Elucidation of the phenotypic, functional, and molecular topography of a myeloerythroid progenitor cell hierarchy

Pronk, Cornelis J.H., Rossi, Derrick J., Månsson, Robert, Attema, Joanne L., Norddahl, Gudmundur Logi, Chan, Charles Kwok Fai, Sigvardsson, Mikael, Weissman, Irving L. +1 more·2007·Cell Stem Cell

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Items 401–500 of 671

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    Jinhong Wang, Zixian Liu, Shan-Shan Zhang, Xiao-Fang Wang, Hai-Tao Bai, Miner Xie, Fang Dong, Hideo Ema · 2019 · Experimental Hematology
  2. miR17~92 restrains pro-apoptotic BIM to ensure survival of haematopoietic stem and progenitor cells
    Kerstin Brinkmann, Ashley P. Ng, Carolyn A. de Graaf, Ladina Di Rago, Craig D. Hyland, Eugenio Morelli, Jai Rautela, Nicholas D. Huntington, Andreas Strasser, Warren S. Alexander et al. · 2019 · Cell Death and Differentiation
  3. PU.1 is required to restrain myelopoiesis during chronic inflammatory stress
    Chavez, James S., Rabe, Jennifer L., Niño, Katia E., Wells, Harrison H., Gessner, Rachel L., Mills, Taylor S., Hernandez, Giovanny, Pietras, Eric M. · 2023 · Frontiers in Cell and Developmental Biology
  4. Synergistic roles of tristetraprolin family members in myeloid cells in the control of inflammation
    Brittany L. Snyder, Rui Huang, Adam Burkholder, Danielle Donahue, Beth W. Mahler, Carl D. Bortner, Wi S. Lai, Perry J. Blackshear · 2023 · Life Science Alliance
  5. Gata1s mutant mice display persistent defects in the erythroid lineage
    Te Ling, Kevin Zhang, Jiayue Yang, Sandeep K. Gurbuxani, John D. Crispino · 2022 · Blood Advances
  6. RBM15-MKL1 fusion protein promotes leukemia via m6A methylation and Wnt pathway activation
    Madeline Y. Mayday, Giulia Biancon, Manyi Wei, Christian Ramirez, Irene Moratti, Andreas P. Pintado-Urbanc, Jether Amos Espinosa, Mi Chen, Lin Wang, Matthew D. Simon et al. · 2025 · Blood
  7. Prospective isolation of radiation induced erythroid stress progenitors reveals unique transcriptomic and epigenetic signatures enabling increased erythroid output
    Sofie Singbrant, Alexander Mattebo, Mikael Sigvardsson, Tobias Strid, Johan Flygare · 2020 · Haematologica
  8. CD45 expression discriminates waves of embryonic megakaryocytes in the mouse
    Isabel Cortegano, Natalia Serrano, Carolina Ruíz, Mercedes Rodríguez, Carmen Prado, Mario Alía, Andrés Hidalgo, Eva Cano, Belén de Andrés, Marı́a-Luisa Gaspar · 2018 · Haematologica
  9. Anatomy of Hematopoiesis and Local Microenvironments in the Bone Marrow. Where to?
    Qingqing Wu, Jizhou Zhang, Daniel Lucas · 2021 · Frontiers in Immunology
  10. High fat diet feeding impairs neutrophil phagocytosis, bacterial killing, and neutrophil-induced hematopoietic regeneration
    Emily Bowers, Gabrielle P Huizinga, Mohammed Toriqul Islam, Ramkumar Mohan, Arianna Lerner, Peter Mancuso, Bethany B. Moore, Kanakadurga Singer · 2025 · The Journal of Immunology
  11. From Hematopoietic Stem Cells to Platelets: Unifying Differentiation Pathways Identified by Lineage Tracing Mouse Models
    B. Manso, A. R. Y. Baena, E. Forsberg · 2024 · Cells
  12. A maximum-likelihood approach for building cell-type trees by lifting
    Nishanth Ulhas Nair, Laura Hunter, Mingfu Shao, Paulina Grnarova, Yu Lin, Philipp Bücher, Bernard M. E. Moret · 2016 · BMC Genomics
  13. Accumulation of Multipotent Hematopoietic Progenitors in Peripheral Lymphoid Organs of Mice Over-expressing Interleukin-7 and Flt3-Ligand
    Fabian Klein, Lilly von Muenchow, Giuseppina Capoferri, Stefan Heiler, Llucia Albertí Servera, Hannie Rolink, Corinne Engdahl, Michael Rolink, Mladen Mitrovic, Grozdan Cvijetic et al. · 2018 · Frontiers in Immunology
  14. HSPCs display within-family homogeneity in differentiation and proliferation despite population heterogeneity
    Tamar Tak, Giulio Prevedello, Gaël Simon, Noémie Paillon, Camélia Benlabiod, Caroline Marty, Isabelle Plo, Ken R. Duffy, Leïla Perié · 2021 · eLife
  15. Dicer is selectively important for the earliest stages of erythroid development
    Natalija Buza-Vidas, Valeriu Bogdan Cismasiu, Susan Moore, Adam J. Mead, Petter S. Woll, Michael Lutteropp, Luca Melchiori, Sidinh Luc, Tiphaine Bouriez‐Jones, Deborah Atkinson et al. · 2012 · Blood
