In Vitro Expansion of Primary Human Hepatocytes with Efficient Liver Repopulation Capacity

Zhang, Kun, Zhang, Ludi, Liu, Wenming, Ma, Xiaolong, Cen, Jin, Sun, Zhen, Wang, Chenhua, Feng, Sisi +13 more·2018·Cell Stem Cell

DOI 10.1016/j.stem.2018.10.018

Cited by (253)

Items 101–200 of 253

Functional Proliferating Human Hepatocytes: In Vitro Hepatocyte Model for Drug Metabolism, Excretion, and Toxicity
Shida Qiao, Sisi Feng, Zhitao Wu, Ting He, Chen Ma, Zhaoliang Peng, E. Tian, Guoyu Pan · 2021 · Drug Metabolism and Disposition
Tissue regeneration: Unraveling strategies for resolving pathological fibrosis
Jiao Li, Shuyong Wang, Jie Yuan, Xiaoxu Mao, Xuan Wang, Lincheng Zhang, Qiulin Dong, Ziye Chen, Yunfang Wang, Nan Tang · 2025 · Cell stem cell
Development of RAG2-/-IL2Rγ-/Y immune deficient FAH-knockout miniature pig
Heng Zhao, Weijian Ye, Jianxiong Guo, Jiaoxiang Wang, Deling Jiao, Kaixiang Xu, Chang Qing Yang, Shuhan Chen, Muhammad Ameen Jamal, Zhongbin Bai et al. · 2022 · Frontiers in Immunology
Small molecule drugs promote repopulation of transplanted hepatocytes by stimulating cell dedifferentiation
Jiang, Mengmeng, Guo, Ren, Ai, Yan, Wang, Gang, Tang, Peilan, Jia, Xiaohui, He, Bingqing, Yuan, Qianting, Xie, Xin · 2023 · JHEP Reports
Advanced 3D bioprinted liver models with human-induced hepatocytes for personalized toxicity screening
Yue Ma, Runbang He, Bo Deng, Miaomiao Luo, Wenjie Zhang, Lina Mao, Wanglai Hu, Yilei Mao, Huayu Yang, Pengyu Huang · 2025 · Journal of Tissue Engineering
Survival‐Assured Liver Injury Preconditioning (SALIC) Enables Robust Expansion of Human Hepatocytes in Fah–/–Rag2–/–IL2rg–/– Rats
Ludi Zhang, Jian‐Yun Ge, Yun‐Wen Zheng, Zhen Sun, Chenhua Wang, Zhaoliang Peng, Baihua Wu, Mei Fang, Kinji Furuya, Xiaolong Ma et al. · 2021 · Advanced Science
Establishment of Functional Liver Spheroids From Human Hepatocyte-Derived Liver Progenitor-Like Cells for Cell Therapy
Wenming Liu, Xu Zhou, Cai–Yang Chen, Dong-Dong Lv, Weijian Huang, Yuan Yang Peng, Hongping Wu, Yi Chen, Dan Tang, Lina Guo et al. · 2021 · Frontiers in Bioengineering and Biotechnology
Regenerative medicine for the hepatobiliary system: A review
Yu Guang Huang, Daisuke Miyamoto, Masaaki Hidaka, Tomohiko Adachi, Weili Gu, Susumu Eguchi · 2020 · Journal of Hepato-Biliary-Pancreatic Sciences
Cell therapy for end-stage liver disease: Current state and clinical challenge
Zhang, Lin, Deng, Yuntian, Bai, Xue, Wei, Xiao, Ren, Yushuang, Chen, Shuang, Deng, Hongxin · 2024 · Chinese Medical Journal
Liver cell therapies: cellular sources and grafting strategies
Wencheng Zhang, Yangyang Cui, Yuan Du, Yong Yang, Ting Fang, Fengfeng Lu, Wei-Xia Kong, Canjun Xiao, Jun Shi, Lola McAdams Reid et al. · 2023 · Frontiers of Medicine
Rapid Self‐Assembly Mini‐Livers Protect Mice Against Severe Hepatectomy‐Induced Liver Failure
Miaomiao Luo, Jiahui Lai, Enhua Zhang, Yue Ma, Runbang He, Lina Mao, Bo Deng, Junjin Zhu, Yan Ding, Jialyu Huang et al. · 2024 · Advanced Science
Efficient hepatocyte differentiation of primary human hepatocyte-derived organoids using three dimensional nanofibers (HYDROX) and their possible application in hepatotoxicity research
Yanran Tong, Yukiko Ueyama-Toba, Jumpei Yokota, Hayato Matsui, Masaki Kanai, Hiroyuki Mizuguchi · 2024 · Scientific Reports
Development of a hepatic differentiation method in 2D culture from primary human hepatocyte-derived organoids for pharmaceutical research
