IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice

Oxidants, oxidative stress and the biology of ageing

Finkel, T., & Holbrook, N. J. (2000) · Nature · doi:10.1038/35041687 · Cited by 9,413 · see citing works

Mice carrying null mutations of the genes encoding insulin-like growth factor I (Igf-1) and type 1 IGF receptor (Igf1r)

Liu, J.-P., Baker, J. C., Perkins, A. S., Robertson, E. J., & Efstratiadis, A. (1993) · Cell · doi:10.1016/s0092-8674(05)80084-4 · Cited by 2,854 · see citing works

daf-2 , an Insulin Receptor-Like Gene That Regulates Longevity and Diapause in Caenorhabditis elegans

Kimura, K. D., Tissenbaum, H. A., Liu, Y., & Ruvkun, G. (1997) · Science · doi:10.1126/science.277.5328.942 · Cited by 2,250 · see citing works

The p66shc adaptor protein controls oxidative stress response and life span in mammals

Migliaccio, E., Giorgio, M., Mele, S., Pelicci, G., Reboldi, P., Pandolfi, P. P., Lanfrancone, L., & Pelicci, P. G. (1999) · Nature · doi:10.1038/46311 · Cited by 1,712 · see citing works

A Mutant Drosophila Insulin Receptor Homolog That Extends Life-Span and Impairs Neuroendocrine Function

Tatar, M., Kopelman, A. H., Epstein, D., Tu, M., Yin, C. ‐., & Garofalo, R. S. (2001) · Science · doi:10.1126/science.1057987 · Cited by 1,630 · see citing works

Extension of Life-Span by Loss of CHICO, a Drosophila Insulin Receptor Substrate Protein

Clancy, D. J., Gems, D., Harshman, L. G., Oldham, S., Stocker, H., Hafen, E., Leevers, S. J., & Partridge, L. (2001) · Science · doi:10.1126/science.1057991 · Cited by 1,436 · see citing works

Genetic pathways that regulate ageing in model organisms

Guarente, L., & Kenyon, C. J. (2000) · Nature · doi:10.1038/35041700 · Cited by 1,337 · see citing works

Tissue-Specific Knockout of the Insulin Receptor in Pancreatic β Cells Creates an Insulin Secretory Defect Similar to that in Type 2 Diabetes

Kulkarni, R., Brüning, J. C., Winnay, J. N., Postic, C., Magnuson, M. A., & Kahn, C. R. (1999) · Cell · doi:10.1016/s0092-8674(00)80546-2 · Cited by 1,148 · see citing works

Dwarf mice and the ageing process

Brown‐Borg, H. M., Borg, K. E., Meliska, C. J., & Bartke, A. (1996) · Nature · doi:10.1038/384033a0 · Cited by 1,091 · see citing works

Lifespan extension and delayed immune and collagen aging in mutant mice with defects in growth hormone production

Flurkey, K., Papaconstantinou, J., Miller, R. A., & Harrison, D. E. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.111158898 · Cited by 826 · see citing works

Roles of Growth Hormone and Insulin-like Growth Factor 1 in Mouse Postnatal Growth

Lupu, F. I., Terwilliger, J. D., Lee, K., Segre, G. V., & Efstratiadis, A. (2001) · Developmental Biology · doi:10.1006/dbio.2000.9975 · Cited by 769 · see citing works

Regulation of C. elegans Life-Span by Insulinlike Signaling in the Nervous System

Wolkow, C. A., Kimura, K. D., Lee, M. S., & Ruvkun, G. (2000) · Science · doi:10.1126/science.290.5489.147 · Cited by 681 · see citing works

Assessment of Growth Parameters and Life Span of GHR/BP Gene-Disrupted Mice ¹

Coschigano, K. T., Clemmons, D., Bellush, L. L., & Kopchick, J. J. (2000) · Endocrinology · doi:10.1210/endo.141.7.7586 · Cited by 611 · see citing works

Irs-2 coordinates Igf-1 receptor-mediated β-cell development and peripheral insulin signalling

Withers, D. J., Burks, D. J., Towery, H. H., Altamuro, S. L., Flint, C. L., & White, M. F. (1999) · Nature Genetics · doi:10.1038/12631 · Cited by 530 · see citing works

A Conserved Regulatory System for Aging

Kenyon, C. J. (2001) · Cell · doi:10.1016/s0092-8674(01)00306-3 · Cited by 529 · see citing works

FLP Recombinase-Mediated Induction of Cu/Zn-Superoxide Dismutase Transgene Expression Can Extend the Life Span of Adult Drosophila melanogaster Flies

