Ascl2 acts as an R-spondin/Wnt-responsive switch to control stemness in intestinal crypts
Schuijers, Jurian, Junker, Jan Philipp, Mokry, Michal, Hatzis, Pantelis, Koo, Bon-Kyoung, Sasselli, Valentina, van der Flier, Laurens G., Cuppen, Edwin +2 more·2015·Cell Stem Cell
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- Requirement of Bccip for the Regeneration of Intestinal ProgenitorsHuimei Lu, Caiyong Ye, Jingmei Liu, Arnold B. Rabson, Michael Paul Verzi, Subhajyoti De, Zhiyuan Shen · 2020 · American Journal Of Pathology
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- PBXIP1 – An indicator for poor outcome and metastatic spread in colorectal cancerMatthias Ilmer, Bernhard Willibald Renz, Florian Kühn, Moritz Drefs, Dionysios Koliogiannis, Jens Martin Werner, Thomas Kirchner, David A. Horst, Christine Woischke · 2022 · Pathology - Research and Practice
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- Lactiplantibacillus plantarum JY039 Ameliorates Necrotizing Enterocolitis via Intestinal Stem Cell RegenerationJinfeng Guo, Ying Zhao, Kaiqi Gao, Yilin Sun, Feng Zhao, Y. G. Zhang, Yujun Jiang · 2025 · Journal of Agricultural and Food Chemistry
- Functional and molecular characterization of equine intestinal organoids across media conditions and intestinal segmentsLauren M. Richardson, Julie Gordon, Carlos Davila, Ana M. Chamoun‐Emanuelli, Christopher Zdyrski, Canaan Whitfield-Cargile · 2026 · BMC Veterinary Research
- Hepatitis E virus replication is maintained in proliferative cells within the intestinal cryptSarah Prallet, Niclas Maier, Albert Li, Cassian Afting, Hao-En Huang, Jungen Hu, Elif Toprak, Deb Purna Keya, Ombretta Colasanti, Nancy León-Janampa et al. · 2026 · Science Advances
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- Sox4 drives Atoh1- independent intestinal secretory differentiation toward tuft and enteroendocrine fatesAdam D. Gracz, Leigh Ann Samsa, Matthew J. Fordham, Danny C. Trotier, Bailey Zwarycz, Yuan‐Hung Lo, Katherine Bao, Joshua Starmer, Noah F. Shroyer, Richard Lee Reinhardt et al. · 2017 · bioRxiv (Cold Spring Harbor Laboratory)
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- The Role of Inflammatory Cytokines in the Causal Pathway From Gut Microbiota to Sjögren’s Syndrome: Evidence From Mendelian RandomizationJunkang Zhao, Jiannan Han, Xiuying Fan, Jie Kang, Ruonan Wu, Yixuan Zhao, Lina Bai, Xue Gao, Dan Ma, Liyun Zhang · 2025 · Mediators of Inflammation
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- ASCL2-mediated macrophage-myofibroblast transition generates immunosuppressive CAF_7 in NSCLC bone metastasesJinfeng Wang, Jin Qian, Xiujia Yang, Chongquan Huang, Tiantian Wei, Jielong Zhou, Guoqing Zhong, Zhang Zh, Y Zhang · 2026 · Journal of Experimental & Clinical Cancer Research
- Developmental timing distinguishes pediatric and adult cancers through retention and rewiring mechanismsShayan Saniei, Elvin Wagenblast · 2026 · Nature Communications
- The Intestinal Stem Cell NicheYuemin Celina Chee, David M. Virshup, Babita Madan · 2015 · Stem cell biology and regenerative medicine
- Induced Pluripotent Stem Cell Approach to Hair Follicle RegenerationAntonella Pinto, Alexey V. Terskikh · 2022 · Stem cell biology and regenerative medicine
- SinCMat: A single-cell-based method for predicting functional maturation transcription factorsSybille Barvaux, Satoshi Okawa, Antonio del Sol · 2024 · Stem Cell Reports
- Digital PCR characterizes epithelial cell populations in murine duodenal organoidsKarla Berenice Acosta-Virgen, Hugo González-Conchillos, Gabriela Vallejo-Flores, Lizbeth Iliana Salazar-Villatoro, Ernesto Guerrero-Sánchez, Adolfo Martínez‐Palomo, Martha Espinosa‐Cantellano · 2025 · PLoS ONE
- High Variability in Cellular Proliferation, Gene Expression, and Cytokine Production in the Nonneoplastic Colonic Epithelium of Young Apc+/Min-FCCC MiceAlyssa A. Leystra, Kristen N. Harvey, Esther Kaunga, Harvey H. Hensley, Lisa Vanderveer, Karthik Devarajan, Margie L. Clapper · 2021 · Frontiers in Oncology
