Cited by 126Sleep and related disordersObstructive Sleep Apnea ResearchCircadian rhythm and melatonin

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Doxepin for insomnia: A systematic review of randomized placebo-controlled trials

Yeung, Wing-Fai, Chung, Ka-Fai, Yung, Kam-Ping, Ng, Tommy Ho-Yee·2015·Sleep Medicine Reviews

DOI 10.1016/j.smrv.2014.06.001

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Abstract

Doxepin, a sedating tricyclic drug, at 3 mg and 6 mg doses was recently approved by the U.S. food and drug administration (FDA) for the treatment of insomnia. The objective of this systematic review was to obtain a precise summary of the efficacy and safety of doxepin as a hypnotic. We searched key databases and trial registers up to March 2014 and contacted pharmaceutical companies and the FDA for unpublished data. A total of nine randomized placebo-controlled trials were analyzed. Six studies were on doxepin 1-6 mg/d, two on doxepin 25-300 mg/d, and one on ramelteon 8 mg and doxepin 3 mg combined. All low-dose studies were industry-sponsored. We found that low-dose doxepin had a small to medium effect size against placebo for sleep maintenance and sleep duration but not for sleep initiation at both immediate and short-term posttreatment. There was no significant next-day residual effect with low-dose doxepin. Headache and somnolence were the most common side effects. We concluded that low-dose doxepin for 1-2 nights appeared to be safe and effective in improving sleep. However, a clear conclusion on its short-term benefits and risks as well as withdrawal effects was not possible due to the small number of studies.

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Cochrane Handbook for Systematic Reviews of Interventions: Cochrane Book Series
(2008) · doi:10.1002/9780470712184 · Cited by 25,048
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Liberati, A., Altman, D. G., Tetzlaff, J., Mulrow, C., Gøtzsche, P. C., Ioannidis, J. P. A., Clarke, M., Devereaux, P. J., Kleijnen, J., & Moher, D. (2009) · Annals of Internal Medicine · doi:10.7326/0003-4819-151-4-200908180-00136 · Cited by 10,349
The International Classification of Sleep Disorders
Greenblatt, D. (1992) · Archives of Neurology · doi:10.1001/archneur.1992.00530270020006 · Cited by 4,406
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Ohayon, M. M. (2002) · Sleep Medicine Reviews · doi:10.1053/smrv.2002.0186 · Cited by 3,743
Clinical Guideline for the Evaluation and Management of Chronic Insomnia in Adults
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Wilson, S., Nutt, D., Alford, C., Argyropoulos, S., Baldwin, D., Bateson, A., Britton, T., Crowe, C., Dijk, D.-J., Espie, C., et al. (2010) · Journal of Psychopharmacology · doi:10.1177/0269881110379307 · Cited by 634
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Authors: Yeung, W.-F., Chung, K.-F., Yung, K.-P., & Ng, T. H.-Y.
Affiliations: University of Hong Kong (HK)
Corresponding author: Chung, Ka-Fai
ORCID: Yeung, Wing-Fai
Chung, Ka-Fai
Ng, Tommy Ho-Yee
Venue: Sleep Medicine Reviews
Publisher: Elsevier BV
Published: 2015-02
Volume: 19
Pages: 75-83
ISSN: 1087-0792 (ISSN-L)
DOI: 10.1016/j.smrv.2014.06.001
OpenAlex: W2007788592
Cited by: 126
References: 29
Citations by year: 2026: 7 · 2025: 14 · 2024: 11 · 2023: 14 · 2022: 10 · 2021: 10 · 2020: 9 · 2019: 17 · 2018: 12 · 2017: 9 · 2016: 11 · 2015: 2
FWCI: 0.99
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Sleep Medicine Reviews (publishedVersion)
PubMed (publishedVersion)
The HKU Scholars Hub (University of Hong Kong) (submittedVersion)
Topics: Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
Health Sciences › Medicine › Physiology (medical) › Obstructive Sleep Apnea Research
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
Keywords: doxepin, insomnia, hypnotics, tricyclic antidepressants, sleep maintenance, sleep duration, sleep initiation, headache, sleepiness, drug safety, drug efficacy
MeSH terms: Adolescent, Adult, Aged, Aged, 80 and over, Dose-Response Relationship, Drug, Doxepin, Drug Therapy, Combination, Female, Humans, Indenes, Sleep Initiation and Maintenance Disorders, Male, Middle Aged, United States, United States Food and Drug Administration, Randomized Controlled Trials as Topic, Treatment Outcome, Young Adult

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Doxepin for insomnia: A systematic review of randomized placebo-controlled trials

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