Elucidation of the phenotypic, functional, and molecular topography of a myeloerythroid progenitor cell hierarchy

Pronk, Cornelis J.H., Rossi, Derrick J., Månsson, Robert, Attema, Joanne L., Norddahl, Gudmundur Logi, Chan, Charles Kwok Fai, Sigvardsson, Mikael, Weissman, Irving L. +1 more·2007·Cell Stem Cell

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Items 201–300 of 671

  1. Runx1 and Cbfβ regulate the development of Flt3+ dendritic cell progenitors and restrict myeloproliferative disorder
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  2. Adult stem cell deficits drive Slc29a3 disorders in mice
    Sreenath Nandakumar Nair, Anne M. Strohecker, Avinash K. Persaud, Bhawana Bissa, Shanmugam Muruganandan, Craig A. McElroy, Rakesh Pathak, Michelle M. Williams, Radhika Raj, Amal Kaddoumi et al. · 2019 · Nature Communications
  3. Clonal and Quantitative In Vivo Assessment of Hematopoietic Stem Cell Differentiation Reveals Strong Erythroid Potential of Multipotent Cells
    Scott W. Boyer, Smrithi Rajendiran, Anna E. Beaudin, Stephanie Smith‐Berdan, Praveen K. Muthuswamy, Jessica Perez-Cunningham, Eric W. Martin, Christa Cheung, Herman Tsang, Mark B. Landon et al. · 2019 · Stem Cell Reports
  4. Inhibiting the biogenesis of myeloid-derived suppressor cells enhances immunotherapy efficacy against mammary tumor progression
    Sean H. Colligan, Andrea M. Amitrano, Robert A. Zollo, Jennifer L. Peresie, Elliot D. Kramer, B. Morreale, J. Barbi, P. Singh, Han Yu, Jian-Min Wang et al. · 2022 · Journal of Clinical Investigation
  5. Developmental differences in IFN signaling affect GATA1s-induced megakaryocyte hyperproliferation
    Andrew J. Woo, Karen Wieland, Hui Huang, Thomas E. Akie, Taylor Piers, Jonghwan Kim, Alan B. Cantor · 2013 · Journal of Clinical Investigation
  6. Loss of Stat1 decreases megakaryopoiesis and favors erythropoiesis in a JAK2-V617F–driven mouse model of MPNs
    Adrian Duek, Pontus Lundberg, Takafumi Shimizu, Jean Grisouard, Axel Karow, Lucia Kubovčáková, Hui Hao-Shen, Stephan Dirnhofer, Radek C. Skoda · 2014 · Blood
  7. Conditional knockout mice demonstrate function of Klf5 as a myeloid transcription factor
    Nur Hezrin Shahrin, Sonya M. Diakiw, Lindsay A. Dent, Anna L Brown, Richard J. D’Andrea · 2016 · Blood
  8. A sticky wicket: Defining molecular functions for CD34 in hematopoietic cells
    Michael R. Hughes, Diana Canals Hernaez, Jessica Cait, Ido Refaeli, Bernard C. Lo, Calvin D. Roskelley, Kelly Marshall McNagny · 2020 · Experimental Hematology
  9. Comprehensive phenotyping of erythropoiesis in human bone marrow: Evaluation of normal and ineffective erythropoiesis
    Hongxia Yan, Abdullah Mahmood Ali, Lionel Blanc, Anupama Narla, Joseph M. Lane, Erjing Gao, Julien Papoin, John Hale, Christopher D. Hillyer, Naomi N. Taylor et al. · 2021 · American Journal of Hematology
  10. Alternative platelet differentiation pathways initiated by nonhierarchically related hematopoietic stem cells
    Joana Carrelha, Stefania Mazzi, Axel Winroth, Michael Hagemann-Jensen, Christoph Ziegenhain, Kari Högstrand, Masafumi Seki, Margs S. Brennan, Madeleine Lehander, Bishan Wu et al. · 2024 · Nature Immunology
  11. Induction of megakaryocyte differentiation drives nuclear accumulation and transcriptional function of MKL1 via actin polymerization and RhoA activation
    Elenoe C. Smith, Alexandra M. Teixeira, Rachel C. Chen, Lin Wang, Yuan Gao, Katherine L. Hahn, Diane S. Krause · 2012 · Blood
