Reciprocal Signaling between Glioblastoma Stem Cells and Differentiated Tumor Cells Promotes Malignant Progression

The Sequence Alignment/Map format and SAMtools

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The Genome Analysis Toolkit: A MapReduce framework for analyzing next-generation DNA sequencing data

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A global reference for human genetic variation

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Fast and accurate long-read alignment with Burrows-Wheeler transform.

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A program for annotating and predicting the effects of single nucleotide polymorphisms, SnpEff: SNPs in the genome of Drosophila melanogaster strain w 1118 ; iso-2; iso-3

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A framework for variation discovery and genotyping using next-generation DNA sequencing data

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Analysis of protein-coding genetic variation in 60,706 humans

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The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells

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deepTools2: a next generation web server for deep-sequencing data analysis

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Chronic hypoxia remodels the tumor microenvironment to support glioma stem cell growth

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Use of microRNAs as Diagnostic, Prognostic, and Therapeutic Tools for Glioblastoma

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Low-intensity pulsed ultrasound-generated singlet oxygen induces telomere damage leading to glioma stem cell awakening from quiescence

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Superenhancers as master gene regulators and novel therapeutic targets in brain tumors

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Multiplex single-cell chemical genomics reveals the kinase dependence of the response to targeted therapy

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Differentiated glioma cell-derived fibromodulin activates integrin-dependent Notch signaling in endothelial cells to promote tumor angiogenesis and growth

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Characterizing the heterogeneity in 5-aminolevulinic acid–induced fluorescence in glioblastoma

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Active targeting co-delivery of therapeutic Sur siRNA and an antineoplastic drug via epidermal growth factor receptor-mediated magnetic nanoparticles for synergistic programmed cell death in glioblastoma stem cells

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Oligodendrocyte Progenitor Cells in the Tumor Microenvironment

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BDNF is a prognostic biomarker involved in immune infiltration of lung adenocarcinoma and is associated with brain metastasis

Yu, Q., Wang, Y., Yi, G., Yang, W., Chen, K., Tan, X., Zhang, X., Xu, Z., Yang, Z., & Peng, Y. (2022) · Immunology · doi:10.1111/imm.13581 · Cited by 21

Subclonal evolution and expansion of spatially distinct THY1-positive cells is associated with recurrence in glioblastoma

Al‐Holou, W. N., Wang, H., Ravikumar, V., Shankar, S., Oneka, M. D., Fehmi, Z., Verhaak, R. G. W., Kim, H., Pratt, D. W., Camelo-Piragua, S. I., et al. (2023) · Neoplasia · doi:10.1016/j.neo.2022.100872 · Cited by 20

Boosting Nanomedicine Efficacy with Hyperbaric Oxygen Therapy

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Patient-derived tumor organoids mimic treatment-induced DNA damage response in glioblastoma

Majc, B., Habič, A., Malavolta, M., Vittori, M., Porčnik, A., Boŝnjak, R., Mlakar, J., Matjašič, A., Zupan, A., Vidmar, M. S., et al. (2024) · iScience · doi:10.1016/j.isci.2024.110604 · Cited by 19

Deciphering the Role of Glutamate Signaling in Glioblastoma Multiforme: Current Therapeutic Modalities and Future Directions

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Branched-chain amino acid transaminase 1 regulates glioblastoma cell plasticity and contributes to immunosuppression

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Integrin αVβ1-activated PYK2 promotes the progression of non-small-cell lung cancer via the STAT3-VGF axis

Wu, Z., Jiao, M., Shu, C., Zhang, S., Wang, J., Pu, J., Zhu, J., Zeng, Y., Zhu, Y., & Liu, Z. (2024) · Cell Communication and Signaling · doi:10.1186/s12964-024-01639-1 · Cited by 18

The semaphorin 3A/neuropilin-1 pathway promotes clonogenic growth of glioblastoma via activation of TGF-β signaling

Jeon, H.-M., Shin, Y. J., Lee, J., Chang, N., Woo, D., Lee, W. J., Nguyen, D., Kang, W., Cho, H. J., Yang, H., et al. (2023) · JCI Insight · doi:10.1172/jci.insight.167049 · Cited by 18

Biomanufacturing of glioblastoma organoids exhibiting hierarchical and spatially organized tumor microenvironment via transdifferentiation

Park, S., Avera, A. D., & Kim, Y. (2022) · Biotechnology and Bioengineering · doi:10.1002/bit.28191 · Cited by 17

Cellular neighborhoods in cancer

Ma, L., Xiong, B., Liu, M., & Tan, K. (2026) · Nature Cancer · doi:10.1038/s43018-025-01107-w · Cited by 16