Sun, J., & Tower, J. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.1.216 · Cited by 467 · see citing works

Extending the Lifespan of Long-Lived Mice

Bartke, A., Wright, J. C., Mattison, J. A., Ingram, D. K., Miller, R. A., & Roth, G. S. (2001) · Nature · doi:10.1038/35106646 · Cited by 422 · see citing works

Spontaneous Testicular Teratomas in an Inbred Strain of Mice

Stevens, L. C., & Little, C. C. (1954) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.40.11.1080 · Cited by 381 · see citing works

β-cell–specific deletion of the Igf1 receptor leads to hyperinsulinemia and glucose intolerance but does not alter β-cell mass

Kulkarni, R. N., Holzenberger, M., Shih, D. Q., Özcan, U., Stoffel, M., Magnuson, M. A., & Kahn, C. R. (2002) · Nature Genetics · doi:10.1038/ng872 · Cited by 363 · see citing works

An Insulin-like Signaling Pathway Affects Both Longevity and Reproduction in Caenorhabditis elegans

Tissenbaum, H. A., & Ruvkun, G. (1998) · Genetics · doi:10.1093/genetics/148.2.703 · Cited by 354 · see citing works

Dietary Restriction in Long-Lived Dwarf Flies

Clancy, D. J., Gems, D., Hafen, E., Leevers, S. J., & Partridge, L. (2002) · Science · doi:10.1126/science.1069366 · Cited by 289 · see citing works

Longevity and Gross Pathology At Death in 22 Inbred Mouse Strains

Storer, J. B. (1966) · Journal of Gerontology · doi:10.1093/geronj/21.3.404 · Cited by 221 · see citing works

Lifespan and Incidence of Cancer and Other Diseases in Selected Long-Lived Inbred Mice and Their F1 Hybrids2

Smith, G. S., Walford, R. L., & Mickey, M. R. (1973) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/50.5.1195 · Cited by 173 · see citing works

Insulin/IGF signalling and ageing: seeing the bigger picture

Gems, D. (2001) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(00)00192-1 · Cited by 173 · see citing works

The Potentiation of Estrogen on Insulin-like Growth Factor I Action in MCF-7 Human Breast Cancer Cells Includes Cell Cycle Components

Dupont, J., Karas, M., & LeRoith, D. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m006741200 · Cited by 153 · see citing works

Oxidative Stress and Life Span Determination in the Nematode Caenorhabditis elegans

Honda, Y., & Honda, S. (2002) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2002.tb02117.x · Cited by 124 · see citing works

Low Body Temperature in Long-Lived Ames Dwarf Mice at Rest and During Stress

Hunter, W. S., Croson, W., Bartke, A., Gentry, M. V., & Meliska, C. J. (1999) · Physiology & Behavior · doi:10.1016/s0031-9384(99)00098-0 · Cited by 106 · see citing works

A Targeted Partial Invalidation of the Insulin-Like Growth Factor I Receptor Gene in Mice Causes a Postnatal Growth Deficit

Holzenberger, M., Leneuve, P., Hamard, G., Ducos, B., Périn, L., Binoux, M., & Bouc, Y. L. (2000) · Endocrinology · doi:10.1210/endo.141.7.7550 · Cited by 106 · see citing works

Experimental IGF-I Receptor Deficiency Generates a Sexually Dimorphic Pattern of Organ-Specific Growth Deficits in Mice, Affecting Fat Tissue in Particular

Holzenberger, M., Hamard, G., Zaoui, R., Leneuve, P., Ducos, B., Beccavin, C., Périn, L., & Bouc, Y. L. (2001) · Endocrinology · doi:10.1210/endo.142.10.8461 · Cited by 100 · see citing works

Mutations prolong life in flies; implications for aging in mammals

Bartke, A. (2001) · Trends in Endocrinology and Metabolism · doi:10.1016/s1043-2760(01)00426-x · Cited by 34 · see citing works

Mitochondria, Oxidants, and Aging

Balaban, R. S., Nemoto, S., & Finkel, T. (2005) · Cell · doi:10.1016/j.cell.2005.02.001 · Cited by 4,388 · see citing works

Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans

Murphy, C. T., McCarroll, S. A., Bargmann, C. I., Fraser, A., Kamath, R. S., Ahringer, J., Li, H., & Kenyon, C. (2003) · Nature · doi:10.1038/nature01789 · Cited by 2,280 · see citing works

Understanding the odd science of aging

Kirkwood, T. B. L. (2005) · Cell · doi:10.1016/j.cell.2005.01.027 · Cited by 1,984 · see citing works