  12. Elevating body temperature enhances hematopoiesis and neutrophil recovery after total body irradiation in an IL-1–, IL-17–, and G-CSF–dependent manner
    Maegan L. Capitano, Michael J. Nemeth, Thomas A. Mace, Christi T. Salisbury-Ruf, Brahm H. Segal, Philip L. McCarthy, Elizabeth A. Repasky · 2012 · Blood
  13. CD86 is expressed on murine hematopoietic stem cells and denotes lymphopoietic potential
    Tomoyuki Shimazu, Ryuji Iida, Qingzhao Zhang, Robert S. Welner, Kay L. Medina, José Alberola‐Ila, Paul W. Kincade · 2012 · Blood
  14. Infection perturbs Bach2- and Bach1-dependent erythroid lineage ‘choice’ to cause anemia
    Hiroki Kato, Ari Itoh‐Nakadai, Mitsuyo Matsumoto, Yusho Ishii, Miki Watanabe‐Matsui, Masatoshi Ikeda, Risa Ebina‐Shibuya, Yuki Sato, Masahiro Kobayashi, Hironari Nishizawa et al. · 2018 · Nature Immunology
  15. Delineating the cellular pathways of hematopoietic lineage commitment
    Sidinh Luc, Natalija Buza-Vidas, Sten Eirik W. Jacobsen · 2008 · Seminars in Immunology
  16. A Novel Assay to Trace Proliferation History In Vivo Reveals that Enhanced Divisional Kinetics Accompany Loss of Hematopoietic Stem Cell Self-Renewal
    Jens Nygren, David Bryder · 2008 · PLoS ONE
  17. The Rothmund-Thomson syndrome helicase RECQL4 is essential for hematopoiesis
    Monique F. M. A. Smeets, Elisabetta DeLuca, Meaghan Wall, Julie Quach, Alistair Morgan Chalk, Andrew J. Deans, Jörg Heierhorst, Louise E. Purton, David J. Izon, Carl R. Walkley · 2014 · Journal of Clinical Investigation
  18. The establishment of B versus T cell identity
    Kazuko Miyazaki, Masaki Miyazaki, Cornelis Murre · 2014 · Trends in Immunology
  19. Human erythrocytes: cytoskeleton and its origin
    Ayelén D. Nigra, César Horacio Casale, Verónica S. Santander · 2019 · Cellular and Molecular Life Sciences
  20. Inducible Fli-1 gene deletion in adult mice modifies several myeloid lineage commitment decisions and accelerates proliferation arrest and terminal erythrocytic differentiation
    Joëlle Starck, Michèle Weiss‐Gayet, Colette Gonnet, Boris Guyot, J.-M. Vicat, François Morlé · 2010 · Blood
  21. Megakaryocyte progenitor cell function is enhanced upon aging despite the functional decline of aged hematopoietic stem cells
    Donna M. Poscablo, Atesh K. Worthington, S. Smith-Berdan, E. Forsberg · 2021 · bioRxiv
  22. eIF6 rebinding dynamically couples ribosome maturation and translation
    Pekka Jaako, Alexandre Faille, Shengjiang Tan, Chi C. Wong, Norberto Escudero-Urquijo, Pablo Castro‐Hartmann, Penny Wright, Christine Hilcenko, David J. Adams, Alan John Warren · 2022 · Nature Communications
  23. Prenatal inflammation perturbs murine fetal hematopoietic development and causes persistent changes to postnatal immunity
    Diego A. López, April C. Apostol, Eric J. Lebish, Clint H. Valencia, Mari Carmen Romero-Mulero, Polina V. Pavlovich, Gloria E. Hernandez, E. Camilla Forsberg, Nina Cabezas‐Wallscheid, Anna E. Beaudin · 2022 · Cell Reports
  24. Factors and networks that underpin early hematopoiesis
    Elinore M. Mercer, Yin Chun Lin, Cornelis Murre · 2011 · Seminars in Immunology
  25. Dynamin 2–dependent endocytosis is required for normal megakaryocyte development in mice
    Markus Bender, Silvia Giannini, Renata Grozovsky, Terese Jönsson, Hilary Christensen, Fred G. Pluthero, Amy Ko, Ann Mullally, Walter H.A. Kahr, Karin M. Hoffmeister et al. · 2014 · Blood