The Interaction between Collagen 1 and High Mannose Type CD133 Up‐Regulates Glutamine Transporter SLC1A5 to Promote the Tumorigenesis of Glioblastoma Stem Cells

Wei, Y., Geng, S., Si, Y., Yang, Y., Chen, Q., Huang, S., Chen, X., Xu, W., Liu, Y., & Jiang, J. (2023) · Advanced Science · doi:10.1002/advs.202306715 · Cited by 16

SUV39H1 maintains cancer stem cell chromatin state and properties in glioblastoma

Li, C., Xie, Q., Ghosh, S., Cao, B., Du, Y., Giau, V. V., Huang, T. Y., Spruck, C., Carpenter, R. L., Wang, Y., et al. (2025) · JCI Insight · doi:10.1172/jci.insight.186344 · Cited by 17

A tropomyosin receptor kinase family protein, NTRK2 is a potential predictive biomarker for lung adenocarcinoma

Wang, X., Xu, Z., Chen, X., Ren, X., Wei, J., Zhou, S., Yang, X., Zeng, S., Qian, L., Wu, G., et al. (2019) · PeerJ · doi:10.7717/peerj.7125 · Cited by 16

BRAF/MEK inhibition induces cell state transitions boosting immune checkpoint sensitivity in BRAFV600E-mutant glioma

Xing, Y. L., Panovska, D., Park, J., Grossauer, S., Koeck, K., Bui, B., Nasajpour, E., Nirschl, J., Feng, Z.-P., Cheung, P., et al. (2025) · Cell Reports Medicine · doi:10.1016/j.xcrm.2025.102183 · Cited by 15

Secretome of Dental Pulp-Derived Stem Cells Reduces Inflammation and Proliferation of Glioblastoma Cells by Deactivating Mapk-Akt Pathway

Prateeksha, P., Howlader, M. S. I., Hansda, S., Naidu, P., Das, M., Abo-Aziza, F. A. M., & Das, H. (2023) · Diseases & Research · doi:10.54457/dr.202302006 · Cited by 16

Investigational treatment strategies in glioblastoma: progress made and barriers to success

Nelson, T. A., & Dietrich, J. (2023) · Expert Opinion on Investigational Drugs · doi:10.1080/13543784.2023.2267982 · Cited by 15

Neural regulation of drug resistance in cancer treatment

Liu, D., Li, X., Chen, X., Sun, Y. H., Tang, A., Li, Z., Zheng, J., & Shi, M. (2018) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2018.10.001 · Cited by 15

GASC1 Promotes Stemness of Esophageal Squamous Cell Carcinoma via NOTCH1 Promoter Demethylation

Jia, R., Yang, L., Yuan, X., Kong, J., Liu, Y., Yin, W., Gao, S., & Zhang, Y. (2019) · Journal of Oncology · doi:10.1155/2019/1621054 · Cited by 15

Biomimetic three-dimensional glioma model printed in vitro for the studies of glioma cells and neurons interactions

Bai, L., Hao, Z., Wang, S., Zhou, J., Yao, S., Pei, N., Zhu, H., Zhang, K., Reis, R. L., Oliveira, J. M., et al. (2023) · International Journal of Bioprinting · doi:10.18063/ijb.715 · Cited by 15

A peptide encoded by upstream open reading frame of MYC binds to tropomyosin receptor kinase B and promotes glioblastoma growth in mice

Li, F., Yang, K., Gao, X., Zhang, M., Gu, D., Wu, X., Lu, C., Wu, Q., Dixit, D., Gimple, R. C., et al. (2024) · Science Translational Medicine · doi:10.1126/scitranslmed.adk9524 · Cited by 14

Propofol Inhibits Glioma Stem Cell Growth and Migration and Their Interaction with Microglia via BDNF-AS and Extracellular Vesicles

Nizar, R., Cazacu, S., Xiang, C., Krasner, M., Barbiro‐Michaely, E., Gerber, D., Schwartz, J., Fried, I., Bar‐Asher, S. Y., Brodie, A., et al. (2023) · Cells · doi:10.3390/cells12151921 · Cited by 14

Heterogeneous Glioma Cell Invasion Under Interstitial Flow Depending on Their Differentiation Status

Namba, N., Chonan, Y., Nunokawa, T., Sampetrean, O., Saya, H., & Sudo, R. (2021) · Tissue Engineering Part A · doi:10.1089/ten.tea.2020.0280 · Cited by 13

Cell Biology Meets Cell Metabolism: Energy Production Is Similar in Stem Cells and in Cancer Stem Cells in Brain and Bone Marrow

