Stem and progenitor cells: origins, phenotypes, lineage commitments, and transdifferentiations

Multilineage potential of adult human mesenchymal stem cells

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Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell

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Neurogenesis in the adult human hippocampus

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Generation of Neurons and Astrocytes from Isolated Cells of the Adult Mammalian Central Nervous System

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Bone marrow cells regenerate infarcted myocardium

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A Direct Measurement of the Radiation Sensitivity of Normal Mouse Bone Marrow Cells1

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Mammalian neural stem cells.

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A Direct Measurement of the Radiation Sensitivity of Normal Mouse Bone Marrow Cells

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More hippocampal neurons in adult mice living in an enriched environment

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Isolation and functional properties of murine hematopoietic stem cells that are replicating in vivo.

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Purification and Characterization of Mouse Hematopoietic Stem Cells

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Muscle Regeneration by Bone Marrow-Derived Myogenic Progenitors

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A clonogenic common myeloid progenitor that gives rise to all myeloid lineages

Akashi, K., Traver, D., Miyamoto, T., & Weissman, I. L. (2000) · Nature · doi:10.1038/35004599 · Cited by 2,617 · see citing works

Bone Marrow as a Potential Source of Hepatic Oval Cells

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Long-Distance Neuronal Migration in the Adult Mammalian Brain

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Purified hematopoietic stem cells can differentiate into hepatocytes in vivo

Lagasse, E., Connors, H., Al-Dhalimy, M., Reitsma, M., Dohse, M., Osborne, L., Wang, X., Finegold, M., Weissman, I. L., & Grompe, M. (2000) · Nature Medicine · doi:10.1038/81326 · Cited by 2,314 · see citing works

Identification of Clonogenic Common Lymphoid Progenitors in Mouse Bone Marrow

Kondo, M., Weissman, I. L., & Akashi, K. (1997) · Cell · doi:10.1016/s0092-8674(00)80453-5 · Cited by 2,253 · see citing works

Identification of a Neural Stem Cell in the Adult Mammalian Central Nervous System

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Direct isolation of human central nervous system stem cells

Uchida, N., Buck, D. W., He, D., Reitsma, M. J., Masek, M., Phan, T. V., Tsukamoto, A. S., Gage, F. H., & Weissman, I. L. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.26.14720 · Cited by 1,829 · see citing works

Stem Cells

Weissman, I. L. (2000) · Cell · doi:10.1016/s0092-8674(00)81692-x · Cited by 1,827 · see citing works

Turning Blood into Brain: Cells Bearing Neuronal Antigens Generated in Vivo from Bone Marrow

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Dystrophin expression in the mdx mouse restored by stem cell transplantation

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From Marrow to Brain: Expression of Neuronal Phenotypes in Adult Mice

Brazelton, T. R., Rossi, F. M. V., Keshet, G. I., & Blau, H. M. (2000) · Science · doi:10.1126/science.290.5497.1775 · Cited by 1,676 · see citing works

Marrow stromal cells migrate throughout forebrain and cerebellum, and they differentiate into astrocytes after injection into neonatal mouse brains

Kopen, G. C., Prockop, D. J., & Phinney, D. G. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.19.10711 · Cited by 1,643 · see citing works

Cytological Demonstration of the Clonal Nature of Spleen Colonies Derived from Transplanted Mouse Marrow Cells

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Turning Brain into Blood: A Hematopoietic Fate Adopted by Adult Neural Stem Cells in Vivo

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Neural stem cells in the adult mammalian forebrain: A relatively quiescent subpopulation of subependymal cells

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Clonal and Population Analyses Demonstrate That an EGF-Responsive Mammalian Embryonic CNS Precursor Is a Stem Cell

Reynolds, B. A., & Weiss, S. (1996) · Developmental Biology · doi:10.1006/dbio.1996.0090 · Cited by 1,365 · see citing works

Proliferating subventricular zone cells in the adult mammalian forebrain can differentiate into neurons and glia.

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Liver from bone marrow in humans

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Epidermal Growth Factor and Fibroblast Growth Factor-2 Have Different Effects on Neural Progenitors in the Adult Rat Brain

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Single factors direct the differentiation of stem cells from the fetal and adult central nervous system.Preprint

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The long-term repopulating subset of hematopoietic stem cells is deterministic and isolatable by phenotype

Morrison, S. J., & Weissman, I. L. (1994) · Immunity · doi:10.1016/1074-7613(94)90037-x · Cited by 1,116 · see citing works

The Adult Rat Hippocampus Contains Primordial Neural Stem Cells

Palmer, T. D., TAKAHASHI, J. C., & Gage, F. H. (1997) · Molecular and Cellular Neuroscience · doi:10.1006/mcne.1996.0595 · Cited by 1,090 · see citing works

Isolation of a candidate human hematopoietic stem-cell population.