  26. Single cell transcriptomics reveals unanticipated features of early hematopoietic precursors
    Jennifer Yang, Yoshiaki Tanaka, Montrell Seay, Zhen Li, Jiaqi Jin, Lana X. Garmire, Xun Zhu, Ashley Taylor, Weidong Li, Ghia M. Euskirchen et al. · 2016 · Nucleic Acids Research
  27. Mapping differentiation pathways from hematopoietic stem cells using Flk2/Flt3 lineage tracing
    Scott W. Boyer, Anna E. Beaudin, E. Camilla Forsberg · 2012 · Cell Cycle
  28. CDK6 coordinates JAK2V617F mutant MPN via NF-κB and apoptotic networks
    Iris Z. Uras, Barbara Maurer, Harini Nivarthi, Philipp Jodl, Karoline Kollmann, Michaela Prchal‐Murphy, Jelena D. Milosevic Feenstra, Markus Zojer, Sabine Lagger, Reinhard Grausenburger et al. · 2019 · Blood
  29. Endoglin: An ‘Accessory’ Receptor Regulating Blood Cell Development and Inflammation
    Steffen K. Meurer, Ralf Weiskirchen · 2020 · International Journal of Molecular Sciences
  30. Development and differentiation of the erythroid lineage in mammals
    Jeffrey Barminko, Brad M. Reinholt, Margaret H. Baron · 2015 · Developmental & Comparative Immunology
  31. A critical role of RUNX1 in governing megakaryocyte-primed hematopoietic stem cell differentiation
    Chen Wang, Zhaowei Tu, Xiongwei Cai, Weinan Wang, Ashley Kuenzi Davis, Kalpana Nattamai, Aditi Paranjpe, Phillip J. Dexheimer, Jianqiang Wu, Frank Lei Huang et al. · 2023 · Blood Advances
  32. The stem cell factor SALL4 is an essential transcriptional regulator in mixed lineage leukemia-rearranged leukemogenesis
    Lina Yang, Li Liu, Hong Gao, J. Pinnamaneni, Deepthi Sanagasetti, V. Singh, Kai Wang, M. Mathison, Qian-Zi Zhang, Feng-Ju Chen et al. · 2017 · Journal of Hematology & Oncology
  33. Mutant CEBPA directly drives the expression of the targetable tumor-promoting factor CD73 in AML
    Janus Schou Jakobsen, Linea Gøricke Laursen, Mikkel Bruhn Schuster, Sachin Pundhir, Erwin M. Schoof, Ying Chun Ge, Teresa D’Altri, Kristoffer Vitting‐Seerup, Nicolas Rapin, Coline Gentil et al. · 2019 · Science Advances
  34. The calcineurin-NFAT pathway negatively regulates megakaryopoiesis
    Alexander Zaslavsky, Stella T. Chou, Keri Schadler, Allyson E. Lieberman, Maxim Pimkin, Yeo Jung Kim, Kwan‐Hyuck Baek, William C. Aird, Mitchell J. Weiss, Sandra W. Ryeom · 2013 · Blood
  35. Genetics of inherited thrombocytopenias
    Julia T. Warren, Jorge Di Paola · 2022 · Blood
  36. Role of the clathrin adaptor PICALM in normal hematopoiesis and polycythemia vera pathophysiology
    Y. Ishikawa, M. Maeda, Mithun R. Pasham, François Aguet, Silvia K. Tacheva-Grigorova, T. Masuda, Hua Fang Yi, S.-U. Lee, Jing Xu, Julie Teruya‐Feldstein et al. · 2014 · Haematologica
  37. Molecular Regulation of Differentiation in Early B-Lymphocyte Development
    Mikael Sigvardsson · 2018 · International Journal of Molecular Sciences
  38. Brief Report: Single-Cell Analysis Reveals Cell Division-Independent Emergence of Megakaryocytes From Phenotypic Hematopoietic Stem Cells
    Aline Roch, Vincent Trachsel, Matthias P. Lütolf · 2015 · Stem Cells
  39. Hematopoietic Stem and Progenitor Cells Exhibit Stage-Specific Translational Programs via mTOR- and CDK1-Dependent Mechanisms
    Christina C. Spevak, Harold Kunal Elias, Lavanya Kannan, Mohamed Ashraf Ali, Gaëlle H. Martin, Shanmugapriya Selvaraj, William S. Eng, Amanda W. Ernlund, Vinagolu K. Rajasekhar, Carolien M. Woolthuis et al. · 2020 · Cell stem cell
