Loss of SATB1 Induces p21-Dependent Cellular Senescence in Post-mitotic Dopaminergic Neurons

Fiji: an open-source platform for biological-image analysis

Schindelin, J., Arganda-Carreras, I., Frise, E., Kaynig, V., Longair, M., Pietzsch, T., Preibisch, S., Rueden, C., Saalfeld, S., Schmid, B., et al. (2012) · Nature Methods · doi:10.1038/nmeth.2019 · Cited by 66,890 · see citing works

Trimmomatic: a flexible trimmer for Illumina sequence data

Bolger, A. M., Lohse, M., & Usadel, B. (2014) · Bioinformatics · doi:10.1093/bioinformatics/btu170 · Cited by 65,548 · see citing works

The Sequence Alignment/Map format and SAMtools

Li, H., Handsaker, B., Wysoker, A., Fennell, T., Ruan, J., Homer, N., Marth, G., Abecasis, G., Durbin, R., & 1000 Genome Project Data Processing Subgroup (2009) · Bioinformatics · doi:10.1093/bioinformatics/btp352 · Cited by 62,041 · see citing works

Fast gapped-read alignment with Bowtie 2

Langmead, B., & Salzberg, S. L. (2012) · Nature Methods · doi:10.1038/nmeth.1923 · Cited by 56,400 · see citing works

Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles

Subramanian, A., Tamayo, P., Mootha, V. K., Mukherjee, S., Ebert, B. L., Gillette, M. A., Paulovich, A., Pomeroy, S. L., Golub, T. R., Lander, E. S., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0506580102 · Cited by 53,625 · see citing works

STAR: ultrafast universal RNA-seq aligner

Dobin, A., Davis, C. A., Schlesinger, F., Drenkow, J., Zaleski, C., Jha, S., Batut, P., Chaisson, M., & Gingeras, T. R. (2013) · Bioinformatics · doi:10.1093/bioinformatics/bts635 · Cited by 51,709 · see citing works

<tt>edgeR</tt> : a Bioconductor package for differential expression analysis of digital gene expression data

Robinson, M. D., McCarthy, D. J., & Smyth, G. K. (2010) · Bioinformatics · doi:10.1093/bioinformatics/btp616 · Cited by 41,364 · see citing works

fastp: an ultra-fast all-in-one FASTQ preprocessor

(2018) · doi:10.1093/bioinformatics/bty560 · Cited by 29,721 · see citing works

Ultrafast and memory-efficient alignment of short DNA sequences to the human genome.

Langmead, B., Trapnell, C., Pop, M., & Salzberg, S. L. (2009) · Genome Biology · doi:10.1186/gb-2009-10-3-r25 · Cited by 21,849 · see citing works

Model-based Analysis of ChIP-Seq (MACS)

Zhang, Y., Liu, T., Meyer, C. A., Eeckhoute, J., Johnson, D. S., Bernstein, B. E., Nusbaum, C., Myers, R. M., Brown, M., Li, W., et al. (2008) · Genome Biology · doi:10.1186/gb-2008-9-9-r137 · Cited by 18,386 · see citing works

Integrative genomics viewer

Robinson, J. T., Thorvaldsdóttir, H., Winckler, W., Guttman, M., Lander, E. S., Getz, G., & Mesirov, J. P. (2011) · Nature Biotechnology · doi:10.1038/nbt.1754 · Cited by 15,390 · see citing works

Staging of brain pathology related to sporadic Parkinson’s disease

Braak, H., Tredici, K. D., Rüb, U., de Vos, R. A. I., Jansen Steur, E. N. H., & Braak, E. (2003) · Neurobiology of Aging · doi:10.1016/s0197-4580(02)00065-9 · Cited by 10,777 · see citing works

PGC-1α-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes

Mootha, V. K., Lindgren, C. M., Eriksson, K.-F., Subramanian, A., Sihag, S., Lehar, J., Puigserver, P., Carlsson, E., Ridderstråle, M., Laurila, E., et al. (2003) · Nature Genetics · doi:10.1038/ng1180 · Cited by 10,197 · see citing works

Integrative Genomics Viewer (IGV): high-performance genomics data visualization and exploration

Thorvaldsdottir, H., Robinson, J. T., & Mesirov, J. P. (2013) · Briefings in Bioinformatics · doi:10.1093/bib/bbs017 · Cited by 9,049 · see citing works

The serial cultivation of human diploid cell strains

Hayflick, L., & Moorhead, P. S. (1961) · Experimental Cell Research · doi:10.1016/0014-4827(61)90192-6 · Cited by 8,508 · see citing works

Parkinson's disease

Kalia, L. V., & Lang, A. E. (2015) · The Lancet · doi:10.1016/s0140-6736(14)61393-3 · Cited by 6,412 · see citing works

A statistical framework for SNP calling, mutation discovery, association mapping and population genetical parameter estimation from sequencing data

Li, H. (2011) · Bioinformatics · doi:10.1093/bioinformatics/btr509 · Cited by 6,283 · see citing works

The limited in vitro lifetime of human diploid cell strains

Hayflick, L. (1965) · Experimental Cell Research · doi:10.1016/0014-4827(65)90211-9 · Cited by 5,876 · see citing works

The senescence-associated secretory phenotype: the dark side of tumor suppression