Suppression of Aging in Mice by the Hormone Klotho

Kurosu, H., Yamamoto, M., Clark, J. D., Pastor, J. V., Nandi, A., Gurnani, P., McGuinness, O. P., Chikuda, H., Yamaguchi, M., Kawaguchi, H., et al. (2005) · Science · doi:10.1126/science.1112766 · Cited by 1,935 · see citing works

Insulin-like growth factors and neoplasia

Pollak, M., Schernhammer, E. S., & Hankinson, S. E. (2004) · Nature reviews. Cancer · doi:10.1038/nrc1387 · Cited by 1,465 · see citing works

The plasticity of aging: insights from long-lived mutants

Kenyon, C. (2005) · Cell · doi:10.1016/j.cell.2005.02.002 · Cited by 1,338 · see citing works

The Endocrine Regulation of Aging by Insulin-like Signals

Tatar, M., Bartke, A., & Antebi, A. (2003) · Science · doi:10.1126/science.1081447 · Cited by 1,327 · see citing works

FOXO transcription factors at the interface between longevity and tumor suppression

Greer, E. L., & Brunet, A. (2005) · Oncogene · doi:10.1038/sj.onc.1209086 · Cited by 1,306 · see citing works

Regulation of the mTOR Complex 1 Pathway by Nutrients, Growth Factors, and Stress

Sengupta, S., Peterson, T. R., & Sabatini, D. M. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.09.026 · Cited by 1,234 · see citing works

The FoxO code

Calnan, D. R., & Brunet, A. (2008) · Oncogene · doi:10.1038/onc.2008.21 · Cited by 1,170 · see citing works

Sirt1 Regulates Aging and Resistance to Oxidative Stress in the Heart

Alcendor, R. R., Gao, S., Zhai, P., Zablocki, D., Holle, E., Yu, X., Tian, B., Wagner, T., Vatner, S. F., & Sadoshima, J. (2007) · Circulation Research · doi:10.1161/01.res.0000267723.65696.4a · Cited by 1,147 · see citing works

Mammalian Hibernation: Cellular and Molecular Responses to Depressed Metabolism and Low Temperature

Carey, H. V., Andrews, M. T., & Martin, S. L. (2003) · Physiological Reviews · doi:10.1152/physrev.00008.2003 · Cited by 1,145 · see citing works

Ribosomal Protein S6 Kinase 1 Signaling Regulates Mammalian Life Span

Selman, C., Tullet, J. M. A., Wieser, D., Irvine, E., Lingard, S. J., Choudhury, A. I., Claret, M., Al-Qassab, H., Carmignac, D., Ramadani, F., et al. (2009) · Science · doi:10.1126/science.1177221 · Cited by 1,120 · see citing works

Finding function in novel targets: C. elegans as a model organism

Kaletta, T., & Hengartner, M. O. (2006) · Nature Reviews Drug Discovery · doi:10.1038/nrd2031 · Cited by 1,091 · see citing works

The role of mitochondria in aging

Bratic, A., & Larsson, N.-G. (2013) · Journal of Clinical Investigation · doi:10.1172/jci64125 · Cited by 1,087 · see citing works

The sirtuin SIRT6 regulates lifespan in male mice

Kanfi, Y., Naiman, S., Amir, G., Peshti, V., Zinman, G., Nahum, L., Bar-Joseph, Z., & Cohen, H. Y. (2012) · Nature · doi:10.1038/nature10815 · Cited by 1,059 · see citing works

Overview of caloric restriction and ageing

Masoro, E. J. (2005) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2005.03.012 · Cited by 1,054 · see citing works

Insulin Receptor Isoforms and Insulin Receptor/Insulin-Like Growth Factor Receptor Hybrids in Physiology and Disease

Belfiore, A., Frasca, F., Pandini, G., Sciacca, L., & Vigneri, R. (2009) · Endocrine Reviews · doi:10.1210/er.2008-0047 · Cited by 1,035 · see citing works

Extension of Chronological Life Span in Yeast by Decreased TOR Pathway Signaling

Powers, R. W., Kaeberlein, M., Caldwell, S. D., Kennedy, B. K., & Fields, S. (2006) · Genes & Development · doi:10.1101/gad.1381406 · Cited by 982 · see citing works

Life and Death: Metabolic Rate, Membrane Composition, and Life Span of Animals

Hulbert, A. J., Pamplona, R., Buffenstein, R., & Buttemer, W. A. (2007) · Physiological Reviews · doi:10.1152/physrev.00047.2006 · Cited by 926 · see citing works

Stems Cells and the Pathways to Aging and Cancer

Rossi, D. J., Jamieson, C. H. M., & Weissman, I. L. (2008) · Cell · doi:10.1016/j.cell.2008.01.036 · Cited by 895 · see citing works

