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Reciprocal Signaling between Glioblastoma Stem Cells and Differentiated Tumor Cells Promotes Malignant Progression
Open accessAbstract
Glioblastoma is the most lethal primary brain tumor; however, the crosstalk between glioblastoma stem cells (GSCs) and their supportive niche is not well understood. Here, we interrogated reciprocal signaling between GSCs and their differentiated glioblastoma cell (DGC) progeny. We found that DGCs accelerated GSC tumor growth. DGCs preferentially expressed brain-derived neurotrophic factor (BDNF), whereas GSCs expressed the BDNF receptor NTRK2. Forced BDNF expression in DGCs augmented GSC tumor growth. To determine molecular mediators of BDNF-NTRK2 paracrine signaling, we leveraged transcriptional and epigenetic profiles of matched GSCs and DGCs, revealing preferential VGF expression by GSCs, which patient-derived tumor models confirmed. VGF serves a dual role in the glioblastoma hierarchy by promoting GSC survival and stemness in vitro and in vivo while also supporting DGC survival and inducing DGC secretion of BDNF. Collectively, these data demonstrate that differentiated glioblastoma cells cooperate with stem-like tumor cells through BDNF-NTRK2-VGF paracrine signaling to promote tumor growth.
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“In line with these observations, it has been recently shown that BDNF produced by glioblastoma (GBM) differentiated cells acts on GBM stem cells, fostering their growth through paracrine signaling [258].”
From Neurotrophic Factor BDNF, Physiological Functions and Therapeutic Potential in Depression, Neurodegeneration and Brain Cancer (2020) · cites this paper as [258]
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Cites
The Sequence Alignment/Map format and SAMtools
Li, H., Handsaker, B., Wysoker, A., Fennell, T., Ruan, J., Homer, N., Marth, G., Abecasis, G., Durbin, R., & 1000 Genome Project Data Processing Subgroup (2009) · Bioinformatics · doi:10.1093/bioinformatics/btp352 · Cited by 62,041
Fast and accurate short read alignment with Burrows-Wheeler transform
Li, H., & Durbin, R. (2009) · Bioinformatics · doi:10.1093/bioinformatics/btp324 · Cited by 58,607
The Genome Analysis Toolkit: A MapReduce framework for analyzing next-generation DNA sequencing data
McKenna, A., Hanna, M., Banks, E., Sivachenko, A., Cibulskis, K., Kernytsky, A., Garimella, K., Altshuler, D., Gabriel, S., Daly, M., et al. (2010) · Genome Research · doi:10.1101/gr.107524.110 · Cited by 27,895
A global reference for human genetic variation
The 1000 Genomes Project Consortium, authors, C., Auton, A., Abecasis, G. R., Steering committee, Altshuler, D. M., Durbin, R. M., Abecasis, G. R., Bentley, D. R., Chakravarti, A., et al. (2015) · Nature · doi:10.1038/nature15393 · Cited by 18,247
Self-citationFast and accurate long-read alignment with Burrows-Wheeler transform.
Li, H., & Durbin, R. (2010) · Bioinformatics · doi:10.1093/bioinformatics/btp698 · Cited by 12,063
Cingolani, P., Platts, A., Wang, L. L., Coon, M., Nguyen, T., Wang, L., Land, S. J., Lu, X., & Ruden, D. M. (2012) · Fly · doi:10.4161/fly.19695 · Cited by 11,816
A framework for variation discovery and genotyping using next-generation DNA sequencing data
DePristo, M. A., Banks, E., Poplin, R. E., Garimella, K. V., Maguire, J., Hartl, C., Philippakis, A., del Angel, G., Rivas, M. A., Hanna, M., et al. (2011) · Nature Genetics · doi:10.1038/ng.806 · Cited by 11,457
