?
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Altered sleep architecture during the first months of life in infants born to depressed mothers
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“The fact that most antidepressant drugs share this REM sleep suppressing effect (Palagini et al., 2012), insinuate that ibogaine might also have antidepressant properties as suggested by human reports (Mash et al., 2000).”
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A cluster of mesopontine GABAergic neurons suppresses REM sleep and curbs cataplexy
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“Modern polysomnographic sleep research has repeatedly found altered sleep structure associated with depression, such as decreases in slow wave sleep (SWS), and increases in the duration and intensity of rapid eye movement (REM) sleep (Palagini et al., 2013).”
BackgroundInfluentialSleep and the recovery from stress
Yu, X., Nollet, M., Franks, N. P., & Wisden, W. (2025) · Neuron · doi:10.1016/j.neuron.2025.04.028 · Cited by 28
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Association of Depressive Symptoms with Sleep Disturbance: A Co-twin Control Study
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Self-citationInteractions between Sleep and Emotions in Humans and Animal Models
Lefter, R. M., Cojocariu, R. O., Ciobica, A. S., Balmuș, I.-M., Mavroudis, I. A., & Kis, A. (2022) · Medicina · doi:10.3390/medicina58020274 · Cited by 25
“In the context of REM sleep impairment effects, REM sleep has also been correlated to depressive behaviors, with altered REM latency (shortened) and density (increased) being currently used as sleep physiology-related markers in depression diagnosis [25].”
BackgroundMethodTo sleep or not to sleep – Effects on memory in normal aging and disease
Kroeger, D., & Vetrivelan, R. (2023) · Aging Brain · doi:10.1016/j.nbas.2023.100068 · Cited by 28
“Individuals with depression exhibit a short REM latency (time to first REM sleep from sleep onset) and significantly higher REM sleep levels [183,184].”
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“…measures, our results converge with a wealth of findings showing reduced latency to and a greater proportion of REM sleep to correspond with depression as well as depression risk (Mendlewicz, Sevy, & De Maertelaer, 1989; Palagini et al., 2013; Riemann et al., 2001; Tsuno et al., 2005).”
BackgroundResultInfluentialSleep-Wake Control by Melanin-Concentrating Hormone (MCH) Neurons: a Review of Recent Findings
Bandaru, S. S., Khanday, M. A., Ibrahim, N., Naganuma, F., & Vetrivelan, R. (2020) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-020-01075-x · Cited by 25
Eye movement patterns correlate with overt emotional behaviours in rapid eye movement sleep
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“A strong association was reported between REM sleep dysregulation and the course of major depressive disorder [26].”
BackgroundEvening light environments can be designed to consolidate and increase the duration of REM-sleep
Vethe, D., Drews, H. J., Scott, J. L., Engstrøm, M., Heglum, H. S. A., Grønli, J., Wisor, J. P., Sand, T., Lydersen, S., Kjørstad, K., et al. (2022) · Scientific Reports · doi:10.1038/s41598-022-12408-w · Cited by 22
Sleep complaints in adolescent depression: one year naturalistic follow-up study
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“inhibiting REM sleep [53], and especially patients with reduced REM sleep latency may respond favourably to antidepressants [54].”
BackgroundSleep at baseline and after electroconvulsive therapy in patients with major depression
Göder, R., Hinrichsen, I., Seeck-Hirschner, M., Pfeiffer, R., Weinhold, S. L., Baier, P. C., Hanss, R., & Schulz-DuBois, C. (2016) · Psychiatry Research · doi:10.1016/j.psychres.2016.10.064 · Cited by 22
“In previous reviews characteristics of rapid eye movement (REM) sleep were suggested as biomarkers or endophenotypes of MDD (Gottesmann and Gottesman, 2007; Steiger and Kimura, 2010; Palagini et al., 2013).”
BackgroundInfluentialComparison of the macro and microstructure of sleep in a sample of sleep clinic hypersomnia cases
Cairns, A., & Bogan, R. (2019) · Neurobiology of Sleep and Circadian Rhythms · doi:10.1016/j.nbscr.2019.02.001 · Cited by 22
“Additionally, a subset of our snoring reference group (as well as our hypersomnia groups) had diagnosed depression, a condition that may endogenously alter REM tendency and amount (Palagini et al., 2013).”
