Clonal Hematopoiesis and Evolution to Hematopoietic Malignancies

Bowman, Robert L., Busque, Lambert, Levine, Ross L.·2018·Cell stem cell

DOI 10.1016/j.stem.2018.01.011

Cited by (454)

Items 101–200 of 454

Full Spectrum of Clonal Haematopoiesis-Driver Mutations in Chronic Heart Failure and their Associations with Mortality
Katharina C. Kiefer, Sebastian Cremer, Evangelia Pardali, Birgit Aßmus, Khalil Abou‐El‐Ardat, Klara Kirschbaum, Lena Dorsheimer, Tina Rasper, Alexander Berkowitsch, Hubert L. Serve et al. · 2021 · ESC Heart Failure
Cytogenetic and molecular aberrations and worse outcome for male patients in systemic mastocytosis
Hanneke C. Kluin‐Nelemans, Mohamad Jawhar, Andreas Reiter, Björn van Anrooij, Jason R. Gotlib, Karin Hartmann, Anja Illerhaus, Hanneke N.G. Oude Elberink, Aleksandra Górska, Marek Niedoszytko et al. · 2020 · Theranostics
Lamin B1 deletion in myeloid neoplasms causes nuclear anomaly and altered hematopoietic stem cell function
Andreea Reilly, John Philip Creamer, Sintra Stewart, Massiel Chavez Stolla, Yuchuan Wang, Jing Du, Rachel Wellington, Stephanie Busch, Elihu H. Estey, Pamela Sue Becker et al. · 2022 · Cell stem cell
Next Generation Sequencing in MPNs. Lessons from the Past and Prospects for Use as Predictors of Prognosis and Treatment Responses
Vibe Skov · 2020 · Cancers
Hematopoietic Stem Cells and Their Niche in Bone Marrow
Munju Kwon, Byoung Soo Kim, Sik Yoon, Sae‐Ock Oh, Dongjun Lee · 2024 · International Journal of Molecular Sciences
Mitochondrial Control of Genomic Instability in Cancer
Massimo Bonora, Sonia Missiroli, Mariasole Perrone, Francesco Fiorica, Paolo Pinton, Carlotta Giorgi · 2021 · Cancers
A macaque clonal hematopoiesis model demonstrates expansion of TET2-disrupted clones and utility for testing interventions
Tae–Hoon Shin, Yifan Zhou, Shirley Chen, Stefan Cordes, Max Z. Grice, Xing Fan, Byung‐Chul Lee, Aisha A. Aljanahi, So Gun Hong, Kelli L. Vaughan et al. · 2022 · Blood
Next generation sequencing for liquid biopsy based testing in non-small cell lung cancer in 2021
Pasquale Pisapia, José Luís Costa, Francesco Pepe, Gianluca Russo, Gianluca Gragnano, Alessandro Russo, Antonino Iaccarino, Diego de Miguel‐Pérez, María José Serrano, Valeria Cecilia Denninghoff et al. · 2021 · Critical Reviews in Oncology/Hematology
Emerging Therapies for Acute Myelogenus Leukemia Patients Targeting Apoptosis and Mitochondrial Metabolism
Germana Castelli, Elvira Pelosi, Ugo Testa · 2019 · Cancers
The chromatin-binding protein Phf6 restricts the self-renewal of hematopoietic stem cells
Satoru Miyagi, Patrycja Sroczyńska, Yuko Kato, Yaeko Nakajima‐Takagi, Motohiko Oshima, Ola Rizq, Naoya Takayama, Atsunori Saraya, Seiya Mizuno, Fumihiro Sugiyama et al. · 2019 · Blood
Single-cell genomics identifies distinct B1 cell developmental pathways and reveals aging-related changes in the B-cell receptor repertoire
Yao Luo, Jing Wang, Kairui Li, Mingxia Li, Shasha Xu, Xingjie Liu, Zhiwei Zhang, Xiang Ming Xu, Yu Zhang, Jiawei Pan et al. · 2022 · Cell & Bioscience
STING activation in TET2-mutated hematopoietic stem/progenitor cells contributes to the increased self-renewal and neoplastic transformation
Jiaying Xie, Mengyao Sheng, Shaoqin Rong, Dan Zhou, Chao Wang, Wanling Wu, Jingru Huang, Yue Sun, Yin Wang, Pingyue Chen et al. · 2023 · Leukemia
From clonal hematopoiesis to myeloid leukemia and what happens in between: Will improved understanding lead to new therapeutic and preventive opportunities?
