Induced Pluripotent Stem Cells Meet Genome Editing

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Items 201–300 of 500

1. Modeling human liver organ development and diseases with pluripotent stem cell-derived organoids
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2. Gene editing with ‘pencil’ rather than ‘scissors’ in human pluripotent stem cells
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3. Genetically Encoded Photoactuators and Photosensors for Characterization and Manipulation of Pluripotent Stem Cells
   Jordan E. Pomeroy, Hung Xuan Nguyen, Brenton D. Hoffman, Nenad Bursac · 2017 · Theranostics
4. A Scaled Framework for CRISPR Editing of Human Pluripotent Stem Cells to Study Psychiatric Disease
   Dane Z. Hazelbaker, Amanda Beccard, Anne M. Bara, Nicole Dabkowski, Angelica Messana, Patrizia Mazzucato, Daisy Lam, Danielle K. Manning, Kevin C. Eggan, Lindy E. Barrett · 2017 · Stem Cell Reports
5. Transcriptional landscape of a RET C634Y -mutated iPSC and its CRISPR-corrected isogenic control reveals the putative role of EGR1 transcriptional program in the development of multiple endocrine neoplasia type 2A-associated cancers
   Julien Hadoux, Christophe Desterke, Olivier Féraud, Mathieu Guibert, Roberta Francesca De Rose, Paule Opolon, Dominique Divers, Emilie Gobbo, Frank Griscelli, Martin Jean Schlumberger et al. · 2017 · Stem Cell Research
6. Modeling Disease with Human Inducible Pluripotent Stem Cells
   Rodrigo A. Grandy, Rute A. Tomaz, Ludovic Vallier · 2018 · Annual Review of Pathology Mechanisms of Disease
7. Human Embryonic Stem Cell-Derived Wilson’s Disease Model for Screening Drug Efficacy
   Dong‐Kyu Kim, Subin Kim, Jung Lim Ryu, Heesu Hong, Jin-Hyuk Chang, Tack-Jin Yoo, Xiong Jie Jin, Han‐Jin Park, Choongseong Han, Beom Hee Lee et al. · 2020 · Cells
8. CRISPR/Cas: An intriguing genomic editing tool with prospects in treating neurodegenerative diseases
   Safikur Rahman, Manali Datta, Jihoe Kim, Arif Tasleem Jan · 2019 · Seminars in Cell and Developmental Biology
9. Stem cell-based multi-tissue platforms to model human autoimmune diabetes
   Karla F. Leavens, Juan R. Alvarez‐Dominguez, Linda T. Vo, Holger A. Russ, Audrey V. Parent · 2022 · Molecular Metabolism
10. Induced pluripotent stem cells from domesticated ruminants and their potential for enhancing livestock production
    Prasanna Weeratunga, Rebecca M. Harman, Gerlinde R. Van de Walle · 2023 · Frontiers in Veterinary Science
11. To Crispr And Beyond: The Evolution Of Genome Editing In Stem Cells
    Kuang-Yui Michael Chen, Paul S. Knoepfler · 2016 · Regenerative Medicine
12. A NEW VIEW OF GENETIC MUTATIONS
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13. Generation of Functional Myocytes from Equine Induced Pluripotent Stem Cells
    Karin R. Amilon, Yennifer Cortés-Araya, Benjamin L. Moore, Seungmee Lee, Simon Geoffrey Lillico, Amandine Breton, Cristina L. Esteves, Francesc Xavier Donadeu · 2018 · Cellular Reprogramming
14. Reversal of the Inflammatory Responses in Fabry Patient iPSC-Derived Cardiovascular Endothelial Cells by CRISPR/Cas9-Corrected Mutation
    Hui-Yung Song, Yi‐Ping Yang, Yueh Chien, Weiyi Lai, Yi‐Ying Lin, Shih‐Jie Chou, Mong‐Lien Wang, Chien‐Ying Wang, Hsin‐Bang Leu, Wen‐Chung Yu et al. · 2021 · International Journal of Molecular Sciences
15. Erythropoietic properties of human induced pluripotent stem cells‐derived red blood cells in immunodeficient mice
    Jiusheng Deng, Moira M. Lancelot, Ryan Philip Jajosky, Qiaomei Deng, Kristin K. Deeb, Natia Saakadze, Yongxing Gao, David L. Jaye, Senquan Liu, Sean R. Stowell et al. · 2021 · American Journal of Hematology
16. High expression of uracil DNA glycosylase determines C to T substitution in human pluripotent stem cells
    Ju-Chan Park, Hyeon-Ki Jang, Jumee Kim, Jun-Hee Han, Youngri Jung, Keun-Tae Kim, Sangsu Bae, Hyuk-Jin Cha · 2021 · Molecular Therapy: Nucleic Acids