  40. Erythropoiesis: From Molecular Pathways to System Properties
    Miroslav Koulnis, Ermelinda Porpiglia, Daniel Hidalgo, Merav Socolovsky · 2014 · Advances in experimental medicine and biology
  41. Endoglin expression in blood and endothelium is differentially regulated by modular assembly of the Ets/Gata hemangioblast code
    John E. Pimanda, Wan Y. I. Chan, Nicola K. Wilson, Aileen M. Smith, Sarah Kinston, Kathy Knezevic, Mary E. Janes, Josette‐Renée Landry, Anja Kolb‐Kokocinski, Jonathan Frampton et al. · 2008 · Blood
  42. Runx1 and Runx2 inhibit fibrotic conversion of cellular niches for hematopoietic stem cells
    Yoshiki Omatsu, Shota Aiba, Tomonori Maeta, Kei Higaki, Kazunari Aoki, Hitomi Watanabe, Gen Kondoh, Riko Nishimura, Shu Takeda, Ung‐il Chung et al. · 2022 · Nature Communications
  43. Expression and role of FLT3 in regulation of the earliest stage of normal granulocyte-monocyte progenitor development
    Charlotta Böiers, Natalija Buza-Vidas, Christina T. Jensen, Cornelis Jan Pronk, Shabnam Kharazi, Lilian Wittmann, Ewa Sitnicka, Anne Hultquist, Sten Eirik W. Jacobsen · 2010 · Blood
  44. Temporal multimodal single-cell profiling of native hematopoiesis illuminates altered differentiation trajectories with age
    Anna Konturek-Cieśla, Parashar Dhapola, Qinyu Zhang, Petter Säwén, Haixia Wan, Göran Karlsson, David Bryder · 2023 · Cell Reports
  45. Dntt expression reveals developmental hierarchy and lineage specification of hematopoietic progenitors
    Fabian Klein, Julien Roux, Grozdan Cvijetic, Patrick Fernandes Rodrigues, Lilly von Muenchow, Ruth Lubin, Paweł Pelczar, Simon Yona, Panagiotis Tsapogas, Roxane Tussiwand · 2022 · Nature Immunology
  46. The Tetraspanin CD9 Affords High-Purity Capture of All Murine Hematopoietic Stem Cells
    Göran Karlsson, Emma Rörby, Cristina Pina, Shamit Soneji, Kristian Reckzeh, Kenichi Miharada, Christine Karlsson, Yanping Guo, Cristina Fugazza, Rajeev Gupta et al. · 2013 · Cell Reports
  47. Genetic and Epigenetic Mechanisms That Maintain Hematopoietic Stem Cell Function
    Christian Kosan, Maren Godmann · 2015 · Stem Cells International
  48. Lysyl oxidase is associated with increased thrombosis and platelet reactivity
    Shinobu Matsuura, Rongjuan Mi, Milka Koupenova, Alexia Eliades, Shenia Patterson, Paul A. Toselli, Jonathan N. Thon, Joseph E. Italiano, Philip C. Trackman, Nikolaos Papadantonakis et al. · 2016 · Blood
  49. Runx1 downregulates stem cell and megakaryocytic transcription programs that support niche interactions
    Kira Behrens, Ioanna Triviai, Maike Schwieger, Nilgün Solak Tekin, Malik Alawi, Michael Spohn, Daniela Indenbirken, Marion Ziegler, Ursula Müller, Warren S. Alexander et al. · 2016 · Blood
  50. Characterization, regulation, and targeting of erythroid progenitors in normal and disordered human erythropoiesis
    Brian M. Dulmovits, Jimmy Hom, Anupama Narla, Narla Mohandas, Lionel Blanc · 2017 · Current Opinion in Hematology
  51. Serum response factor is an essential transcription factor in megakaryocytic maturation
    Stephanie Halene, Yuan Gao, Katherine L. Hahn, Stephanie Ann Massaro, Joseph E. Italiano, Vincent Schulz, Sharon Lin, Gary M. Kupfer, Diane S. Krause · 2010 · Blood
  52. Origin of Osteoclasts: Osteoclast Precursor Cells
