The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
Wnt7a Activates the Planar Cell Polarity Pathway to Drive the Symmetric Expansion of Satellite Stem Cells
Open accessAbstract
Summary Satellite cells in skeletal muscle are a heterogeneous population of stem cells and committed progenitors. We found that quiescent satellite stem cells expressed the Wnt-receptor Fzd7, and that its candidate ligand Wnt7a was upregulated during regeneration. Notably, Wnt7a markedly stimulated the symmetric expansion of satellite stem cells but did not affect the growth or differentiation of myoblasts. Silencing of Fzd7 abrogated Wnt7a binding and stimulation of stem cell expansion. Wnt7a signaling induced the polarized distribution of the planar cell polarity effector Vangl2. Silencing of Vangl2 inhibited Wnt7a action on satellite stem cell expansion. Wnt7a overexpression enhanced muscle regeneration and increased both the number of satellite cells and the proportion of satellite stem cells. Muscle lacking Wnt7a exhibited a marked decrease in satellite cell number following regeneration. Therefore, Wnt7a signaling through the planar cell polarity pathway controls the homeostatic level of satellite stem cells and hence regulates the regenerative potential of muscle.
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Cites
Asymmetric self-renewal and commitment of satellite stem cells in muscle
Kuang, S., Kuroda, K., Le Grand, F., & Rudnicki, M. A. (2007) · Cell · doi:10.1016/j.cell.2007.03.044 · Cited by 1,449
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Direct Isolation of Satellite Cells for Skeletal Muscle Regeneration
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“, 2005), or FACS-sorted satellite cells (Kuang et al., 2007; Montarras et al., 2005), or individual cells (Sacco et al.”
BackgroundSelf-renewal and expansion of single transplanted muscle stem cells
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Identification of Vangl2 and Scrb1 as planar polarity genes in mammals
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The Wnt/β-catenin pathway directs neuronal differentiation of cortical neural precursor cells
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Niche Regulation of Muscle Satellite Cell Self-Renewal and Differentiation
Kuang, S., Gillespie, M. A., & Rudnicki, M. A. (2008) · Cell Stem Cell · doi:10.1016/j.stem.2007.12.012 · Cited by 507 · cited 1×
“During skeletal muscle regeneration, the satellite cell population is maintained by a stem cell subpopulation, thus allowing tissue homeostasis and multiple rounds of regeneration during the life span of an individual (Kuang et al., 2008).”
BackgroundSelf-citationDistinct WNT Pathways Regulating AER Formation and Dorsoventral Polarity in the Chick Limb Bud
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Cited by
Satellite Cells and the Muscle Stem Cell Niche
Yin, H., Price, F., & Rudnicki, M. A. (2013) · Physiological Reviews · doi:10.1152/physrev.00043.2011 · Cited by 2,166
Self-citationSubstrate Elasticity Regulates Skeletal Muscle Stem Cell Self-Renewal in Culture
Gilbert, P. M., Havenstrite, K. L., Magnusson, K. E. G., Sacco, A., Leonardi, N. A., Kraft, P., Nguyen, N. K., Thrun, S., Lutolf, M. P., & Blau, H. M. (2010) · Science · doi:10.1126/science.1191035 · Cited by 1,587
Mechanisms regulating skeletal muscle growth and atrophy
Schiaffino, S., Dyar, K. A., Ciciliot, S., Blaauw, B., & Sandri, M. (2013) · The FEBS Journal · doi:10.1111/febs.12253 · Cited by 1,492
Building Muscle: Molecular Regulation of Myogenesis
Bentzinger, C. F., Wang, Y. X., & Rudnicki, M. A. (2012) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a008342 · Cited by 1,195
Self-citationSatellite Cells and Skeletal Muscle Regeneration
Dumont, N. A., Bentzinger, C. F., Sincennes, M., & Rudnicki, M. A. (2015) · Comprehensive Physiology · doi:10.1002/cphy.c140068 · Cited by 719
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Metadata
- Authors
- Le Grand, F., Jones, A. E., Seale, V., Scimè, A., & Rudnicki, M. A.
- Venue
- Cell Stem Cell
- Publisher
- Elsevier BV
- Published
- 2009-06
- Volume
- 4
- Issue
- 6
- Pages
- 535-547
- ISSN
- 1875-9777 (ISSN-L)
- 1934-5909
- OpenAlex
- W2069943755
- Cited by
- 539
- References
- 14
- FWCI
- 12.36
- Type
- journal article
- Language
- en
- Open access
- bronze
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