Yukiko Ueyama-Toba, Yanran Tong, Jumpei Yokota, Kazuhiro Murai, Hayato Hikita, Hidetoshi Eguchi, Tetsuo Takehara, Hiroyuki Mizuguchi · 2024 · iScience
Small Molecule Epigenetic Modulators in Pure Chemical Cell Fate Conversion
Zhao-Di Yuan, Weining Zhu, Ke-Zhi Liu, Zhan‐Peng Huang, Yan-Chuang Han · 2020 · Stem Cells International
Pluripotent Stem Cell-derived Strategies to Treat Acute Liver Failure: Current Status and Future Directions
Jingfeng Liu, Zhiming Yuan, Qingwen Wang · 2022 · Journal of Clinical and Translational Hepatology
Extensively expanded murine‐induced hepatic stem cells maintain high‐efficient hepatic differentiation potential for repopulation of injured livers
Bing Yu, Hengyu Li, Jie Chen, Zhiying He, Haixiang Sun, Guang-Shun Yang, Changzhen Shang, Xin Wang, Chuanjiang Li, Yajin Chen et al. · 2020 · Liver International
ROCK inhibition enhanced hepatocyte liver engraftment by retaining membrane CD59 and attenuating complement activation
Haoxin Ma, Chao Wang, Shulong Liang, Xinlu Yu, Yuan Yuan, Zhuanman Lv, Jiqianzhu Zhang, Caixia Jin, Jiangbo Zhu, Chao Wang et al. · 2023 · Molecular Therapy
CD47 and PD-L1 overexpression in proliferating human hepatocytes attenuated immune responses and ameliorated acute liver injury in mice.
Chen-Hui Ma, Huiying Cao, Zhen Sun, Qiang-Qiang Deng, Wen-Jing Liu, Yingying Xin, Shida Qiao, Jin Cen, Yajing Shu, Kai Qi et al. · 2023 · American Journal of Transplantation
Biomimetic Design for Bio-Matrix Interfaces and Regenerative Organs
Quanfu Xu, Ying Pei, Jing Ren, Na Kong, Yang Wang, Yigang Li, Yuan Yao, David Lee Kaplan, Shengjie Ling · 2020 · Tissue Engineering Part B Reviews
Advances in 3D bioprinting technology for liver regeneration
Changcan Li, Zhuoran Jiang, Huayu Yang · 2022 · HepatoBiliary Surgery and Nutrition
Primary Human Tissue Models for Metabolic Dysfunction‐Associated Liver Disease ‐ toward Streamlining Drug Discovery with Patient‐Derived Assays
Youhanna, Sonia, Taebnia, Nayere, Liang, Yingxin, Cheng, Ningtao, Wang, Yi, Michel, Maurice, Lauschke, Volker M. · 2025 · Advanced Biology
Stem Cell-Based Strategies: The Future Direction of Bioartificial Liver Development
Feng, Lei, Wang, Yi, Fu, Yu, Li, Ting, He, Guolin · 2024 · Stem Cell Reviews and Reports
Co-culture with mouse embryonic fibroblasts improves maintenance of metabolic function of human small hepatocyte progenitor cells
Sengupta, Srikumar, Johnson, Brian, Seirup, Morten, Ardalani, Hamisha, Duffin, Bret, Barrett-Wilt, Gregory A., Stewart, Ron, Thomson, James A. · 2020 · Current Research in Toxicology
An in vivo mimetic liver-lobule-chip (LLoC) for stem cell maturation, and zonation of hepatocyte-like cells on chip
Philip Dalsbecker, Siiri Suominen, Muhammad Asim Faridi, Reza Mahdavi, Julia Johansson, Charlotte Hamngren Blomqvist, Mattias Goksör, Katriina Aalto‐Setälä, Leena E. Viiri, Caroline B. Adiels · 2025 · Lab on a Chip
Challenges, highlights, and opportunities in cellular transplantation: A white paper of the current landscape
Ronald F. Parsons, Angeles Baquerizo, Varvara A. Kirchner, Sayeed Khan Malek, Chirag Sureshchandra Desai, Austin D. Schenk, Erik B. Finger, Todd V. Brennan, Kalpaj R. Parekh, Malcolm P. MacConmara et al. · 2021 · American Journal of Transplantation
Ex vivo factor VIII ‐modified proliferating human hepatocytes therapy for haemophilia A
