Loss of SATB1 Induces p21-Dependent Cellular Senescence in Post-mitotic Dopaminergic Neurons

Riessland, Markus, Kolisnyk, Benjamin, Kim, Tae Wan, Cheng, Jia, Ni, Jason, Pearson, Jordan A., Park, Emily J., Dam, Kevin +9 more·2019·Cell Stem Cell

Cited by (181)

Items 101–181 of 181

  1. Treating Senescence like Cancer: Novel Perspectives in Senotherapy of Chronic Diseases
    Alessia Mongelli, Sandra Atlante, Veronica Barbi, Tiziana Bachetti, Fabio Martelli, Antonella Farsetti, Carlo Gaetano · 2020 · International Journal of Molecular Sciences
  2. Cellular Senescence in Health, Disease and Aging: Blessing or Curse?
    Markus Rießland · 2021 · Life
  3. Anastasis Drives Senescence and Non-Cell Autonomous Neurodegeneration in the Astrogliopathy Alexander Disease
    Liqun Wang, Hassan Bukhari, Linghai Kong, Tracy L. Hagemann, Su-Chun Zhang, Albee Messing, Mel Β. Feany · 2022 · Journal of Neuroscience
  4. CircSATB1 Promotes Colorectal Cancer Liver Metastasis through Facilitating FKBP8 Degradation via RNF25‐Mediated Ubiquitination
    Chuan Zhang, Chuanxin Tian, Renzhong Zhu, Chen Chen, Chi Jin, Xiaowei Wang, Lejia Sun, Wen Peng, Dongjian Ji, Yue Zhang et al. · 2025 · Advanced Science
  5. Association analysis of 15 GWAS-linked loci with Parkinson’s disease in Chinese Han population
    Xinchao Hu, Chengyuan Mao, Zhengwei Hu, Zhongxian Zhang, Shuo Zhang, Zhihua Yang, Yu Fan, Liyuan Fan, Huimin Zheng, Jing Yang et al. · 2020 · Neuroscience Letters
  6. Identifying Age‐Modulating Compounds Using a Novel Computational Framework for Evaluating Transcriptional Age
    Chao Zhang, Nathalie G. Saurat, Daniela Cornacchia, Sun Young Chung, Trisha Sikder, Adrianne Nemchik, Andrew P. Minotti, Lorenz Studer, Doron Betel · 2025 · Aging Cell
  7. Gene expression composite scores of cellular senescence predict aging health outcomes in the Health and Retirement Study
    Qiao Wu, Eric T. Klopack, Jung Ki Kim, Thalida Em Arpawong, Bharat Thyagarajan, Steve Cole, Jessica D. Faul, Fengxue Zhou, Eileen M. Crimmins · 2025 · Nature Communications
  8. Systematic profiling reveals distinct senescence signatures and regulators across human brain cell types
    Taylor Russo, Jonathan Plessis‐Belair, Roger B. Sher, Markus Rießland · 2025 · Nature Communications
  9. Sox6 and ALDH1A1 Truncation by Asparagine Endopeptidase Defines Selective Neuronal Vulnerability in Parkinson's Disease
    Shuke Nie, Bowei Li, Mengmeng Wang, Zijun Chen, Jiayan Ren, Zixuan Li, Xinli Xu, Zhengjiang Qian, Zhongyun Xie, Jianxin Han et al. · 2024 · Advanced Science
  10. SATB1 is a Dopaminergic Neuron‐Specific Regulator of Cellular Senescence
    Alexandra M. Cancio-Bello, Sara Sáez-Atiénzar · 2020 · Movement Disorders
  11. Nuclear Import Defects Drive Cell Cycle Dysregulation in Neurodegeneration
    Jonathan Plessis‐Belair, Taylor Russo, Markus Rießland, Roger B. Sher · 2025 · Aging Cell
  12. Inhibition of UBE2C Promotes Parkin‐Mediated K63‐Linked Ubiquitination of TOP2A to Induce Senescence and Increase Sensitivity of Doxorubicin in Breast Cancer
    Yihui Yang, Wan Li, Hong Yang, Fang Xu, Sen Zhang, Wanxin Cao, Xiaoxue Li, Xu Zhang, Xiangyin Chi, Hongquan Wang et al. · 2025 · Advanced Science
  13. Senolytics: Opening avenues in drug discovery to find novel therapeutics for Parkinson’s Disease