Analysis of protein-coding genetic variation in 60,706 humans
Exome Aggregation Consortium, Lek, M., Karczewski, K. J., Minikel, E. V., Samocha, K. E., Banks, E., Fennell, T., O’Donnell-Luria, A. H., Ware, J. S., Hill, A. J., et al. (2016) · Nature · doi:10.1038/nature19057 · Cited by 9,587
The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells
Mani, S. A., Guo, W., Liao, M.-J., Eaton, E. N., Ayyanan, A., Zhou, A. Y., Brooks, M. W., Reinhard, F., Zhang, C. C., Shipitsin, M. V., et al. (2008) · Cell · doi:10.1016/j.cell.2008.03.027 · Cited by 8,839
deepTools2: a next generation web server for deep-sequencing data analysis
Ramírez, F., Ryan, D. P., Grüning, B., Bhardwaj, V., Kilpert, F., Richter, A. S., Heyne, S., Dündar, F., & Manke, T. (2016) · Nucleic Acids Research · doi:10.1093/nar/gkw257 · Cited by 8,096
Stupp, R., Hegi, M. E., Mason, W. P., van den Bent, M. J., TAPHOORN, M. J. B., Janzer, R. C., Ludwin, S. K., Allgeier, A., Fisher, B., Bélanger, K., et al. (2009) · The Lancet Oncology · doi:10.1016/s1470-2045(09)70025-7 · Cited by 7,980
Van der Auwera, G. A., Carneiro, M. O., Hartl, C., Poplin, R., del Angel, G., Levy‐Moonshine, A., Jordan, T., Shakir, K., Roazen, D., Thibault, J., et al. (2013) · Current Protocols in Bioinformatics · doi:10.1002/0471250953.bi1110s43 · Cited by 6,687
Glioma stem cells promote radioresistance by preferential activation of the DNA damage response
Bao, S., Wu, Q., McLendon, R. E., Hao, Y., Shi, Q., Hjelmeland, A. B., Dewhirst, M. W., Bigner, D. D., & Rich, J. N. (2006) · Nature · doi:10.1038/nature05236 · Cited by 6,517
Self-citationThe Somatic Genomic Landscape of Glioblastoma
Brennan, C. W., Verhaak, R. G. W., McKenna, A., Campos, B., Noushmehr, H., Salama, S. R., Zheng, S., Chakravarty, D., Sanborn, J. Z., Berman, S. H., et al. (2013) · Cell · doi:10.1016/j.cell.2013.09.034 · Cited by 5,016
Reynolds, B. A., & Weiss, S. (1992) · Science · doi:10.1126/science.1553558 · Cited by 4,482
Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts
Sato, T., van Es, J. H., Snippert, H. J., Stange, D. E., Vries, R. G., van den Born, M., Barker, N., Shroyer, N. F., van de Wetering, M., & Clevers, H. (2011) · Nature · doi:10.1038/nature09637 · Cited by 2,510
A restricted cell population propagates glioblastoma growth after chemotherapy
Chen, J., Li, Y., Yu, T.-S., McKay, R. M., Burns, D. K., Kernie, S. G., & Parada, L. F. (2012) · Nature · doi:10.1038/nature11287 · Cited by 2,354
Neurotrophins and their receptors: A convergence point for many signalling pathways
Chao, M. V. (2003) · Nature Reviews Neuroscience · doi:10.1038/nrn1078 · Cited by 2,298
A Perivascular Niche for Brain Tumor Stem Cells
Calabrese, C. R., Poppleton, H., Koçak, M., Hogg, T. L., Fuller, C. E., Hamner, J. B., Oh, E. Y., Gaber, M. W., Finklestein, D., Allen, M., et al. (2007) · Cancer Cell · doi:10.1016/j.ccr.2006.11.020 · Cited by 2,253
Neurotrophin-regulated signalling pathways
Reichardt, L. F. (2006) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2006.1894 · Cited by 2,195
Hu, Y., & Smyth, G. K. (2009) · Journal of Immunological Methods · doi:10.1016/j.jim.2009.06.008 · Cited by 2,084
The NIH Roadmap Epigenomics Mapping Consortium
Bernstein, B. E., Stamatoyannopoulos, J. A., Costello, J. F., Ren, B., Milosavljevic, A., Meissner, A., Kellis, M., Marra, M. A., Beaudet, A. L., Ecker, J. R., et al. (2010) · Nature Biotechnology · doi:10.1038/nbt1010-1045 · Cited by 1,892