Kun Zhang, Ning Wu, Jing Cen, Jie Li, Zhen Wang, Qiang Xia, Lijian Hui · 2023 · Cell Proliferation
Impelling force and current challenges by chemicals in somatic cell reprogramming and expansion beyond hepatocytes
Jian-Yun Ge, Yun‐Wen Zheng, Li‐Ping Liu, Hiroko Isoda, Tatsuya Oda · 2019 · World Journal of Stem Cells
From fatty hepatocytes to impaired bile flow: Matching model systems for liver biology and disease
Roni F. Kunst, Marije Niemeijer, Luc J. W. van der Laan, Bart Spee, Stan F.J. van de Graaf · 2020 · Biochemical Pharmacology
High-efficiency c-Myc-mediated induction of functional hepatoblasts from the human umbilical cord mesenchymal stem cells
Jie V. Deng, Kai Luo, Pengchao Xu, Qingyuan Jiang, Yuan Wang, Yunqi Yao, Xiaolei Chen, Fuyi Cheng, Dan Xie, Hongxin Deng · 2021 · Stem Cell Research & Therapy
Single-cell morphological tracking of cell states to identify small-molecule modulators of liver differentiation
Rebecca E. Graham, Runshi Zheng, Jesko Wagner, Asier Unciti‐Broceta, David C. Hay, Stuart John Forbes, Victoria L. Gadd, Neil O. Carragher · 2025 · iScience
Evaluating the synergistic use of advanced liver models and AI for the prediction of drug-induced liver injury
Yitian Zhou, Yi Zhong, Volker Martin Lauschke · 2025 · Expert Opinion on Drug Metabolism & Toxicology
A Dual Role of HGF-ERK Signaling in IL6/HGF-induced Hepatocyte Proliferation
Jingwei Zhang, Shitong Wang, Jiani Yu, Bing Li, Shun Wang, Na Suo, Ren Feng Guo, Xin Xie · 2025 · Cellular and Molecular Gastroenterology and Hepatology
Downregulation of Augmenter of Liver Regeneration Impairs the Therapeutic Efficacy of Liver Epithelial Progenitor Cells Against Acute Liver Injury by Enhancing Mitochondrial Fission
Yuan Dong, Wei-ning Kong, Wei An · 2021 · Stem Cells
In vitro expansion of cirrhosis derived liver epithelial cells with defined small molecules
Bin Li, Yuhan Wang, Carl Pelz, Josh Moss, Ruth Shemer, Yuval Dor, Yassmine K. Akkari, Pamela S. Canady, Willscott E. Naugler, Susan L. Orloff et al. · 2021 · Stem Cell Research
Chronotoxici‐Plate Containing Droplet‐Engineered Rhythmic Liver Organoids for Drug Toxicity Evaluation
Jiaqi Zhou, Yi‐chun Huang, Wanlong Wang, Jiawei Li, Yibo Hou, Ziqi Yi, Haowei Yang, Keer Hu, Yu Zhu, Zitian Wang et al. · 2024 · Advanced Science
The breakthrough in primary human hepatocytes in vitro expansion
Translational Cancer Research Center, Feng, Mei, Department of General Surgery, Peking University First Hospital, Beijing 100034, China, Ruirui, Kong, Translational Cancer Research Center, Yisheng, Pan, Translational Cancer Research Center; Department of General Surgery, Peking University First Hospital, Beijing 100034, China · 2019 · Cancer Biology & Medicine
In vitro liver models for toxicological research
Ichiro Fukunaga, Takanori Takebe · 2025 · Drug Metabolism and Pharmacokinetics
Bile acid-FXR signaling facilitates the long-term maintenance of hepatic characteristics in human iPSC-derived organoids
Taro Shimizu, Masato Miyoshi, Sei Kakinuma, Jun Tsuchiya, Daisuke Yamane, Keiya Watakabe, Tomohiro Mochida, Kento Inada, Kaho Yamada, Kotomi Shinozaki et al. · 2025 · Cell Reports
Cell-based clinical and experimental methods for assisting the function of impaired livers – Present and future of liver support systems
Krzysztof Dariusz Pluta, Małgorzata Ciężkowska, Monika Joanna Wisniewska, Agnieszka Wencel, Dorota G. Pijanowska · 2021 · Journal of Applied Biomedicine