    Violina Kakoty, Sarathlal Kalarikkal Chandran, Monica Gulati, Bey Hing Goh, Kamal Dua, Sachin Kumar Singh · 2023 · Drug Discovery Today
  14. BRD7 regulates cellular senescence and apoptosis in ALS by modulating p21 expression and p53 mitochondrial translocation respectively
    Xingli Tan, Xiaoli Su, Ying Wang, Weiwei Liang, Di Wang, Di Huo, Hongyong Wang, Yan Qi, Wenmo Zhang, Ling Han et al. · 2024 · Neuroscience
  15. Role of Cellular Senescence in Parkinson’s Disease: Potential for Disease-Modification Through Senotherapy
    David J. Rademacher, Jacob E. Exline, Eileen M. Foecking · 2025 · Biomedicines
  16. Identification of a novel enhancer essential for Satb1 expression in T H 2 cells and activated ILC2s
    Aneela Nomura, Michiko Ohno‐Oishi, Tetsuro Kobayashi, Wooseok Seo, Kiyokazu Kakugawa, Sawako Muroi, Hideyuki Yoshida, Takaho A. Endo, Kazuyo Moro, Ichiro Taniuchi · 2023 · Life Science Alliance
  17. A Need for Refined Senescence Biomarkers and Measures of Senolytics in the Brain
    Miranda E. Orr · 2024 · Journal of Alzheimer s Disease
  18. Senolytics prevent age-associated changes in female mice brain
    Olívia Wyse Faria, Mayara Sandrielly Pereira Soares, Júlia Eisenhardt de Mello, Fernando Lopez Alvez, Karina Pereira Luduvico, Driele Neske Garcia, Augusto Schneider, Michał M. Masternak, Rosélia Maria Spanevello, Francieli Moro Stefanello · 2024 · Neuroscience Letters
  19. Bazi Bushen improves cognitive dysfunction in 5×FAD mice by targeting amyloid pathology, neuroinflammation and cellular senescence
    Huixian Huang, Wensi Lu, Yusi Huang, Yanshan Su, Ran Luo, Yinyun Zeng, Chunhua Yuan, Zhenhua Jia, Wang Xuemin · 2025 · Journal of Ethnopharmacology
  20. Cellular senescence in brain aging and neurodegeneration: from molecular mechanisms to translational opportunities
    Yahveth Cantero‐Fortiz, Christopher Butler, Xavier Montalbán, Merçé Boada · 2026 · Frontiers in Cellular Neuroscience
  21. Advances in human pluripotent stem cell reporter systems
    Lesly Puspita, Virginia Blessy Juwono, Jaewon Shim · 2024 · iScience
  22. SATB1, senescence and senescence‐related diseases
    Wenjing Qi, Jinping Bai, Ruoxi Wang, Xianlu Zeng, Lihui Zhang · 2024 · Journal of Cellular Physiology
  23. HucMSC extracellular vesicles increasing SATB 1 to activate the Wnt/β‐catenin pathway in 6‐ OHDA ‐induced Parkinson's disease model
    Ying He, Ruicheng Li, Yuxi Yu, Zhiran Xu, Jiaxin Gao, Cancan Wang, Chusheng Huang, Zhongquan Qi · 2024 · IUBMB Life
  24. Procyanidin C1 is a natural agent with senolytic activity against aging and age-related diseases
    Qixia Xu, Qiang Fu, Zi Li, Hanxin Liu, Ying Wang, Xu Lin, Ruikun He, Xuguang Zhang, Judith Campisi, James L. Kirkland et al. · 2021 · bioRxiv (Cold Spring Harbor Laboratory)
  25. The emerging role of cellular senescence in amyotrophic lateral sclerosis
    Xingli Tan, Naiyong Gao · 2025 · Frontiers in Neuroscience
  26. Dual SMAD inhibition as a versatile platform in human pluripotent stem cell–based regenerative medicine and disease modeling
    Lesly Puspita, Magdalena Deline, Jaewon Shim · 2025 · Molecules and Cells
  27. Target anesthesia and surgery induced senescent cell via composite microsphere hydrogels as nose-to-brain amplifiers of platelet factor 4 delivery for neurocognitive dysfunction repair