    Jefferson Tsai, Kaichi Kaneko, Andrew J. Suh, Richard S. Bockman, Kyung‐Hyun Park‐Min · 2023 · Journal of Bone Metabolism
  53. RUNX1B Expression Is Highly Heterogeneous and Distinguishes Megakaryocytic and Erythroid Lineage Fate in Adult Mouse Hematopoiesis
    Julia E. Draper, Patrycja Sroczyńska, Olga Tsoulaki, Hui Sun Leong, Muhammad Zaki Hidayatullah Fadlullah, Crispin J. Miller, Valérie Kouskoff, Georges Lacaud · 2016 · PLoS Genetics
  54. Autonomous role of Wiskott-Aldrich syndrome platelet deficiency in inducing autoimmunity and inflammation
    Lucia Piceni Sereni, Maria Carmina Castiello, Francesco Marangoni, Achille Anselmo, Dario Di Silvestre, Sara Motta, Elena Draghici, Stefano Mantero, Adrian James Thrasher, Silvia Clara Giliani et al. · 2018 · Journal of Allergy and Clinical Immunology
  55. Sphingosine-1-phosphate signaling modulates terminal erythroid differentiation through the regulation of mitophagy
    Chong Yang, Michihiro Hashimoto, Quy Xiao Xuan Lin, Darren Qiancheng Tan, Toshio Suda · 2019 · Experimental Hematology
  56. Transcriptomic analysis implicates necroptosis in disease progression and prognosis in myelodysplastic syndromes
    Guillermo Montalban Bravo, Caleb A. Class, Irene Gañán‐Gómez, Rashmi Kanagal‐Shamanna, Koji Sasaki, Guillaume Richard‐Carpentier, Kiran Naqvi, Yue Wei, Hui Yang, Kelly A. Soltysiak et al. · 2019 · Leukemia
  57. IL-33 promotes anemia during chronic inflammation by inhibiting differentiation of erythroid progenitors
    James W. Swann, Lada A. Koneva, Daniel Regan-Komito, Stephen Nicholas Sansom, Fiona M. Powrie, Thibault Griseri · 2020 · The Journal of Experimental Medicine
  58. Alcam Regulates Long-Term Hematopoietic Stem Cell Engraftment and Self-Renewal
    Robin Jeannet, Qi Cai, Hongjun Liu, Hieu Vu, Ya‐Huei Kuo · 2012 · Stem Cells
  59. Adult murine hematopoietic stem cells and progenitors: an update on their identities, functions, and assays
    Louise E. Purton · 2022 · Experimental Hematology
  60. Frequency determination of rare populations by flow cytometry: A hematopoietic stem cell perspective
    Alexandra Rundberg Nilsson, David Bryder, Cornelis Jan Pronk · 2013 · Cytometry Part A
  61. The blood-borne sialyltransferase ST6Gal-1 is a negative systemic regulator of granulopoiesis
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  62. Hematopoietic Stem Cells but Not Multipotent Progenitors Drive Erythropoiesis during Chronic Erythroid Stress in EPO Transgenic Mice
    Rashim Pal Singh, Tatyana Grinenko, Beáta Ramasz, Kristin Franke, Mathias Lesche, Andreas Dahl, Max Gassmann, Triantafyllos Chavakis, Ian Henry, Ben Wielockx · 2018 · Stem Cell Reports
  63. Open-source personal pipetting robots with live-cell incubation and microscopy compatibility
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  64. Delineating stages of erythropoiesis using imaging flow cytometry
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  66. The human NPM1 mutation A perturbs megakaryopoiesis in a conditional mouse model
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  67. Transcriptome-wide Profiling and Posttranscriptional Analysis of Hematopoietic Stem/Progenitor Cell Differentiation toward Myeloid Commitment
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  68. Kmt2c mutations enhance HSC self-renewal capacity and convey a selective advantage after chemotherapy
