Ascl2 acts as an R-spondin/Wnt-responsive switch to control stemness in intestinal crypts
Schuijers, Jurian, Junker, Jan Philipp, Mokry, Michal, Hatzis, Pantelis, Koo, Bon-Kyoung, Sasselli, Valentina, van der Flier, Laurens G., Cuppen, Edwin +2 more·2015·Cell Stem Cell
Cited by (272)
Items 101–200 of 272
- Bufalin inhibits gastric cancer invasion and metastasis by down-regulating Wnt/ASCL2 expressionJie Wang, Han Cai, Yue Xia, Shiying Wang, Likai Xing, Chao Chen, Yong Zhang, Jie Xu, Peihao Yin, Yiming Jiang et al. · 2018 · Oncotarget
- BCL-3 promotes a cancer stem cell phenotype by enhancing β-catenin signalling in colorectal tumour cellsDanny Legge, Alex P. Shephard, T J Collard, Alexander Greenhough, A Chambers, Richard W. E. Clarkson, Christos Paraskeva, Ann Caroline Williams · 2019 · Disease Models & Mechanisms
- The Regulatory Capacity of Bivalent Genes—A Theoretical ApproachTorsten Thalheim, Maria Herberg, Markus Loeffler, Joerg Galle · 2017 · International Journal of Molecular Sciences
- C3a Enhances the Formation of Intestinal Organoids through C3aR1Naoya Matsumoto, Abhigyan Satyam, Mayya Geha, Peter H. Lapchak, Jurandir J. Dalle Lucca, Maria Tsokos, George C. Tsokos · 2017 · Frontiers in Immunology
- Neonatal-Onset Chronic Diarrhea Caused by Homozygous Nonsense WNT2B MutationsAmy E. O’Connell, Fanny Zhou, Manasvi S. Shah, Quinn Murphy, Hannah Rickner, Judith R. Kelsen, John Boyle, Jefferson James Doyle, Bharti R. Nihalani, Jay R. Thiagarajah et al. · 2018 · The American Journal of Human Genetics
- Genome-wide mapping of DNA-binding sites identifies stemness-related genes as directly repressed targets of SNAIL1 in colorectal cancer cellsSven Beyes, Geoffroy Andrieux, Monika Schrempp, David Aicher, Janna Wenzel, Pablo Antón-García, Melanie Boerries, Andreas Hecht · 2019 · Oncogene
- Prolonged Absence of Mechanoluminal Stimulation in Human Intestine Alters the Transcriptome and Intestinal Stem Cell NicheMinna M. Wieck, Christopher R. Schlieve, Matthew Edward Thornton, Kathryn L. Fowler, Mubina A. Isani, Christa N. Grant, Ashley E. Hilton, Xiaogang Hou, Brendan H. Grubbs, Mark R. Frey et al. · 2017 · Cellular and Molecular Gastroenterology and Hepatology
- Differences in DNA methylation profiles by histologic subtype of paediatric germ cell tumours: a report from the Children’s Oncology GroupLindsay A. Williams, Lauren J. Mills, Anthony J. Hooten, Erica K. Langer, Michelle A. Roesler, A. Lindsay Frazier, Mark Krailo, Heather H. Nelson, Jessica Bestrashniy, James F. Amatruda et al. · 2018 · British Journal of Cancer
- Design and Analysis of a Novel Chaos-Based Image Encryption Algorithm via Switch Control MechanismShenyong Xiao, ZhiJun Yu, Yashuang Deng · 2020 · Security and Communication Networks
- CRISPR screens identify a novel combination treatment targeting BCL-XL and WNT signaling for KRAS/BRAF-mutated colorectal cancersHae Rim Jung, Yumi Oh, Deukchae Na, Seoyeon Min, Jinjoo Kang, Dongjun Jang, Seungjae Shin, Ji‐Won Kim, Sang Eun Lee, Eui Man Jeong et al. · 2021 · Oncogene
- The Transcription Co-Repressors MTG8 and MTG16 Regulate Exit of Intestinal Stem Cells From Their Niche and Differentiation Into Enterocyte vs Secretory LineagesAnna Baulies, Nikolaos Angelis, Valentina Foglizzo, Erik Thomas Danielsen, Harshil Patel, Laura Novellasdemunt, Anna Kucharska, Joana Carvalho, Emma L. Nye, Paolo De Coppi et al. · 2020 · Gastroenterology
