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Mouse Spermatogenic Stem Cells Continually Interconvert between Equipotent Singly Isolated and Syncytial States
Open accessAbstract
The identity and behavior of mouse spermatogenic stem cells have been a long-standing focus of interest. In the prevailing "As model," stem cell function is restricted to singly isolated (As) spermatogonia. By examining single-cell dynamics of GFRα1+ stem cells in vivo, we evaluate an alternative hypothesis that, through fragmentation, syncytial spermatogonia also contribute to stem cell function in homeostasis. We use live imaging and pulse labeling to quantitatively determine the fates of individual GFRα1+ cells and find that, during steady-state spermatogenesis, the entire GFRα1+ population comprises a single stem cell pool, in which cells continually interconvert between As and syncytial states. A minimal biophysical model, relying only on the rates of incomplete cell division and syncytial fragmentation, precisely predicts the stochastic fates of GFRα1+ cells during steady state and postinsult regeneration. Thus, our results define an alternative and dynamic model for spermatogenic stem cell function in the mouse testis.
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Cited by
The adult human testis transcriptional cell atlas
Guo, J., Grow, E. J., Mlcochova, H., Maher, G. J., Lindskog, C., Nie, X., Guo, Y., Takei, Y., Yun, J., Cai, L., et al. (2018) · Cell Research · doi:10.1038/s41422-018-0099-2 · Cited by 710
A Comprehensive Roadmap of Murine Spermatogenesis Defined by Single-Cell RNA-Seq
Green, C. D., Ma, Q., Manske, G. L., Shami, A. N., Zheng, X., Marini, S., Moritz, L., Sultan, C., Gurczynski, S. J., Moore, B. B., et al. (2018) · Developmental Cell · doi:10.1016/j.devcel.2018.07.025 · Cited by 521
Spermatogonial stem cells and spermatogenesis in mice, monkeys and men
Fayomi, A. P., & Orwig, K. E. (2018) · Stem Cell Research · doi:10.1016/j.scr.2018.04.009 · Cited by 346
The Neonatal and Adult Human Testis Defined at the Single-Cell Level
Sohni, A., Tan, K., Song, H.-W., Burow, D., de Rooij, D. G., Laurent, L., Hsieh, T.-C., Rabah, R., Hammoud, S. S., Vicini, E., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.01.045 · Cited by 339
The nature and dynamics of spermatogonial stem cells
de Rooij, D. G. (2017) · Development · doi:10.1242/dev.146571 · Cited by 313
Metadata
- Authors
- Hara, K., Nakagawa, T., Enomoto, H., Suzuki, M., Yamamoto, M., Simons, B. D., & Yoshida, S.
- Venue
- Cell Stem Cell
- Publisher
- Elsevier BV
- Published
- 2014-05
- Volume
- 14
- Issue
- 5
- Pages
- 658-672
- ISSN
- 1875-9777 (ISSN-L)
- 1934-5909
- OpenAlex
- W2040104847
- Cited by
- 312
- References
- 0
- FWCI
- 26.68
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- The paper
- Hara, K., Nakagawa, T., Enomoto, H., Suzuki, M., Yamamoto, M., Simons, B. D., & Yoshida, S. (2014). Mouse Spermatogenic Stem Cells Continually Interconvert between Equipotent Singly Isolated and Syncytial States. Cell Stem Cell. https://doi.org/10.1016/j.stem.2014.01.019
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