In Vitro Expansion of Primary Human Hepatocytes with Efficient Liver Repopulation Capacity

Zhang, Kun, Zhang, Ludi, Liu, Wenming, Ma, Xiaolong, Cen, Jin, Sun, Zhen, Wang, Chenhua, Feng, Sisi +13 more·2018·Cell Stem Cell

Cited by (253)

Items 201–253 of 253

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  2. Bioengineering Liver Transplantation
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  4. In vitro experimental models for the study of hepatitis B virus cccDNA
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  5. Scaffold-Free Biofabrication of Liver
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  10. Recent Advances in Regenerative Medicine of the Liver and Bile Duct System by Chemically Induced Liver Progenitor Cells (CLiPs) in Nagasaki Experience
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  11. Advances in Cell Therapy for Liver Regeneration
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  13. Additional file 1 of High-efficiency c-Myc-mediated induction of functional hepatoblasts from the human umbilical cord mesenchymal stem cells
    Jie Deng, Kai Luo, Pengchao Xu, Qingyuan Jiang, Yuan Wang, Yunqi Yao, Chen, Xiaolei, Fuyi Cheng, Dan Xie, Hongxin Deng · 2021 · Figshare
  14. Recent Advances in Regenerative Medicine of the Liver and Bile Duct System by Chemically Induced Liver Progenitor Cells (CLiPs) in Nagasaki Experience
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  15. Novel hepatocyte-like liver organoids recapitulate crucial mature hepatic functions
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  16. Application of Human Liver Organoids for Pharmaceutical Research
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  18. Achieving scalable expansion of therapeutic porcine hepatocytes in vivo through serial transplantation
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  19. Biliary tree stem cell transplantation
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  21. Bioartificial liver system for liver failure: A therapeutic UTOpiA on the horizon
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  22. Rescue of extreme hepatectomy mice by primary hepatocyte-derived 3D bio-printed organ transplantation
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  24. Additional file 3 of Single cell Raman spectroscopy to identify different stages of proliferating human hepatocytes for cell therapy
    Ma, Chen, Zhang, Ludi, He, Ting, Huiying Cao, Xiongzhao Ren, Ma, Chenhui, Yang, Jiale, Huang, Ruimin, Pan, Guoyu · 2021 · Figshare
  25. Additional file 1 of CD24+LCN2+ liver progenitor cells in ductular reaction contributed to macrophage inflammatory responses in chronic liver injury
    Huang, Wei-Jian, Qiu, Bi-Jun, Qi, Xiao-Shu, Chen, Cai-Yang, Liu, Wen-Ming, Zhou, Shen-ao, Ding, Min, Lu, Feng-Feng, Zhao, Jie, Dan Tang et al. · 2023 · Figshare
  26. Additional file 2 of Generation of immunodeficient pig with hereditary tyrosinemia type 1 and their preliminary application for humanized liver
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  27. Additional file 3 of Generation of immunodeficient pig with hereditary tyrosinemia type 1 and their preliminary application for humanized liver
    Ren, Jilong, Yu, Dawei, Wang, Jing, Xu, Kai, Xu, Yanan, Sun, Renren, An, Peipei, Li, Chongyang, Feng, Guihai, Zhang, Ying et al. · 2022 · Figshare
  28. Additional file 1 of Generation of immunodeficient pig with hereditary tyrosinemia type 1 and their preliminary application for humanized liver
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  29. Additional file 1 of Drug metabolic activity is a critical cell-intrinsic determinant for selection of hepatocytes during long-term culture
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  30. Additional file 1 of Anti-cancer effect of nano-encapsulated boswellic acids, curcumin and naringenin against HepG-2 cell line
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  31. Additional file 2 of High-efficiency c-Myc-mediated induction of functional hepatoblasts from the human umbilical cord mesenchymal stem cells