- The WNT5A Agonist Foxy5 Reduces the Number of Colonic Cancer Stem Cells in a Xenograft Mouse Model of Human Colonic CancerJanina Osman, Kishan Bellamkonda, Qing Liu, Tommy Andersson, Anita Sjölander · 2019 · Anticancer Research
- An Eye Organoid Approach Identifies Six3 Suppression of R-spondin 2 as a Critical Step in Mouse Neuroretina DifferentiationNozomu Takata, Deepti Abbey, Luciano Fiore, Sandra Acosta, Ruopeng Feng, Hyea Jin Gil, Alfonso Lavado, Xin Geng, Ashley Interiano, Geoffrey A. M. Neale et al. · 2017 · Cell Reports
- Casein kinase 1‐epsilon or 1‐delta required for Wnt‐mediated intestinal stem cell maintenanceYael Morgenstern, Upasana Das Adhikari, Muneef Ayyash, Ela Elyada, Beáta Tóth, Andreas E. Moor, Shalev Itzkovitz, Yinon Ben‐Neriah · 2017 · The EMBO Journal
- Cholera toxin inhibits SNX27-retromer-mediated delivery of cargo proteins to the plasma membraneVarsha Singh, Jianbo Yang, Jianyi Yin, Robert Norman Cole, Ming C. Tse, Diego E. Berman, Scott A. Small, Gregory A. Petsko, Mark Donowitz · 2018 · Journal of Cell Science
- Development of Intestinal Scaffolds that Mimic Native Mammalian Intestinal TissueMitchell R. Ladd, Cait M. Costello, Carolyn E. Gosztyla, Adam D. Werts, Blake A. Johnson, William B. Fulton, Laura Y. Martin, Elizabeth J. Redfield, Bryan Crawford, Rohan Panaparambil et al. · 2019 · Tissue Engineering Part A
- Epigenetic regulation of intestinal stem cell differentiationMichael Paul Verzi, Ramesh A. Shivdasani · 2020 · American Journal of Physiology-Gastrointestinal and Liver Physiology
- Elevated expression of ASCL2 is an independent prognostic indicator in lung squamous cell carcinomaXu‐Gang Hu, Lu Chen, Qingliang Wang, Xilong Zhao, Juan Tan, You‐Hong Cui, Xindong Liu, Xia Zhang, Xiu‐Wu Bian · 2015 · Journal of Clinical Pathology
- LGR4 and LGR5 Function Redundantly During Human Endoderm DifferentiationYu-Hwai Tsai, David R. Hill, Namit Kumar, Sha Huang, Alana M. Chin, Briana R. Dye, Melinda S. Nagy, Michael Paul Verzi, Jason R. Spence · 2016 · Cellular and Molecular Gastroenterology and Hepatology
- Application of porcine gastrointestinal organoid units as a potential in vitro tool for drug discovery and developmentAdedamola Olayanju, Lauren G. Jones, Karin Vicente Greco, Christopher E. Goldring, Tahera Ansari · 2018 · Journal of Applied Toxicology
- Paneth Cells: Dispensable yet Irreplaceable for the Intestinal Stem Cell NicheMichaela K. Quintero, Linda C. Samuelson · 2024 · Cellular and Molecular Gastroenterology and Hepatology
- Clone wars: From molecules to cell competition in intestinal stem cell homeostasis and diseaseGabriele Colozza, So‐Yeon Park, Bon‐Kyoung Koo · 2022 · Experimental & Molecular Medicine
- The Zinc Finger Transcription Factor PLAGL2 Enhances Stem Cell Fate and Activates Expression of ASCL2 in Intestinal Epithelial CellsAshlee M. Strubberg, Daniel Veronese-Paniagua, Tingting Zhao, Leeran Dublin, Thomas Pritchard, Peter O. Bayguinov, James A. J. Fitzpatrick, Blair Madison · 2018 · Stem Cell Reports