Baum, C. M., Weissman, I. L., Tsukamoto, A. S., Buckle, A., & Péault, B. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.7.2804 · Cited by 1,084 · see citing works

Generalized Potential of Adult Neural Stem Cells

Clarke, D. L., Johansson, C. B., Wilbertz, J. H., Veress, B., Nilsson, E. D., Karlström, H., Lendahl, U., & Frisén, J. (2000) · Science · doi:10.1126/science.288.5471.1660 · Cited by 1,057 · see citing works

Multipotential stem cells from the adult mouse brain proliferate and self-renew in response to basic fibroblast growth factor

Gritti, A., Parati, E. A., Cova, L., Frolichsthal, P., Galli, R., Wanke, E., Faravelli, L., Morassutti, D. J., Roisen, F. J., Nickel, D. D., et al. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-03-01091.1996 · Cited by 1,029 · see citing works

The molecular control of cell division, differentiation commitment and maturation in haemopoietic cells

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Neuronal production, migration, and differentiation in a vocal control nucleus of the adult female canary brain.

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Embryonic Stem Cell-Derived Glial Precursors: A Source of Myelinating Transplants

Brüstle, O., Jones, K. N., Learish, R. D., Karram, K., Choudhary, K., Wiestler, O. D., Duncan, I. D., & McKay, R. D. G. (1999) · Science · doi:10.1126/science.285.5428.754 · Cited by 976 · see citing works

Are New Neurons Formed in the Brains of Adult Mammals?

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Derivation of hepatocytes from bone marrow cells in mice after radiation-induced myeloablation

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Hematopoietic potential of stem cells isolated from murine skeletal muscle

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Cultured adherent cells from marrow can serve as long-lasting precursor cells for bone, cartilage, and lung in irradiated mice.

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Autoradiographic and histological studies of postnatal neurogenesis. I. A longitudinal investigation of the kinetics, migration and transformation of cells incoorporating tritiated thymidine in neonate rats, with special reference to postnatal neurogenesis in some brain regions

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Oligodendrocyte Precursor Cells Reprogrammed to Become Multipotential CNS Stem Cells

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<i>In vivo</i> proliferation and cell cycle kinetics of long-term self-renewing hematopoietic stem cells

Cheshier, S. H., Morrison, S. J., Liao, X., & Weissman, I. L. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.6.3120 · Cited by 858 · see citing works

Translating Stem and Progenitor Cell Biology to the Clinic: Barriers and Opportunities

Weissman, I. L. (2000) · Science · doi:10.1126/science.287.5457.1442 · Cited by 852 · see citing works

Isolation of a stem cell for neurons and glia from the mammalian neural crest

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Alternative Neural Crest Cell Fates Are Instructively Promoted by TGFβ Superfamily Members

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Engraftable human neural stem cells respond to development cues, replace neurons, and express foreign genes

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Prospective Identification, Isolation by Flow Cytometry, and In Vivo Self-Renewal of Multipotent Mammalian Neural Crest Stem Cells

Morrison, S. J., White, P. M., Zock, C., & Anderson, D. J. (1999) · Cell · doi:10.1016/s0092-8674(00)80583-8 · Cited by 749 · see citing works

Transient Notch Activation Initiates an Irreversible Switch from Neurogenesis to Gliogenesis by Neural Crest Stem Cells

Morrison, S. J., Perez, S. E., Zhou, Q., Verdi, J. M., Hicks, C. D., Weinmaster, G., & Anderson, D. J. (2000) · Cell · doi:10.1016/s0092-8674(00)80860-0 · Cited by 721 · see citing works

Evidence that hematopoietic stem cells express mouse c-kit but do not depend on steel factor for their generation.

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A self-renewing multipotential stem cell in embryonic rat cerebral cortex

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Site-Specific Migration and Neuronal Differentiation of Human Neural Progenitor Cells after Transplantation in the Adult Rat Brain

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De novo generation of neuronal cells from the adult mouse brain.

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In Vitro Expansion of a Multipotent Population of Human Neural Progenitor Cells

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EXPERIMENTAL STUDIES ON THE DEVELOPMENT OF THE THYMUS

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Glial growth factor restricts mammalian neural crest stem cells to a glial fate

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Can stem cells cross lineage boundaries?

Anderson, D. J., Gage, F. H., & Weissman, I. L. (2001) · Nature Medicine · doi:10.1038/86439 · Cited by 489 · see citing works

Identification of a lineage of multipotent hematopoietic progenitors

Morrison, S. J., Wandycz, A. M., Hemmati, H. D., Wright, D. E., & Weissman, I. L. (1997) · Development · doi:10.1242/dev.124.10.1929 · Cited by 482 · see citing works

AML1/ETO-expressing nonleukemic stem cells in acute myelogenous leukemia with 8;21 chromosomal translocation

Miyamoto, T., Weissman, I. L., & Akashi, K. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.13.7521 · Cited by 465 · see citing works

Proliferation, differentiation, and long-term culture of primary hippocampal neurons.

