The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
SSEA-1 Is an Enrichment Marker for Tumor-Initiating Cells in Human Glioblastoma
Open accessAbstract
SUMMARY CD133+ populations of human glioblastoma multiforme (GBM) cells are reportedly enriched for tumor stem cells (TSCs) or tumor-initiating cells (TICs). Approximately 40% of freshly isolated GBM specimens, however, do not contain CD133+ tumor cells, raising the possibility that CD133 may not be a universal enrichment marker for GBM TSCs/TICs. Here we demonstrate that stage-specific embryonic antigen 1(SSEA-1/LeX)+ GBM cells fulfill the functional criteria for TSC/TIC, since (1) SSEA-1+ cells are highly tumorigenic in vivo, unlike SSEA-1- cells; (2) SSEA-1+ cells can give rise to both SSEA-1+ and SSEA-1− cells, thereby establishing a cellular hierarchy; and (3) SSEA-1+ cells have self-renewal and multilineage differentiation potentials. A distinct subpopulation of SSEA-1+ cells was present in all but one of the primary GBMs examined (n = 24), and most CD133+ tumor cells were also SSEA-1+, suggesting that SSEA-1 may be a general TSC/TIC enrichment marker in human GBMs.
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Cites
Bmi-1 determines the proliferative capacity of normal and leukaemic stem cells.
Lessard, J., & Sauvageau, G. (2003) · Nature · doi:10.1038/nature01572 · Cited by 1,452
Mirzadeh, Z., Merkle, F. T., Soriano-Navarro, M., Garcia-Verdugo, J. M., & Alvarez-Buylla, A. (2008) · Cell stem cell · doi:10.1016/j.stem.2008.07.004 · Cited by 1,015 · cited 2×
“…data are applicable to the human and whether mRNA expression correlates with immunopositivity of CD133 antibodies that recognize glycosylationdependent epitopes remain unanswered questions (Coskun et al., 2008; Mirzadeh et al., 2008; Shmelkov et al., 2008; Uchida et al., 2000; Zhu et al., 2009).”
Stem and progenitor cells: origins, phenotypes, lineage commitments, and transdifferentiations
Weissman, I. L., Anderson, D. J., & Gage, F. (2001) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.17.1.387 · Cited by 948
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Cancer stem cells in glioblastoma
Lathia, J. D., Mack, S. C., Mulkearns-Hubert, E. E., Valentim, C. L. L., & Rich, J. N. (2015) · Genes & Development · doi:10.1101/gad.261982.115 · Cited by 1,520
Adaptive Chromatin Remodeling Drives Glioblastoma Stem Cell Plasticity and Drug Tolerance
Liau, B. B., Sievers, C., Donohue, L. K., Gillespie, S. M., Flavahan, W. A., Miller, T. E., Venteicher, A. S., Hebert, C. H., Carey, C. D., Rodig, S. J., et al. (2017) · Cell stem cell · doi:10.1016/j.stem.2016.11.003 · Cited by 535
Glioblastoma stem cells: lessons from the tumor hierarchy in a lethal cancer
Gimple, R. C., Bhargava, S., Dixit, D., & Rich, J. N. (2019) · Genes & Development · doi:10.1101/gad.324301.119 · Cited by 514
Modeling Patient-Derived Glioblastoma with Cerebral Organoids
Linkous, A., Balamatsias, D., Snuderl, M., Edwards, L., Miyaguchi, K., Milner, T., Reich, B., Cohen-Gould, L., Storaska, A., Nakayama, Y., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.02.063 · Cited by 502
Self-citationOuter Radial Glia-like Cancer Stem Cells Contribute to Heterogeneity of Glioblastoma
Bhaduri, A., Di Lullo, E., Jung, D., Müller, S., Crouch, E. E., Espinosa, C. S., Ozawa, T., Alvarado, B., Spatazza, J., Cadwell, C. R., et al. (2020) · Cell Stem Cell · doi:10.1016/j.stem.2019.11.015 · Cited by 419
Metadata
- Authors
- Son, M. J., Woolard, K., Nam, D.-H., Lee, J., & Fine, H. A.
- Venue
- Cell Stem Cell
- Publisher
- Elsevier BV
- Published
- 2009-05
- Volume
- 4
- Issue
- 5
- Pages
- 440-452
- ISSN
- 1875-9777 (ISSN-L)
- 1934-5909
- OpenAlex
- W1988986134
- Cited by
- 672
- References
- 3
- FWCI
- 26.70
- Type
- journal article
- Language
- en
- Open access
- bronze
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