- The intestinal stem cell regulating gene ASCL2 is required for L1-mediated colon cancer progressionSayon Basu, Nancy S. Gavert, Thomas Brabletz, Avri Ben‐Ze'ev · 2018 · Cancer Letters
- Signaling and epigenetic mechanisms of intestinal stem cells and progenitors: insight into crypt homeostasis, plasticity, and nichesRyan J. Smith, Abilasha Rao‐Bhatia, Tae‐Hee Kim · 2017 · Wiley Interdisciplinary Reviews Developmental Biology
- Neurogenin3 phosphorylation controls reprogramming efficiency of pancreatic ductal organoids into endocrine cellsR. Azzarelli, S. Rulands, Sonia Nestorowa, J. Davies, S. Campinoti, S. Gillotin, P. Bonfanti, B. Göttgens, M. Huch, B. Simons et al. · 2018 · Scientific Reports
- Opposing JAK-STAT and Wnt signaling gradients define a stem cell domain by regulating differentiation at two bordersDavid Melamed, Daniel Kalderon · 2020 · eLife
- Molecular versatility during pluripotency progressionG. Furlan, A. Huyghe, N. Combémorel, F. Lavial · 2023 · Nature Communications
- Novel Insights into Gastric Cancer: Methylation of R-spondins and Regulation of LGR5 by SP1Franziska Wilhelm, Éva Simon, Christine Böger, Hans‐Michael Behrens, Sandra Krüger, Christoph Röcken · 2017 · Molecular Cancer Research
- Cullin 4b-RING ubiquitin ligase targets IRGM1 to regulate Wnt signaling and intestinal homeostasisYujia Fan, Xiaohan Huo, Beibei Guo, Xiaohui Zhang, Yang Yang, Jiabei Lian, Xinyuan Meng, Yiwen Shao, Yongxin Zou, Haiyang Guo et al. · 2022 · Cell Death and Differentiation
- TET2–BCLAF1 transcription repression complex epigenetically regulates the expression of colorectal cancer gene Ascl2 via methylation of its promoterYangyang Shang, Tao Jiang, Lijian Ran, Wenjing Hu, Yun Wu, Jun Ye, Zhihong Peng, Lei Chen, Rongquan Wang · 2022 · Journal of Biological Chemistry
- Impaired intestinal stem cell activity in ETEC infection: enterotoxins, cyclic nucleotides, and Wnt signalingLulu Ren, Jiayi Zhou, Shaojie Liang, Xiuqi Wang · 2022 · Archives of Toxicology
- Dynamic Intestinal Stem Cell Plasticity and Lineage Remodeling by a Nutritional Environment Relevant to Human Risk for TumorigenesisJiahn Choi, Xusheng Zhang, Wenge Li, Michele A. Houston, Karina Peregrina, Robert Dubin, Kenny Q. Ye, Leonard H. Augenlicht · 2023 · Molecular Cancer Research
- Sleeping Beauty transposon mutagenesis identified genes and pathways involved in inflammation-associated colon tumor developmentKana Shimomura, Naoko Hattori, Naoko Iida, Yukari Muranaka, Kotomi Sato, Yuichi Shiraishi, Yasuhito Arai, Natsuko Hama, Tatsuhiro Shibata, Daichi Narushima et al. · 2023 · Nature Communications
- Stem cell heterogeneity, plasticity, and regulationZiyang Cui, Hope Wei, Colin R. Goding, Rutao Cui · 2023 · Life Sciences
- Troy is expressed in human stomach mucosa and a novel putative prognostic marker of intestinal type gastric cancerFranziska Wilhelm, Christine Böger, Sandra Krüger, Hans‐Michael Behrens, Christoph Röcken · 2016 · Oncotarget
- Breast milk nutrients driving intestinal epithelial layer maturation via Wnt and Notch signaling: Implications for necrotizing enterocolitisJudith C. W. de Jong, Noortje Ijssennagger, Saskia W. C. van Mil · 2021 · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
