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Cited by 373

The DOI matches its Crossref record; 147 of the 147 references it cites were found in a registry or an index.

Engineering Stem Cell Self-organization to Build Better Organoids

Open access
Brassard, Jonathan A., Lutolf, Matthias P.·2019·Cell Stem Cell

Abstract

Organoids form through self-organization processes in which initially homogeneous populations of stem cells spontaneously break symmetry and undergo in-vivo-like pattern formation and morphogenesis, though the processes controlling this are poorly characterized. While these in vitro self-organized tissues far exceed the microscopic and functional complexity obtained by current tissue engineering technologies, they are non-physiological in shape and size and have limited function and lifespan. Here, we discuss how engineering efforts for guiding stem-cell-based development at multiple stages can form the basis for the assembly of highly complex and rationally designed self-organizing multicellular systems with increased robustness and physiological relevance.

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Crossref · 10.1016/j.stem.2019.05.005

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Metadata

Authors
Brassard, J. A., & Lutolf, M. P.
Venue
Cell Stem Cell
Publisher
Elsevier BV
Published
2019-06
Volume
24
Issue
6
Pages
860-876
ISSN
  • 1875-9777 (ISSN-L)
  • 1934-5909
OpenAlex
W2948284511
Cited by
373
References
147
FWCI
14.43
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Engineering Stem Cell Self-organization to Build Better Organoids. https://app.cochat.ai/papers/10.1016/j.stem.2019.05.005
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Brassard, J. A., & Lutolf, M. P. (2019). Engineering Stem Cell Self-organization to Build Better Organoids. Cell Stem Cell. https://doi.org/10.1016/j.stem.2019.05.005

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.