    Zheng Xie, Zehao Chen, Weifeng Wu, Miaomiao Fei, Wenting Li, Silu Cao, Nan Wang, Xiaoxiao Sun, Xiaoxiao Sun, Qiang Liu et al. · 2025 · Biomaterials
  28. Dysregulated circRNA–miRNA–mRNA networks reveal stage-specific mRNA expression changes in Parkinson’s disease
    Yulan Gao, Konii Takenaka, Kristina Santucci, Grace Lindner, Si-Mei Xu, Yuning Cheng, Michael Janitz · 2025 · Molecular Brain
  29. Implications of cellular senescence in Parkinson’s disease: Recent developments and future directions
    Julie Kay Andersen · 2026 · Current Opinion in Neurobiology
  30. A genome-wide analysis of 340 318 participants identifies four novel loci associated with the age of first spectacle wear
    Karina Patasova, Anthony P. Khawaja, Robert Wojciechowski, Omar A. Mahroo, Mario Falchi, Jugnoo Sangeeta Rahi, Christopher J. Hammond, Pirro G. Hysi, Rupal L. Shah, Jeremy A. Guggenheim · 2022 · Human Molecular Genetics
  31. Inhibition of Cyclin F Promotes Cellular Senescence through Cyclin-dependent Kinase 1-mediated Cell Cycle Regulation
    Xun Li, You-jian Li, Mengjie Wang, Kepeng Ou, Yaqi Chen · 2023 · Current Medical Science
  32. A human developmental and adult brain atlas benchmarks dopaminergic stem cell models and cell therapy candidates
    Vittoria Dickinson Bocchi, Ken To, Leslie Weber, Paul Zumbo, Lisa Kim, Iwasaki Yuko Shida, Donghe Yang, Petter Storm, Alessandro Fiorenzano, Edoardo Sozzi et al. · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
  33. Elevated p16Ink4a Expression Enhances Tau Phosphorylation in Neurons Differentiated From Human‐Induced Pluripotent Stem Cells
    Kristopher Holloway, Kashfia Neherin, Yingduo Song, Kazuhito Sato, Andrew Houston, Feng Chen, Ding Li, Hong Zhang · 2025 · Aging Cell
  34. LINC02593 impedes cell senescence via COP1-mediated p53 degradation in cervical cancer
    Qian Jing, Qin Chen, Guosong Wang, Tong Wu, Lingli Wang, Qunli Xiong, Xiaojuan Yang, Lei Qiu, Junhong Han · 2025 · Cellular Signalling
  35. Dynamic interplay of cellular senescence, chronic neuroinflammation and synaptic plasticity in age-related neurodegeneration
    Ning Li, Xinzhe Huang, Tiantian Zou, Xinjian Wu, Shuo Yang, Zhenyuan Xu, Jian Dai, Kai Wang, Jiannong Zhao · 2025 · Oral Science and Homeostatic Medicine
  36. Investigating the ageing-Parkinson’s disease nexus: standardisation of in vitro models and techniques by the PD-AGE network
    Alexander G. Bury, Alicja Olejnik, Chiara Tocco, Nathalie G. Saurat, Elezabeth Stephen, Dirk F. Hockemeyer, Jens Christian Schwamborn, Lorenz Studer, Pier G. Mastroberardino, Silvia Bolognin et al. · 2025 · npj Parkinson s Disease
  37. Organelle Dysfunction and TNT-Mediated Aggregate Spreading in Neurodegeneration
    Valentine Thomas, Chiara Zurzolo · 2026 · Physiology
  38. Characterizing the SASP ‐Dependent Paracrine Spreading of Senescence Between Human Brain Cell Types
    Taylor Russo, Markus Rießland · 2026 · Aging Cell
  39. Cellular senescence and nanoparticle-based therapies: Current developments and perspectives
    Agata Henschke, Angelika Mielcarek, Bartosz F. Grześkowiak, Patrick M. Perrigue, Kaja Jaskot, Emerson L. Coy, Sergio Enrique Moya · 2024 · Nanotechnology Reviews
  40. Unlocking the potential of histone deacetylase inhibitors in combatting age-related retinal degenerative diseases
