The DOI matches its Crossref record; 126 of the 126 references it cites were found in a registry or an index.
Therapeutic Implications of Cellular Heterogeneity and Plasticity in Breast Cancer
Open accessAbstract
Summary Cellular heterogeneity represents one of the greatest challenges in cancer therapeutics. In many malignancies, this heterogeneity is generated during tumor evolution through a combination of genetic alterations and epigenetic events that recapitulate normal developmental processes including stem cell self-renewal and differentiation. Many, if not most, tumors display similar hierarchal organization, at the apex of which are “stem-like cells” that drive tumor growth, mediate metastasis and contribute to treatment resistance. Using breast cancer as a model, we discuss how an improved understanding of tumor cellular heterogeneity and plasticity may lead to development of more effective therapeutic strategies.
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2 retracted
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Self-citationThe Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells
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Cited by
Visualization and targeting of LGR5+ human colon cancer stem cells
Shimokawa, M., Ohta, Y., Nishikori, S., Matano, M., Takano, A., Fujii, M., Date, S., Sugimoto, S., Kanai, T., & Sato, T. (2017) · Nature · doi:10.1038/nature22081 · Cited by 728
Targeting Cancer Stemness in the Clinic: From Hype to Hope
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The multi-factorial nature of clinical multidrug resistance in cancer
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Drug Resistance Driven by Cancer Stem Cells and Their Niche
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Acquisition of a hybrid E/M state is essential for tumorigenicity of basal breast cancer cells
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Metadata
- Authors
- Brooks, M. D., Burness, M. L., & Wicha, M. S.
- Venue
- Cell Stem Cell
- Publisher
- Elsevier BV
- Published
- 2015-09
- Volume
- 17
- Issue
- 3
- Pages
- 260-271
- ISSN
- 1875-9777 (ISSN-L)
- 1934-5909
- OpenAlex
- W1833050134
- Cited by
- 374
- References
- 126
- FWCI
- 15.60
- Type
- journal article
- Language
- en
- Open access
- bronze
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