- Disabling de novo DNA methylation in embryonic stem cells allows an illegitimate fate trajectoryMasaki Kinoshita, Meng Amy Li, Michael Barber, William M. Mansfield, Sabine Dietmann, Austin G Smith · 2021 · Proceedings of the National Academy of Sciences
- DL-methionine and DL-methionyl-DL-methionine increase intestinal development and activate Wnt/β-catenin signaling activity in domestic pigeons (Columba livia)Zhong Chen, Di‐qing Tong, Yaru Zhang, Xiuqi Wang, Hui‐chao Yan, Huize Tan, Chun‐qi Gao · 2021 · Poultry Science
- Ascl2 Reinforces Intestinal Stem Cell IdentityKelley S. Yan, Calvin Jay Kuo · 2015 · Cell stem cell
- Msx1 loss suppresses formation of the ectopic crypts developed in the Apc-deficient small intestinal epitheliumMonika Horázná, Lucie Janečková, Jiří Švec, Oľga Babošová, Dušan Hrčkulák, Martina Vojtěchová, Kateřina Galušková, Eva Šloncová, Michal Kolář, Hynek Strnad et al. · 2019 · Scientific Reports
- Metabolic regulation of intestinal homeostasis: molecular and cellular mechanisms and diseasesRuolan Zhang, Ansu O. Perekatt, Lei Chen · 2024 · MedComm
- Introducing the Stem Cell ASCL2 Reporter STAR into Intestinal OrganoidsMaria C. Heinz, Koen C. Oost, Hugo J.G. Snippert · 2020 · STAR Protocols
- Recombinant Porcine R-Spondin 1 Facilitates Intestinal Stem Cell Expansion along the Crypt–Villus Axis through Potentiating Wnt/β-Catenin Signaling in Homeostasis and Deoxynivalenol InjuryJiayi Zhou, Geng-xiu Zan, Qiu-jie Zhu, Chun‐qi Gao, Hui‐chao Yan, Xiuqi Wang · 2022 · Journal of Agricultural and Food Chemistry
- Stem Cells in the Intestine: Possible Roles in Pathogenesis of Irritable Bowel SyndromeSutheera Ratanasirintrawoot, Nipan Israsena · 2016 · Journal of Neurogastroenterology and Motility
- R-spondin1/Wnt-enhanced Ascl2 autoregulation controls the self-renewal of colorectal cancer progenitor cellsJun Ye, Shanxi Liu, Yangyang Shang, Haoyuan Chen, Rongquan Wang · 2018 · Cell Cycle
- Protective C allele of the single-nucleotide polymorphism rs1335532 is associated with strong binding of Ascl2 transcription factor and elevated CD58 expression in B-cellsNikita A. Mitkin, Alisa M. Muratova, Kirill V. Korneev, Vsevolod Vyacheslavovich Pavshintsev, Konstantin A. Rumyantsev, Murad S. Vagida, Aksinya Nicolaevna Uvarova, Marina A. Afanasyeva, A. M. Schwartz, Dmitry V. Kuprash · 2018 · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
- ASCL2 expression contributes to gastric tumor migration and invasion by downregulating miR223 and inducing EMTQingsong Zuo, Jie Wang, Chao Chen, Yong Zhang, Dian-xu Feng, Ronghua Zhao, Teng Chen · 2018 · Molecular Medicine Reports
- TNFα-induced Up-regulation of Ascl2 Affects the Differentiation and Proliferation of Neural Stem CellsZhongfeng Liu, Xuan Wang, Kewen Jiang, Xunming Ji, Y.Alex Zhang, Zhiguo Chen · 2018 · Aging and Disease
- Novel Protein-Based Vaccine against Self-Antigen Reduces the Formation of Sporadic Colon Adenomas in MiceElodie Belnoue, Alyssa A. Leystra, Susanna Carboni, Harry S. Cooper, Rodrigo Tavares Macedo, Kristen N. Harvey, Kimberly B. Colby, Kerry S. Campbell, Lisa Vanderveer, Margie L. Clapper et al. · 2021 · Cancers
- Transcriptional activity mediated by β-CATENIN and TCF/LEF family members is completely dispensable for survival and propagation of multiple human colorectal cancer cell linesJanna Fröhlich, Katja Rose, Andreas Hecht · 2023 · Scientific Reports