BackgroundZhai, B., Guan, Y., Catt, M., & Plötz, T. (2021) · Proceedings of the ACM on Interactive Mobile Wearable and Ubiquitous Technologies · doi:10.1145/3494961 · Cited by 23
“For instance, reduced REM sleep latency, along with increased REM sleep duration and REM sleep density, have been considered to be an objective indicator of depressive disorder and inversely correlated to its severity [40, 68, 75].”
BackgroundMcCall, W. V., Rosenquist, P. B., & Miller, B. J. (2022) · Current Psychiatry Reports · doi:10.1007/s11920-022-01315-6 · Cited by 21
“The premise of state-trait markers has been entertained with other biomarkers in psychiatry, such as abnormal REM latencies during remission of depressive illness that become progressively more abnormal during a depressive relapse [84, 85].”
BackgroundMelatonin-related dysfunction in chronic restraint stress triggers sleep disorders in mice
Xia, T., Wang, Z., Jin, S.-W., Liu, X., Liu, Y., Zhang, S., Pan, R., Jiang, N., Liao, Y., Yan, M., et al. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1210393 · Cited by 22
“In addition, shortened REM latency has been considered a biological marker of depression in human (Palagini et al., 2013).”
BackgroundManosso, L. M., Duarte, L. A., Martinello, N. S., de Mathia, G. B., & Réus, G. Z. (2023) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/0118715273254093231020052002 · Cited by 25
New data on psychological traits and sleep profiles of patients affected by nocturnal eating
Vinai, P., Ferri, R., Anelli, M. M., Ferini‐Strambi, L., Zucconi, M., Oldani, A., & Manconi, M. (2015) · Sleep Medicine · doi:10.1016/j.sleep.2014.12.020 · Cited by 22
“We found, in NES patients, an interesting positive correlation between the scores on the BITE and sleep efficiency and a negative correlationwithWASO and REM sleep latency, which is a common feature of patients affected by depression [63].”
BackgroundSuppression-induced forgetting diminishes following a delay of either sleep or wake
Davidson, P., Hellerstedt, R., Jönsson, P., & Johansson, M. (2019) · Journal of Cognitive Psychology · doi:10.1080/20445911.2019.1705311 · Cited by 20
Vaidya, S. P., Guerin, A. A., Walker, L. C., & Lawrence, A. J. (2022) · CNS Drugs · doi:10.1007/s40263-022-00964-8 · Cited by 23
“It has been hypothesised that REM sleep alterations in depression aid in the progression of depressive symptoms, including cognitive distortions and negative self-esteem [65].”
BackgroundREM sleep and depressive symptoms in a population‐based study of middle‐aged and elderly persons
Luik, A. I., Zuurbier, L. A., Whitmore, H. R., Albert Hofman, D., & Tiemeier, H. W. (2015) · Journal of Sleep Research · doi:10.1111/jsr.12273 · Cited by 20
“Clinical research suggests that a decreased rapid eye movement (REM) sleep latency, increased REM sleep duration and increased REM density are prominent in persons with depressive disorders (Palagini et al., 2013).”
BackgroundÄmmälä, A., Urrila, A. S., Lahtinen, A., Santangeli, O., Hakkarainen, A., Kantojärvi, K., Castaneda, A. E., Lundbom, N. M. I., MARTTUNEN, M. J., & Paunio, T. (2019) · Sleep Medicine · doi:10.1016/j.sleep.2019.01.050 · Cited by 21
Davidson, P., & Pace-Schott, E. F. (2021) · Current Sleep Medicine Reports · doi:10.1007/s40675-020-00200-z · Cited by 22
Leitner, C., Piagge, F. D., Tomic, T., Nozza, F., Fasiello, E., Castronovo, V., Gennaro, L. D., Baglioni, C., Ferini‐Strambi, L., & Galbiati, A. (2025) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2025.102048 · Cited by 25
Self-citationSleep, Narcolepsy, and Sodium Oxybate
Mamelak, M. (2021) · Current Neuropharmacology · doi:10.2174/1570159x19666210407151227 · Cited by 19
“These observations suggest that clinical depression may be viewed as a stress-induced cholinergic supersensitivity state and that this sensitivity accounts for the short REM sleep latencies found in patients with depression [85, 146, 147].”