    Bo Liu, Minglu Wang, Ning Pu, Jiale Wang, Wenhui Fan, Chengkang Qu, Hao Wu, Zongming Song, Ye Tao · 2025 · Ageing Research Reviews
  41. Acute intoxication with diisopropylfluorophosphate promotes cellular senescence in the adult male rat brain
    Yi‐Hua Tsai, Eduardo A. González, Ana Cristina Grodzki, Donald A. Bruun, Naomi H. Saito, Danielle Jenine Harvey, Pamela J. Lein · 2024 · Frontiers in Toxicology
  42. Identifying novel age-modulating compounds and quantifying cellular aging using novel computational framework for evaluating transcriptional age
    Chao Zhang, Nathalie G. Saurat, Daniela Cornacchia, Sun Young Chung, Trisha Sikder, Andrew P. Minotti, Lorenz Studer, Doron Betel · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
  43. Identification of markers for neurescence through transcriptomic profiling of postmortem human brains
    Shiva Kazempour Dehkordi, Sogand Sajedi, Amirreza Heshmat, Miranda E. Orr, Habil Zare · 2025 · npj Aging
  44. Investigating causal relations between brain morphology and genetic risk variants in Parkinson’s disease
    Gabrielle Dagasso, Vibujithan Vigneshwaran, Anthony J Winder, Raissa Souza, Erik Y. Ohara, Matthias Wilms, Nils D. Forkert · 2025 · NeuroImage Clinical
  45. NLRP3 facilitates α-synuclein-induced dopaminergic neuronal senescence in a mouse model of Parkinson's disease through SATB1/DNA damage/p21 signaling pathway.
    Lei-lei Chen, Qing-qing Shen, Liping Sun, Yu-Xiang Song, Wen-ting Jia, Le Qu, Jun-Xia Xie · 2026 · Acta Pharmacologica Sinica
  46. Human pluripotent stem cell engineering with CRISPR–Cas9 for Parkinson’s disease
    Seung Bin Park, Jae‐Joong Kim, Yuri Ha, Min Seong Kim, Tae Wan Kim · 2026 · Experimental & Molecular Medicine
  47. Sustained Epigenetic Reactivation in Fragile X Neurons with an RNA-Binding Small Molecule
    Christina W. Kam, Jason G. Dumelie, Gabriele Ciceri, Wang-Yong Yang, Matthew David Disney, Lorenz Studer, Samie R. Jaffrey · 2025 · Genes
  48. Trisomy X syndrome with dystonia and a pathogenic SATB1 variant
    Ján Necpál, Michael Zech, Juliane Winkelmann, Robert Jech · 2021 · Neurological Sciences
  49. Age-related nigral downregulation of the Parkinson’s risk factor FAM49B primes human microglia for inflammaging
    Jacqueline Martin, Guan-Ju Lai, Christopher Y. Park, Colista West, Trevor Van Brunt, Samarah Ahmed, Saheed Lawal, Maya Dickson, Taylor Russo, Wendy Akmentin et al. · 2025 · npj Aging
  50. Targeting innovative therapeutic approaches to the hallmarks of aging to combat Alzheimer’s disease
    Michal Izrael, Orli Miriam Frenkel · 2025 · Neural Regeneration Research
  51. Celastrol Targets Hsc70‐Bim Interaction as a Novel Senolytic to Extend Lifespan and Mitigate Organ Fibrosis
    Weitong Xu, Honghan Chen, Hui Gong, Tingmei Zhao, Yu Yang, Fangfang Wang, Ning Huang, Ming Yang, Nan Gao, Huan Li et al. · 2026 · Phytotherapy Research
  52. Cellular senescence in neurodegenerative diseases: A bibliometric analysis and mechanistic synthesis linking translational pathways to therapeutic implications
    Runjin Zhou, Xiaoling Lin, Jian Lin, Zhenge Liao, Haojie Ni, Xingdong Lin, Qiuxing He, Weimin Ning · 2026 · Ageing Research Reviews
  53. Spatial and single-cell transcriptomics reveals senescence-associated changes in MIA-induced ASD male mouse brain