Jan Philipp Bewersdorf, Anastasia Ardasheva, Nikolai Alexandrovich Podoltsev, Abhay Singh, Giulia Biancon, Stephanie Halene, Amer Methqal Zeidan · 2019 · Blood Reviews
SHP2 inhibition reduces leukemogenesis in models of combined genetic and epigenetic mutations
Ruchi Pandey, Baskar Ramdas, Changlin Wan, George Earl Sandusky, Morvarid Mohseni, Chi Zhang, Reuben Kapur · 2019 · Journal of Clinical Investigation
The Clinical Challenge of Idiopathic Cytopenias of Undetermined Significance (ICUS) and Clonal Cytopenias of Undetermined Significance (CCUS)
David P. Steensma · 2019 · Current Hematologic Malignancy Reports
The Akt–mTOR network at the interface of hematopoietic stem cell homeostasis
Feng Wu, Zhe Chen, Jingbo Liu, Yu Hou · 2021 · Experimental Hematology
Circles of Life: linking metabolic and epigenetic cycles to immunity
Chan‐Wang Jerry Lio, Stanley Ching‐Cheng Huang · 2020 · Immunology
Targeting Immunophenotypic Markers on Leukemic Stem Cells: How Lessons from Current Approaches and Advances in the Leukemia Stem Cell (LSC) Model Can Inform Better Strategies for Treating Acute Myeloid Leukemia (AML)
Kelly Mitchell, Ulrich G. Steidl · 2019 · Cold Spring Harbor Perspectives in Medicine
Recent advances of nanodrug delivery system in the treatment of hematologic malignancies
Qian-Ling Ye, Yun Hsuan Lin, Ruihao Li, Huaiji Wang, Chunyan Dong · 2022 · Seminars in Cancer Biology
The sculpting of somatic mutational landscapes by evolutionary forces and their impacts on aging‐related disease
Fabio Marongiu, James V. DeGregori · 2022 · Molecular Oncology
The ClinGen Brain Malformation Variant Curation Expert Panel: Rules for somatic variants in AKT3, MTOR, PIK3CA, and PIK3R2
Abbe Lai, Aubrie Soucy, Christelle Moufawad El Achkar, A. James Barkovich, Yang Cao, Marina T. DiStefano, Michael J. Evenson, Renzo Guerrini, Devon Knight, Yi-Shan Lee et al. · 2022 · Genetics in Medicine
DNA damage accumulation and repair defects in FLT3‐ITD acute myeloid leukemia: Implications for clonal evolution and disease progression
Francisco Alejandro Lagunas‐Rangel · 2022 · Hematological Oncology
Clonal Hematopoiesis and risk of Acute Myeloid Leukemia
Pinkal M. Desai, Duane C. Hassane, Gail J. Roboz · 2019 · Best Practice & Research Clinical Haematology
Insights into clonal hematopoiesis and its relation to cancer risk
Shaneice Renee Mitchell, Jayakrishnan Gopakumar, Siddhartha Jaiswal · 2021 · Current Opinion in Genetics & Development
Clonal Hematopoiesis: Updates and Implications at the Solid Tumor-Immune Interface
Marco M. Buttigieg, Michael J. Rauh · 2023 · JCO Precision Oncology
Decoding leukemia at the single-cell level: clonal architecture, classification, microenvironment, and drug resistance
Jianche Liu, Penglei Jiang, Zezhen Lu, Zebin Yu, Pengxu Qian · 2024 · Experimental Hematology and Oncology
Cadmium Activates Noncanonical Wnt Signaling to Impair Hematopoietic Stem Cell Function in Mice
Yifan Zhao, Qian Li, Zhengli Yang, Yiming Shao, Peng Xue, Weidong Qu, Xiaodong Jia, Longzhen Cheng, Miao He, Rui He et al. · 2018 · Toxicological Sciences
Molecular Minimal Residual Disease in Acute Myeloid Leukemia
Laurent Mauvieux, Laurent Miguet, Luc‐Matthieu Fornecker · 2018 · New England Journal of Medicine
Hematopoietic-specific heterozygous loss of Dnmt3a exacerbates colitis-associated colon cancer
