Wnt/β-Catenin Signaling in Development and Disease

Clevers, Hans

doi:10.1016/j.cell.2006.10.018

Cited by 5,568Wnt/β-catenin signaling in development and cancerDevelopmental Biology and Gene RegulationHedgehog Signaling Pathway Studies

Wnt/β-Catenin Signaling in Development and Disease

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Clevers, Hans·2006·Cell

DOI 10.1016/j.cell.2006.10.018

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Abstract

A remarkable interdisciplinary effort has unraveled the WNT (Wingless and INT-1) signal transduction cascade over the last two decades. Wnt genes encode small secreted proteins that are found in all animal genomes. Wnt signaling is involved in virtually every aspect of embryonic development and also controls homeostatic self-renewal in a number of adult tissues. Germline mutations in the Wnt pathway cause several hereditary diseases, and somatic mutations are associated with cancer of the intestine and a variety of other tissues.

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A large number of binding partners for β-catenin in the nucleus has been uncovered and perhaps the best characterized are the members of the LEF/TCF DNA-binding transcription factors.
“A large number of binding partners for β-catenin in the nucleus has been uncovered and perhaps the best characterized are the members of the LEF/TCF DNA-binding transcription factors.47,48”
From Wnt signal transduction pathways (2008) · cites this paper as [47]
Canonical Wnt signaling also controls subsequent posterior patterning and tail formation, as well as formation of various organ systems including the heart, lungs, kidney, skin and bone.
“Canonical Wnt signaling also control subsequent posterior patterning and tail formation, as well as for formation of various organ systems including the heart, lungs, kidney, skin and bone.3,4,47,48,56”
From Wnt signal transduction pathways (2008) · cites this paper as [47]

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Authors: Clevers, H.
Affiliations: Utrecht University (NL)
Corresponding author: Clevers, Hans
ORCID: Clevers, Hans
Venue: Cell
Publisher: Elsevier BV
Published: 2006-11
Volume: 127
Issue: 3
Pages: 469-480
ISSN: 0092-8674 (ISSN-L)
DOI: 10.1016/j.cell.2006.10.018
OpenAlex: W2107648723
Cited by: 5,568
References: 15
Citations by year: 2026: 112 · 2025: 169 · 2024: 189 · 2023: 208 · 2022: 233 · 2021: 254 · 2020: 313 · 2019: 288 · 2018: 299 · 2017: 327 · 2016: 314 · 2015: 356 · 2014: 320 · 2013: 375 · 2012: 389
FWCI: 18.24
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 2450 d)
doi.org/10.15223/policy-017 (stm-asf)
doi.org/10.15223/policy-037 (stm-asf)
doi.org/10.15223/policy-012 (stm-asf)
doi.org/10.15223/policy-029 (stm-asf)
doi.org/10.15223/policy-004 (stm-asf)
Locations: Cell (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Wnt/β-catenin signaling in development and cancer
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Hedgehog Signaling Pathway Studies
Keywords: Wnt signaling, β-catenin, Wnt/β-catenin signaling, signal transduction, embryonic development, tissue homeostasis, stem cell self-renewal, germline mutations, genetic disorders, intestinal cancer, somatic mutations
MeSH terms: Adult, Animals, Humans, Intestinal Neoplasms, Signal Transduction, Trans-Activators, Gene Expression Regulation, Neoplastic, Germ-Line Mutation, Gene Expression Regulation, Developmental, Embryonic Development, Wnt Proteins, beta Catenin

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