Noorden, C. J. F. V., Breznik, B., Novak, M., van Dijck, A. J., Tanan, S., Vittori, M., Bogataj, U., Bakker, N., Khoury, J. D., Molenaar, R. J., et al. (2021) · Journal of Histochemistry & Cytochemistry · doi:10.1369/00221554211054585 · Cited by 15

Heterogeneity of Extracellular Vesicles and Particles: Molecular Voxels in the Blood Borne “Hologram” of Organ Function, Dysfunction and Cancer

Rak, J. W., & Strządała, L. (2023) · Archivum Immunologiae et Therapiae Experimentalis · doi:10.1007/s00005-023-00671-2 · Cited by 13

An Update on Glioblastoma Biology, Genetics, and Current Therapies: Novel Inhibitors of the G Protein-Coupled Receptor CCR5

Turnšek, T. L., Jiao, X., Novak, M., Jammula, S., Cicero, G., Ashton, A. W., Joyce, D. A., & Pestell, R. G. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22094464 · Cited by 14

Identification of glioblastoma stem cell-associated lncRNAs using single-cell RNA sequencing datasets

Hazra, R., Utama, R., Naik, P. K., Dobin, A., & Spector, D. L. (2023) · Stem Cell Reports · doi:10.1016/j.stemcr.2023.10.004 · Cited by 12

Expression and pharmacological inhibition of TrkB and EGFR in glioblastoma

Pinheiro, K. V., Thomaz, A., Souza, B. K., Metcalfe, V. A., Freire, N. H., Brunetto, A. T., de Farias, C. B., Jaeger, M. D. C., Bambini-Júnior, V., Smith, C. G., et al. (2020) · Molecular Biology Reports · doi:10.1007/s11033-020-05739-2 · Cited by 11

Cells Isolated from Residual Intracranial Tumors after Treatment Express iPSC Genes and Possess Neural Lineage Differentiation Plasticity

Palanichamy, K., Jacob, J. R., Litzenberg, K. T., Ray‐Chaudhury, A., & Chakravarti, A. (2018) · EBioMedicine · doi:10.1016/j.ebiom.2018.09.019 · Cited by 11

Spatial epigenomic niches underlie glioblastoma cell state plasticityPreprint

Kint, S., Younes, S. T., Bao, S., Long, G., Wouters, D., Stephenson, E. L., Lou, X., Zhong, M., Zhang, D., Su, G., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.05.09.653178 · Cited by 11

Multi-omics analysis identifies glioblastoma dependency on H3K9me3 methyltransferase activity

Xie, Q., Du, Y., Ghosh, S., Rajendran, S., Cohen-Gadol, A. A., Baizabal, J.-M., Nephew, K. P., Han, L., & Shen, J. (2025) · NPJ Precision Oncology · doi:10.1038/s41698-025-00829-5 · Cited by 10

Unlocking Glioblastoma Vulnerabilities with CRISPR-Based Genetic Screening

Fang, Y., Li, X., & Tian, R. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25115702 · Cited by 12

Neuropeptide Precursor VGF Promotes Liver Metastatic Colonization of Gαq Mutant Uveal Melanoma by Facilitating Tumor Microenvironment via Paracrine Loops

Ouyang, S., Shi, S., Ding, W., Yang, G., Su, Y., Mo, J., Peng, K., Zhang, Q., Liu, G., Xiao, W., et al. (2024) · Advanced Science · doi:10.1002/advs.202407967 · Cited by 10

Tumor Innervation: From Bystander to Emerging Therapeutic Target for Cancer

Ji, Z. Z., Chan, M. K., Tang, P. C., Ng, C. S. H., Li, C., Zhang, D., Nikolic‐Paterson, D. J., To, K., Jiang, X., & Tang, P. M.-K. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26189257 · Cited by 11

Chromium (VI)‐induced ALDH1A1/EGF axis promotes lung cancer progression

Ge, X. Q., Li, M., Song, G., Zhang, Z., Yin, J., Ge, Z., Shi, Z., Liu, L.-Z., Jiang, B., Qian, X., et al. (2022) · Clinical and Translational Medicine · doi:10.1002/ctm2.1136 · Cited by 9

m6A-lncRNA landscape highlights reduced levels of m6A modification in glioblastoma as compared to low-grade glioma

Steponaitis, G., Dragūnaitė, R., Stakaitis, R., Sharma, A., Tamašauskas, A., & Skiriutė, D. (2025) · Molecular Medicine · doi:10.1186/s10020-025-01254-x · Cited by 12

A molecularly distinct subset of glioblastoma requires serum‐containing media to establish sustainable bona fide glioblastoma stem cell cultures