Yang Feng, Qingchen Yuan, Rachel C. Newsome, Troy M. Robinson, Robert L. Bowman, Ashley N. Zuniga, Kendra N. Hall, Cassandra M. Bernsten, Daniil E. Shabashvili, Kathryn I. Krajcik et al. · 2023 · The Journal of Experimental Medicine
Evaluating Clonal Hematopoiesis in Tumor-Infiltrating Leukocytes in Breast Cancer and Secondary Hematologic Malignancies
Elizabeth Anne Comen, Robert L. Bowman, Pier Selenica, Maria Kleppe, Noushin Rahnamay Farnoud, Fresia G. Pareja, Britta Weigelt, Corinne E. Hill, Abigail Alon, Felipe Correa Geyer et al. · 2019 · JNCI Journal of the National Cancer Institute
Aging and leukemic evolution of hematopoietic stem cells under various stress conditions
Shuhei Kurosawa, Atsushi Iwama · 2020 · Inflammation and Regeneration
Clonal Hematopoiesis and Mutations of Myeloproliferative Neoplasms
Lasse Kjær · 2020 · Cancers
Loss of a 7q gene,CUX1, disrupts epigenetically driven DNA repair and drives therapy-related myeloid neoplasms
Molly K. Imgruet, Julian Lutze, Ningfei An, Bonnie Y. Hu, Saira Saeed Khan, Jeffrey L. Kurkewich, Tanner C. Martinez, Donald J. Wolfgeher, Sandeep K. Gurbuxani, Stephen J. Kron et al. · 2021 · Blood
Molecular Landscape of Therapy-related Myeloid Neoplasms in Patients Previously Treated for Gynecologic and Breast Cancers
Sabine Khalife‐Hachem, Khalil Saleh, Florence Pasquier, Christophe Willekens, Anthony Tarabay, Leony Antoun, Thomas Grinda, Cristina Castilla‐Llorente, Matthieu Duchmann, Cyril Quivoron et al. · 2021 · HemaSphere
Whole genome deep sequencing analysis of cell-free DNA in samples with low tumour content
Devika Ganesamoorthy, Alan J. Robertson, Wenhan Chen, Michael B. Hall, Minh Duc Cao, Kaltin Ferguson, Sunil R. Lakhani, Kátia Nones, Peter T. Simpson, Lachlan Coin · 2022 · BMC Cancer
Association of clonal hematopoiesis mutations with clinical outcomes: A systematic review and meta‐analysis
Malgorzata Klaudia Nowakowska, Taebeom Kim, Mikayla T. Thompson, Kelly L. Bolton, Anita Deswal, Steven H. Lin, Paul Scheet, Mackenzie R. Wehner, Kevin Thomas Nead · 2022 · American Journal of Hematology
Clonal Hematopoiesis and therapy related MDS/AML
Pinkal M. Desai, Gail J. Roboz · 2019 · Best Practice & Research Clinical Haematology
Response to Rucaparib in BRCA-Mutant Metastatic Castration-Resistant Prostate Cancer Identified by Genomic Testing in the TRITON2 Study
Andrea Loehr, Akash Patnaik, David Colin Campbell, Jeremy David Shapiro, Alan Haruo Bryce, Ray McDermott, Brieuc R. Sautois, Nicholas J. Vogelzang, Richard Martin Bambury, Éric Voog et al. · 2021 · Clinical Cancer Research
Distinct and opposite effects of leukemogenic Idh and Tet2 mutations in hematopoietic stem and progenitor cells
Jérôme Fortin, Ming-Feng Chiang, Cem Meydan, Jonathan Foox, Parameswaran Ramachandran, Julie Leca, François Lemonnier, Wanda Y. Li, Miki S. Gams, Takashi Sakamoto et al. · 2023 · Proceedings of the National Academy of Sciences
Somatic mutations and T-cell clonality in patients with immunodeficiency
Paula Savola, Timi Martelius, Matti Kankainen, Jani Huuhtanen, Sofie Lundgren, Yrjö Koski, Samuli Eldfors, Tiina Kelkka, Mikko A. I. Keränen, Pekka Ellonen et al. · 2019 · Haematologica
Mitochondria-enriched hematopoietic stem cells exhibit elevated self-renewal capabilities, thriving within the context of aged bone marrow
Haruhito Totani, Takayoshi Matsumura, Rui Yokomori, Terumasa Umemoto, Yuji Takihara, Chong Yang, Lee Hui Chua, Atsushi Watanabe, Takaomi Sanda, Toshio Suda · 2025 · Nature Aging