- Endoplasmic reticulum stress regulates the intestinal stem cell state through CtBP2Bartolomeus Joannes Meijer, Wouter L. Smit, Pim J. Koelink, B. Florien Westendorp, Ruben J. de Boer, Jonathan H. M. van der Meer, Jacqueline L.M. Vermeulen, James C. Paton, Adrienne W. Paton, Jun Qin et al. · 2021 · Scientific Reports
- ASCL2 Maintains Stemness Phenotype through ATG9B and Sensitizes Gliomas to Autophagy InhibitorLihong Wang, Ye Yuan, Jiao Wang, Ying Luo, Yang Lan, Jia Ge, Lei Li, Feng Liu, Qing Deng, Zexuan Yan et al. · 2022 · Advanced Science
- Glutamine Promotes Porcine Intestinal Epithelial Cell Proliferation through the Wnt/β-Catenin PathwayYong-xia Fang, En-Qing Lu, Yu-jie Cheng, E. Xu, Min Zhu, Xiang Chen · 2024 · Journal of Agricultural and Food Chemistry
- Cellular population dynamics control the robustness of the stem cell nicheAdam L. MacLean, Paul Kirk, Michael P. H. Stumpf · 2015 · Biology Open
- Different in vivo and in vitro transformation of intestinal stem cells in mismatch repair deficiencyKerstin Keysselt, Tobias Kreutzmann, Karen Rother, Christiane Kerner, Knuth Krohn, Jens Przybilla, Peter Buske, Henry Loeffler‐Wirth, Markus Loeffler, Joerg Galle et al. · 2016 · Oncogene
- Unique Gene Expression Signatures in the Intestinal Mucosa and Organoids Derived from Germ-Free and Monoassociated MiceLucie Janečková, Klara Kostovcikova, Jiří Švec, Monika Šťastná, Hynek Strnad, Michal Kolář, Tomáš Hudcovic, Jitka Stančíková, Jolana Turečková, Nikol Dibus et al. · 2019 · International Journal of Molecular Sciences
- Three-dimensional analysis of single molecule FISH in human colon organoidsManja Omerzu, Nicola Fenderico, Buys de Barbanson, Joep Sprangers, Jeroen de Ridder, Madelon M. Maurice · 2019 · Biology Open
- WiNTRLINC1/ASCL2/c-Myc Axis Characteristics of Colon Cancer with Differentiated Histology at Young Onset and Essential for Cell ViabilityKazuko Yokota, Yôko Tanaka, Hiroki Harada, Takeshi Kaida, Syuji Nakamoto, Takafumi Soeno, Yoshiki Fujiyama, Mitsuo Yokota, Ken Kojo, Hirohisa Miura et al. · 2019 · Annals of Surgical Oncology
- W nt Signaling Inhibition Deprives Small Intestinal Stem Cells of Clonogenic CapacityLucie Janečková, Bohumil Fafílek, Michaela Krausová, Monika Horázná, Martina Vojtěchová, Meritxell Alberich-Jordà, Eva Šloncová, Kateřina Galušková, Radislav Sedláček, Miroslava Anděrová et al. · 2016 · genesis
- A multimodal cross-species comparison of pancreas developmentKaiyuan Yang, Hannah Spitzer, Michael Sterr, Karin Hrovatin, Sean de la O, Xinghao Zhang, Eunike Sawitning Ayu Setyono, Minhaz Ud‐Dean, Thomas Walzthoeni, Krzysztof Flisikowski et al. · 2025 · Nature Communications
- Polycomb Repressive Complex 2 Regulates Genes Necessary for Intestinal Microfold Cell (M Cell) DevelopmentJoel Johnson George, Mikko Oittinen, Laura Martín-Díaz, Veronika Zapilko, Sharif Iqbal, Terhi Rintakangas, Fábio Tadeu Arrojo Martins, Henri Niskanen, Pekka Katajisto, Minna Unelma Kaikkonen et al. · 2021 · Cellular and Molecular Gastroenterology and Hepatology
- The Rise of Induced Pluripotent Stem Cell Approach to Hair RestorationAntonella Pinto, Alexey V. Terskikh · 2021 · Plastic & Reconstructive Surgery