Maturi, N. P., Tan, E., Xie, Y., Sundström, A., Bergström, T., Jiang, Y., & Uhrbom, L. (2019) · Glia · doi:10.1002/glia.23773 · Cited by 9

Cell-of-Origin and Genetic, Epigenetic, and Microenvironmental Factors Contribute to the Intra-Tumoral Heterogeneity of Pediatric Intracranial Ependymoma

Servidei, T., Lucchetti, D., Navarra, P., Sgambato, A., Riccardi, R., & Ruggiero, A. (2021) · Cancers · doi:10.3390/cancers13236100 · Cited by 9

Novel CAR-T cells targeting TRKB for the treatment of solid cancer

Liang, D., Tang, J., Sun, B., He, S., Yang, D., Ma, H., Yun, Y., Zhu, Y., Wei, W., Chen, H., et al. (2024) · APOPTOSIS · doi:10.1007/s10495-024-01936-7 · Cited by 8

Dual-triggered biomimetic vehicles enable treatment of glioblastoma through a cancer stem cell therapeutic strategy

Geng, W., Zou, H. L., Wang, H., Dai, Y., Lu, G., Sun, Z., Lü, Y., Ding, X., & Yu, Y. (2021) · Nanoscale · doi:10.1039/d0nr08899d · Cited by 8

Atypical cellular responses mediated by intracellular constitutive active TrkB (NTRK2) kinase domains and a solely intracellular NTRK2-fusion oncogene

Gupta, R., Dittmeier, M., Wohlleben, G., Nickl, V., Bischler, T., Luzak, V., Wegat, V., Doll, D., Sodmann, A., Bady, E., et al. (2024) · Cancer Gene Therapy · doi:10.1038/s41417-024-00809-0 · Cited by 7

Xiao‐Chai‐Hu‐Tang Ameliorates Depressive Symptoms via Modulating Neuro‐Endocrine Network in Chronic Unpredictable Mild Stress‐Induced Mice

Feng, Y., Wang, W., Zhang, Y., Feng, Y., Zhao, Y., Zhang, Z., & Wang, Y. (2025) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.70290 · Cited by 7

N-acetyltransferase 10 promotes glioblastoma malignancy via mRNA stabilization of jumonji and AT-rich interaction domain containing 2

Inoki, T., Tsuruta, A., Masakado, Y., Kai, Y., Yoshida, Y., Matsunaga, N., Ohdo, S., & Koyanagi, S. (2025) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2025.108544 · Cited by 7

Endothelial cells-derived SEMA3G suppresses glioblastoma stem cells by inducing c-Myc degradation

Min, P., Feng, L.-L., Zhang, Y., Jiang, C., Zhang, H.-Z., Chen, Y., Fukunaga, K., Liu, F., Zhang, Y., Sasaki, T., et al. (2025) · Cell Death and Differentiation · doi:10.1038/s41418-025-01534-3 · Cited by 7

Stress granules restrain ferroptosis by sequestering ferritin

Ge, Z., Wang, Z., Zhao, E., Guo, Y., Zhang, L., Tian, F., Li, M., L, Y., Ding, F., He, L., et al. (2026) · Nature Cell Biology · doi:10.1038/s41556-026-01953-5 · Cited by 7

PLEKHA4 is Associated with Tumour Microenvironment, Stemness, Proliferation and Poor Prognosis of Gliomas

Gao, X., Liu, Y., Hong, S., Yang, H., Guan, B., & Ma, X. (2023) · Journal of Integrative Neuroscience · doi:10.31083/j.jin2205130 · Cited by 7

Lineage specification in glioblastoma is regulated by METTL7B

Constantinou, M., Nicholson, J., Zhang, X., Maniati, E., Lucchini, S., Rosser, G., Vinel, C., Wang, J., Lim, Y. M., Brandner, S., et al. (2024) · Cell Reports · doi:10.1016/j.celrep.2024.114309 · Cited by 7

Nerve growth factor inducible ( VGF ) is a secreted mediator for metastatic breast cancer tropism to the brain

Carvalho, R., Santos, L., Conde, I., Leitão, R. A., Ferreira, H. R. S., Gomes, C. M. F., Silva, A. P., Schmitt, F. C., Carvalho‐Maia, C., Lobo, J., et al. (2024) · The Journal of Pathology · doi:10.1002/path.6319 · Cited by 8

Mini-Review: PDPK1 (3-phosphoinositide dependent protein kinase-1), An Emerging Cancer Stem Cell Target

Domrachev, B., Singh, S. S., Li, D., & Rudloff, U. (2021) · Journal of Cancer Treatment and Diagnosis · doi:10.29245/2578-2967/2021/1.1194 · Cited by 7