Isocitrate Dehydrogenase Mutations in Myelodysplastic Syndromes and in Acute Myeloid Leukemias
Ugo Testa, Germana Castelli, Elvira Pelosi · 2020 · Cancers
Inherited blood cancer predisposition through altered transcription elongation
Jiawei Zhao, Liam D. Cato, Uma P. Arora, Erik L. Bao, Samuel C. Bryant, Nicholas Williams, Yuemeng Jia, Seth Raphael Goldman, Jyoti Nangalia, Michael A. Erb et al. · 2024 · Cell
Hematopoietic Stem Cells Self-Renew Symmetrically or Gradually Proceed to Differentiation
Melania Barile, Katrin Busch, Ann-Kathrin Fanti, Alessandro Greco, Xi Wang, Hideyuki Oguro, Qin Zhang, Sean J. Morrison, Hans-Reimer Rodewald, Thomas Höfer · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
BRCA1/BRCA2 germline mutations and chemotherapy-related hematological toxicity in breast cancer patients
Alex Friedlaender, Aurélie Vuilleumier, Valeria Viassolo, Aurélie Ayme, Solène De Talhouet, Jean‐Damien Combes, Julien Péron, Alexandre Bodmer, Sophie Giraud, Adrien Buisson et al. · 2019 · Breast Cancer Research and Treatment
Hematopoietic alterations in chronic heart failure patients by somatic mutations leading to clonal hematopoiesis
Lena Dorsheimer, Birgit Aßmus, Tina Rasper, Christina A. Ortmann, Khalil Abou‐El‐Ardat, Katharina C. Kiefer, Jedrzej Hoffmann, Florian Hartmut Seeger, Halvard B. Bonig, Stefanie Dimmeler et al. · 2019 · Haematologica
Colony Stimulating Factor 1 Receptor in Acute Myeloid Leukemia
Kristine Yttersian Sletta, Oriol Castells, Bjørn Tore Gjertsen · 2021 · Frontiers in Oncology
Resistance to Hypomethylating Agents in Myelodysplastic Syndrome and Acute Myeloid Leukemia From Clinical Data and Molecular Mechanism
Guangjie Zhao, Qian Wang, S. Li, Xiaoqin Wang · 2021 · Frontiers in Oncology
Novel Markers for Liquid Biopsies in Cancer Management: Circulating Platelets and Extracellular Vesicles
Sara Corvigno, Anna Maria Johnson, Kwong‐Kwok Wong, Min Soon Cho, Vahid Afshar‐Kharghan, David G. Menter, Anil K. Sood · 2022 · Molecular Cancer Therapeutics
Inherited Causes of Clonal Hematopoiesis of Indeterminate Potential in TOPMed Whole Genomes
Alexander G. Bick, Joshua S. Weinstock, Satish Kumar Nandakumar, Charles P. Fulco, Matthew Joseph Leventhal, Erik L. Bao, Joseph Nasser, Seyedeh Maryam Zekavat, Mindy D Szeto, Cecelia A. Laurie et al. · 2019 · bioRxiv (Cold Spring Harbor Laboratory)
Minimal Residual Disease Detection: Implications for Clinical Diagnosis and Cancer Patient Treatment
Meiling Song, Wenjing Pan, Xinjie Yu, Jie Ren, Congli Tang, Zhu Chen, Zhe Wang, Yan Deng, Nongyue He, Hongna Liu et al. · 2025 · MedComm
Clonal hematopoiesis with DNMT3A and PPM1D mutations impairs regeneration in autologous stem cell transplant recipients
Patrick Stelmach, Sarah Richter, Sandra Sauer, Margarete A. Fabre, Muxin Gu, Christian Rohde, Maike Janssen, Nora Liebers, Rumyana Proynova, Niels Weinhold et al. · 2023 · Haematologica
Clonal hematopoiesis of indeterminate potential and its impact on patient trajectories after stem cell transplantation
Derek S. Park, Afua Adutwumwa Akuffo, David E. Muench, H. Leighton Grimes, Pearlie K. Epling‐Burnette, Philip K. Maini, Alexander R.A. Anderson, Michael B. Bonsall · 2019 · PLoS Computational Biology
Clonal hematopoiesis driven by somatic mutations: A new player in atherosclerotic cardiovascular disease
Marta Amorós-Pérez, José J. Fuster · 2020 · Atherosclerosis
Sex-Related Differences in Chronic Myeloid Neoplasms: From the Clinical Observation to the Underlying Biology