  16. Utilization of imaging flow cytometry to define intermediates of megakaryopoiesis in vivo and in vitro
    Kathleen E. McGrath · 2015 · Journal of Immunological Methods
  17. Analysis of Murine Hematopoietic Stem Cell Proliferation During Inflammation
    Emilie Jalbert, Eric Martin Pietras · 2017 · Methods in molecular biology
  18. Single-Cell Multiomics Reveals Distinct Cell States at the Top of the Human Hematopoietic Hierarchy
    Mikael N.E. Sommarin, Parashar Dhapola, Fatemeh Safi, Rebecca Warfvinge, Linda Geironson Ulfsson, Eva Erlandsson, Anna Konturek-Cieśla, Ram Krishna Thakur, Charlotta Böiers, David Bryder et al. · 2021 · bioRxiv (Cold Spring Harbor Laboratory)
  19. Chromatin modifier Hmga2 promotes adult hematopoietic stem cell function and blood regeneration in stress conditions
    Sho Kubota, Yuqi Sun, Mariko Morii, Jie Bai, Takako Ideue, Mayumi Hirayama, Supannika Sorin, Eerdunduleng, Takako Yokomizo-Nakano, Motomi Osato et al. · 2024 · EMBO Journal
  20. Heterogeneity of high-potency multilineage hematopoietic stem cells and identification of “Super” transplantability
    Fang Dong, Sen Zhang, Caiying Zhu, Zining Yang, Lisha Wang, Yao Ma, Jiayi Lu, Xialin Li, Xiaofang Wang, Nini Wang et al. · 2025 · Blood
  21. Reduced repression of cytokine signaling ameliorates age‐induced decline in hematopoietic stem cell function
    Gudmundur Logi Norddahl, Martin Wahlestedt, Santiago Gisler, Mikael Sigvardsson, David Bryder · 2012 · Aging Cell
  22. Endothelial Cell-Selective Adhesion Molecule Expression in Hematopoietic Stem/Progenitor Cells Is Essential for Erythropoiesis Recovery after Bone Marrow Injury
    Takao Sudo, Takafumi Yokota, Daisuke Okuzaki, Tomoaki Ueda, Michiko Ichii, Tomohiko Ishibashi, Tomomi Isono, Yoko Habuchi, Kenji Oritani, Yuzuru Kanakura · 2016 · PLoS ONE
  23. Leukaemia-associated Rho guanine nucleotide exchange factor (LARG) plays an agonist specific role in platelet function through RhoA activation
    Siying Zou, Alexandra M. Teixeira, Mingzhu Yin, Yaozu Xiang, Juliana Xavier-Ferruccio, Pingxia Zhang, John Hwa, Min Wang, Diane S. Krause · 2016 · Thrombosis and Haemostasis
  24. Identification of a Multipotent Progenitor Population in the Spleen That Is Regulated by NR4A1
    Melanie D. Mumau, Ashley Vanderbeck, Elizabeth D. Lynch, Sophia B Golec, Stephen G. Emerson, Jennifer A. Punt · 2017 · The Journal of Immunology
  25. The histone chaperone NAP1L3 is required for haematopoietic stem cell maintenance and differentiation
    Yaser Heshmati, Shabnam Kharazi, Gözde Türköz, David Chang, Esmat Kamali Dolatabadi, Johan Boström, Aleksandra Krstic, Theodora Boukoura, Emma Wagner, Nadir Kadri et al. · 2018 · Scientific Reports
  26. Enhancing mitochondrial function in vivo rescues MDS-like anemia induced by pRb deficiency
    Taha Sen, Mayur Vilas Jain, Magnus Gram, Alexander Mattebo, Shamit Soneji, Carl R. Walkley, Sofie Singbrant · 2020 · Experimental Hematology
  27. Genomics based analysis of interactions between developing B-lymphocytes and stromal cells reveal complex interactions and two-way communication
    Jenny Zetterblad, Hong Qian, Sasan Zandi, Robert Månsson, Anna Lagergren, Frida Hansson, David Bryder, Nils Paulsson, Mikael Sigvardsson · 2010 · BMC Genomics
  28. Mitochondrial pyruvate metabolism and glutaminolysis toggle steady-state and emergency myelopoiesis
    Hannah A. Pizzato, Y. Alan Wang, Michael J. Wolfgang, Brian N. Finck, Gary J. Patti, Deepta Bhattacharya · 2023 · The Journal of Experimental Medicine
  29. Zinc Finger Protein 521 Regulates Early Hematopoiesis through Cell-Extrinsic Mechanisms in the Bone Marrow Microenvironment
    Courtney J. Fleenor, Tessa Arends, Hong Lei, Josefine Åhsberg, Kazuki Okuyama, Jacob Kuruvilla, Susana Cristóbal, Jennifer L. Rabe, Ahwan Pandey, Thomas Danhorn et al. · 2018 · Molecular and Cellular Biology
  30. Interplay between FLI-1 and the LDB1 complex in murine erythroleukemia cells and during megakaryopoiesis
    Guillaume Giraud, Petros Kolovos, Ilias Boltsis, Jente van Staalduinen, Boris Guyot, Michèle Weiss‐Gayet, Wilfred F. J. van IJcken, François Morlé, Frank G. Grosveld · 2021 · iScience
