Ascl2 acts as an R-spondin/Wnt-responsive switch to control stemness in intestinal crypts

Schuijers, Jurian, Junker, Jan Philipp, Mokry, Michal, Hatzis, Pantelis, Koo, Bon-Kyoung, Sasselli, Valentina, van der Flier, Laurens G., Cuppen, Edwin +2 more·2015·Cell Stem Cell

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Items 201–272 of 272

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  5. Requirement of Bccip for the Regeneration of Intestinal Progenitors
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  9. Adaptive Plasticity Tumor Cells Modulate MAPK-Targeting Therapy Response in Colorectal Cancer
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  17. Lactiplantibacillus plantarum JY039 Ameliorates Necrotizing Enterocolitis via Intestinal Stem Cell Regeneration
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  18. Functional and molecular characterization of equine intestinal organoids across media conditions and intestinal segments
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  22. Notch Pathway Regulation of Intestinal Cell Fate
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  26. Notch Signaling in the Normal Intestine and Intestinal Cancer
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  28. Necessary, Legendary and Detrimental Components of Human Colorectal Organoid Culture Medium: Raising Awareness to Reduce Experimental Bugs
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  29. ASCL2-mediated macrophage-myofibroblast transition generates immunosuppressive CAF_7 in NSCLC bone metastases
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  30. Developmental timing distinguishes pediatric and adult cancers through retention and rewiring mechanisms
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  31. The Intestinal Stem Cell Niche
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  34. Digital PCR characterizes epithelial cell populations in murine duodenal organoids
    Karla Berenice Acosta-Virgen, Hugo González-Conchillos, Gabriela Vallejo-Flores, Lizbeth Iliana Salazar-Villatoro, Ernesto Guerrero-Sánchez, Adolfo Martínez‐Palomo, Martha Espinosa‐Cantellano · 2025 · PLoS ONE
  35. High Variability in Cellular Proliferation, Gene Expression, and Cytokine Production in the Nonneoplastic Colonic Epithelium of Young Apc+/Min-FCCC Mice
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  36. The Wnt/β-Catenin Pathway
    Chunming Liu, Yannik Régimbald‐Dumas, Xiaojuan Zhang, Xi He · 2015 · Elsevier eBooks
  37. Map3k2 -Regulated Intestinal Stromal Cells (MRISC) Define a Distinct Sub-cryptic Stem Cell Niche for Damage Induced Wnt Agonist R-spondin1 Production
    Ningbo Wu, Hongxiang Sun, Xiaoyun Zhao, Lei Chen, Yuanyuan Qi, Yuheng Han, Xianan Liu, Caixia Gao, Qun Wang, Lingjuan He et al. · 2019 · bioRxiv (Cold Spring Harbor Laboratory)
  38. The oncogenic function of PLAGL2 is mediated via specific target genes through a Wnt-independent mechanism in colorectal cancer
    Anthony D. Fischer, Daniel Veronese-Paniagua, Shriya Swaminathan, Hajime Kashima, Deborah C. Rubin, Blair Madison · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
  39. Disabling de novo DNA methylation in embryonic stem cells allows an illegitimate fate trajectory
    Masaki Kinoshita, Meng Amy Li, Michael Barber, William Mansfield, Sabine Dietmann, Austin G Smith · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
  40. Sensitivity analysis based ranking reveals unknown biological hypotheses for down regulated genes in time buffer during administration of PORCN-WNT inhibitor ETC-1922159 in CRC †
    Shriprakash Sinha · 2017 · bioRxiv (Cold Spring Harbor Laboratory)
  41. Transcriptional activity mediated by β-CATENIN and TCF/LEF family members is completely dispensable for survival of multiple human colorectal cancer cell lines
    Janna Fröhlich, Katja Rose, Andreas Hecht · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
  42. Design principles of small intestinal crypt maintenance
    Isidora Banjac, Martti Maimets, Ingrid Ho Ching Tsang, Marius Dioli, Stine Lind Hansen, Kata Krizic, Raul Bardini Bressan, Cecilia Lövkvist, Kim Bak Jensen · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
  43. The transcription factor Chronophage/BCL11A/B promotes intestinal stem cell proliferation and endocrine differentiation
    E. KING, Eleanor Jacobsen, Nicholas Woolner, Joaquín de Navascués, Owen J. Marshall, Jerome Korzelius · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
  44. BCL-3 enhances β-catenin signalling in colorectal tumour cells promoting a cancer stem cell phenotype
    Danny Legge, Alex P. Shephard, T J Collard, Alexander Greenhough, A Chambers, Richard W. E. Clarkson, Christos Paraskeva, Ann Caroline Williams · 2017 · bioRxiv (Cold Spring Harbor Laboratory)
  45. Stem and progenitor cells of the gastrointestinal tract: applications for tissue engineering the intestine
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  46. Cullin 4b Complex Targets IRGM1 to Regulate Intestinal Stem Cell Stemness and Niche
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  48. Faculty Opinions recommendation of Single-cell transcriptome analysis reveals differential nutrient absorption functions in human intestine.
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  49. Faculty Opinions recommendation of BMP restricts stemness of intestinal Lgr5+ stem cells by directly suppressing their signature genes.
    Linheng Li · 2019 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
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  51. Data from Liver Colonization by Colorectal Cancer Metastases Requires YAP-Controlled Plasticity at the Micrometastatic Stage
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