Theodoros Karantanos, Tania Jain, Alison R. Moliterno, Richard John Jones, Amy Elizabeth Dezern · 2021 · International Journal of Molecular Sciences
Cell-type-specific consequences of mosaic structural variants in hematopoietic stem and progenitor cells
Karen Grimes, Hyobin Jeong, Amanda Amoah, Nuo Xu, Julian Niemann, Benjamin Raeder, Patrick Hasenfeld, Catherine Stober, Tobias Rausch, Eva Benito et al. · 2024 · Nature Genetics
Loss of Kmt2c or Kmt2d primes urothelium for tumorigenesis and redistributes KMT2A–menin to bivalent promoters
Naitao Wang, Mohini R. Pachai, Dan Li, Cindy J. Lee, Sarah Warda, Makhzuna N. Khudoynazarova, Woo Hyun Cho, Guojia Xie, Sagar R Shah, Yao Li et al. · 2025 · Nature Genetics
Clonal expansion dictates the efficacy of mitochondrial lineage tracing in single cells
Xin Wang, Kun Wang, Weixing Zhang, Zhongjie Tang, Hao Zhang, Yuying Cheng, Da Zhou, Chao Zhang, Wen‐Zhao Zhong, Qing Ma et al. · 2025 · Genome biology
Protein phosphatase, Mg2+/Mn2+‐dependent 1D (PPM1D) mutations in haematological cancer
Simon Husby, Emma Hjermind Justesen, Kirsten Grønbæk · 2020 · British Journal of Haematology
ID2 and HIF-1α collaborate to protect quiescent hematopoietic stem cells from activation, differentiation, and exhaustion
Brad L. Jakubison, Tanmoy Sarkar, Kristbjorn O. Gudmundsson, Shweta Singh, Lei Sun, Holly M. Morris, Kimberly D. Klarmann, Jonathan R. Keller · 2022 · Journal of Clinical Investigation
Single-cell methods in myeloproliferative neoplasms: old questions, new technologies
Jennifer O’Sullivan, Adam J. Mead, Bethan Psaila · 2022 · Blood
Measurable Residual Disease Detection in Acute Myeloid Leukemia: Current Challenges and Future Directions
Jennifer M. Moritz, Antonia Schwab, Andreas Reinisch, Armin Zebisch, Heinz Sill, Albert Wölfler · 2024 · Biomedicines
Detection of Circulating Tumor DNA in Liquid Biopsy: Current Techniques and Potential Applications in Melanoma
Clara Martínez-Vila, Cristina Teixidó, Francisco Aya, Roberto Martín, Europa Azucena González‐Navarro, Llúcia Alós, Natalia Castrejón de Anta, Ana Maria Arance · 2025 · International Journal of Molecular Sciences
Recent technologies enhancing the clinical utility of circulating tumor DNA
Aarthi Manoharan, Sambandam Ravikumar, Vishnu Ballambattu Bhat · 2020 · Clinica Chimica Acta
In vivo genome-wide CRISPR screening in murine acute myeloid leukemia uncovers microenvironmental dependencies
F. Mercier, Jian-Tao Shi, D. Sykes, T. Oki, M. Jankovic, C. Man, Y. Kfoury, Elizabeth Miller, Shu-Tao He, A. Zhu et al. · 2022 · Blood Advances
Clonal hematopoiesis of indeterminate potential and clonal cytopenias of undetermined significance: 2023 update on clinical associations and management recommendations
Abhishek Avinash Mangaonkar, Mrinal M. Patnaik · 2023 · American Journal of Hematology
Blood‐based circulating tumor DNA mutations as a diagnostic and prognostic biomarker for lung cancer
Maria Leung, Maxim B. Freidin, Maxim Freydin, C. Von Crease, Paulo De Sousa, Monica T. Barbosa, Andrew Gordon Nicholson, Eric Kian Saik Lim · 2020 · Cancer
From Clonal Hematopoiesis to Therapy-Related Myeloid Neoplasms: The Silent Way of Cancer Progression
Carmelo Gurnari, Emiliano Fabiani, Giulia Falconi, Serena Travaglini, Tiziana Ottone, Antonio Cristiano, Maria Teresa Voso · 2021 · Biology