Enhanced ammonia detoxification to urea in hepatocytes transduced with human aquaporin‐8 gene
Alejo M. Capiglioni, Gabriela Leticia Müller, Julieta Marrone · 2021 · Biotechnology and Bioengineering
The Progress and Promise of Lineage Reprogramming Strategies for Liver Regeneration
Shuyong Wang, Xuan Wang, Yunfang Wang · 2024 · Cellular and Molecular Gastroenterology and Hepatology
SETDB1 promotes mammalian liver regeneration by stimulating cytokine CSF3 in hepatocytes
Xiaoyan Huang, Dong Yang, Yinzhe Liu, Enxiang Zhang, Qiao Yang, Wang Kang, Xiao-Ou Zhang, Junwei Shi, Chun‐Qing Song · 2025 · Cell Reports
Functional mouse hepatocytes derived from interspecies chimeric livers effectively mitigate chronic liver fibrosis
Cheng Huang, Haiping Jiang, Jingxi Dong et al. · 2024 · Stem Cell Reports
Generation of human hepatobiliary organoids with a functional bile duct from chemically induced liver progenitor cells
Peilin Li, Daisuke Miyamoto, Masayuki Fukumoto, Yuta Kawaguchi, Mampei Yamashita, Hanako Tetsuo, Tomohiko Adachi, Masaaki Hidaka, Takanobu Hara, Akihiko Soyama et al. · 2024 · Stem Cell Research & Therapy
Hepatocyte-derived liver progenitor-like cells attenuate liver cirrhosis via induction of apoptosis in hepatic stellate cells
Xu Yang Zhou, Wenming Liu, Hanyong Sun, Yuan Peng, Ren-Jie Huang, Cai–Yang Chen, Hongdan Zhang, Shen-Ao Zhou, Hongping Wu, Dan Tang et al. · 2025 · Hepatology Communications
Adenoviral Transfer of Human Aquaporin-8 Gene to Mouse Liver Improves Ammonia-Derived Ureagenesis
Alejo M. Capiglioni, María Celeste Capitani, Julieta Marrone, Raúl A. Marinelli · 2023 · Cells
Evidence for in vitro extensive proliferation of adult hepatocytes and biliary epithelial cells
Takeshi Katsuda, JONATHAN S. SUSSMAN, Jinyang Li, Allyson J. Merrell, William P. Vostrejs, Anthony J. Secreto, Juntaro Matsuzaki, Takahiro Ochiya, Ben Z. Stanger · 2023 · Stem Cell Reports
Founder cells for hepatocytes during liver regeneration: from identification to application
Saisai Wei, Jiacheng Tang, Xiujun Cai · 2020 · Cellular and Molecular Life Sciences
Identifying In Vitro Cultured Human Hepatocytes Markers with Machine Learning Methods Based on Single-Cell RNA-Seq Data
Zhandong Li, FeiMing Huang, Lei Chen, Tao Huang, Yu‐Dong Cai · 2022 · Frontiers in Bioengineering and Biotechnology
Forthcoming Developments in Models to Study the Hepatitis B Virus Replication Cycle, Pathogenesis, and Pharmacological Advancements
Sajad Ahmad Bhat, Ishfaq Ahmad Ahanger, Syed Naqui Kazim · 2023 · ACS Omega
IL-22 supports long-term expansion of mouse and human hepatocytes
Bing Li, Ren Guo, Shitong Wang, Jingwei Zhang, Shun Wang, Qianting Yuan, Huixiang Zheng, Yaxuan Wang, Bin Sun, Erjiang Tang et al. · 2026 · Journal of Hepatology
Patient-derived organoid models to decode liver pathophysiology
Benjamin J. Dwyer, Janina E. E. Tirnitz‐Parker · 2024 · Trends in Endocrinology and Metabolism
Liver Organoids From Hepatocytes of Healthy Humans and Non-alcoholic Fatty Liver Disease (NAFLD) Patients Display Multilineage Architecture and can be Used to Develop an In Vitro Model of Steatohepatitis
Yamini Goswami, Akash Baghel, Ghanshyam Sharma, Phulwanti K. Sharma, Sagnik Biswas, Rajni Yadav, Pramod Kumar Garg, S. Shalimar, Ruchi Tandon · 2024 · Journal of Clinical and Experimental Hepatology