  31. A20 deficiency in hematopoietic stem cells causes lymphopenia and myeloproliferation due to elevated Interferon-γ signals
    Masahiro Marshall Nakagawa, Chozha Vendan Rathinam · 2019 · Scientific Reports
  32. Concurrent Zrsr2 mutation and Tet2 loss promote myelodysplastic neoplasm in mice
    Cristian García-Ruiz, Cristina Martínez-Valiente, Lourdes Cordón, Alessandro Liquori, Raúl Fernández‐González, Eva Pericuesta, Juan Sandoval, José Cervera, Alfonso Gutiérrez‐Adán, Alejandra Sanjuán-Pla · 2022 · Leukemia
  33. A glycan-based approach to cell characterization and isolation: Hematopoiesis as a paradigm
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  34. Basal type I interferon signaling has only modest effects on neonatal and juvenile hematopoiesis
    Ya-Nan Li, Wei Yang, Helen C. Wang, Riddhi M. Patel, Emily B. Casey, Elisabeth D. Denby, Jeffrey A. Magee · 2022 · bioRxiv
  35. Applying attractor dynamics to infer gene regulatory interactions involved in cellular differentiation
    Ahmadreza Ghaffarizadeh, Gregory J. Podgorski, Nicholas S. Flann · 2017 · Biosystems
  36. Transcription Factor Stoichiometry Drives Cell Fate: Single-Cell Proteomics to the Rescue
    Thomas Graf · 2019 · Cell stem cell
  37. Computational modeling of stem and progenitor cell kinetics identifies plausible hematopoietic lineage hierarchies
    Lisa Bast, Michèle C. Buck, Judith S. Hecker, Robert A.J. Oostendorp, Katharina S. S. Götze, Carsten Marr · 2021 · iScience
  38. Transgenic, inducible RNAi in megakaryocytes and platelets in mice
    Megumi Takiguchi, Chloé James, Emma C. Josefsson, Catherine Carmichael, Prem K. Premsrirut, Scott W. Lowe, Justin R. Hamilton, David C.S. Huang, Benjamin T. Kile, Ross A. Dickins · 2010 · Journal of Thrombosis and Haemostasis
  39. Novel Hematopoietic Progenitor Populations Revealed by Direct Assessment of GATA1 Protein Expression and cMPL Signaling Events
    Garrett C. Heffner, Matthew R. Clutter, Garry P. Nolan, Irving L. Weissman · 2011 · Stem Cells
  40. Blood stem cell PU.1 upregulation is a consequence of differentiation without fast autoregulation
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  41. The ontogenesis and heterogeneity of basophils
    Jiyeon Park, Suk‐Jo Kang · 2024 · Discovery Immunology
  42. Lipoprotein metabolism mediates hematopoietic stem cell responses under acute anemic conditions
    Kiyoka Saito, Mark van der Garde, Terumasa Umemoto, Natsumi Miharada, Julia Sjöberg, Valgarður Sigurðsson, Haruki Shirozu, Shunsuke Kamei, Višnja Radulović, Mitsuyoshi Suzuki et al. · 2024 · Nature Communications
  43. The acidic domain of Hmga2 and the domain’s linker region are critical for driving self-renewal of hematopoietic stem cell
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  44. Distinct roles of the preparatory and payoff phases of glycolysis in hematopoietic stem cells
    Kohei Shiroshita, Hiroshi Kobayashi, S. Watanuki, Daiki Karigane, Yuriko Sorimachi, Shinpei Tamaki, Miho Haraguchi, Masamichi Yamamoto, Ayako Nakamura‐Ishizu, Shinichiro Okamoto et al. · 2023 · Experimental Hematology
  45. Loss of endothelial membrane KIT ligand affects systemic KIT ligand levels but not bone marrow hematopoietic stem cells
    Sahoko Matsuoka, R Facchini, Tiago Cunha Luis, Joana Carrelha, Petter S. Woll, Takuo Mizukami, Bishan Wu, Hanane Boukarabila, Mario Buono, Ruggiero Norfo et al. · 2023 · Blood
  46. Lack of the p42 form of C/EBPα leads to spontaneous immortalization and lineage infidelity of committed myeloid progenitors
    Mikkel Bruhn Schuster, Anne-Katrine Frank, Frederik Otzen Bagger, Nicolas Rapin, Jonas Vikesaa, Bo Torben Porse · 2013 · Experimental Hematology
  47. Cadmium Suppresses Bone Marrow Thrombopoietin Production and Impairs Megakaryocytopoiesis in Mice
    Yifan Zhao, Yufan Zhang, Jinyi He, Yue Zhai, Guangrui Yang, Peng Xue, Ye Yao, Miao He, Weidong Qu, Yubin Zhang · 2022 · Toxicological Sciences
  48. A novel prospective isolation of murine fetal liver progenitors to study in utero hematopoietic defects