Differential H4K16ac levels ensure a balance between quiescence and activation in hematopoietic stem cells
Cecília Pessoa Rodrigues, Asifa Akhtar · 2021 · Science Advances
Comprehensive landscape and interference of clonal haematopoiesis mutations for liquid biopsy: A Chinese pan‐cancer cohort
Enwu Xu, Kai Su, Yang Zhou, Longlong Gong, Yiwen Xuan, Ming Liao, Jiawang Cao, Yaqian Li, Yujiao Lu, Yi Zhao et al. · 2021 · Journal of Cellular and Molecular Medicine
Clonal Hematopoiesis and Premalignant Diseases
Justin D. Kaner, Pinkal M. Desai, Nuria Mencia-Trinchant, Mónica L. Guzmán, Gail J. Roboz, Duane C. Hassane · 2019 · Cold Spring Harbor Perspectives in Medicine
Joint representation and visualization of derailed cell states with Decipher
Achille Nazaret, Joy Linyue Fan, Vincent‐Philippe Lavallée, Cassandra Burdziak, Andrew E. Cornish, Vaidotas Kiseliovas, Robert L. Bowman, Ignas Masilionis, Jaeyoung Chun, Shira Esther Eisman et al. · 2025 · Genome biology
Stem cell mutations can be detected in myeloma patients years before onset of secondary leukemias
Ashwin Sridharan, Carolina Schinke, George Ivanov Georgiev, Mariana da Silva Ferreira, Victor J. Thiruthuvanathan, Ian C. MacArthur, Tushar Damodar Bhagat, Gaurav S. Choudhary, Srinivas Aluri, Jiahao Chen et al. · 2019 · Blood Advances
Modification of stem cell states by alcohol and acetaldehyde
Ryan N. Serio, Lorraine J. Gudas · 2019 · Chemico-Biological Interactions
Engineering human hematopoietic environments through ossicle and bioreactor technologies exploitation
Pia Sommerkamp, François Mercier, Adam C. Wilkinson, Dominique A. Bonnet, Paul Emile Bourgine · 2020 · Experimental Hematology
Molecular diagnosis of T-cell lymphoma: a correlative study of PCR-based T-cell clonality assessment and targeted NGS
Charlotte Syrykh, Pauline Gorez, Sarah Péricart, David Grand, Fréderic Escudié, Bastien Cabarrou, Lucie Obéric, Loïc Ysebaert, Laurence Lamant, Camille Laurent et al. · 2021 · Blood Advances
Single-Cell Epigenomics Reveals Mechanisms of Cancer Progression
Lindsay M. LaFave, Rachel E. Savage, Jason D. Buenrostro · 2022 · Annual Review of Cancer Biology
A fetal tumor suppressor axis abrogates MLL-fusion-driven acute myeloid leukemia
Mohamed Eldeeb, Ouyang Yuan, Nicola Guzzi, Phuong Cao Thi Ngoc, Anna Konturek-Cieśla, Trine Ahn Kristiansen, Sowndarya Muthukumar, Jeffrey A. Magee, Cristian Bellodi, Joan Yuan et al. · 2023 · Cell Reports
A View on Drug Development for Cancer Prevention
Andrew R. Reynolds, Michele Moschetta, Alula R. Yohannes, Farzana L. Walcott, Marianne B. Ashford, Zoltán Szűcs, Tina Sarbajna, James Hadfield, Eden Harrison, Benjamin Challis et al. · 2023 · Cancer Discovery
GTAC enables parallel genotyping of multiple genomic loci with chromatin accessibility profiling in single cells
Sven Turkalj, Niels Asger Jakobsen, Angus Groom, Marlen Metzner, Simone G. Riva, Eran Gur, Batchimeg Usukhbayar, Mirian Angulo Salazar, Lance D. Hentges, Gerda Mickute et al. · 2023 · Cell stem cell
Therapeutic targeting of leukemia stem cells in acute myeloid leukemia
Karina Barbosa, A. Deshpande · 2023 · Frontiers in Oncology
Hematopoietic Stem Cell Heterogeneity
Roland Jurecic · 2019 · Advances in experimental medicine and biology
Dynamic clonal hematopoiesis and functional T-cell immunity in a supercentenarian
Erik B. van den Akker, Stavros Makrodimitris, Marc Hulsman, Martijn H. Brugman, Tatjana Nikolić, Ted Bradley, Quinten Waisfisz, Frank Baas, Marja E. Jakobs, Daphne de Jong et al. · 2020 · Leukemia