An integrated view of oxidative stress in aging: basic mechanisms, functional effects, and pathological considerations

Kregel, K. C., & Zhang, H. J. (2007) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00327.2006 · Cited by 883 · see citing works

Opposing activities protect against age-onset proteotoxicity

Cohen, E., Bieschke, J., Perciavalle, R. M., Kelly, J. W., & Dillin, A. (2006) · Science · doi:10.1126/science.1124646 · Cited by 843 · see citing works

Longer lifespan, altered metabolism, and stress resistance in <i>Drosophila</i> from ablation of cells making insulin-like ligands

Broughton, S. J., Piper, M. D. W., Ikeya, T., Bass, T. M., Jacobson, J., Driege, Y., Martinez, P., Hafen, E., Withers, D. J., Leevers, S. J., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0405775102 · Cited by 822 · see citing works

Stem cell aging: mechanisms, regulators and therapeutic opportunities

Oh, J., Lee, Y. D., & Wagers, A. J. (2014) · Nature Medicine · doi:10.1038/nm.3651 · Cited by 796 · see citing works

How increased oxidative stress promotes longevity and metabolic health: The concept of mitochondrial hormesis (mitohormesis)

Ristow, M., & Zarse, K. (2010) · Experimental Gerontology · doi:10.1016/j.exger.2010.03.014 · Cited by 789 · see citing works

Resveratrol Prolongs Lifespan and Retards the Onset of Age-Related Markers in a Short-Lived Vertebrate

Valenzano, D. R., Tozzini, E. T., Genade, T., Cattaneo, A., Domenici, L., & Cellerino, A. (2006) · Current Biology · doi:10.1016/j.cub.2005.12.038 · Cited by 786 · see citing works

Regulation of H SF 1 Function in the Heat Stress Response: Implications in Aging and Disease

Anckar, J., & Sistonen, L. (2011) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-060809-095203 · Cited by 779 · see citing works

Stress-activated cap’n’collar transcription factors in aging and human disease

Sykiotis, G. P., & Bohmann, D. (2010) · Science Signaling · doi:10.1126/scisignal.3112re3 · Cited by 776 · see citing works

Defects in IGF-1 receptor, insulin receptor and IRS-1/2 in Alzheimer’s disease indicate possible resistance to IGF-1 and insulin signalling

Moloney, A. M., Griffin, R. J., Timmons, S., O’Connor, R., Ravid, R., & O’Neill, C. (2010) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2008.04.002 · Cited by 764 · see citing works

The aging of Wolff’s “law”: Ontogeny and responses to mechanical loading in cortical bone

Pearson, O. M., & Lieberman, D. E. (2004) · American Journal of Physical Anthropology · doi:10.1002/ajpa.20155 · Cited by 745 · see citing works

Growth Hormone Receptor Deficiency Is Associated with a Major Reduction in Pro-Aging Signaling, Cancer, and Diabetes in Humans

Guevara‐Aguirre, J., Balasubramanian, P., Guevara‐Aguirre, M., Wei, M., Madia, F., Cheng, C., Hwang, D., Martín‐Montalvo, A., Saavedra, J., Ingles, S. A., et al. (2011) · Science Translational Medicine · doi:10.1126/scitranslmed.3001845 · Cited by 735 · see citing works

Regulation of Longevity in Caenorhabditis elegans by Heat Shock Factor and Molecular Chaperones

Morley, J. F., & Morimoto, R. I. (2003) · Molecular Biology of the Cell · doi:10.1091/mbc.e03-07-0532 · Cited by 725 · see citing works

SKN-1 links C. elegans mesendodermal specification to a conserved oxidative stress responsePreprint

An, J. H., & Blackwell, T. K. (2003) · Genes & Development · doi:10.1101/gad.1107803 · Cited by 722 · see citing works

Extending life span by increasing oxidative stress

Ristow, M., & Schmeisser, S. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.05.010 · Cited by 718 · see citing works

Molecular mechanisms of dietary restriction promoting health and longevity

Green, C. L., Lamming, D. W., & Fontana, L. (2022) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-021-00411-4 · Cited by 714 · see citing works

The TOR pathway interacts with the insulin signaling pathway to regulate C. elegans larval development, metabolism and life span

Jia, K., Chen, D., & Riddle, D. L. (2004) · Development · doi:10.1242/dev.01255 · Cited by 705 · see citing works

Functionally significant insulin-like growth factor I receptor mutations in centenarians