BackgroundMatsuda, Y., Ozawa, N., Shinozaki, T., Aoki, K., Nihonmatsu-Kikuchi, N., Shinba, T., & Tatebayashi, Y. (2021) · Scientific Reports · doi:10.1038/s41598-021-96094-0 · Cited by 23
Abeysekera, N. W. B. Y., & Zoysa, E. D. (2021) · BMC Geriatrics · doi:10.1186/s12877-021-02536-9 · Cited by 20
“Furthermore, some previous researches which was conducted in recent past revealed that accelerated agerelated changes in sleep architecture may be linked to depressed mood in older adults and symptoms of depression, fatigue, and insomnia were more severe in subjects with moderate-to extreme pain interference than in t…”
Li, M., Cui, J., Xu, B., Wei, Y., Fu, C., Lv, X., Xiong, L., & Qin, D. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.827541 · Cited by 23
Maski, K., Amos, L. B., Carter, J. C., Koch, E., Kazmi, U., & Rosen, C. L. (2023) · Journal of Clinical Sleep Medicine (JCSM) · doi:10.5664/jcsm.10974 · Cited by 15
BIOMARKERS IN PEDIATRIC DEPRESSION
Rao, U. (2013) · Depression and Anxiety · doi:10.1002/da.22171 · Cited by 18
“There are a number of reasons to consider the regulation of sleep as an essential component for understanding the pathophysiology and treatment of depression.[2, 6] There is a significant overlap in the control of sleep and mood regulation.”
BackgroundSchmidt, F. M., Nowak, C. N., Kratzsch, J., Sander, C., Hegerl, U., & Schönknecht, P. (2015) · Journal of Affective Disorders · doi:10.1016/j.jad.2015.03.039 · Cited by 19
“…to an impairment of sleep and wakefulness regulation frequently found in MDD, e.g. extended sleep latency, decreased rapid eye movement (REM) latency, increased total REM sleep, reduced total SWS (Palagini et al., 2013), and a hyperstable vigilance regulation during rest (Hegerl and Hensch, 2014).”
BackgroundInfluentialDisruption of sleep-wake continuum in myotonic dystrophy type 1: Beyond conventional sleep staging
Bonanni, E., Carnicelli, L., Crapanzano, D., Maestri, M., Simoncini, C., Baldanzi, S., Falorni, M., Garbarino, S., Mancuso, M., Bonuccelli, U., et al. (2018) · Neuromuscular Disorders · doi:10.1016/j.nmd.2018.02.004 · Cited by 20
Transcranial Magnetic Stimulation of the Medial Prefrontal Cortex Decreases Emotional Memory Schemas
Bovy, L., Berkers, R. M. W. J., Pottkämper, J. C. M., Varatheeswaran, R., Fernández, G., Tendolkar, I., & Dresler, M. (2019) · Cerebral Cortex · doi:10.1093/cercor/bhz329 · Cited by 19
“REM sleep disinhibition has been considered a biological marker of depression, which is substantiated by decreased REM latency, increased REM duration, and increased REM density (Palagini et al. 2013).”
BackgroundChrobok, A. I., Krause, D., Winter, C., Plörer, D., Martin, G., Koller, G., Adorjan, K., Canolli, M., Adam, R., Wagner, E. M., et al. (2020) · Journal of Psychoactive Drugs · doi:10.1080/02791072.2020.1751900 · Cited by 19
“In particular, mental disorders which often co-occur with substance use, like depression, also have high rates of sleep impairment (Palagini et al. 2013; Watson et al. 2014).”