Analysis of gene expression and chemoresistance of CD133+ cancer stem cells in glioblastoma
Liu, G., Yuan, X., Zeng, Z., Tunici, P., Ng, H., Abdulkadir, I. R., Lu, L., Irvin, D. K., Black, K. L., & Yu, J. S. (2006) · Molecular Cancer · doi:10.1186/1476-4598-5-67 · Cited by 1,844
The role of pericytes in blood-vessel formation and maintenance
Bergers, G., & Song, S. (2005) · Neuro-Oncology · doi:10.1215/s1152851705000232 · Cited by 1,584
Stem Cell–like Glioma Cells Promote Tumor Angiogenesis through Vascular Endothelial Growth Factor
Bao, S., Wu, Q., Sathornsumetee, S., Hao, Y., Li, Z., Hjelmeland, A. B., Shi, Q., McLendon, R. E., Bigner, D. D., & Rich, J. N. (2006) · Cancer Research · doi:10.1158/0008-5472.can-06-1010 · Cited by 1,347
Self-citationBone morphogenetic proteins inhibit the tumorigenic potential of human brain tumour-initiating cells
Piccirillo, S. G. M., Reynolds, B. A., Zanetti, N., Lamorte, G., Binda, E., Broggi, G., Brem, H., Olivi, A., DiMeco, F., & Vescovi, A. L. (2006) · Nature · doi:10.1038/nature05349 · Cited by 1,199
Reconstructing and Reprogramming the Tumor-Propagating Potential of Glioblastoma Stem-like Cells
Suvà, M. L., Rheinbay, E., Gillespie, S. M., Patel, A. P., Wakimoto, H., Rabkin, S. D., Riggi, N., Chi, A. S., Cahill, D. P., Nahed, B. V., et al. (2014) · Cell · doi:10.1016/j.cell.2014.02.030 · Cited by 956
Zhou, W., Ke, S. Q., Huang, Z., Flavahan, W., Fang, X., Paul, J., Wu, L., Sloan, A. E., McLendon, R. E., Li, X., et al. (2015) · Nature Cell Biology · doi:10.1038/ncb3090 · Cited by 940
Self-citationGlioblastoma Stem Cells Generate Vascular Pericytes to Support Vessel Function and Tumor Growth
Cheng, L., Huang, Z., Zhou, W., Wu, Q., Donnola, S., Liu, J. K., Fang, X., Sloan, A. E., Mao, Y., Lathia, J. D., et al. (2013) · Cell · doi:10.1016/j.cell.2013.02.021 · Cited by 905
Self-citationEyes Wide Open: A Critical Review of Sphere-Formation as an Assay for Stem Cells
Pastrana, É., Silva-Vargas, V., & Doetsch, F. K. (2011) · Cell stem cell · doi:10.1016/j.stem.2011.04.007 · Cited by 856
GlioVis data portal for visualization and analysis of brain tumor expression datasets
Bowman, R. L., Wang, Q., Carro, Á., Verhaak, R. G. W., & Squatrito, M. (2016) · Neuro-Oncology · doi:10.1093/neuonc/now247 · Cited by 855
Tumour-initiating cells: challenges and opportunities for anticancer drug discovery
Zhou, B. S., Zhang, H., Damelin, M. I., Geles, K. G., Grindley, J. C., & Dirks, P. B. (2009) · Nature Reviews Drug Discovery · doi:10.1038/nrd2137 · Cited by 846
Bleau, A., Hambardzumyan, D., Ozawa, T., Fomchenko, E. I., Huse, J. T., Brennan, C., & Holland, E. C. (2009) · Cell stem cell · doi:10.1016/j.stem.2009.01.007 · Cited by 803
Making a tumour's bed: glioblastoma stem cells and the vascular niche
Gilbertson, R. J., & Rich, J. N. (2007) · Nature reviews. Cancer · doi:10.1038/nrc2246 · Cited by 737
Self-citationIntegrin Alpha 6 Regulates Glioblastoma Stem Cells
Lathia, J. D., Gallagher, J., Heddleston, J. M., Wang, J., Eyler, C. E., MacSwords, J., Wu, Q., Vasanji, A., McLendon, R. E., Hjelmeland, A. B., et al. (2010) · Cell stem cell · doi:10.1016/j.stem.2010.02.018 · Cited by 655
Self-citationA Pan-Cancer Proteogenomic Atlas of PI3K/AKT/mTOR Pathway Alterations
Zhang, Y., Kwok-Shing Ng, P., Kucherlapati, M., Chen, F., Liu, Y., Tsang, Y. H., de Velasco, G., Jeong, K. J., Akbani, R., Hadjipanayis, A., et al. (2017) · Cancer Cell · doi:10.1016/j.ccell.2017.04.013 · Cited by 626 · cited 2×
“(Zhang et al., 2017) and glioblastoma genes (Brennan et al.”