    Wei Zhang, Kaizhao Chen, Yue Ke, Dejun Yan, Ziyang Lin, Longjun Chen, Ziqing Gao, Yuke Shen, Haoyang Wan, Xi Yang et al. · 2026 · Cell Reports
  54. Suppression of ATM kinase signaling accelerates cellular senescence
    Kei‐ichi Ishikawa, Takahiro Shiga, Takumi Hirose, Naoko Kuzumaki, Sakura Miyoshi, Akihiro Yamaguchi, Hidetaka Tamune, Avijite Kumer Sarkar, Kento Nakai, Kazuyoshi Baba et al. · 2026 · Stem Cell Reports
  55. Protocol for analysis of senescent neuronal stem cells in genetic-modified embryonic mice using in utero electroporation technique
    Liping Chen, Ying Li, Yan Wu, Shen Li, Xin Chang, Haitao Wu · 2022 · STAR Protocols
  56. Neuroprotective effects of gastrodin in both in vivo and in vitro models of Parkinson's disease: Mechanisms from the perspective of oxidative stress, ferroptosis, and cellular senescence
    Shanshan Li, Meng Wang, Buyun Jia, Baikun Li, Hui Cheng, Shasha Tian, Qinglin Li · 2025 · Journal of Functional Foods
  57. Regulatory Network Inference of Induced Senescent Midbrain Cell Types Reveals Cell Type-Specific Senescence-Associated Transcriptional Regulators
    Taylor Russo, Jonathan Plessis‐Belair, Roger B. Sher, Markus Rießland · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  58. Deciphering cell-type specific signal transduction in the brain: Challenges and promises
    Jean-Pierre Roussarie, Patricia Rodriguez‐Rodriguez · 2020 · Advances in pharmacology
  59. Cellular senescence in the ageing brain
    Nynke Talma · 2022
  60. Genes and dietary metals in Parkinson's disease
    Shiek Fareeth Ahmed, Jency Roshni, S. Mahima, V. Janakiraman · 2023 · Elsevier eBooks
  61. Effects of acupuncture on SATB1/p21 signaling pathway and SASPs in MPTP-induced Parkinson disease model mice
    Guona Li, Chen Zhao, Zhaoqin Wang, Xue-gui Hua, Luyi Wu, Xiyin Zhang, Lin Shen, Ziyi Chen, Wenqing Hu, Yiyi Chen et al. · 2024 · Journal of Acupuncture and Tuina Science
  62. A rat Satb1 truncation causes neurodevelopmental abnormalities recapitulating the symptoms of patients with SATB1 mutations
    Zhibin Hu, Wei-tang Liu, Yiwei Li, Ling Hu, Ying Huang, Xi-yue Liu, Qiong Zhang, Yubing Wang, Jiayin Chen, Ze-Xuan Li et al. · 2025 · Acta Pharmacologica Sinica
  63. Methylomic signatures of tau and amyloid-beta in transgenic mouse models of Alzheimer’s disease neuropathology
    Szi Kay Leung, Emma Walker, Stefania S S Policicchio, Aisha Dahir, Dorothea Seiler Vellame, Adam R. Smith, Rhian Swarbrick, Katie Lunnon, Emma Louise Dempster, Zeshan Ahmed et al. · 2026 · npj Dementia
  64. Neurodegeneration in the Aging Brain: Role of Cellular Senescence
    Abida Khan, Saleh Ibrahim Alaqel, Mashael N. Alanazi, Muhammad Irfan Siddique, Mohd Imran · 2025 · Springer eBooks
  65. Cellular Senescence in Parkinson’s Disease (PD)
    Muhammad Afzal · 2025 · Springer eBooks
  66. Additional file 1 of Nuclear alpha-synuclein accelerates cell senescence and neurodegeneration
    Du, Tingfu, Li, Guoxiang, Qinglan Zong, Haiyu Luo, Pan, Yue, Ma, Kaili · 2024 · Figshare
  67. Senescence-associated Cdkn1a (p21) is upregulated in rodent dorsal root ganglion neurons across lesion-based neuropathic pain models
    Philipp Niklas Ostermann, Rebecca Dinnendahl, Jörg Isensee, Tim B. Hucho · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
  68. Protein aggregation inhibitors induce divergent transcriptional responses in a cellular model of ɑ-synuclein seeded aggregation