BackgroundThe ‘affect tagging and consolidation’ (ATaC) model of depression vulnerability
Harrington, M. O., Pennington, K., & Durrant, S. J. (2017) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2017.02.003 · Cited by 19
“1; Luik et al., 2015; Nutt, Wilson, & Paterson, 2008; Palagini et al., 2013; Pillai et al., 2011; Schulz, Lund, Cording, & Dirlich, 1979).”
InfluentialYu, N., Song, H., Chu, G., Zhan, X., Liu, B., Mu, Y., Wang, J., & Lu, Y. (2022) · Neuroscience Bulletin · doi:10.1007/s12264-022-00962-2 · Cited by 20
“The basal forebrain cholinergic circuit plays an essential role in memory, cognitive flexibility, navigation, sleep, and appetite control [61–63], all of which can be dysregulated in patients suffering from depression [64, 65].”
BackgroundA REM-active basal ganglia circuit that regulates anxiety
Ba, W., Nollet, M., Yin, C., Yu, X., Wong, S., Miao, A., Beckwith, E. J., Harding, E. C., Ma, Y., Yustos, R., et al. (2024) · Current Biology · doi:10.1016/j.cub.2024.06.010 · Cited by 21
The brain, rapid eye movement sleep, and major depressive disorder: A multimodal neuroimaging study
Liu, S., Chen, J., Guan, L., Li, X., Cai, H., Wang, J., Zhu, D., Zhu, J., & Yu, Y. (2024) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2024.111151 · Cited by 17
The Dorsal Medial Habenula Minimally Impacts Circadian Regulation of Locomotor Activity and Sleep
Hsu, Y. A., Gile, J. J., Perez, J. G., Morton, G., Ben‐Hamo, M., Turner, E. E., & de la Iglesia, H. O. (2017) · Journal of Biological Rhythms · doi:10.1177/0748730417730169 · Cited by 18
“Both sleep fragmentation and prolonged REM sleep bouts that lead to an overall increase in REM sleep are signature sleep symptoms in depressed patients (Palagini et al., 2013).”
Orexin/hypocretin receptor, Orx1, gene variants are associated with major depressive disorder
Cengiz, M., Karaj, V., Kocabaşoğlu, N., Gozubatik‐Celik, G., Dırıcan, A., & Bayoğlu, B. (2018) · International Journal of Psychiatry in Clinical Practice · doi:10.1080/13651501.2018.1551549 · Cited by 18
Hein, M., Lanquart, J., Loas, G., Hubain, P., & Linkowski, P. (2019) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2019.08.003 · Cited by 18
Young, V. M., Bernal, R., Baril, A., Zeynoun, J., Wiedner, C. D., Gaona, C. A., Beiser, A., Teixeira, A. L., Salardini, A., Pase, M. P., et al. (2025) · Alzheimer s & Dementia · doi:10.1002/alz.70160 · Cited by 16
“23 Depression-related alterations in sleep architecture, such as reduced slow-wave sleep (SWS) and rapid eye movement (REM) sleep, 24 have been linked to cognitive impairment.”
Distribution of MCH-containing fibers in the feline brainstem: Relevance for REM sleep regulation
Costa, A., Castro‐Zaballa, S., Lagos, P., Chase, M. H., & Torterolo, P. (2018) · Peptides · doi:10.1016/j.peptides.2018.04.009 · Cited by 17
“Mood balance A short REM sleep latency, as well as an increase in the duration of REM sleep and the density of rapid-eye movements during this state, are considered important biological markers of depression [52].”
Tucker, J. A., Osann, K., Hsieh, S., Wahi, A., Monk, B. J., Wenzel, L. B., & Nelson, E. L. (2021) · International Journal of Behavioral Medicine · doi:10.1007/s12529-020-09950-0 · Cited by 19
BaHammam, A. S., Pirzada, A. R., & Pandi-Perumal, S. R. (2022) · Sleep And Breathing · doi:10.1007/s11325-022-02602-5 · Cited by 20
“Changes in REMS latency, density, and duration have been considered biological markers of depression [62].”