Suh, Y., Atzmon, G., Cho, M.-O., Hwang, D., Liu, B., Leahy, D. J., Barzilai, N., & Cohen, P. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0705467105 · Cited by 703 · see citing works

Calorie restriction and aging: review of the literature and implications for studies in humans

Heilbronn, L. K., & Ravussin, E. (2003) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/78.3.361 · Cited by 701 · see citing works

Insulin Action in Brain Regulates Systemic Metabolism and Brain Function

Kleinridders, A., Ferris, H. A., Cai, W., & Kahn, C. R. (2014) · Diabetes · doi:10.2337/db14-0568 · Cited by 688 · see citing works

DAF-16 Target Genes That Control <i>C. elegans</i> Life-Span and Metabolism

Lee, S. S., Kennedy, S., Tolonen, A. C., & Ruvkun, G. (2003) · Science · doi:10.1126/science.1083614 · Cited by 669 · see citing works

Insulin-like growth factor signaling in fish

Wood, A. W., Duan, C., & Bern, H. A. (2005) · International Review of Cytology · doi:10.1016/s0074-7696(05)43004-1 · Cited by 657 · see citing works

Mitochondria-Ros Crosstalk in the Control of Cell Death and Aging

Marchi, S., Giorgi, C., Suski, J. M., Agnoletto, C., Bononi, A., Bonora, M., Marchi, E. D., Missiroli, S., Patergnani, S., Poletti, F., et al. (2011) · Journal of Signal Transduction · doi:10.1155/2012/329635 · Cited by 639 · see citing works

The role of oxidative damage and stress in aging

Bokov, A. F., Chaudhuri, A. R., & Richardson, A. G. (2004) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2004.07.009 · Cited by 621 · see citing works

Redox regulation of PI 3‐kinase signalling via inactivation of PTEN

Leslie, N. R., Bennett, D., Lindsay, Y. E., Stewart, H., Gray, A., & Downes, C. P. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg513 · Cited by 614 · see citing works

Is the oxidative stress theory of aging dead?

Pérez, V. I., Bokov, A., Remmen, H. V., Mele, J., Ran, Q., Ikeno, Y., & Richardson, A. (2009) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2009.06.003 · Cited by 604 · see citing works

FoxO transcription factors in the maintenance of cellular homeostasis during aging

Salih, D. A., & Brunet, A. (2008) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2008.02.005 · Cited by 604 · see citing works

Aging and Survival: The Genetics of Life Span Extension by Dietary Restriction

Mair, W. B., & Dillin, A. G. (2008) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.77.061206.171059 · Cited by 600 · see citing works

Regulation and Function of the FGF23/Klotho Endocrine Pathways

Martin, A., David, V., & Quarles, L. D. (2012) · Physiological Reviews · doi:10.1152/physrev.00002.2011 · Cited by 595 · see citing works

The Drosophila Forkhead transcription factor FOXO mediates the reduction in cell number associated with reduced insulin signaling

Jünger, M. A., Rintelen, F., Stocker, H., Wasserman, J. D., Végh, M., Radimerski, T., Greenberg, M. E., & Hafen, E. (2003) · Journal of Biology · doi:10.1186/1475-4924-2-20 · Cited by 595 · see citing works

Sex Differences in Lifespan

Austad, S. N., & Fischer, K. E. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.05.019 · Cited by 591 · see citing works

Starvation-dependent differential stress resistance protects normal but not cancer cells against high-dose chemotherapy.

Raffaghello, L., Lee, C., Safdie, F. M., Wei, M., Madia, F., Bianchi, G., & Longo, V. D. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0708100105 · Cited by 587 · see citing works

Modulation of mammalian life span by the short isoform of p53

Maier, B., Gluba, W., Bernier, B., Turner, T., Mohammad, K., Guise, T., Sutherland, A., Thorner, M., & Scrable, H. (2004) · Genes &amp; Development · doi:10.1101/gad.1162404 · Cited by 586 · see citing works

A low dose of dietary resveratrol partially mimics caloric restriction and retards aging parameters in mice

Barger, J. L., Kayo, T., Vann, J. M., Arias, E. B., Wang, J., Hacker, T. A., Wang, Y., Raederstorff, D., Morrow, J. D., Leeuwenburgh, C., et al. (2008) · PLoS ONE · doi:10.1371/journal.pone.0002264 · Cited by 580 · see citing works

The GH/IGF-1 axis in ageing and longevity

Junnila, R. K., List, E. O., Berryman, D. E., Murrey, J. W., & Kopchick, J. J. (2013) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2013.67 · Cited by 574 · see citing works

Dynamic O-GlcNAc Modification of Nucleocytoplasmic Proteins in Response to Stress

Zachara, N. E., O'Donnell, N., Cheung, W. D., Mercer, J. J., Marth, J. D., & Hart, G. W. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m403773200 · Cited by 568 · see citing works

A Conceptual History of Modern Embryology

Gilbert, S. F. (1991) · Springer eBooks · doi:10.1007/978-1-4615-6823-0 · Cited by 559 · see citing works

Oxidative stress as a life‐history constraint: the role of reactive oxygen species in shaping phenotypes from conception to death

Metcalfe, N. B., & Alonso‐Álvarez, C. (2010) · Functional Ecology · doi:10.1111/j.1365-2435.2010.01750.x · Cited by 559 · see citing works

C. elegans dauer formation and the molecular basis of plasticityPreprint

Fielenbach, N., & Antebi, A. (2008) · Genes & Development · doi:10.1101/gad.1701508 · Cited by 556 · see citing works

Aging and Genome Maintenance: Lessons from the Mouse?

Hasty, P., Campisi, J., Hoeijmakers, J., van Steeg, H., & Vijg, J. (2003) · Science · doi:10.1126/science.1079161 · Cited by 553 · see citing works

Telomerase gene therapy in adult and old mice delays aging and increases longevity without increasing cancer

Bernardes de Jesus, B., Vera, E., Schneeberger, K., Tejera, A. M., Ayuso, E., Bosch, F., & Blasco, M. A. (2012) · EMBO Molecular Medicine · doi:10.1002/emmm.201200245 · Cited by 548 · see citing works

Genetics of Longevity in Model Organisms: Debates and Paradigm Shifts

Gems, D., & Partridge, L. (2012) · Annual Review of Physiology · doi:10.1146/annurev-physiol-030212-183712 · Cited by 545 · see citing works

Optical coherence tomography: a review of clinical development from bench to bedside

Zysk, A. M., Nguyen, F. T., Oldenburg, A. L., Marks, D. L., & Boppart, S. A. (2007) · Journal of Biomedical Optics · doi:10.1117/1.2793736 · Cited by 543 · see citing works

Vascular Cell Senescence: Contribution to Atherosclerosis

Minamino, T., & Komuro, I. (2007) · Circulation Research · doi:10.1161/01.res.0000256837.40544.4a · Cited by 542 · see citing works

PHA-4/Foxa mediates diet-restriction-induced longevity of C. elegans

Panowski, S. H., Wolff, S., Aguilaniu, H., Durieux, J., & Dillin, A. G. (2007) · Nature · doi:10.1038/nature05837 · Cited by 538 · see citing works

JNK Extends Life Span and Limits Growth by Antagonizing Cellular and Organism-Wide Responses to Insulin Signaling

Wang, M. C., Bohmann, D., & Jasper, H. (2005) · Cell · doi:10.1016/j.cell.2005.02.030 · Cited by 537 · see citing works

Mitohormesis: Promoting Health and Lifespan by Increased Levels of Reactive Oxygen Species (ROS)

Ristow, M., & Schmeisser, K. (2014) · Dose-Response · doi:10.2203/dose-response.13-035.ristow · Cited by 534 · see citing works

Mechanisms of Vascular Aging: New Perspectives

Ungvari, Z. I., Kaley, G., de Cabo, R., Sonntag, W. E., & Csiszár, A. (2010) · The Journals of Gerontology Series A · doi:10.1093/gerona/glq113 · Cited by 534 · see citing works

Evidence for lifespan extension and delayed age–related biomarkers in insulin receptor substrate 1 null mice

Selman, C., Lingard, S., Choudhury, A. I., Batterham, R. L., Claret, M., Clements, M., Ramadani, F., Okkenhaug, K., Schuster, E., Blanc, E., et al. (2008) · The FASEB Journal · doi:10.1096/fj.07-9261com · Cited by 532 · see citing works

Insulin/insulin-like growth factor signaling in C. elegans

Murphy, C. T. (2013) · WormBook · doi:10.1895/wormbook.1.164.1 · Cited by 527 · see citing works

Demography of Dietary Restriction and Death in Drosophila

Mair, W. B., Goymer, P., Pletcher, S. D., & Partridge, L. (2003) · Science · doi:10.1126/science.1086016 · Cited by 526 · see citing works

A systematic RNAi screen for longevity genes in C. elegansPreprint

Hamilton, B., Dong, Y., Shindo, M., Liu, W., Odell, I., Ruvkun, G., & Lee, S. S. (2005) · Genes & Development · doi:10.1101/gad.1308205 · Cited by 513 · see citing works

Transient Receptor Potential Channels as Drug Targets: From the Science of Basic Research to the Art of Medicine

Nilius, B., & SZALLASI, A. (2014) · Pharmacological Reviews · doi:10.1124/pr.113.008268 · Cited by 504 · see citing works

Reduced IGF-1 signaling delays age-associated proteotoxicity in mice

Cohen, E., Paulsson, J. F., Blinder, P., Burstyn-Cohen, T., Du, D., Estepa, G., Adame, A., Pham, H. M., Holzenberger, M., Kelly, J. W., et al. (2009) · Cell · doi:10.1016/j.cell.2009.11.014 · Cited by 488 · see citing works

The Insulin-Like Growth Factor System and Its Pleiotropic Functions in Brain

Russo, V. C., Gluckman, P. D., Feldman, E. L., & Werther, G. A. (2005) · Endocrine Reviews · doi:10.1210/er.2004-0024 · Cited by 488 · see citing works

Disruption of the Ang II type 1 receptor promotes longevity in mice

Benigni, A., Corna, D., Zoja, C., Sonzogni, A., Latini, R., Salio, M., Conti, S., Rottoli, D., Longaretti, L., Cassis, P., et al. (2009) · Journal of Clinical Investigation · doi:10.1172/jci36703 · Cited by 486 · see citing works

Prolonged Fasting Reduces IGF-1/PKA to Promote Hematopoietic-Stem-Cell-Based Regeneration and Reverse Immunosuppression

Cheng, C., Adams, G. B., Perin, L., Wei, M., Zhou, X., Lam, B. S., Sacco, S. D., Mirisola, M. G., Quinn, D. I., Dorff, T. B., et al. (2014) · Cell stem cell · doi:10.1016/j.stem.2014.04.014 · Cited by 484 · see citing works

Lifespan Regulation by Evolutionarily Conserved Genes Essential for Viability

Curran, S. P., & Ruvkun, G. (2007) · PLoS Genetics · doi:10.1371/journal.pgen.0030056 · Cited by 479 · see citing works

The sirtuin SIRT6 blocks IGF-Akt signaling and development of cardiac hypertrophy by targeting c-Jun

Sundaresan, N. R., Vasudevan, P., Zhong, L., Kim, G. H., Samant, S. A., Parekh, V., Pillai, V. B., Veeranna, R. P., Gupta, M., Jeevanandam, V., et al. (2012) · Nature Medicine · doi:10.1038/nm.2961 · Cited by 477 · see citing works

Superoxide dismutase evolution and life span regulation

Landis, G. N., & Tower, J. (2004) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2004.08.012 · Cited by 474 · see citing works

Beneficial effects of intermittent fasting and caloric restriction on the cardiovascular and cerebrovascular systems

Mattson, M. P., & Wan, R. (2005) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2004.12.007 · Cited by 464 · see citing works

Insulin/IGF-I-signaling pathway: an evolutionarily conserved mechanism of longevity from yeast to humans

Barbieri, M., Bonafè, M., Franceschi, C., & Paolisso, G. (2003) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00296.2003 · Cited by 456 · see citing works

The Many Forks in FOXO's Road

Tran, H. G., Brunet, A., Griffith, E. C., & Greenberg, M. E. (2003) · Science Signaling · doi:10.1126/stke.2003.172.re5 · Cited by 456 · see citing works

Update on the oxidative stress theory of aging: Does oxidative stress play a role in aging or healthy aging?

Salmon, A. B., Richardson, A. G., & Pérez, V. (2009) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2009.12.015 · Cited by 444 · see citing works

Increased susceptibility to oxidative stress as a proximate cost of reproduction

Alonso‐Álvarez, C., Bertrand, S., Devevey, G., Prost, J., Faivre, B., & Sorci, G. (2004) · Ecology Letters · doi:10.1111/j.1461-0248.2004.00594.x · Cited by 444 · see citing works

Sex and Death: What Is the Connection?

Partridge, L., Gems, D., & Withers, D. J. (2005) · Cell · doi:10.1016/j.cell.2005.01.026 · Cited by 443 · see citing works

Aging and Autophagy in the Heart

Shirakabe, A., Ikeda, Y., Sciarretta, S., Zablocki, D., & Sadoshima, J. (2016) · Circulation Research · doi:10.1161/circresaha.116.307474 · Cited by 443 · see citing works

The landscape of aging

Cai, Y., Song, W., Li, J., Jing, Y., Liang, C., Zhang, L., Zhang, X., Zhang, W., Liu, B., An, Y., et al. (2022) · Science China Life Sciences · doi:10.1007/s11427-022-2161-3 · Cited by 436 · see citing works