Charles, N., Ozawa, T., Squatrito, M., Bleau, A.-M., Brennan, C. W., Hambardzumyan, D., & Holland, E. C. (2010) · Cell Stem Cell · doi:10.1016/j.stem.2010.01.001 · Cited by 550
Brain tumor initiating cells adapt to restricted nutrition through preferential glucose uptake
Flavahan, W. A., Wu, Q., Hitomi, M., Rahim, N., Kim, Y., Sloan, A. E., Weil, R. J., Nakano, I., Sarkaria, J. N., Stringer, B. W., et al. (2013) · Nature Neuroscience · doi:10.1038/nn.3510 · Cited by 511
Self-citationZhu, T. S., Costello, M. A., Talsma, C. E., Flack, C. G., Crowley, J. G., Hamm, L. L., He, X., Hervey‐Jumper, S. L., Heth, J., Muraszko, K. M., et al. (2011) · Cancer Research · doi:10.1158/0008-5472.can-10-4269 · Cited by 414
Wakimoto, H., Kesari, S., Farrell, C. J., Curry, W. T., Zaupa, C., Aghi, M. K., Kuroda, T., Stemmer-Rachamimov, A. O., Shah, K., Liu, T., et al. (2009) · Cancer Research · doi:10.1158/0008-5472.can-08-3886 · Cited by 361
Alder, J., Thakker‐Varia, S., Bangasser, D. A., Kuroiwa, M., Plummer, M. R., Shors, T. J., & Black, I. B. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-34-10800.2003 · Cited by 302
Bonni, A., Ginty, D. D., Dudek, H., & Greenberg, M. E. (1995) · Molecular and Cellular Neuroscience · doi:10.1006/mcne.1995.1015 · Cited by 290
Molecular Cloning of a Gene Sequence Regulated by Nerve Growth Factor
Levi, A., Eldridge, J. D., & Paterson, B. M. (1985) · Science · doi:10.1126/science.3839317 · Cited by 288
Ostrom, Q. T., Gittleman, H. R., de Blank, P. M. K., Finlay, J. L., Gurney, J. G., McKean‐Cowdin, R., Stearns, D. S., Wolff, J. E. A., Liu, M. B., Wolinsky, Y., et al. (2015) · Neuro-Oncology · doi:10.1093/neuonc/nov297 · Cited by 275
Antidepressant actions of the exercise-regulated gene VGF
Hunsberger, J. G., Newton, S. S., Bennett, A., Duman, C. H., Russell, D., Salton, S. R., & Duman, R. S. (2007) · Nature Medicine · doi:10.1038/nm1669 · Cited by 270
Deadly Teamwork: Neural Cancer Stem Cells and the Tumor Microenvironment
Lathia, J. D., Heddleston, J. M., Venere, M., & Rich, J. N. (2011) · Cell stem cell · doi:10.1016/j.stem.2011.04.013 · Cited by 269
Self-citationBrain Cancer Stem Cells Display Preferential Sensitivity to Akt Inhibition
Eyler, C. E., Foo, W., LaFiura, K. M., McLendon, R. E., Hjelmeland, A. B., & Rich, J. N. (2008) · Stem Cells · doi:10.1634/stemcells.2007-1073 · Cited by 242
Self-citationKim, H., Li, Q., Hempstead, B. L., & Madri, J. A. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m404115200 · Cited by 214
CopywriteR: DNA copy number detection from off-target sequence data
Kuilman, T., Velds, A., Kemper, K., Ranzani, M., Bombardelli, L., Hoogstraat, M., Nevedomskaya, E., Xu, G., de Ruiter, J., Lolkema, M. P., et al. (2015) · Genome biology · doi:10.1186/s13059-015-0617-1 · Cited by 212
Therapeutic activation of macrophages and microglia to suppress brain tumor-initiating cells
Sarkar, S., Döring, A., Zemp, F. J., Silva, C., Lun, X. Q., Wang, X., Kelly, J. J., Hader, W. J., Hamilton, M. G., Mercier, P., et al. (2013) · Nature Neuroscience · doi:10.1038/nn.3597 · Cited by 207
Self-citationActivation of tumor cell integrin α v β 3 controls angiogenesis and metastatic growth in the brain
Lorger, M., Krueger, J. S., O’Neal, M. A., Staflin, K., & Felding‐Habermann, B. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0903035106 · Cited by 185
Laminin alpha 2 enables glioblastoma stem cell growth
Lathia, J. D., Li, M., Hall, P. E., Gallagher, J., Hale, J. S., Wu, Q., Venere, M., Levy, E. R., Rani, M. R. S., Huang, P., et al. (2012) · Annals of Neurology · doi:10.1002/ana.23674 · Cited by 175
Self-citationGlioma cancer stem cells secrete Gremlin1 to promote their maintenance within the tumor hierarchyPreprint
Yan, K., Wu, Q., Yan, D. H., Lee, C. H., Rahim, N., Tritschler, I., DeVecchio, J., Kalady, M. F., Hjelmeland, A. B., & Rich, J. N. (2014) · Genes & Development · doi:10.1101/gad.235515.113 · Cited by 158
Self-citationLawn, S. O., Krishna, N., Pisklakova, A., Qu, X., Fenstermacher, D. A., Fournier, M., Vrionis, F. D., Tran, N., Chan, J. A.-W., Kenchappa, R. S., et al. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.599373 · Cited by 151
