Self-Renewal, Multipotency, and the Existence of Two Cell Populations within an Epithelial Stem Cell Niche
Open accessAbstract
In adult skin, each hair follicle contains a reservoir of stem cells (the bulge), which can be mobilized to regenerate the new follicle with each hair cycle and to reepithelialize epidermis during wound repair. Here we report new methods that permit their clonal analyses and engraftment and demonstrate the two defining features of stem cells, namely self-renewal and multipotency. We also show that, within the bulge, there are two distinct populations, one of which maintains basal lamina contact and temporally precedes the other, which is suprabasal and arises only after the start of the first postnatal hair cycle. This spatial distinction endows them with discrete transcriptional programs, but surprisingly, both populations are growth inhibited in the niche but can self-renew in vitro and make epidermis and hair when grafted. These findings suggest that the niche microenvironment imposes intrinsic "stemness" features without restricting the establishment of epithelial polarity and changes in gene expression.
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The common quiescent stem cell signature shows downregulation of genes involved in DNA replication and cell cycle progression.
“the signature reveals the downregulation of genes that are involved in DNA replication and cell cycle progression.”
From Molecular regulation of stem cell quiescence (2013) · cites this paper as [43]
Comparison of gene expression profiles of HSCs, MuSCs, and HFSCs reveals a common gene signature in quiescent stem cells.
“a comparison of gene expression profiles of different types of quiescent stem cells, including HSCs45, MuSCs15 and HFSCs43, reveals a gene signature that is common to these quiescent stem cells (TABLE 1).”
From Molecular regulation of stem cell quiescence (2013) · cites this paper as [43]
Cyclin A2, cyclin B1, cyclin E2, and survivin are downregulated in quiescent HSCs, MuSCs, and HFSCs.
“Examples of genes that are downregulated in all three quiescent cell types (HSCs, MuSCs and HFSCs) include genes encoding cyclin A2, cyclin B1, cyclin E2 and survivin”
From Molecular regulation of stem cell quiescence (2013) · cites this paper as [43]
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From Conditional telomerase induction causes proliferation of hair follicle stem cells (2005) · cites this paper as [29]
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- Authors
- Blanpain, C., Lowry, W. E., Geoghegan, A., Polak, L., & Fuchs, E.
- Affiliations
- Howard Hughes Medical Institute (US)
- Corresponding author
- Fuchs, Elaine
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2004-09
- Volume
- 118
- Issue
- 5
- Pages
- 635-648
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2151011478
- Cited by
- 1,428
- References
- 37
- Citations by year
- 2026: 16 · 2025: 28 · 2024: 43 · 2023: 43 · 2022: 50 · 2021: 47 · 2020: 56 · 2019: 55 · 2018: 46 · 2017: 68 · 2016: 60 · 2015: 62 · 2014: 85 · 2013: 84 · 2012: 97
- FWCI
- 82.26
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 3241 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- Dépôt institutionnel de l'Université libre de Bruxelles (Université Libre de Bruxelles) (submittedVersion)
- Funders
- National Institutes of Health (2r01ar050452-21)
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (AR050452, AR 31737, R01AR031737, R01-AR050452)
- Topics
- Health Sciences › Medicine › Urology › Hair Growth and Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Skin and Cellular Biology Research
- Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
- Keywords
- hair follicle stem cells, bulge, stem cell niche, self-renewal, multipotency, clonal analysis, engraftment, wound healing, transcriptional programs, epithelial polarity, stemness
- MeSH terms
- Epidermal Cells, Animals, Basement Membrane, Cell Differentiation, Clone Cells, Epidermis, Epithelial Cells, Mice, Transgenic, Regeneration, RNA, Messenger, Transcription, Genetic, 3T3 Cells, Cell Polarity, Gene Expression Regulation, Developmental, Hair Follicle, Multipotent Stem Cells, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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