Manganese is a potent inducer of lysosomal activity that inhibits de novo HBV infection
Lin Yu, Hao Chang, Wentao Xie, Yuan Zheng, Le Yang, Qiong Wu, Fan Bu, Yuanfei Zhu, Youhua Xie, Guoyu Pan et al. · 2025 · PLoS Pathogens
Small-molecule inhibitor cocktail promotes the proliferation of pre-existing liver progenitor cells
Qingjie Fu, Shunsuke Ohnishi, Goki Suda, Naoya Sakamoto · 2022 · Stem Cell Reports
Advances in Genetic Reprogramming: Prospects from Developmental Biology to Regenerative Medicine
Daljeet Singh Dhanjal, Reena Singh, Varun Sharma, Eugenie Nepovimová, Vojtěch Adam, Kamil Kuča, Chirag Chopra · 2023 · Current Medicinal Chemistry
Cell therapies and liver organogenesis technologies: Promising strategies for end-stage liver disease
Shaoyang Qin, Xiaochen Bo, Hongyuan Liu, Zhishuo Zhang, Zhicong Zhao, Qiang Xia · 2025 · Hepatology
Humanized liver mouse models in preclinical drug development: current status, translation challenges and emerging technologies
Xumiao Zhang, Lu Lu, Wei Xiao, Yuanbin Song · 2026 · Drug Discovery Today
Liver Organoid and Liver‐On‐A‐Chip Platforms for Modeling Alcoholic Liver Disease: A Comparative Review
Qiannan Chen, Chengpan Li, Weiping Ding, Derun Kong · 2025 · Advanced Healthcare Materials
Availability, Functionality, and Safety as well as Quality Control of Hepatocytes as Seeding Cells in Liver Regenerative Medicine: State of the Art and Challenges
Run-Tong Lian, An-Qi Zhuang, Jing Yue, Yan Chen, Kuifen Ma, Yi-Hang Wu · 2023 · Current Stem Cell Research & Therapy
Applications and limitations of pluripotent stem cell-derived liver organoids
Zhiwei Feng, Bingrui Zhou, Qizhi Shuai, Jianbing Mu, Jun Xie · 2025 · Chinese Medical Journal
Label-Free Imaging Techniques to Evaluate Metabolic Changes Caused by Toxic Liver Injury in PCLS
Svetlana A. Rodimova, Artem M. Mozherov, Vadim V. Elagin et al. · 2023 · International Journal of Molecular Sciences
A new paradigm in transplant immunology: At the crossroad of synthetic biology and biomaterials
Zijie Zhang, Lu-yue Ding, Xiao-lei Zuo, Hao Feng, Qiang Xia · 2023 · Med
Distinctive small molecules blend: Promotes lacrimal gland epithelial cell proliferation in vitro and accelerates lacrimal gland injury repair in vivo.
B. Zeng, Lina Xu, Guoliang Wang, Ruize Shi, Ke-Rui Wang, Shurong Wang, Cheng Li · 2024 · The ocular surface
Cell identity conversion in liver regeneration after injury
Qiang He, Lei Cui, Xiang Yuan, Mengyao Wang, Lijian Hui · 2022 · Current Opinion in Genetics & Development
Mass Generation and Long-term Expansion of Hepatobiliary Organoids from Adult Primary Human Hepatocytes
Ary Marsee, Arabela Ritchie, Adam Myszczyszyn, Shicheng Ye, Jung‐Chin Chang, Arif Ibrahim Ardisasmita, Indi P. Joore, Jose Castro-Alpízar, Sabine A. Fuchs, Kerstin Schneeberger et al. · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
Human placental hydrolysate promotes the long-term culture of hepatocyte-like cells derived from canine bone marrow
Sakurako Neo, Eri MAKIISHI, Ayumi Fujimoto, Masaharu Hisasue · 2020 · Journal of Veterinary Medical Science
Expansion of human hepatocytes and their application in three-dimensional culture and genetic manipulation
Kun Zhang, Xiang Yuan, Shuang Lü, Yajing Shu, Chenhua Wang, Jin Cen, Baihua Wu, Lijian Hui · 2025 · Nature Protocols
Identification and Phylogenetic Characterisation of Novel Adeno‐Associated Virus Capsids in Non‐Human Primate Tissues