- The Wnt/β-Catenin PathwayChunming Liu, Yannik Régimbald‐Dumas, Xiaojuan Zhang, Xi He · 2015 · Elsevier eBooks
- Map3k2 -Regulated Intestinal Stromal Cells (MRISC) Define a Distinct Sub-cryptic Stem Cell Niche for Damage Induced Wnt Agonist R-spondin1 ProductionNingbo Wu, Hongxiang Sun, Xiaoyun Zhao, Lei Chen, Yuanyuan Qi, Yuheng Han, Xianan Liu, Caixia Gao, Qun Wang, Lingjuan He et al. · 2019 · bioRxiv (Cold Spring Harbor Laboratory)
- The oncogenic function of PLAGL2 is mediated via specific target genes through a Wnt-independent mechanism in colorectal cancerAnthony D. Fischer, Daniel Veronese-Paniagua, Shriya Swaminathan, Hajime Kashima, Deborah C. Rubin, Blair Madison · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
- Disabling de novo DNA methylation in embryonic stem cells allows an illegitimate fate trajectoryMasaki Kinoshita, Meng Amy Li, Michael Barber, William Mansfield, Sabine Dietmann, Austin G Smith · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
- Sensitivity analysis based ranking reveals unknown biological hypotheses for down regulated genes in time buffer during administration of PORCN-WNT inhibitor ETC-1922159 in CRC †Shriprakash Sinha · 2017 · bioRxiv (Cold Spring Harbor Laboratory)
- Transcriptional activity mediated by β-CATENIN and TCF/LEF family members is completely dispensable for survival of multiple human colorectal cancer cell linesJanna Fröhlich, Katja Rose, Andreas Hecht · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
- Design principles of small intestinal crypt maintenanceIsidora Banjac, Martti Maimets, Ingrid Ho Ching Tsang, Marius Dioli, Stine Lind Hansen, Kata Krizic, Raul Bardini Bressan, Cecilia Lövkvist, Kim Bak Jensen · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
- The transcription factor Chronophage/BCL11A/B promotes intestinal stem cell proliferation and endocrine differentiationE. KING, Eleanor Jacobsen, Nicholas Woolner, Joaquín de Navascués, Owen J. Marshall, Jerome Korzelius · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
- BCL-3 enhances β-catenin signalling in colorectal tumour cells promoting a cancer stem cell phenotypeDanny Legge, Alex P. Shephard, T J Collard, Alexander Greenhough, A Chambers, Richard W. E. Clarkson, Christos Paraskeva, Ann Caroline Williams · 2017 · bioRxiv (Cold Spring Harbor Laboratory)
- Stem and progenitor cells of the gastrointestinal tract: applications for tissue engineering the intestineKathryn M. Maselli, Christopher R. Schlieve, Mark R. Frey, Tracy Cannon Grikscheit · 2020 · Elsevier eBooks
- Cullin 4b Complex Targets IRGM1 to Regulate Intestinal Stem Cell Stemness and NicheYujia Fan, Xiaohan Huo, Beibei Guo, Xiaohui Zhang, Yang Yang, Jiabei Lian, Xinyuan Meng, Baichun Jiang, Yongxin Zou, Haiyang Guo et al. · 2021 · SSRN Electronic Journal
- Faculty Opinions recommendation of Ascl2-Dependent Cell Dedifferentiation Drives Regeneration of Ablated Intestinal Stem Cells.Malcolm Ronald Alison · 2020 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
- Faculty Opinions recommendation of Single-cell transcriptome analysis reveals differential nutrient absorption functions in human intestine.Leigh A. Knodler · 2020 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
- Faculty Opinions recommendation of BMP restricts stemness of intestinal Lgr5+ stem cells by directly suppressing their signature genes.Linheng Li · 2019 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
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- Data from Liver Colonization by Colorectal Cancer Metastases Requires YAP-Controlled Plasticity at the Micrometastatic StageMaria C. Heinz, Niek A. Peters, Koen C. Oost, Rik G.H. Lindeboom, Lisa van Voorthuijsen, Arianna Fumagalli, Mirjam C. van der Net, Gustavo de Medeiros, Joris H. Hageman, Ingrid Verlaan-Klink et al. · 2023
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