17. Induced Pluripotent Stem Cells to Study Mechanisms of Laminopathies: Focus on Epigenetics
    Silvia Crasto, Elisa Di Pasquale · 2018 · Frontiers in Cell and Developmental Biology
18. CRISPR-Cas9‒Based Genomic Engineering in Keratinocytes: From Technology to Application
    Jos P.H. Smits, Luca D. Meesters, Berber G.W. Maste, Huiqing Zhou, Patrick L.J.M. Zeeuwen, Ellen H. J. van den Bogaard · 2021 · JID Innovations
19. PCD Genes—From Patients to Model Organisms and Back to Humans
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20. Unveiling the role of iPLA2β in neurodegeneration: From molecular mechanisms to advanced therapies
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21. Mapping the global landscape for induced pluripotent stem cells from patents and clinical trials
    Liyang Lyu, Feng Ye, Borong Huang, Ren‐He Xu, Hu Yuanjia · 2024 · Nature Biotechnology
22. Enhanced spinal cord repair using bioengineered induced pluripotent stem cell-derived exosomes loaded with miRNA
    Azar Abbas, Xiaosheng Huang, Aftab Ullah, Lishi Luo, Wenqun Xi, Yuanjiao Qiao, Kun Zeng · 2024 · Molecular Medicine
23. Pluripotent stem cell-based gene therapy approach: human de novo synthesized chromosomes
    S. Sinenko, S. Ponomartsev, A. Tomilin · 2020 · Cellular and Molecular Life Sciences
24. Functional Interrogation of a Depression-Related Serotonergic Single Nucleotide Polymorphism, rs6295, Using a Humanized Mouse Model
    Ashley M. Cunningham, Tabia L. Santos, Vanessa A. Gutzeit, Heather C. Hamilton, René Hen, Zoe R. Donaldson · 2019 · ACS Chemical Neuroscience
25. Tracking connectivity maps in human stem cell–derived neuronal networks by holographic optogenetics
    Felix Schmieder, Rouhollah Habibey, Johannes Striebel, Lars Büttner, Jürgen W. Czarske, Volker Busskamp · 2022 · Life Science Alliance
26. Functional genomics in stroke: current and future applications of iPSCs and gene editing to dissect the function of risk variants
    Alessandra Granata · 2023 · BMC Cardiovascular Disorders
27. Integrated Genomic Medicine
    Nicholas J. Schork, Kristopher L. Nazor · 2017 · Advances in genetics
28. Genetic Modification of Animals: Scientific and Ethical Issues
    Jarrod Bailey · 2019 · BRILL eBooks
29. Applications for Induced Pluripotent Stem Cells in Disease Modelling and Drug Development for Heart Diseases
    Shu Nakao, Dai Ihara, Koji Hasegawa, Teruhisa Kawamura · 2020 · European Cardiology Review
30. Neurodegeneration in a dish: advancing human stem-cell-based models of Alzheimer’s disease
    Julien Klimmt, Angelika Dannert, Dominik Paquet · 2020 · Current Opinion in Neurobiology
31. Bioengineering Systems for Modulating Notch Signaling in Cardiovascular Development, Disease, and Regeneration
    Angello Huerta Gomez, Sanika Joshi, Yong Suk Yang, Johnathan D. Tune, Mingtao Zhao, Huaxiao Yang · 2021 · Journal of Cardiovascular Development and Disease
32. Cardiac Tissue Engineering for the Treatment of Myocardial Infarction
    Dongmin Yu, Xiaowei Wang, Lei Ye · 2021 · Journal of Cardiovascular Development and Disease
33. Endogenous Telomerase Reverse Transcriptase N-Terminal Tagging Affects Human Telomerase Function at Telomeres In Vivo
    Kunitoshi Chiba, Jacob M. Vogan, R. Alex Wu, Manraj S. Gill, Xiaozhu Zhang, Kathleen Collins, Dirk F. Hockemeyer · 2016 · Molecular and Cellular Biology
34. Hepatitis C virus-induced innate immune responses in human iPS cell-derived hepatocyte-like cells
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35. 3D intestinal organoids in metabolic research: virtual reality in a dish
    Anastasia Tsakmaki, Patricia Fonseca Pedro, Gavin A. Bewick · 2017 · Current Opinion in Pharmacology
36. A path to efficient gene editing
    Fyodor D. Urnov · 2018 · Nature Medicine
37. Three-dimensional midbrain organoids: a next-generation tool for Parkinson’s disease modelling and drug discovery
    Rosalie Elvira, Eng‐King Tan, Zhidong Zhou · 2025 · Stem Cell Research & Therapy