- Cellular responses and gene expression profiles of colonic Lgr5+ stem cells after low-dose/low-dose-rate radiation exposureKensuke Otsuka, Keiji Suzuki, Yuki FUJIMICHI, Masanori Tomita, Toshiyasu Iwasaki · 2017 · Journal of Radiation Research
- Dynamics and plasticity of stem cells in the regenerating human colonic epitheliumKoen C. Oost, Maurice Kahnwald, Silvia Barbiero, Gustavo de Medeiros, Simon Suppinger, Véronique Kalck, Ludivine Challet Meylan, Sébastien A. Smallwood, Michael B. Stadler, Prisca Liberali · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
- The Microbial Bile Acid Metabolite 3-Oxo-LCA Inhibits Colorectal Cancer ProgressionFei Sun, Ke Wang, Xingchen Dong, Henry Secaira-Morocho, Alisa Hui, Chunmiao Cai, Johnny Sze, Brian Low, Shirsa Udgata, Cheri A. Pasch et al. · 2025 · Cancer Research
- Recent evolution of the developing human intestine affects metabolic and barrier functionsQianhui Yu, Umut Kilik, Stefano Secchia, Lukas Adam, Yu-Hwai Tsai, Christiana Fauci, Jasper Janssens, Charlie J. Childs, Katherine D. Walton, Rubén López-Sandoval et al. · 2025 · Science
- Microbial bile salt hydrolase activity influences gene expression profiles and gastrointestinal maturation in infant miceMaría Ángeles Núñez‐Sánchez, Florence M. Herisson, Jonathan M. Keane, Natalia García-González, Valerio Rossini, Jorge Pinhiero, Jack Daly, Milán Bustamante-Garrido, Cara M. Hueston, Shriram H. Patel et al. · 2022 · Gut Microbes
- A contemporary snapshot of intestinal stem cells and their regulationRyo Seishima, Nick Barker · 2019 · Differentiation
- ARHGAP25 suppresses the development of breast cancer by an ARHGAP25/Wnt/ASCL2 feedback loopSijia Han, Xueying Jin, Tianyu Hu, Feng Chi · 2023 · Carcinogenesis
- TIGAR/AP-1 axis accelerates the division of Lgr5− reserve intestinal stem cells to reestablish intestinal architecture after lethal radiationFei Chen, Yushuo Zhang, Songling Hu, Xiaolin Shi, Zhongmin Wang, Zicheng Deng, Longxin Lin, Jianghong Zhang, Yan Pan, Yang Bai et al. · 2020 · Cell Death and Disease
- The Role of Long Noncoding RNAs in Intestinal Health and Diseases: A Focus on the Intestinal BarrierQianying Lu, Yangfan Liang, Xiangyan Meng, Yanmei Zhao, Haojun Fan, Shike Hou · 2023 · Biomolecules
- BMP suppresses Wnt signaling via the Bcl11b-regulated NuRD complex to maintain intestinal stem cellsYehua Li, Xiaodan Wang, Meimei Huang, Xu Wang, Chunlin Li, Siqi Li, Yuhui Tang, Shicheng Yu, Yalong Wang, Wanlu Song et al. · 2024 · The EMBO Journal
- Loss of mismatch repair signaling impairs the WNT–bone morphogenetic protein crosstalk and the colonic homeostasisKatrine Nørgaard, Carolin Müller, Nadja R. Christensen, María López Chiloeches, Cesilie Lind Madsen, Sabine Sparre Nielsen, Tine E. Thingholm, A. Belcheva · 2019 · Journal of Molecular Cell Biology
- Taking a Step Back: Insights into the Mechanisms Regulating Gut Epithelial DedifferentiationShaida Ouladan, Alex Gregorieff · 2021 · International Journal of Molecular Sciences
- Lactoferrin promotes intestinal stem cell‐mediated epithelial regeneration by activating Wnt signalingWeiru Yu, Yingying Lin, Yao Lü, Yuqi Wang, Dan Zhang, Heng Quan, Yujia Luo, Yuning Zhang, Zhengqiang Jiang, Juan Chen et al. · 2024 · Food Frontiers