Processing, Distribution, and Function of VGF, a Neuronal and Endocrine Peptide Precursor
Levi, A., Ferri, G., Watson, E., Possenti, R., & Salton, S. R. (2004) · Cellular and Molecular Neurobiology · doi:10.1023/b:cemn.0000023627.79947.22 · Cited by 141
Current clinical development of PI3K pathway inhibitors in glioblastoma
Wen, P. Y., Lee, E. Q., Reardon, D. A., Ligon, K. L., & Yung, W. K. A. (2012) · Neuro-Oncology · doi:10.1093/neuonc/nos117 · Cited by 133
MYC-Regulated Mevalonate Metabolism Maintains Brain Tumor–Initiating Cells
Wang, X., Huang, Z., Wu, Q., Prager, B. C., Mack, S. C., Yang, K., Kim, L. J. Y., Gimple, R. C., Shi, Y., Lai, S., et al. (2017) · Cancer Research · doi:10.1158/0008-5472.can-17-0114 · Cited by 125
Self-citationLewis, J. E., Brameld, J. M., & Jethwa, P. H. (2015) · Frontiers in Endocrinology · doi:10.3389/fendo.2015.00003 · Cited by 88
Neurotrophin signaling in cancer stem cells
Chopin, V., Lagadec, C. H., Toillon, R., & Bourhis, X. L. (2016) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-016-2156-7 · Cited by 87
Wang, L., Rahn, J. J., Lun, X. Q., Sun, B., Kelly, J. J., Weiss, S., Robbins, S. M., Forsyth, P. A., & Senger, D. L. (2008) · PLoS Biology · doi:10.1371/journal.pbio.0060289 · Cited by 78
Neurotrophin signaling endosomes: biogenesis, regulation, and functions
Yamashita, N., & Kuruvilla, R. (2016) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2016.06.004 · Cited by 78
Hwang, W., Chiu, Y.-F., Kuo, M.-H., Lee, K.-L., Lee, A.-C., Yu, C.-C., Chang, J.-L., Huang, W.-C., Hsiao, S.-H., Lin, S., et al. (2017) · Cancer Research · doi:10.1158/0008-5472.can-16-3168 · Cited by 78
Ferri, G., Noli, B., Brancia, C., D’Amato, F., & Cocco, C. (2011) · Journal of Chemical Neuroanatomy · doi:10.1016/j.jchemneu.2011.05.007 · Cited by 76
Forsyth, P. A., Krishna, N., Lawn, S. O., Valadez, J. G., Qu, X., Fenstermacher, D. A., Fournier, M., Potthast, L., Chinnaiyan, P., Gibney, G. T., et al. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.513762 · Cited by 76
Cancer stem cell-vascular endothelial cell interactions in glioblastoma
Sharma, A., & Shiras, A. (2015) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2015.12.022 · Cited by 66
Ahn, B. Y., Saldanha-Gama, R. F. G., Rahn, J. J., Hao, X., Zhang, J., Dang, N.-H., Alshehri, M. M., Robbins, S. M., & Senger, D. L. (2015) · Oncogene · doi:10.1038/onc.2015.199 · Cited by 64
Expression of the neurotrophin receptors Trk A and Trk B in adult human astrocytoma and glioblastoma
Wadhwa, S., Nag, T. C., Jindal, A., Kushwaha, R. C., Mahapatra, A. K., & Sarkar, C. (2003) · Journal of Biosciences · doi:10.1007/bf02706217 · Cited by 64
Samaras, V. D., Piperi, C., Korkolopoulou, P. A., Zisakis, A., Levidou, G., Themistocleous, M. S., Boviatsis, E. I., Sakas, D. E., Lea, R. W., Kalofoutis, A., et al. (2007) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-007-9517-3 · Cited by 57
Paracrine and autocrine actions of neurotrophic factors
Davies, A. M. (1996) · Neurochemical Research · doi:10.1007/bf02532296 · Cited by 50
Watson, E., Fargali, S., Okamoto, H., Sadahiro, M., Gordon, R. E., Chakraborty, T. R., Sleeman, M. W., & Salton, S. R. (2009) · BMC Physiology · doi:10.1186/1472-6793-9-19 · Cited by 43
Neurotrophin receptors expression and JNK pathway activation in human astrocytomas
Assimakopoulou, M., Kondyli, M., Gatzounis, G. D., Maraziotis, T., & Varakis, J. N. (2007) · BMC Cancer · doi:10.1186/1471-2407-7-202 · Cited by 41
Tyrosine receptor kinase B is a drug target in astrocytomas
Ni, J., Xie, S., Ramkissoon, S. H., Luu, V., Sun, Y., Bandopadhayay, P., Beroukhim, R., Roberts, T. M., Stiles, C. D., Segal, R. A., et al. (2016) · Neuro-Oncology · doi:10.1093/neuonc/now139 · Cited by 37
Hostile Takeover: Glioma Stem Cells Recruit TAMs to Support Tumor Progression
Shi, Y., Ping, Y., Zhang, X., & Bian, X. (2015) · Cell stem cell · doi:10.1016/j.stem.2015.02.008 · Cited by 33
Self-citationVGF, a New Player in Antidepressant Action?