Coppé, J.-P., Desprez, P.-Y., Krtolica, A., & Campisi, J. (2010) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev-pathol-121808-102144 · Cited by 5,206 · see citing works

Chronic Inflammation (Inflammaging) and Its Potential Contribution to Age-Associated Diseases

Franceschi, C., & Campisi, J. (2014) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/glu057 · Cited by 3,891 · see citing works

Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders

Baker, D. J., Wijshake, T., Tchkonia, T., LeBrasseur, N. K., Childs, B. G., van de Sluis, B., Kirkland, J. L., & van Deursen, J. M. (2011) · Nature · doi:10.1038/nature10600 · Cited by 3,670 · cited 2× · see citing works

Highly efficient neural conversion of human ES and iPS cells by dual inhibition of SMAD signaling

Chambers, S. M., Fasano, C. A., Papapetrou, E. P., Tomishima, M., Sadelain, M., & Studer, L. (2009) · Nature Biotechnology · doi:10.1038/nbt.1529 · Cited by 3,620 · see citing works

ATAC-seq: a method for assaying chromatin accessibility genome-wide

Buenrostro, J. D., Wu, B., Chang, H. Y., & Greenleaf, W. J. (2015) · Current Protocols in Molecular Biology · doi:10.1002/0471142727.mb2129s109 · Cited by 3,289 · see citing works

Aging, Cellular Senescence, and Cancer

Campisi, J. (2013) · Annual Review of Physiology · doi:10.1146/annurev-physiol-030212-183653 · Cited by 2,954 · cited 1× · see citing works

Naturally occurring p16Ink4a-positive cells shorten healthy lifespan

Baker, D. J., Childs, B. G., Durik, M., Wijers, M. E., Sieben, C. J., Zhong, J., A. Saltness, R., Jeganathan, K. B., Verzosa, G. C., Pezeshki, A., et al. (2016) · Nature · doi:10.1038/nature16932 · Cited by 2,891 · see citing works

Cellular senescence: from physiology to pathology

Muñoz-Espín, D., & Serrano, M. (2014) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3823 · Cited by 2,818 · see citing works

The role of senescent cells in ageing

van Deursen, J. M. (2014) · Nature · doi:10.1038/nature13193 · Cited by 2,623 · see citing works

The Achilles' heel of senescent cells: from transcriptome to senolytic drugs

Zhu, Y., Tchkonia, T., Pirtskhalava, T., Gower, A. C., Ding, H., Giorgadze, N., Palmer, A. K., Ikeno, Y., Hubbard, G. B., Lenburg, M., et al. (2015) · Aging Cell · doi:10.1111/acel.12344 · Cited by 2,562 · cited 2× · see citing works

Identification of novel risk loci, causal insights, and heritable risk for Parkinson's disease: a meta-analysis of genome-wide association studies

Nalls, M. A., Blauwendraat, C., Vallerga, C. L., Heilbron, K., Bandres-Ciga, S., Chang, D., Tan, M., Kia, D. A., Noyce, A. J., Xue, A., et al. (2019) · The Lancet Neurology · doi:10.1016/s1474-4422(19)30320-5 · Cited by 2,454 · see citing works

Cas-OFFinder: A fast and versatile algorithm that searches for potential off-target sites of Cas9 RNA-guided endonucleases

Bae, S., Park, J., & Kim, J.-S. (2014) · Bioinformatics · doi:10.1093/bioinformatics/btu048 · Cited by 2,339 · see citing works

Senolytics improve physical function and increase lifespan in old age

Xu, M., Pirtskhalava, T., Farr, J. N., Weigand, B. M., Palmer, A. K., Weivoda, M. M., Inman, C. L., Ogrodnik, M. B., Hachfeld, C. M., Fraser, D. G., et al. (2018) · Nature Medicine · doi:10.1038/s41591-018-0092-9 · Cited by 2,287 · see citing works

A complex secretory program orchestrated by the inflammasome controls paracrine senescence

Acosta, J. C., Banito, A., Wuestefeld, T., Georgilis, A., Janich, P., Morton, J. P., Athineos, D., Kang, T.-W., Lasitschka, F., Andrulis, M., et al. (2013) · Nature Cell Biology · doi:10.1038/ncb2784 · Cited by 2,278 · cited 2× · see citing works

Dopamine neurons derived from human ES cells efficiently engraft in animal models of Parkinson’s disease

Kriks, S., Shim, J., Piao, J., Ganat, Y. M., Wakeman, D. R., Xie, Z., Carrillo‐Reid, L., Auyeung, G., Antonacci, C. L., Buch, A., et al. (2011) · Nature · doi:10.1038/nature10648 · Cited by 1,912 · see citing works

Chemokine signaling via the CXCR2 receptor reinforces senescence

Acosta, J. C., O'Loghlen, A., Banito, A., Guijarro, M. V., Augert, A., Raguz, S., Fumagalli, M., Da Costa, M., Brown, C., Popov, N., et al. (2008) · Cell · doi:10.1016/j.cell.2008.03.038 · Cited by 1,801 · see citing works

Senescence surveillance of pre-malignant hepatocytes limits liver cancer development

Kang, T.-W., Yevsa, T., Woller, N., Hoenicke, L., Wuestefeld, T., Dauch, D., Hohmeyer, A., Gereke, M., