The DOI matches its Crossref record; 134 of the 134 references it cites were found in a registry or an index.
Colorectal Cancer Stem Cells: From the Crypt to the Clinic
Open accessAbstract
Since their first discovery, investigations of colorectal cancer stem cells (CSCs) have revealed some unexpected properties, including a high degree of heterogeneity and plasticity. By exploiting a combination of genetic, epigenetic, and microenvironmental factors, colorectal CSCs metastasize, resist chemotherapy, and continually adapt to a changing microenvironment, representing a formidable challenge to cancer eradication. Here, we review the current understanding of colorectal CSCs, including their origin, relationship to stem cells of the intestine, phenotypic characterization, and underlying regulatory mechanisms. We also discuss limitations to current preclinical models of colorectal cancer and how understanding CSC plasticity can improve the development of clinical strategies.
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Cites
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Cited by
The prognostic landscape of genes and infiltrating immune cells across human cancers
Gentles, A. J., Newman, A. M., Liu, C. L., Bratman, S. V., Feng, W., Kim, D., Nair, V. S., Xu, Y., Khuong, A., Hoang, C. D., et al. (2015) · Nature Medicine · doi:10.1038/nm.3909 · Cited by 3,118
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From tumour heterogeneity to advances in precision treatment of colorectal cancer
Punt, C. J. A., Koopman, M., & Vermeulen, L. (2017) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2016.171 · Cited by 654
Drug resistance and new therapies in colorectal cancer
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Targeting Cancer Stemness in the Clinic: From Hype to Hope
Saygin, C., Matei, D., Majeti, R., Reizes, O., & Lathia, J. D. (2019) · Cell Stem Cell · doi:10.1016/j.stem.2018.11.017 · Cited by 517
Metadata
- Authors
- Zeuner, A., Todaro, M., Stassi, G., & De Maria, R.
- Venue
- Cell Stem Cell
- Publisher
- Elsevier BV
- Published
- 2014-12
- Volume
- 15
- Issue
- 6
- Pages
- 692-705
- ISSN
- 1875-9777 (ISSN-L)
- 1934-5909
- OpenAlex
- W1988758354
- Cited by
- 368
- References
- 134
- FWCI
- 12.21
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Zeuner, A., Todaro, M., Stassi, G., & De Maria, R. (2014). Colorectal Cancer Stem Cells: From the Crypt to the Clinic. Cell Stem Cell. https://doi.org/10.1016/j.stem.2014.11.012
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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