    Deng, Jie, Luo, Kai, Xu, Pengchao, Jiang, Qingyuan, Wang, Yuan, Yunqi Yao, Chen, Xiaolei, Fuyi Cheng, Dan Xie, Deng, Hongxin · 2021 · Figshare
  32. Additional file 2 of Single cell Raman spectroscopy to identify different stages of proliferating human hepatocytes for cell therapy
    Ma, Chen, Zhang, Ludi, He, Ting, Huiying Cao, Xiongzhao Ren, Ma, Chenhui, Yang, Jiale, Huang, Ruimin, Pan, Guoyu · 2021 · Figshare
  33. Additional file 4 of Single cell Raman spectroscopy to identify different stages of proliferating human hepatocytes for cell therapy
    Ma, Chen, Zhang, Ludi, He, Ting, Huiying Cao, Xiongzhao Ren, Ma, Chenhui, Yang, Jiale, Huang, Ruimin, Pan, Guoyu · 2021 · Figshare
  34. Additional file 1 of Integration of ATAC-Seq and RNA-Seq reveals FOSL2 drives human liver progenitor-like cell aging by regulating inflammatory factors
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  35. Additional file 1 of Robust expansion and functional maturation of human hepatoblasts by chemical strategy
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  36. Additional file 1 of Single cell Raman spectroscopy to identify different stages of proliferating human hepatocytes for cell therapy
    Ma, Chen, Zhang, Ludi, He, Ting, Huiying Cao, Xiongzhao Ren, Ma, Chenhui, Yang, Jiale, Huang, Ruimin, Pan, Guoyu · 2021 · Figshare
  37. Developmental Characteristics of the Embryonic Liver Tissue and Long‐Term Culture of Primary Hepatocytes in Duck
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  38. Patient-specific liver assembloids for disease modeling
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  39. A genome-wide gain-of-function screen identifies CDKN2C as HBV host factor
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  40. Artificial Liver Support
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  41. Advancing hepatocyte-based therapies: A translational perspective
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  42. Precursor of chemically expanded hepatocytes (pre-cHep) with 1-million-fold expansion potential and liver repopulation capacity
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  43. Liver Tissue Engineering
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  44. Lentiviral SgRNA Delivery for CRISPR/Cas9 Editing in Cre-Dependent Cas9 Knock-in Primary Mouse Hepatocytes
    Lulu Zhang, Yi Zhang, Yijia Chi, Yong Ren, Qian Zhao, Dongxin Zhao · 2026 · Journal of Visualized Experiments
  45. A DPHV–liver module recapitulates AML infiltration and chemotherapy-induced hepatotoxicity with translational utility
    Bo Deng, Yue Ma, W Y Huang, Xiguang Xian, Yiyi Ding, Yifan Lu, Yi Yang, Wei Guo, Lina Mao, Xiaoli Wang et al. · 2026 · Science Advances
  46. Next-Generation Hepatocyte Expansion: Bridging Molecular Reprogramming with Multicellular Organoids for Clinical Translation
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  47. Innovative models to explore hepatic involvement in Prader-Willi syndrome
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  48. Transient culture of adult human hepatocytes as organoids improves engineered liver engraftment
    Sarah H. Saxton, Inkyung Kang, Shannon Mitchell, Jeremy Lotto, A. Upadhyay, Chen-Hui Zou, C. Quirk, Tara N. McCray, Olivia Prado, Fredrik Johansson et al. · 2026 · Biomaterials
  49. Evaluating the translational feasibility and safety of IL-22 driven long-term hepatocyte expansion
    Katie Harrison, Jessica Nulty, Eirini Kyrana · 2026 · Journal of Hepatology
  50. Application of human liver cell models in drug development and toxicity studies: The role of membrane transporters
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  51. Liver organoids: modelling complexity in homeostasis and disease
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  52. Time-Dependent Phospholipid Remodeling in Cultured Primary Mouse Hepatocytes: Associations with PEMT Status and Methionine Availability
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  53. Powering the liver toxicity assessment in the organoid era
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