The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Molecular Analysis of Stem Cells and Their Descendants during Cell Turnover and Regeneration in the Planarian Schmidtea mediterranea
Open accessAbstract
In adult planarians the replacement of cells lost to physiological turnover or injury is sustained by the proliferation and differentiation of stem cells known as neoblasts. Neoblast lineage relationships and the molecular changes that take place during differentiation into the appropriate cell types are poorly understood. Here we report the identification and characterization of a cohort of genes specifically expressed in neoblasts and their descendents. We find that genes with severely downregulated expression after irradiation molecularly define at least three discrete subpopulations of cells. Simultaneous BrdU labeling and in situ hybridization experiments in intact and regenerating animals indicate that these cell subpopulations are related by lineage. Our data demonstrate not only the ability to measure and study the in vivo population dynamics of adult stem cells during tissue homeostasis and regeneration, but also the utility of studies in planarians to broadly inform stem cell biology in adult organisms.
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Citations
Cites
Blanpain, C., Lowry, W. E., Geoghegan, A., Polak, L., & Fuchs, E. (2004) · Cell · doi:10.1016/j.cell.2004.08.012 · Cited by 1,428
β-Catenin Defines Head Versus Tail Identity During Planarian Regeneration and Homeostasis
Gurley, K. A., Rink, J. C., & Alvarado, A. S. (2008) · Science · doi:10.1126/science.1150029 · Cited by 469
Self-citation
Cited by
Cell type atlas and lineage tree of a whole complex animal by single-cell transcriptomics
Plass, M., Solana, J., Wolf, F. A., Ayoub, S., Misios, A., Glažar, P., Obermayer, B., Theis, F. J., Kocks, C., & Rajewsky, N. (2018) · Science · doi:10.1126/science.aaq1723 · Cited by 474
Cell type transcriptome atlas for the planarian Schmidtea mediterranea
Fincher, C. T., Wurtzel, O., de Hoog, T., Kravarik, K. M., & Reddien, P. W. (2018) · Science · doi:10.1126/science.aaq1736 · Cited by 436
Sandoval-Guzmán, T., Wang, H., Khattak, S., Schuez, M., Roensch, K., Nacu, E., Tazaki, A., Joven, A., Tanaka, E. M., & Simon, A. (2014) · Cell Stem Cell · doi:10.1016/j.stem.2013.11.007 · Cited by 326
King, R. S., & Newmark, P. A. (2013) · BMC Developmental Biology · doi:10.1186/1471-213x-13-8 · Cited by 310
Muscle cells provide instructions for planarian regeneration
Witchley, J. N., Mayer, M., Wagner, D. E., Owen, J. H., & Reddien, P. W. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.07.022 · Cited by 264
Metadata
- Authors
- Eisenhoffer, G. T., Kang, H., & Alvarado, A. S.
- Venue
- Cell Stem Cell
- Publisher
- Elsevier BV
- Published
- 2008-09
- Volume
- 3
- Issue
- 3
- Pages
- 327-339
- ISSN
- 1875-9777 (ISSN-L)
- 1934-5909
- OpenAlex
- W2049284181
- Cited by
- 416
- References
- 2
- FWCI
- 7.32
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Eisenhoffer, G. T., Kang, H., & Alvarado, A. S. (2008). Molecular Analysis of Stem Cells and Their Descendants during Cell Turnover and Regeneration in the Planarian Schmidtea mediterranea. Cell Stem Cell. https://doi.org/10.1016/j.stem.2008.07.002
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