Loss of SIRT1 inhibits hematopoietic stem cell aging and age-dependent mixed phenotype acute leukemia
Zhiqiang Wang, Chunxiao Zhang, Charles Warden, Zheng Liu, Yate‐Ching Yuan, Chao Guo, Charles Wang, Jinhui Wang, Xiwei Wu, Richard W. Ermel et al. · 2022 · Communications Biology
Targeting stem cells in myelodysplastic syndromes and acute myeloid leukemia
Petter S. Woll, Tetsuichi Yoshizato, Eva Hellström‐Lindberg, Thoas Fioretos, Benjamin L. Ebert, Sten Eirik W. Jacobsen · 2022 · Journal of Internal Medicine
Advances in nano-immunotherapy for hematological malignancies
Jian Xu, Wenqi Liu, Fengjuan Fan, Bo Zhang, Chunyan Sun, Yu Hu · 2024 · Experimental Hematology and Oncology
Diagnostic molecular techniques in haematology: recent advances
Aikaterini Koutsi, Elisavet‐Christina Vervesou · 2018 · Annals of Translational Medicine
From the niche to malignant hematopoiesis and back: reciprocal interactions between leukemia and the bone marrow microenvironment
Celia A. Soto, Cristina Lo Celso, Louise E. Purton, Benjamin J. Frisch · 2021 · JBMR Plus
Engineered Tissue Models to Replicate Dynamic Interactions within the Hematopoietic Stem Cell Niche
Aidan E. Gilchrist, Brendan A.C. Harley · 2021 · Advanced Healthcare Materials
Somatic mutation panels: Time to clear their names
Amy M. Trottier, Marcela Cavalcante de Andrade Silva, Zejuan Li, Lucy A. Godley · 2019 · Cancer Genetics
Selective pressures of platinum compounds shape the evolution of therapy-related myeloid neoplasms
Eline J.M. Bertrums, Jurrian K. de Kanter, Lucca L. M. Derks, Mark Verheul, Laurianne Trabut, Markus J. van Roosmalen, Henrik Hasle, Evangelia Antoniou, Dirk Reinhardt, Michael Norbert Dworzak et al. · 2024 · Nature Communications
Mouse acute leukemia develops independent of self-renewal and differentiation potentials in hematopoietic stem and progenitor cells.
Fang Dong, Hai-Tao Bai, Xiao-Fang Wang, Shan-Shan Zhang, Zhao Wang, Miner Xie, Sen Zhang, Jinhong Wang, Hao Sha, T. Cheng et al. · 2019 · Blood Advances
Preleukemic and leukemic evolution at the stem cell level
Jacob Stauber, John M. Greally, Ulrich G. Steidl · 2020 · Blood
Inflammation and hematopoietic stem cells aging
Hanqing He, Jianwei Wang · 2020 · Blood Science
Clonal approaches to understanding the impact of mutations on hematologic disease development
Jyoti Nangalia, Emily Mitchell, Anthony Richard Green · 2019 · Blood
Life style factors, tumor cell plasticity and cancer stem cells
Ilaria Chiodi, Chiara Mondello · 2020 · Mutation Research/Reviews in Mutation Research
Gene expression changes contribute to stemness and therapy resistance of relapsed acute myeloid leukemia: roles of SOCS2, CALCRL, MTSS1, and KDM6A
Alexander M. Grandits, Rotraud Wieser · 2021 · Experimental Hematology
Molecular Pathways in Clonal Hematopoiesis: From the Acquisition of Somatic Mutations to Transformation into Hematologic Neoplasm
Charles Gaulin, Katalin Kelemen, Cecilia Arana Yi · 2022 · Life
Clonal hematopoiesis in myeloid malignancies and solid tumors
Xiurong Cai, Robert L. Bowman, Jennifer J. Trowbridge · 2025 · Nature Cancer
Epigenetic and proteomic signatures associate with clonal hematopoiesis expansion rate
Taralynn Mack, Michael A. Raddatz, Yash Pershad, Daniel C. Nachun, Kent D. Taylor, Xiuqing Guo, Alan R. Shuldiner, Jeffrey R. O’Connell, Eimear E. Kenny, Ruth J. F. Loos et al. · 2024 · Nature Aging