Liyu Zhu, Kai Xu, Yali Ding, Kailun Liu, Jing Liu, Zongren Hou, Rui Niu, Ning Yang, Hualing Qin, Baoyang Hu et al. · 2025 · Cell Proliferation
Establishment and Genetic Manipulation of Murine Hepatocyte Organoids
Jiabei Lian, Xinyuan Meng, Xiaohui Zhang, Huili Hu · 2022 · Journal of Visualized Experiments
Long-Term Expansion of Murine Primary Hepatocyte Organoids
Thomas A. Kluiver, Lianne J. Kraaier, Weng Chuan Peng · 2022 · Methods in molecular biology
Embryonic growth and effect of embryonic age on quantitative and functional characteristics of duck primary hepatocytes
Jie Wei, Bo Zhang, Jing Tang, Junting Cao, Chenchen Du, Zhen Wang, Yunsheng Zhang, Ming Xie, Zhengkui Zhou, Shuisheng Hou · 2024 · Poultry Science
Human Hepatocyte Transplantation
Minh Phuong Nguyen, Vandana Jain, Anil Kumar Dhawan · 2023 · Springer eBooks
Magnetotactic hepatocytes promote liver repopulation after transplantation
Shengwei Shen, Wencheng Zhang, Chang Xu et al. · 2024 · Chemical Engineering Journal
HDAC inhibitors support long-term expansion of porcine hepatocytes in vitro
Li, Guanhong, Zeng, Min, Yan, Zhengming, Cai, Shaoru, Ma, Yi, Wang, Yuting, Li, Shao, Li, Yang, Zhong, Kebo, Xiao, Mingjia et al. · 2024 · Biomedicine & Pharmacotherapy
A review of current state-of-the-art materiobiology and technological approaches for liver tissue engineering
Shadil Ibrahim Wani, Tanveer Ahmad Mir, Makoto M. Nakamura, Tomoshi Tsuchiya, Alaa Alzhrani, Shintaroh Iwanaga, Kenichi Arai, Eman A. Alshehri, Talal Shamma, Dalia Abdullah Obeid et al. · 2024 · Bioprinting
Enhancement of hepatic differentiation from induced pluripotent stem cells by suppressing epithelial–mesenchymal transition
Na Li, Rui Wei, Yangyang Yuan, Mingdan Deng, Yang Hu, Chi-Wa Cheng, Jiayin Yang, Wai-In Ho, Ka‐Wing Au, Yiu-Lam Tse et al. · 2025 · Hepatology Communications
Resveratrol effectively promoted hepatocyte differentiation of hESCs by enhancing mitochondrial function through PGC-1α PPARγ pathway
Yiyu Wang, Huanhuan Shan, Haibin Wu, Xueyan Zhang, Xiangting Cao, Shoupei Liu, Yuyou Duan · 2025 · Biochemical and Biophysical Research Communications
Drug metabolic activity as a selection factor for pluripotent stem cell-derived hepatic progenitor cells
Saeko Akiyama, Noriaki Saku, Shoko Miyata, Kenta Ite, Hidenori Nonaka, Masashi Toyoda, Akihide Kamiya, Tohru Kiyono, Tohru Kimura, Mureo Kasahara et al. · 2023 · Progress in molecular biology and translational science
Recent Advances in the Development of Sulfamoyl-Based Hepatitis B Virus Nucleocapsid Assembly Modulators
Sandesha Nayak, Jayaraj Gowda, Syed Azeem Abbas · 2023 · Viruses
An Ultrathin Coating of Microcapsules Enhances the Function of Encapsulated Hepatocyte Spheroids
Daheui Choi, Kihak Gwon, José M. de Hoyos‐Vega · 2024 · ACS Applied Materials & Interfaces
Cell therapy for liver diseases: From hepatocyte transplantation to bioartificial livers
Xiang Yuan, Zhen Sun, Jingqi Wu, Lijian Hui, Ludi Zhang · 2024 · Current Opinion in Biomedical Engineering
Transplantable Liver Organoids, Too Many Cell Types to Choose: a Need for Scientific Self-Organization
Pedro M. Baptista, Louis C. Penning · 2020 · Current Transplantation Reports
Liver stem cells
Dagmara Szkolnicka, David C. Hay · 2020 · Elsevier eBooks
Generation of Human Liver Chimeric Mice and Harvesting of Human Hepatocytes from Mouse Livers
Rui Wei, Chi-Wa Cheng, Wai-In Ho · 2022 · Methods in molecular biology