Novel exosome-related risk signature as prognostic biomarkers in glioblastoma

Ding, M., Xu, Q., Jin, X., Han, Z., Jiang, H., Sun, H., Jin, Y., Piao, Z., & Zhang, S. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1071023 · Cited by 7

The tumour ecology of quiescence: Niches across scales of complexity

Castillo, S. P., Gálvez‐Cancino, F., Liu, J., Pollard, S. M., Quezada, S. A., & Yuan, Y. (2023) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2023.04.004 · Cited by 7

Activated KRAS reprograms neural progenitor cells to glioma stem cell‑like phenotype

Qin, Z., Liang, W., Zhang, Z., Li, P., Wang, T., Chen, Q., Guo, B., Zhong, Y., Kang, H., & Wang, L. (2023) · International Journal of Oncology · doi:10.3892/ijo.2023.5536 · Cited by 7

The upregulation of VGF enhances the progression of oral squamous carcinoma

Chou, C., Yen, C.-H., Liu, C., Tu, H., Lin, S., & Chang, K. (2024) · Cancer Cell International · doi:10.1186/s12935-024-03301-9 · Cited by 7

Kernel Differential Subgraph Analysis to Reveal the Key Period Affecting Glioblastoma

Xie, J., Sun, J., Feng, J., Yang, F., Wang, J., Wen, T., & Nie, Q. H. (2020) · Biomolecules · doi:10.3390/biom10020318 · Cited by 7

Prognostic Value of mRNAsi/Corrected mRNAsi Calculated by the One-Class Logistic Regression Machine-Learning Algorithm in Glioblastoma Within Multiple Datasets

Zhang, M., Chen, H., Liang, B., Wang, X., Gu, N., Xue, F., Yue, Q., Zhang, Q., & Hong, J. (2021) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2021.777921 · Cited by 7

Proteomic and functional comparison between human induced and embryonic stem cellsPreprint

Brenes, A. J., Griesser, E., Sinclair, L. V., Davidson, L., Prescott, A. R., Singh, F., Hogg, E. K. J., Espejo-Serrano, C., Jiang, H., Yoshikawa, H., et al. (2024) · eLife · doi:10.7554/elife.92025.3 · Cited by 7

Advancements in 3D gel culture systems for enhanced angiogenesis in bone tissue engineering

Shi, A., Shi, Y., Li, J., Ye, M., Ma, X., Peng, Y., Gai, K., & Chen, J. (2025) · Journal of Materials Chemistry B · doi:10.1039/d4tb01139b · Cited by 6

Nuclear cholesterol regulates nuclear size and DNA damage responses in cancer stem cells

Duan, T., Taori, S., Bhargava, S., Lai, S., Zhong, C., Yomtoubian, S., Yuan, H., Wu, X., Zhang, P., Huang, T., et al. (2025) · Neuro-Oncology · doi:10.1093/neuonc/noaf110 · Cited by 6

Thinking in 3 dimensions: philosophies of the microenvironment in organoids and organs-on-chip

Caianiello, S., Bertolaso, M., & Militello, G. (2023) · History & Philosophy of the Life Sciences · doi:10.1007/s40656-023-00560-z · Cited by 6

Overexpression of PRKCH promotes tumorigenesis in patients with glioma and influences glioma stem cell properties

Pang, F., He, W., Liu, X., Zou, Z., Wu, W., Wang, Y., Yang, P., Wen, B., Jiang, J., Teng, Y., et al. (2022) · Pathology - Research and Practice · doi:10.1016/j.prp.2022.154236 · Cited by 6

Activation of CXCL12-CXCR4 signalling induces conversion of immortalised embryonic kidney cells into cancer stem-like cells

Oh, S.-I., Jeong, H., Park, H.-S., Choi, K., Hwang, I.-S., Lee, J., Cho, J., & Hong, S. (2020) · Artificial Cells Nanomedicine and Biotechnology · doi:10.1080/21691401.2020.1841783 · Cited by 6

Development of Experimental Three-Dimensional Tumor Models to Study Glioblastoma Cancer Stem Cells and Tumor Microenvironment

Ruiz-Garcia, H., Zarco, N., Watanabe, F., Farias, V., Suárez-Meade, P., Guerrero‐Cazares, H., Imitola, J., Quiñones‐Hinojosa, A., & Trifiletti, D. M. (2022) · Methods in molecular biology · doi:10.1007/978-1-0716-2703-7_9 · Cited by 6

Innovative radiotherapies for the treatment of glioblastoma

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Interdependencies of the Neuronal, Immune and Tumor Microenvironment in Gliomas

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