    Julia E. Draper, Patrycja Sroczyńska, Muhammad Zaki Hidayatullah Fadlullah, Rahima Patel, Gillian Newton, Wolfgang Breitwieser, Valérie Kouskoff, Georges Lacaud · 2018 · PLoS Genetics
  49. Niche-derived Semaphorin 4A safeguards functional identity of myeloid-biased hematopoietic stem cells
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  50. A unified multimodal single-cell framework reveals a discrete state model of hematopoiesis in mice
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  51. Dynamic rRNA methylation regulates translation in the hematopoietic system and is essential for stem cell fitness
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  52. Globin vector regulatory elements are active in early hematopoietic progenitor cells
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  53. A Novel Combination Therapy of Erythropoietin and Thrombopoietin to Treat Erythropoietin-Resistance anemia
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  54. Cellular and metabolic characteristics of pre-leukemic hematopoietic progenitors with GATA2 haploinsufficiency
    Avigail Rein, Ifat Geron, Eitan Kugler, Hila Fishman, Eyal Gottlieb, Ifat Abramovich, Amir Giladi, Ido Amit, Roger Mulet‐Lazaro, Ruud Delwel et al. · 2022 · Haematologica
  55. Circadian regulation of the immune-hematopoietic system
    Georges J. M. Maestroni · 2023 · Exploration of neuroscience
  56. Biological Characteristics and Regulation of Early Megakaryocytopoiesis
    Jin-Gang Yang, Song Zhao, D. Ma · 2019 · Stem Cell Reviews and Reports
  57. Darbepoietin-alfa has comparable erythropoietic stimulatory effects to recombinant erythropoietin whilst preserving the bone marrow microenvironment
    Sita R. Dewamitta, Megan R. Russell, Harshal H. Nandurkar, Carl R. Walkley · 2012 · Haematologica
  58. Murine tribbles homolog 2 deficiency affects erythroid progenitor development and confers macrocytic anemia on mice
    Kou-Ray Lin, Hsin‐Fang Yang‐Yen, Huang-Wei Lien, Wei‐Hao Liao, Chang‐Jen Huang, Liang‐In Lin, Chung‐Leung Li, Jeffrey Jong-Young Yen · 2016 · Scientific Reports
  59. Altered Erythro-Myeloid Progenitor Cells Are Highly Expanded in Intensively Regenerating Hematopoiesis
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  60. High-dimensional spatiotemporal single-cell atlas and 3D imaging of the bone marrow microenvironment during CML progression
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  61. Comparison of cell state models derived from single-cell RNA sequencing data: graph versus multi-dimensional space
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  62. Asxl1 deletion disrupts MYC and RNA polymerase II function in granulocyte progenitors
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  63. Kmt2c restricts G-CSF-driven HSC mobilization and granulocyte production in a methyltransferase-independent manner
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  64. Looking Under the Hood at the Cytoskeletal Engine of Platelet Production
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  65. Single-Cell PCR Profiling of Gene Expression in Hematopoiesis
    José Teles, Tariq Enver, Cristina Pina · 2014 · Methods in molecular biology
  66. Eosinophils and mast cells: a lineage apart
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  67. Autism-associated chromatin remodeler CHD8 regulates erythroblast cytokinesis and fine-tunes the balance of Rho GTPase signaling
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  68. Multimodal cartography of human lymphopoiesis reveals B and T/NK/ILC lineages are subjected to differential regulation
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  69. PKC-epsilon deficiency alters progenitor cell populations in favor of megakaryopoiesis
    John C. Kostyak, Elisabetta Liverani, Satya P. Kunapuli · 2017 · PLoS ONE
  70. Evolving insights into the synergy between erythropoietin and thrombopoietin and the bipotent Erythroid/Megakaryocytic progenitor cell
    T. Papayannopoulou, K. Kaushansky · 2016 · Experimental Hematology
  71. Potency finds its niches
    Nina Cabezas-Wallscheid, A. Trumpp · 2016 · Science
  72. Simultaneous tracking of division and differentiation from individual hematopoietic stem and progenitor cells reveals within-family homogeneity despite population heterogeneity