Data of ureagenesis from ammonia, glutamine and alanine, and mitochondrial aquaporin-8 expression in thioacetamide-treated hepatocytes
Alejo M. Capiglioni, María de Luján Álvarez, Raúl A. Marinelli · 2020 · Data in Brief
Expandable, Functional Hepatocytes Derived from Primary Cells Enable Liver Therapeutics
Sunil K. Mallanna, Soujanya S. Karanth, Joseph E. Marturano, Abhijith Kundadka Kudva, Marcus Lehmann, Julie K. Morse, Morgan Jamiel, Timothy J. Norman, Christopher Wilson, Fabiola Munarin et al. · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
Unsupervised Segmentation of Muscle Precursor Cell Images In Situ
Lihua Ruan, Yongchun Yuan, Tao Zhang · 2023 · Applied Sciences
Applying machine learning for multi-individual Raman spectroscopic data to identify different stages of proliferating human hepatocytes
Bihan Shen, Chen Ma, Lili Tang, Zhitao Wu, Zhaoliang Peng, Guoyu Pan, Hong Li · 2024 · iScience
Aberrant differentiation and proliferation of hepatocytes in chronic liver injury and liver tumors
Yuji Nishikawa · 2024 · Pathology International
Proposal for a non-adhesive single-cell culture technology for primary hepatocytes
Mario K. Uehara, Ronald Perocho Bual, Muhammad Shafiq, Kozue Yoshida, Hiroyuki Ijima · 2024 · Cytotechnology
Identification of deferasirox as a human xanthine oxidase inhibitor
Yunfei Qi, Xinheng He, Xiaoshan Wu et al. · 2025 · Life Medicine
Phase I safety and tolerability dose escalation study of microencapsulated hepatocyte intraperitoneal transplantation therapy in adult patients with liver failure: a study protocol
Taihua Yang, Xinye Zhu, Mei Long, Lijian Hui, Xiang Yuan, Zhen Sun, Ludi Zhang, Qiang Xia, Ping Wan · 2025 · BMJ Open
Developing chemical reprogramming strategies of non-hepatocytes for liver regeneration
Dong-Xue Ge, Wan-Qi Yang, Hao-Zhen Ren, Jing-Lin Wang · 2025 · Journal of Advanced Research
Three-dimensional bioprinting of ‘histomimetic’ liver construct using hepatic organoid as tissue building blocks
Roopesh R. Pai, Senthilkumar Muthusamy, Shiny Velayudhan, Anil Kumar P.R. · 2025 · Biofabrication
Image-guided injectable niche for hepatocyte transplantation
Vardhman Kumar, Joa Yun, Susanna K. Elledge et al. · 2026 · Cell Biomaterials
Generation of proliferative hESC-derived grape-clustered hepatocyte organoids with multipolar architecture as regenerative counterpart via synergy of YAP and IGF2 pathways
Haibin Wu, Shoupei Liu, Sen Chen, Changlu Qin, Wenjiao Yan, Xiangting Cao, Yongjian Zhou, Yuyou Duan · 2026 · Cell Death and Disease
Oxidation-driven mtDNA B-Z transition activates ZBP1 to mediate acetaminophen hepatotoxicity
Zhang-Hua Yang, Bo-Xin Zhang, Huan-Feng Ye, Liang Shi, Rui Gong, Zhiyu Cai, Qiang Chen, Lei Wu, Jia Huang, Le Zhang et al. · 2026 · Vita
Autologous chemically induced liver progenitor cell transplantation ameliorates steatosis and fibrosis in a preclinical miniature pig model of metabolic dysfunction–associated fatty liver disease: A pilot study
Takanobu Hara, Yasuhiro Maruya, Daisuke Miyamoto, Masayuki Fukumoto, Hajime Imamura, Hajime Matsushima, Akihiko Soyama, Tomohiko Adachi, Takahiro Ochiya, Susumu Eguchi · 2026 · Cell Transplantation
Living Devices for Organ Replacement: The Rise of Bioartificial Organ Engineering
Salvatore Pezzino, Davide Tumino, Caterina Crescimanno, Tonia Luca, Stefano Puleo, Sergio Castorina · 2026 · Applied Sciences