38. Use of CRISPR/Cas ribonucleoproteins for high throughput gene editing of induced pluripotent stem cells
    Qi Wang, Sueanne Chear, Kristof Wing, David Stellon, Minh Thuan Nguyen Tran, Jana Talbot, Alice Pébay, Alex William Hewitt, Anthony L Cook · 2021 · Methods
39. Insulin resistance in diabetes: The promise of using induced pluripotent stem cell technology
    Ahmed Kamel Elsayed, Selvaraj Vimalraj, Manjula Nandakumar, Essam Mohamed Abdelalim · 2021 · World Journal of Stem Cells
40. The Role of Bone Morphogenetic Protein Receptor Type 2 (BMPR2) and the Prospects of Utilizing Induced Pluripotent Stem Cells (iPSCs) in Pulmonary Arterial Hypertension Disease Modeling
    A. Sadasivam Devendran, Sumanta Kar, Rasheed A. Bailey, Maria Giovanna Trivieri · 2022 · Cells
41. Modeling tumors of the peripheral nervous system associated with Neurofibromatosis type 1: Reprogramming plexiform neurofibroma cells
    Helena Mazuelas, Meritxell Carrió, Eduard Serra · 2020 · Stem Cell Research
42. Two decades of induced pluripotent stem cell research: From discovery to diverse applications
    Shinya Yamanaka · 2026 · Cell stem cell
43. Combining hiPSCs and Human Genetics: Major Applications in Drug Development
    Jin Zhang, Hu Li, Alan O. Trounson, Joseph C. Wu, Paul Nioi · 2017 · Cell stem cell
44. Stem cell-derived porcine macrophages as a new platform for studying host-pathogen interactions
    Stephen E. Meek, Tom Watson, Lél Eöry, Gus R. McFarlane, Felicity Wynne, Stephen McCleary, Laura E. M. Dunn, Emily M. Charlton, Chloe Craig, Barbara Bo-Ju Shih et al. · 2022 · BMC Biology
45. Generation of Human Isogenic Induced Pluripotent Stem Cell Lines with CRISPR Prime Editing
    Lori L. Bonnycastle, Amy J. Swift, Erin C. Mansell, Angela Lee, Elizabeth Winnicki, Elizabeth S. Li, Catherine C. Robertson, Victoria A. Parsons, Trung Huynh, Chad Krilow et al. · 2024 · The CRISPR Journal
46. Modeling Hematological Diseases and Cancer With Patient-Specific Induced Pluripotent Stem Cells
    Huensuk Kim, Christoph Schaniel · 2018 · Frontiers in Immunology
47. Future Match Making: When Pediatric Oncology Meets Organoid Technology
    Virginie Barbet, Laura Broutier · 2021 · Frontiers in Cell and Developmental Biology
48. Conditional gene knockout and reconstitution in human iPSCs with an inducible Cas9 system
    Mengyao Wu, Senquan Liu, Yongxing Gao, Hao Bai, Vasiliki Machairaki, Gang Li, Tong Chen, Linzhao Cheng · 2018 · Stem Cell Research
49. Mouse models of nesprin-related diseases
    Can Zhou, Li Rao, Derek T Warren, Catherine M. Shanahan, Qiuping Zhang · 2018 · Biochemical Society Transactions
50. Induced Pluripotent Stem Cells and Induced Pluripotent Cancer Cells in Cancer Disease Modeling
    Dandan Zhu, Celine Shuet Lin Kong, Julian A. Gingold, Ruiying Zhao, Dung‐Fang Lee · 2018 · Advances in experimental medicine and biology
51. The advances in CRISPR technology and 3D genome
    William Wang, Linlin Zhang, Xiangdong Wang, Yiming Zeng · 2018 · Seminars in Cell and Developmental Biology
52. Stem Cell-Related Studies and Stem Cell-Based Therapies in Liver Diseases
    Wei Zhou, Erek Nelson, Anan Abdelmoti Abu Rmilah, Bruce P. Amiot, Scott L. Nyberg · 2019 · Cell Transplantation
53. In vivo generated hematopoietic stem cells from genome edited induced pluripotent stem cells are functional in platelet-targeted gene therapy of murine hemophilia A
    Dawei Wang, Guowei Zhang, Junjie Gu, Xiaohu Shao, Yuting Dai, Jianfeng Li, Xiaohong Pan, Shuxian Yao, Aining Xu, Ying Jin et al. · 2019 · Haematologica
54. iPSC models of mitochondrial diseases
    Sonja Heiduschka, Alessandro Prigione · 2025 · Neurobiology of Disease
55. Molecular characterization of precise in vivo targeted gene integration in human cells using AAVHSC15
    Huei-Mei Chen, Rachel Resendes, Azita Ghodssi, Danielle Sookiasian, Michael Tian, Serena Dollive, Laura A. Adamson-Small, Nancy Avila, Cagdas Tazearslan, John F. Thompson et al. · 2020 · PLoS ONE