- tRNA-derived RNA fragment, tRF-18-8R6546D2, promotes pancreatic adenocarcinoma progression by directly targeting ASCL2Sihua Lan, Sixue Liu, Ke Wang, Wenying Chen, Dandan Zheng, Yanyan Zhuang, Shineng Zhang · 2024 · Gene
- FZD5 controls intestinal crypt homeostasis and colonic Wnt surrogate agonist responseQinghui Mu, Andrew Ha, António J. M. Santos, Yuan‐Hung Lo, Vincent van Unen, Yi Miao, Madeline G. Tomaske, Veronica K Guzman, Samira Alwahabi, Jenny Yuan et al. · 2024 · Developmental Cell
- Innate immunity of the gut epithelium: Blowing in the WNT?Maaike Hillegonda de Vries, Ewart Kuijk, Edward E. S. Nieuwenhuis · 2025 · Mucosal Immunology
- HMGA1 acts as an epigenetic gatekeeper of ASCL2 and Wnt signaling during colon tumorigenesisLi Luo, Jung‐Hyun Kim, Iliana Herrera, Shaoguang Wu, Xinqun Wu, Seong‐Sik Park, Juyoung Cho, Leslie Cope, Lingling Xian, Bailey E. West et al. · 2025 · Journal of Clinical Investigation
- Self-antigen MASH2 combined with the AS15 immunostimulant induces tumor protection in colorectal cancer mouse modelsClément R. Rioux, Margie L. Clapper, Harry S. Cooper, Jean Michaud, Natalie St-Amant, Hossein Koohsari, Laura Workman, Esther Kaunga, Harvey H. Hensley, Anthony Pilorget et al. · 2019 · PLoS ONE
- Maturation of human intestinal epithelium from pluripotency in vitroUmut Kilik, Qianhui Yu, René Holtackers, Makiko Seimiya, Aline Xavier da Silveira dos Santos, Barbara Treutlein, Jason R. Spence, J. Gray Camp · 2021 · bioRxiv (Cold Spring Harbor Laboratory)
- Single-cell RNA-seq of small-intestinal neuroendocrine tumors reveals the cell of origin and gene expression of early tumor developmentYoshitatsu Sei, Joanne Forbes, Cihan Oguz, Paul Schaughency, Gustavo Gutierrez-Cruz, Faiza Naz, Stephen R. Brooks, Stefania Dell’Orso, Pradeep Kumar Dagur, Jianying Feng et al. · 2025 · Cell Reports
- Identification of feature genes in intestinal epithelial cell typesRuoyu Lou, Wanlu Song, Shicheng Yu, Xiaodan Wang, Yuan Liu, Ye‐Guang Chen, Yalong Wang · 2024 · Cell Regeneration
- Therapeutic targeting of the NOTCH1 and neddylation pathways in T cell acute lymphoblastic leukemiaKalay Bertulfo, Pablo Pérez‐Durán, Hannah I. Miller, Cindy Ma, Alberto Ambesi‐Impiombato, Jeremy B. Samon, Adam L. Mackey, Wen-Hsuan Wendy Lin, Adolfo A. Ferrando, Teresa Palomero · 2025 · Proceedings of the National Academy of Sciences
- p57Kip2 acts as a transcriptional corepressor to regulate intestinal stem cell fate and proliferationJustine Creff, Ada Nowosad, Anne Prel, Anne Pizzoccaro, Marion Aguirrebengoa, Nicolas Duquesnes, Caroline Callot, Thomas Jungas, Christine Dozier, Arnaud Besson · 2023 · Cell Reports
- TGF-β signaling redirects Sox11 gene regulatory activity to promote partial EMT and collective invasion of oncogenically transformed intestinal organoidsYu-Hsiang Teng, Bismark Appiah, Geoffroy Andrieux, Monika Schrempp, Katja Rose, Angelika Hofmann, Manching Ku, Sven Beyes, Melanie Boerries, Andreas Hecht · 2025 · Oncogenesis
- The oncogenic function of PLAGL2 is mediated via ASCL2 and IGF2 and a Wnt-independent mechanism in colorectal cancerAnthony D. Fischer, Daniel Veronese-Paniagua, Shriya Swaminathan, Hajime Kashima, Deborah C. Rubin, Blair Madison · 2023 · American Journal of Physiology-Gastrointestinal and Liver Physiology
