The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Isolation of Epiblast Stem Cells from Preimplantation Mouse Embryos
Open accessAbstract
SUMMARY Pluripotent stem cells provide a platform to interrogate control elements that function to generate all cell types of the body. Despite their utility for modeling development and disease, the relationship of mouse and human pluripotent stem cell states to one another remains largely undefined. We have shown that mouse embryonic stem (ES) cells and epiblast stem cells (EpiSCs) are distinct, pluripotent states isolated from pre- and post-implantation embryos respectively. Human ES cells are different than mouse ES cells and share defining features with EpiSCs, yet are derived from pre-implantation human embryos. Here we show that EpiSCs can be routinely derived from pre-implantation mouse embryos. The pre-implantation-derived EpiSCs exhibit molecular features and functional properties consistent with bona fide EpiSCs. These results provide a simple method for isolating EpiSCs and offer direct insight into the intrinsic and extrinsic mechanisms that regulate the acquisition of distinct pluripotent states.
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Cites
The ground state of embryonic stem cell self-renewal
Ying, Q.-L., Wray, J., Nichols, J., Batlle-Morera, L., Doble, B., Woodgett, J., Cohen, P., & Smith, A. (2008) · Nature · doi:10.1038/nature06968 · Cited by 3,442
A parallel circuit of LIF signalling pathways maintains pluripotency of mouse ES cells
Niwa, H., Ogawa, K., Shimosato, D., & Adachi, K. (2009) · Nature · doi:10.1038/nature08113 · Cited by 872
Reflections on the biology of embryonic stem (ES) cells
Gardner, R. L., & Brook, F. A. (1997) · The International Journal of Developmental Biology · doi:10.1387/ijdb.9184330 · Cited by 123
Cited by
Theunissen, T. W., Powell, B. E., Wang, H., Mitalipova, M., Faddah, D. A., Reddy, J., Fan, Z. P., Maetzel, D., Ganz, K., Shi, L., et al. (2014) · Cell Stem Cell · doi:10.1016/j.stem.2014.07.002 · Cited by 888
Dynamic stem cell states: Naive to primed pluripotency in rodents and humans
Weinberger, L., Ayyash, M., Novershtern, N., & Hanna, J. H. (2016) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2015.28 · Cited by 622
Derivation of Pluripotent Stem Cells with In Vivo Embryonic and Extraembryonic Potency
Yang, Y., Liu, B., Xu, J., Wang, J., Wu, J., Shi, C., Xu, Y., Dong, J., Wang, C., Lai, W., et al. (2017) · Cell · doi:10.1016/j.cell.2017.02.005 · Cited by 502
Drug-based modulation of endogenous stem cells promotes functional remyelination in vivo
Najm, F. J., Madhavan, M., Zaremba, A., Shick, E., Karl, R. T., Factor, D. C., Miller, T. E., Nevin, Z. S., Kantor, C., Sargent, A., et al. (2015) · Nature · doi:10.1038/nature14335 · Cited by 424
Self-citationKojima, Y., Kaufman-Francis, K., Studdert, J. B., Steiner, K. A., Power, M. D., Loebel, D. A. F., Jones, V., Hor, A., de Alencastro, G., Logan, G. J., et al. (2014) · Cell Stem Cell · doi:10.1016/j.stem.2013.09.014 · Cited by 302
Metadata
- Authors
- Najm, F. J., Chenoweth, J. G., Anderson, P. D., Nadeau, J. H., Redline, R. W., McKay, R. D. G., & Tesar, P. J.
- Venue
- Cell Stem Cell
- Publisher
- Elsevier BV
- Published
- 2011-03
- Volume
- 8
- Issue
- 3
- Pages
- 318-325
- ISSN
- 1875-9777 (ISSN-L)
- 1934-5909
- OpenAlex
- W1974775907
- Cited by
- 163
- References
- 3
- FWCI
- 9.17
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Najm, F. J., Chenoweth, J. G., Anderson, P. D., Nadeau, J. H., Redline, R. W., McKay, R. D. G., & Tesar, P. J. (2011). Isolation of Epiblast Stem Cells from Preimplantation Mouse Embryos. Cell Stem Cell. https://doi.org/10.1016/j.stem.2011.01.016
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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