56. Personalized Medicine Using Cutting Edge Technologies for Genetic Epilepsies
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57. CRaTER enrichment for on-target gene editing enables generation of variant libraries in hiPSCs
    Clayton E. Friedman, Shawn Fayer, Sriram Pendyala, Wei‐Ming Chien, Alexander M. Loiben, Linda N. Tran, Leslie S. Chao, Ashley Mckinstry, Dania Ahmed, Elaheh Karbassi et al. · 2023 · Journal of Molecular and Cellular Cardiology
58. Differentiation, Transcriptomic Profiling, and Calcium Imaging of Human Hypothalamic Neurons
    Hsiao‐Jou Cortina Chen, Simone Mazzaferro, Tian Tian, Iman D. Mali, Florian T. Merkle · 2023 · Current Protocols
59. Von Willebrand Disease: From In Vivo to In Vitro Disease Models
    Suzan de Boer, Jeroen C.J. Eikenboom · 2019 · HemaSphere
60. Pipeline for the Generation and Characterization of Transgenic Human Pluripotent Stem Cells Using the CRISPR/Cas9 Technology
    Joffrey Mianné, Chloé Bourguignon, Chloé Nguyen Van, Mathieu Fieldès, Amel Nasri, Saïd Assou, John De Vos · 2020 · Cells
61. Cardiac Cell Cycle Activation as a Strategy to Improve iPSC-Derived Cardiomyocyte Therapy
    June‐Wha Rhee, Joseph C. Wu · 2018 · Circulation Research
62. Continuous muscle, glial, epithelial, neuronal, and hemocyte cell lines for Drosophila research
    Nikki Coleman-Gosser, Yanhui Hu, Shane M. Stitzinger, Yanhui Hu, Weihang Chen, Arthur Luhur, Daniel Mariyappa, Molly Josifov, Andrew C. Zelhof, Stephanie Elizabeth Mohr et al. · 2023 · eLife
63. Advances in Treatments for Epidermolysis Bullosa (EB): Emphasis on Stem Cell-Based Therapy
    Ramin Raoufinia, Hamid Reza Rahimi, Neda Keyhanvar, Meysam Moghbeli, Nima Abdyazdani, Mehdi Rostami, Karim Naghipoor, Fatemeh Forouzanfar, Sara Foroudi, Ehsan Saburi · 2024 · Stem Cell Reviews and Reports
64. Advances in the discovery of genetic risk factors for complex forms of neurodegenerative disorders: contemporary approaches, success, challenges and prospects
    Sumeet Kumar, Navneesh Yadav, Sanjay Pandey, Bittianda Kuttapa Thelma · 2018 · Journal of Genetics
65. Patient-Derived Induced Pluripotent Stem Cell Models for Phenotypic Screening in the Neuronal Ceroid Lipofuscinoses
    Ahmed Morsy, Angelica V. Carmona, Paul C. Trippier · 2021 · Molecules
66. Pluripotent Stem Cell-derived Strategies to Treat Acute Liver Failure: Current Status and Future Directions
    Jingfeng Liu, Zhiming Yuan, Qingwen Wang · 2022 · Journal of Clinical and Translational Hepatology
67. Highly Efficient CRISPR/Cas9‐Mediated Genome Editing in Human Pluripotent Stem Cells
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68. Generating universal chimeric antigen receptor expressing cell products from induced pluripotent stem cells: beyond the autologous CAR-T cells
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69. Understanding the genetics behind complex human disease with large-scale iPSC collections
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70. Technology used to build and transfer mammalian chromosomes
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71. Cytosine and adenosine base editing in human pluripotent stem cells using transient reporters for editing enrichment
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72. Controlling homology-directed repair outcomes in human stem cells with dCas9
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73. Human iPSC-derived NK cells armed with CCL19, CCR2B, high-affinity CD16, IL-15, and NKG2D complex enhance anti-solid tumor activity
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74. Stem cells as potential therapeutics for hearing loss
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75. Hydrogels - From Tradition to Innovative Platforms with Multiple Applications