Impaired insulin/IGF1 signaling extends life span by promoting mitochondrial L-proline catabolism to induce a transient ROS signal

Zarse, K., Schmeisser, S., Groth, M., Priebe, S., Beuster, G., Kuhlow, D., Guthke, R., Platzer, M., Kahn, C. R., & Ristow, M. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.02.013 · Cited by 430 · see citing works

O-GlcNAc a sensor of cellular state: the role of nucleocytoplasmic glycosylation in modulating cellular function in response to nutrition and stress

Zachara, N. E., & Hart, G. W. (2004) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2004.03.016 · Cited by 425 · see citing works

Mitochondria and ageing: Role in heart, skeletal muscle and adipose tissue

Boengler, K., Kosiol, M., Mayr, M., Schulz, R., & Rohrbach, S. (2017) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.12178 · Cited by 421 · see citing works

Calorie restriction mimetics: an emerging research field

Ingram, D. K., Zhu, M., Mamczarz, J., Zou, S., Lane, M. A., Roth, G. S., & de Cabo, R. (2006) · Aging Cell · doi:10.1111/j.1474-9726.2006.00202.x · Cited by 415 · see citing works

Aging in inbred strains of mice: study design and interim report on median lifespans and circulating IGF1 levels

Yuan, R., Tsaih, S., Petkova, S. B., de Evsikova, C. M., Xing, S., Marion, M. A., Bogue, M. A., Mills, K. D., Peters, L. L., Bult, C. J., et al. (2009) · Aging Cell · doi:10.1111/j.1474-9726.2009.00478.x · Cited by 414 · see citing works

Targeting mammalian target of rapamycin (mTOR) for health and diseases

Tsang, C. K., Qi, H., Liu, L. F., & Zheng, X. (2006) · Drug Discovery Today · doi:10.1016/j.drudis.2006.12.008 · Cited by 403 · see citing works

Sirtuins: The ‘ <i>magnificent seven</i> ’, function, metabolism and longevity

Dali‐Youcef, N., Lagouge, M., Froelich, S., Koehl, C., Schoonjans, K., & Auwerx, J. (2007) · Annals of Medicine · doi:10.1080/07853890701408194 · Cited by 402 · see citing works

Shared Transcriptional Signature in Caenorhabditis elegans Dauer Larvae and Long-lived daf-2 Mutants Implicates Detoxification System in Longevity Assurance

McElwee, J. J., Schuster, E. F., Blanc, E., Thomas, J. H., & Gems, D. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m406207200 · Cited by 402 · see citing works

Fasting and cancer treatment in humans: A case series report

Safdie, F. M., Dorff, T. B., Quinn, D. I., Fontana, L., Wei, M., Lee, C. D., Cohen, P., & Longo, V. D. (2009) · Aging · doi:10.18632/aging.100114 · Cited by 401 · see citing works

Long‐term effects of calorie or protein restriction on serum IGF‐1 and IGFBP‐3 concentration in humans

Fontana, L., Weiss, E. P., Villareal, D. T., Klein, S., & Holloszy, J. O. (2008) · Aging Cell · doi:10.1111/j.1474-9726.2008.00417.x · Cited by 396 · see citing works

GSK-3 is essential in the pathogenesis of Alzheimer's disease

Takashima, A. (2006) · Journal of Alzheimer s Disease · doi:10.3233/jad-2006-9s335 · Cited by 395 · see citing works

Regulation of C. elegans Longevity by Specific Gustatory and Olfactory Neurons

Alcedo, J., & Kenyon, C. (2004) · Neuron · doi:10.1016/s0896-6273(03)00816-x · Cited by 388 · see citing works

IGF-1 Receptors in Mammalian Longevity: Less is More

Holzenberger, M. (2004) · Research and perspectives in endocrine interactions · doi:10.1007/978-3-662-07019-2_3

Absence makes the mouse live longer

Bussell, K. (2003) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1023

The Role of Insulin-Like Signalling in the Regulation of Ageing

Holzenberger, M. (2004) · Hormone Research in Paediatrics · doi:10.1159/000080765 · Cited by 20 · see citing works

Does Reduced IGF-1R Signaling in Igf1r+/− Mice Alter Aging?

Bokov, A. F., Garg, N., Ikeno, Y., Thakur, S., Musi, N., DeFronzo, R. A., Zhang, N., Erickson, R. C., Gelfond, J., Hubbard, G. B., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0026891 · Cited by 150 · see citing works

Hormonal regulation of aging and life span

Brown‐Borg, H. M. (2003) · Trends in Endocrinology and Metabolism · doi:10.1016/s1043-2760(03)00051-1 · Cited by 28 · see citing works