- Attenuation of Chronic Inflammation in Intestinal Organoids with Graphene Oxide-Mediated Tumor Necrosis Factor-α_Small Interfering RNA DeliverySadman Sakib, Shan Zou · 2024 · Langmuir
- Marked stem/progenitor cell expansion occurs early after murine ileostomy: a new modelKathryn L. Fowler, Minna M. Wieck, Ashley E. Hilton, Xiaogang Hou, Christopher R. Schlieve, Tracy Cannon Grikscheit · 2017 · Journal of Surgical Research
- Stem Cell Marker Expression in Early Stage Colorectal Cancer is Associated with Recurrent Intestinal NeoplasiaBrett S. Walker, Luai R. Zarour, Nicole Wieghard, Alexandra C. Gallagher, John R. Swain, Sheila A. Weinmann, Christian Lanciault, Kevin G. Billingsley, Vassiliki Liana Tsikitis, Melissa Hirose Wong · 2020 · World Journal of Surgery
- A genome-wide meta-analysis reveals shared and population-specific variants for allergic sensitizationEmiko Noguchi, Wataru Morii, Haruna Kitazawa, Tomomitsu Hirota, Kyuto Sonehara, Hironori Masuko, Yukinori Okada, Nobuyuki Hizawa · 2024 · Journal of Allergy and Clinical Immunology
- Development of Sheep Duodenum Intestinal Organoids and Implementation of High-Throughput Screening Platform for Veterinary ApplicationsGiulio Galli, Estela Melcón-Fernández, María Gracia de Garnica García, B. Martínez-Fernández, Mahsa Dehnavi, Sonia Andrés, Yolanda Pérez‐Pertejo, Rosa Maria Reguera, Carlos García‐Estrada, María Martínez Valladares et al. · 2025 · International Journal of Molecular Sciences
- Inferring regulators of cell identity in the human adult pancreasLotte Vanheer, F. Fantuzzi, San-Kit To, A. Schiavo, Matthias Van Haele, Tessa Ostyn, Tine Haesen, Xiaoyuan Yi, A. Janiszewski, J. Chappell et al. · 2023 · NAR Genomics and Bioinformatics
- A Novel CRISPR/Cas9-mediated Mouse Model of Colon CarcinogenesisHajime Kashima, Anthony D. Fischer, Daniel Veronese-Paniagua, Vered A. Gazit, Changqing Ma, Yan Yan, Marc S. Levin, Blair Madison, Deborah C. Rubin · 2024 · Cellular and Molecular Gastroenterology and Hepatology
- Stem cell dynamics and pretumor progression in the intestinal tractHuiying Ma, Folkert H.M. Morsink, G. Johan A. Offerhaus, Wendy W.J. de Leng · 2016 · Journal of Gastroenterology
- LDL regulates intestinal stem cell homeostasis via PPAR pathwayRuicheng Shi, Wei Lu, Zhiming Zhao, Bo Wang · 2025 · Journal of Lipid Research
- Injury-induced intestinal stem cell renewal requires capillary morphogenesis gene 2Lucie Josepha Bracq, Audrey Chuat, Béatrice Kunz, Olivier Burri, Romain Guiet, Julien Duc, Nathalie Brandenberg, F Gisou van der Goot · 2025 · EMBO Molecular Medicine
- Comprehensive multiomics profiling reveals the protective function of gypenosides against dextran sulfate sodium-induced colitisYuan Hang Yang, Xinyuan Li, Fan Huang, Fuchao Cai, Xufeng Ning, Qian Jiang, Lingshan Zhou, Bin Zeng, Weiwei Zhou, Guangsheng Hu · 2025 · Scientific Reports
- Bacteroides -associated NAD⁺ depletion correlates with exacerbated radiation-induced colorectal injury and impaired mucosal proliferative capacityJiayuan Huang, Qiyuan Qin, Xiangyu Li, Keming Jiang, Jun Xu, Yudan Mao, Wanying Kang, Rongsui Gao, Yikan Cheng, Wenjing Zhao et al. · 2026 · Gut Microbes