BackgroundSleep and Adolescent Depression
Fontanellaz-Castiglione, C. E. G., & Tarokh, L. (2023) · Clinical and Translational Neuroscience · doi:10.3390/ctn8010003 · Cited by 22
“The pathophysiology of depression remains unclear, and treatment outcomes are often unsatisfying, with up to 60% of patients suffering from treatment resistance [121].”
BackgroundSleep disturbances and incident risk of major depressive disorder in a population-based cohort
Solelhac, G., Imler, T., Strippoli, M. F., Marchi, N. A., Berger, M., Haba‐Rubio, J., Raffray, T., Bayon, V., Lombardi, A.-S., Ranjbar, S., et al. (2024) · Psychiatry Research · doi:10.1016/j.psychres.2024.115934 · Cited by 21
“…then proposed as a biomarker of depression status, and has been shown to be a putative vulnerability marker for affective disorders and a predictor of treatment efficiency in depression (Clark et al., 2000; Friess et al., 2008; Modell et al., 2005; Palagini et al., 2013; Steiger and Kimura, 2010).”
Jones, B. J., Fitzroy, A. B., & Spencer, R. M. C. (2019) · Frontiers in Psychology · doi:10.3389/fpsyg.2019.00500 · Cited by 19
“Negative memory consolidation has been associated with REM sleep (Wagner et al., 2001; Nishida et al., 2009; Cairney et al., 2014), slow wave sleep (Groch et al., 2011; Cairney et al., 2014; Payne et al., 2015; Alger et al., 2018), and spindle activity (Kaestner et al., 2013; Alger et al., 2018).”
BackgroundJu, X., Wang, S., Yan, P., Zhu, C., Hu, X., Dong, J., & Tan, Z. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.599399 · Cited by 17
Restless leg syndrome in hospitalized psychiatric patients in Lebanon: a pilot study
Talih, F. R., Ajaltouni, J., & Kobeissy, F. H. (2016) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s116271 · Cited by 16
Sesso, G., Bat‐Pitault, F., Guyon, A., Plancoulaine, S., Banfi, T., Milioli, G., Parrino, L., Faraguna, U., & Franco, P. (2017) · Sleep Medicine · doi:10.1016/j.sleep.2017.05.013 · Cited by 16
Papp, N., Vas, S., Bogáthy, E., Kátai, Z., Kostyalik, D., & Bagdy, G. (2018) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2018.06.012 · Cited by 17
Metadata
- Authors
- Palagini, L., Baglioni, C., Ciapparelli, A., Gemignani, A., & Riemann, D.
- Affiliations
- University of Pisa (IT)
- University of Freiburg (DE)
- Corresponding author
- Palagini, Laura
- Venue
- Sleep Medicine Reviews
- Publisher
- Elsevier BV
- Published
- 2013-10
- Volume
- 17
- Issue
- 5
- Pages
- 377-390
- ISSN
- 1087-0792 (ISSN-L)
- OpenAlex
- W2022024201
- Cited by
- 513
- References
- 230
- Citations by year
- 2026: 53 · 2025: 59 · 2024: 42 · 2023: 61 · 2022: 35 · 2021: 45 · 2020: 31 · 2019: 38 · 2018: 35 · 2017: 24 · 2016: 31 · 2015: 30 · 2014: 18 · 2013: 10
- FWCI
- 2.52
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Sleep Medicine Reviews (publishedVersion)
- PubMed (publishedVersion)
- CINECA IRIS Institutial research information system (University of Pisa) (submittedVersion)
- IRIS Research product catalog (Sapienza University of Rome) (submittedVersion)
- Institutional Research Information System University of Ferrara (University of Ferrara) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Keywords
- REM sleep, depression, REM latency, REM density, REM sleep duration, sleep architecture, slow-wave sleep, depression biomarkers, endophenotypes, chronobiology, genetic susceptibility, allostatic load, maladaptive stress response, emotional memory consolidation, cognitive distortions, recurrence prediction
- MeSH terms
- Antidepressive Agents, Brain, Depression, Humans, Sleep Deprivation, Sleep Wake Disorders, Sleep, REM, Stress, Psychological
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