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CYTOLOGICAL EVIDENCE FOR A RELATIONSHIP BETWEEN NORMAL HEMATOPOIETIC COLONY-FORMING CELLS AND CELLS OF THE LYMPHOID SYSTEM

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Stem cells in the adult mammalian central nervous system

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Development of CD8α-Positive Dendritic Cells from a Common Myeloid Progenitor

Traver, D. J., Akashi, K., Manz, M. G., Mérad, M., Miyamoto, T., Engleman, E. G., & Weissman, I. L. (2000) · Science · doi:10.1126/science.290.5499.2152 · Cited by 392 · see citing works

Cell-fate conversion of lymphoid-committed progenitors by instructive actions of cytokines

Kondo, M., Scherer, D. C., Miyamoto, T., King, A. G., Akashi, K., Sugamura, K., & Weissman, I. L. (2000) · Nature · doi:10.1038/35030112 · Cited by 382 · see citing works

Cloning and growth of multipotential neural precursors: Requirements for proliferation and differentiation

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Isolation of Lineage-Restricted Neuronal Precursors from Multipotent Neuroepithelial Stem Cells

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Searching for hematopoietic stem cells: evidence that Thy-1.1lo Lin- Sca-1+ cells are the only stem cells in C57BL/Ka-Thy-1.1 bone marrow.

Uchida, N., & Weissman, I. L. (1992) · The Journal of Experimental Medicine · doi:10.1084/jem.175.1.175 · Cited by 359 · see citing works

Isolation of two early B lymphocyte progenitors from mouse marrow: A committed Pre-Pre-B cell and a clonogenic Thy-1lo hematopoietic stem cell

Müller‐Sieburg, C. E., Whitlock, C. A., & Weissman, I. L. (1986) · Cell · doi:10.1016/0092-8674(86)90274-6 · Cited by 325 · see citing works

Stem cells and pattern formation in the nervous system: the possible versus the actual.

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Cyclophosphamide/granulocyte colony-stimulating factor induces hematopoietic stem cells to proliferate prior to mobilization

Morrison, S. J., Wright, D. E., & Weissman, I. L. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.5.1908 · Cited by 314 · see citing works

Pharmacological correction of neonatal lethal hepatic dysfunction in a murine model of hereditary tyrosinaemia type I

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Chimeric brains generated by intraventricular transplantation of fetal human brain cells into embryonic rats

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Neuroepithelial Stem Cells from the Embryonic Spinal Cord: Isolation, Characterization, and Clonal Analysis

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Bone marrow stromal cell lines with lymphopoietic activity express high levels of a pre-B neoplasia-associated molecule

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Cloned multipotential precursors from the mouse cerebrum require FGF-2, whereas glial restricted precursors are stimulated with either FGF-2 or EGF

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Experimental analysis of the origin of cell types in the development of the mouse thymus

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Cyclophosphamide/granulocyte colony-stimulating factor causes selective mobilization of bone marrow hematopoietic stem cells into the blood after M phase of the cell cycle

Wright, D. E., Cheshier, S. H., Wagers, A. J., Randall, T. D., Christensen, J. L., & Weissman, I. L. (2001) · Blood · doi:10.1182/blood.v97.8.2278 · Cited by 208 · see citing works

Transplantation of highly purified CD34+Thy-1+ hematopoietic stem cells in patients with metastatic breast cancer

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Bone marrow cells give rise to distinct cell clones within the thymus

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Neural Crest Stem Cells Undergo Cell-Intrinsic Developmental Changes in Sensitivity to Instructive Differentiation Signals

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Integration of multiple instructive cues by neural crest stem cells reveals cell-intrinsic biases in relative growth factor responsiveness

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High doses of purified stem cells cause early hematopoietic recovery in syngeneic and allogeneic hosts.

Uchida, N., Tsukamoto, A., He, D., Friera, A. M., Scollay, R. G., & Weissman, I. L. (1998) · Journal of Clinical Investigation · doi:10.1172/jci1681 · Cited by 132 · see citing works

Stem cell potential: Can anything make anything?

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Transplantation of purified hematopoietic stem cells: requirements for overcoming the barriers of allogeneic engraftment.

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Transplantation with selected autologous peripheral blood CD34+Thy1+ hematopoietic stem cells (HSCs) in multiple myeloma

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Lineage commitment of hemopoietic progenitor cells in developing blast cell colonies: influence of colony-stimulating factors.

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Clonal remissions in acute nonlymphocytic leukemia: evidence for a multistep pathogenesis of the malignancy

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Isolated rat cortical progenitor cells are maintained in division in vitro by membrane-associated factors

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Grafting immortalized neurons to the CNS

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Should Polymerase Chain Reaction Analysis to Detect Minimal Residual Disease in Patients With Chronic Myelogenous Leukemia Be Used in Clinical Decision Making?

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