The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
Prolonged Fasting Reduces IGF-1/PKA to Promote Hematopoietic-Stem-Cell-Based Regeneration and Reverse Immunosuppression
Open accessAbstract
SUMMARY Immune system defects are at the center of aging and a range of diseases. Here we show that prolonged fasting reduces circulating IGF-1 levels and PKA activity in various cell populations, leading to signal transduction changes in long-term hematopoietic stem cells (LT-HSC) and niche cells that promote stress resistance, self-renewal and lineage-balanced regeneration. Multiple cycles of fasting abated the immunosuppression and mortality caused by chemotherapy, and reversed age-dependent myeloid-bias in mice, in agreement with preliminary data on the protection of lymphocytes from chemotoxicity in fasting patients. The pro-regenerative effects of fasting on stem cells were recapitulated by deficiencies in either IGF-1 or PKA and blunted by exogenous IGF-1. These findings link the reduced levels of IGF-1 caused by fasting, to PKA signaling and establish their crucial role in regulating hematopoietic stem cell protection, self-renewal and regeneration.
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Metadata
- Authors
- Cheng, C.-W., Adams, G. B., Perin, L., Wei, M., Zhou, X., Lam, B. S., Da Sacco, S., Mirisola, M., Quinn, D. I., Dorff, T. B., Kopchick, J. J., & Longo, V. D.
- Venue
- Cell Stem Cell
- Publisher
- Elsevier BV
- Published
- 2014-06
- Volume
- 14
- Issue
- 6
- Pages
- 810-823
- ISSN
- 1875-9777 (ISSN-L)
- 1934-5909
- OpenAlex
- W1984358237
- Cited by
- 483
- References
- 12
- FWCI
- 21.43
- Type
- journal article
- Language
- en
- Open access
- bronze
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