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  69. Mitochondria transfer from early stages of erythroblasts to their macrophage niche via tunnelling nanotubes
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  70. BMP2/SMAD pathway activation in JAK2/p53-mutant megakaryocyte/erythroid progenitors promotes leukemic transformation
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  71. Improved quantitative analysis of primary bone marrow megakaryocytes utilizing imaging flow cytometry
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  72. Targeting the PI3K/Akt pathway in murine MDS/MPN driven by hyperactive Ras
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  74. Piwi Genes Are Dispensable for Normal Hematopoiesis in Mice
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  75. Reversibility of Defective Hematopoiesis Caused by Telomere Shortening in Telomerase Knockout Mice
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  76. Contribution of clonal hematopoiesis to adult-onset hemophagocytic lymphohistiocytosis
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  78. Hematopoietic cytokine-induced transcriptional regulation and Notch signaling as modulators of MDSC expansion
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  80. Characterization of thrombopoietin (TPO)-responsive progenitor cells in adult mouse bone marrow with in vivo megakaryocyte and erythroid potential
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  81. CD45 phosphatase is crucial for human and murine acute myeloid leukemia maintenance through its localization in lipid rafts
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  82. Selective dissociation between LSD1 and GFI1B by a LSD1 inhibitor NCD38 induces the activation ofERGsuper-enhancer in erythroleukemia cells
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  83. Early Lineage Priming by Trisomy of Erg Leads to Myeloproliferation in a Down Syndrome Model
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  84. Impact of gene dosage, loss of wild-type allele, and FLT3 ligand on Flt3-ITD–induced myeloproliferation
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  85. Fetal liver macrophages contribute to the hematopoietic stem cell niche by controlling granulopoiesis
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  86. Corepressor Rcor1 is essential for murine erythropoiesis.
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  87. Molecular and cellular effects of oncogene cooperation in a genetically accurate AML mouse model
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  88. Variability of Inducible Expression across the Hematopoietic System of Tetracycline Transactivator Transgenic Mice
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  89. Secretory MPP3 reinforce myeloid differentiation trajectory and amplify myeloid cell production
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  92. Mice lacking the sodium-dependent phosphate import protein, PiT1 (SLC20A1), have a severe defect in terminal erythroid differentiation and early B cell development
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  94. The serum response factor (SRF)/megakaryocytic acute leukemia (MAL) network participates in megakaryocyte development
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  98. Methylation of dual-specificity phosphatase 4 controls cell differentiation
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