Cited by 4,482

The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.

Generation of Neurons and Astrocytes from Isolated Cells of the Adult Mammalian Central Nervous System

Reynolds, Brent A., Weiss, Samuel·1992·Science

Abstract

Neurogenesis in the mammalian central nervous system is believed to end in the period just after birth; in the mouse striatum no new neurons are produced after the first few days after birth. In this study, cells isolated from the striatum of the adult mouse brain were induced to proliferate in vitro by epidermal growth factor. The proliferating cells initially expressed nestin, an intermediate filament found in neuroepithelial stem cells, and subsequently developed the morphology and antigenic properties of neurons and astrocytes. Newly generated cells with neuronal morphology were immunoreactive for γ-aminobutyric acid and substance P, two neurotransmitters of the adult striatum in vivo. Thus, cells of the adult mouse striatum have the capacity to divide and differentiate into neurons and astrocytes.

Overview

Integrity signals

Registry

Crossref · 10.1126/science.1553558

Cites

2 of 2 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Flagged first, then by citations

Research works printed but not linked: 20

  1. ANCHAN, R.M., EGF AND TGF-ALPHA STIMULATE RETINAL NEUROEPITHELIAL CELL-PROLIFERATION INVITRO, NEURON 6: 923 (1991). · DOI
  2. BAYER, S.A., NEURON PRODUCTION IN THE HIPPOCAMPUS AND OLFACTORY-BULB OF THE ADULT-RAT BRAIN - ADDITION OR REPLACEMENT, ANNALS OF THE NEW YORK ACADEMY OF SCIENCES 457: 163 (1985). · DOI
  3. BIRECREE, E, EPIDERMAL GROWTH-FACTOR AND ITS RECEPTOR IN THE DEVELOPING HUMAN NERVOUS-SYSTEM, DEVELOPMENTAL BRAIN RESEARCH 60: 145 (1991). · DOI
  4. Carpenter, G., Peptide Growth Factors and Their Receptors 1: 69 (1990).
  5. CATTANEO, E, IDENTIFYING AND MANIPULATING NEURONAL STEM-CELLS, TRENDS IN NEUROSCIENCES 14: 338 (1991). · DOI
  6. 10.1126/science.6144184 · DOI
  7. FENTRESS, J.C., OBSERVATIONS ON THE DEVELOPMENT OF THE STRIATUM IN MICE AND RATS, ANATOMY AND EMBRYOLOGY 163: 275 (1981). · DOI
  8. FREDERIKSEN, K, JOURNAL OF NEUROSCIENCE 8: 1144 (1988). · DOI
  9. GENSBURGER, C, BRAIN BASIC FIBROBLAST GROWTH-FACTOR STIMULATES THE PROLIFERATION OF RAT NEURONAL PRECURSOR CELLS-INVITRO, FEBS LETTERS 217: 1 (1987). · DOI
  10. GOMEZPINILLA, F, EPIDERMAL GROWTH-FACTOR RECEPTOR IMMUNOREACTIVITY IN RAT-BRAIN - DEVELOPMENT AND CELLULAR-LOCALIZATION, BRAIN RESEARCH 438: 385 (1988). · DOI
  11. Jacobsen M. Developmental Neurobiology 3: 41 (1991). · DOI
  12. KAY, A.R., ISOLATION OF NEURONS SUITABLE FOR PATCH-CLAMPING FROM ADULT MAMMALIAN CENTRAL NERVOUS SYSTEMS, JOURNAL OF NEUROSCIENCE METHODS 16: 227 (1986). · DOI
  13. LENDAHL, U, CNS STEM-CELLS EXPRESS A NEW CLASS OF INTERMEDIATE FILAMENT PROTEIN, CELL 60: 585 (1990). · DOI
  14. MORRISON, R.S., TROPHIC STIMULATION OF CULTURED NEURONS FROM NEONATAL RAT-BRAIN BY EPIDERMAL GROWTH-FACTOR, SCIENCE 238: 72 (1987). · DOI
  15. MORSHEAD, C.M., POSTMITOTIC DEATH IS THE FATE OF CONSTITUTIVELY PROLIFERATING CELLS IN THE SUBEPENDYMAL LAYER OF THE ADULT-MOUSE BRAIN, JOURNAL OF NEUROSCIENCE 12: 249 (1992). · DOI
  16. MURPHY, M, FIBROBLAST GROWTH-FACTOR STIMULATES THE PROLIFERATION AND DIFFERENTIATION OF NEURAL PRECURSOR CELLS-INVITRO, JOURNAL OF NEUROSCIENCE RESEARCH 25: 463 (1990). · DOI
  17. SIMPSON, D.L., EPIDERMAL GROWTH-FACTOR BINDING AND MITOGENIC ACTIVITY ON PURIFIED POPULATIONS OF CELLS FROM THE CENTRAL NERVOUS-SYSTEM, JOURNAL OF NEUROSCIENCE RESEARCH 8: 453 (1982). · DOI
  18. WEISS, S, SYNAPTOGENESIS OF CULTURED STRIATAL NEURONS IN SERUM-FREE MEDIUM - A MORPHOLOGICAL AND BIOCHEMICAL-STUDY, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 83: 2238 (1986).
  19. WERNER, M.H., LOCALIZATION OF IMMUNOREACTIVE EPIDERMAL GROWTH-FACTOR RECEPTORS IN HUMAN NERVOUS-SYSTEM, JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY 36: 81 (1988). · DOI
  20. WILLIAMS, J.S., N-METHYL-D-ASPARTATE EVOKES THE RELEASE OF SOMATOSTATIN FROM STRIATAL INTERNEURONS IN PRIMARY CULTURE, NEUROSCIENCE 43: 437 (1991). · DOI

Cited by

Sorted by citations

Metadata

Authors
Reynolds, B. A., & Weiss, S.
Affiliations
Neuroscience Research Group, Department of Pathology, and Department of Pharmacology and Therapeutics, University of Calgary Faculty of Medicine, Calgary, Alberta, Canada T2N 4N1.
Venue
Science
Published
1992-03-27
Volume
255
Issue
5052
Pages
1707-1710
ISSN
  • 0036-8075
  • 1095-9203
Cited by
4,482
References
2
Language
en

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review