    Tamar Tak, Giulio Prevedello, Gaël Simon, Noémie Paillon, Ken R. Duffy, Leïla Perié · 2019 · bioRxiv (Cold Spring Harbor Laboratory)
  73. Combined single-cell gene and isoform expression analysis in haematopoietic stem and progenitor cells
    Laura Mincarelli, Vladimir Uzun, Stuart A. Rushworth, Wilfried Haerty, Iain C. Macaulay · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
  74. Schlafen2 is a regulator of quiescence in adult murine hematopoietic stem cells
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  75. A mouse model of Zhu-Tokita-Takenouchi-Kim syndrome reveals indispensable SON functions in organ development and hematopoiesis
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  76. Myeloid Cell Origins, Differentiation, and Clinical Implications
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  77. Endocytosis of the thrombopoietin receptor Mpl regulates megakaryocyte and erythroid maturation in mice
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  78. Layered immunity and layered leukemogenicity: Developmentally restricted mechanisms of pediatric leukemia initiation
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  80. Wnt/β-Catenin-Signaling Modulates Megakaryopoiesis at the Megakaryocyte-Erythrocyte Progenitor Stage in the Hematopoietic System
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  81. Hematopoietic stem and multipotent progenitor cells produce IL-17, IL-21 and other cytokines in response to TLR signals associated with late apoptotic products and augment memory Th17 and Tc17 cells in the bone marrow of normal and lupus mice
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  82. Exploring the multifaceted nature of the common lymphoid progenitor compartment
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  83. GM-CSF and IL-4 Fusion Cytokine Induces B Cell-Dependent Hematopoietic Regeneration
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  84. Immunophenotypic Identification of Early Myeloerythroid Development
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  85. Type I interferon upregulation and deregulation of genes involved in monopoiesis in chronic myelomonocytic leukemia
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  86. TLX1 (HOX11) Immortalization of Embryonic Stem Cell–Derived and Primary Murine Hematopoietic Progenitors
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  87. Loss of Murine FOXO3 in Cells of the Myeloid Lineage Enhances Myelopoiesis but Protects from K/BxN-Serum Transfer-Induced Arthritis
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  88. Mathematical modeling with single-cell sequencing data
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  89. Inhibition of RhoA-mediated secretory autophagy in megakaryocytes mitigates myelofibrosis in mice
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  91. Learning stochastic processes with intrinsic noise from cross-sectional biological data
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  93. Suppression of multiple anti‐apoptotic BCL2 family proteins recapitulates the effects of JAK2 inhibitors in JAK2V617F driven myeloproliferative neoplasms
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  94. Iron- and erythropoietin-resistant anemia in a spontaneous breast cancer mouse model
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  96. Analysis of Immunophenotypic Changes during Ex Vivo Human Erythropoiesis and Its Application in the Study of Normal and Defective Erythropoiesis
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  97. PRDM11 is dispensable for the maintenance and function of hematopoietic stem and progenitor cells
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  98. Perturbed hematopoiesis in mice lacking ATMIN
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  99. Aberrant Alternative Splicing in U2af1/Tet2 Double Mutant Mice Contributes to Major Hematological Phenotypes
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  100. Why Single-Cell Sequencing Has Promise in MDS
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