Malberg, J. E., & Monteggia, L. M. (2008) · Science Signaling · doi:10.1126/stke.118pe19 · Cited by 30
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Metadata
- Authors
- Wang, X., Prager, B. C., Wu, Q., Kim, L. J. Y., Gimple, R. C., Shi, Y., Yang, K., Morton, A. R., Zhou, W., Zhu, Z., Obara, E. A. A., Miller, T. E., Song, A., Lai, S., Hubert, C. G., Jin, X., Huang, Z., Fang, X., Dixit, D., Tao, W., Zhai, K., Chen, C., Dong, Z., Zhang, G., Dombrowski, S. M., Hamerlik, P., Mack, S. C., Bao, S., & Rich, J. N.
- Affiliations
- University of California San Diego (US)
- Army Medical University (CN)
- Cleveland Clinic Lerner College of Medicine (US)
- Case Western Reserve University (US)
- Cleveland Clinic Research (US)
- Danish Cancer Society (DK)
- Baylor College of Medicine (US)
- Corresponding author
- Rich, Jeremy N.
- ORCID
- Wang, Xiuxing
- Prager, Briana C.
- Wu, Qiulian
- Kim, Leo J.Y.
- Gimple, Ryan C.
- Shi, Yu
- Yang, Kailin
- Morton, Andrew R.
- Zhou, Wenchao
- Zhu, Zhe
- Miller, Tyler E.
- Song, Anne
- Lai, Sisi
- Hubert, Christopher G.
- Jin, Xun
- Huang, Zhi
- Fang, Xiaoguang
- Dixit, Deobrat
- Tao, Weiwei
- Zhai, Kui
- Chen, Cong
- Dong, Zhen
- Zhang, Guoxin
- Dombrowski, Stephen M.
- Hamerlik, Petra
- Mack, Stephen C.
- Bao, Shideng
- Rich, Jeremy N.
- Venue
- Cell Stem Cell
- Publisher
- Elsevier BV
- Published
- 2018-04
- Volume
- 22
- Issue
- 4
- Pages
- 514-528.e5
- ISSN
- 1875-9777 (ISSN-L)
- 1934-5909
- PMC
- PMC5947947
- OpenAlex
- W2796407886
- Cited by
- 285
- References
- 74
- Citations by year
- 2026: 20 · 2025: 28 · 2024: 54 · 2023: 42 · 2022: 25 · 2021: 40 · 2020: 31 · 2019: 30 · 2018: 14
- FWCI
- 16.26
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell stem cell (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- NIH (CA197718, CA154130, CA169117, CA171652, NS087913, NS089272, CA184090, NS091080, NS099175)
- Topics
- Health Sciences › Medicine › Oncology › Glioma Diagnosis and Treatment
- Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- glioblastoma, glioblastoma stem cells, tumor microenvironment, brain-derived neurotrophic factor, NTRK2, VGF, paracrine signaling, tumor progression, stemness, tumor growth, patient-derived tumor models, epigenetic profiles
- MeSH terms
- Brain Neoplasms, Cell Differentiation, Glioblastoma, Humans, Neoplastic Stem Cells, Signal Transduction, Disease Progression
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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