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76. Modeling nervous system tumors with human stem cells and organoids
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77. Emergent challenges for CRISPR: biosafety, biosecurity, patenting, and regulatory issues
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78. Genome Editing Human Pluripotent Stem Cells to Model β-Cell Disease and Unmask Novel Genetic Modifiers
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79. Modeling Leukemia with Human Induced Pluripotent Stem Cells
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80. PINE-TREE enables highly efficient genetic modification of human cell lines.
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81. Endothelial dysfunction and cardiovascular diseases: The role of human induced pluripotent stem cells and tissue engineering
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82. Cell Culture Models for Hepatitis B and D Viruses Infection: Old Challenges, New Developments and Future Strategies
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83. Transformative Potential of Induced Pluripotent Stem Cells in Congenital Heart Disease Research and Treatment
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84. Reprogramming of somatic cells
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85. Patient-derived cellular models of primary ciliopathies
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86. “iPSC-derived liver organoids and inherited bleeding disorders: Potential and future perspectives”
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87. Automated Patch-Clamp and Induced Pluripotent Stem Cell-Derived Cardiomyocytes: A Synergistic Approach in the Study of Brugada Syndrome
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88. Can pluripotent/multipotent stem cells reverse Parkinson’s disease progression?
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89. Cell transplantation strategies for acquired and inherited disorders of peripheral myelin
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90. Regenerating the Cardiovascular System Through Cell Reprogramming; Current Approaches and a Look Into the Future
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91. The treatment of knee cartilage lesions: state of the art.
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92. Scanning the horizon for high value-add manufacturing science: Accelerating manufacturing readiness for the next generation of disruptive, high-value curative cell therapeutics
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93. Guidelines for Fluorescent Guided Biallelic HDR Targeting Selection With PiggyBac System Removal for Gene Editing
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94. Efficient Generation of Chondrocytes From Bone Marrow–Derived Mesenchymal Stem Cells in a 3D Culture System: Protocol for a Practical Model for Assessing Anti-Inflammatory Therapies
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95. Induced Pluripotent Stem Cells in Birds: Opportunities and Challenges for Science and Agriculture
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96. Long-term correction of hemophilia A via integration of a functionally enhanced FVIII gene into the AAVS1 locus by nickase in patient-derived iPSCs
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97. Application of human iPSC-derived white, beige, and brown adipocytes for metabolic disease modeling and transplantation therapy
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98. Trichostatin A for Efficient CRISPR-Cas9 Gene Editing of Human Pluripotent Stem Cells
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99. Application of Patient-Specific iPSCs for Modelling and Treatment of X-Linked Cardiomyopathies
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100. An Episomal CRISPR/Cas12a System for Mediating Efficient Gene Editing
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