    Paulien Van Minsel, Chris Van den Haute, Eline Vonck, Shirine Hentati, Michele Curcio, Xinran Song, Qian Yu, Matthias Versele, Kenneth W. Young, Patrick Chaltin et al. · 2026 · npj Parkinson s Disease
  69. SATB1 Exhibits a Protective Role in HAmylin‐ Oligomer‐Induced Neuronal Damage and Cognition Decline
    Yuan Xing, Wen Zhang, Zuxiao Yang, Xia Qin, Ting Zhou, Nan Zhang · 2026 · CNS Neuroscience & Therapeutics
  70. Modeling sporadic Alzheimer’s disease using brain organoids: Emerging trends and translational opportunities
    Muhammad Kamal Hossain, Hyung‐Ryong Kim · 2026 · Tissue and Cell
  71. Redox bioenergetics of neuronal senescence in Alzheimer’s disease
    Erdem Atasever, Şeydanur Turgut, Gülnur Andican, Ufuk Çakatay · 2026 · International review of neurobiology
  72. LaminA/C-dependent cellular senescence signaling promotes skeletal muscle atrophy and abnormalities in Parkinson’s disease
    Jaydeep Sharma, Somnath Mondal, Krishna Singh Bisht, Ankit Biswas, Lakshmikanthan Panneerselvam, Tushar Kanti Maiti, Sam J. Mathew · 2026 · Cell Death and Disease
  73. Mitochondrial transplantation reverses the senescence phenotype of SH-SY5Y cells
    Liqun Xu, Yilang Wu, Wanfei Wu, Xiao Li, Ruijuan Deng, Haibao Zhu, Aihua Mao, Pingnan Sun, Xin Zhang, Wencan Xu et al. · 2026 · Molecular Therapy Advances
  74. Integrated plasma proteomics and metabolomes reveal potential biomolecules linking PM2.5 to depression
    Lan Chen, Dashan Zheng, Shengtao Wei, Ge Chen, Yang Shen, Leiyuan Liu, Hualiang Lin · 2026 · Environmental Toxicology and Pharmacology
  75. Beyond phenotypic markers: rethinking dopaminergic identity in iPSC-derived neurons
    Duc‐Hiep Bach, Thanh Liem Nguyen · 2026 · Cell Communication and Signaling
  76. Rethinking Senescence Hallmarks in the Brain: Lessons From Peripheral Tissues and Challenges in Defining Neuronal Senescence
    Miraj Ud Din Momand, Kristína Macová, Dominika Fričová · 2026 · Aging Cell
  77. Conserved signaling pathways and transcriptional regulators drive ovarian aging across species
    Mingyue Gao, Junnan Zhang, Jing Yang, Shenghan Gao, Ning Yang, Congjiao Sun · 2026 · Poultry Science
  78. Decoding subtype development and function in human pluripotent stem cell-derived midbrain dopaminergic neurons
    Donghe Yang, Sejoon Choi, Jinghua Piao, Alessandro Evangelisti, Zhe Yang, Vittoria Dickinson Bocchi, Shkurte Ademi Donohue, Nidia Claros, Johannes Jungverdorben, Mega Sidharta et al. · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
  79. Astrocyte Structure–Function Relationship in Senescence and Neurodegeneration
    Daria V. Serebryanaya, Ksenia A. Kolgaeva, German A. Dya, Ivan M. Ermakov, Vsevolod Vadimovich Belousov · 2026 · Biochemistry (Moscow)
  80. Cellular senescence in ageing and neurodegenerative disorders: Molecular mechanisms, biomarkers, and therapeutic strategies
    Aanchal Verma, Ahsas Goyal, Neetu Agrawal, Harlokesh Narayan Yadav · 2026 · Progress in Neuro-Psychopharmacology and Biological Psychiatry
  81. Senescence‐Associated Cdkn1a (p21) Is Upregulated in Rodent Dorsal Root Ganglion Neurons Across Lesion‐Based Neuropathic Pain Models
    Philipp Niklas Ostermann, Rebecca Dinnendahl, Jörg Isensee, Tim B. Hucho · 2026 · Pain Research and Management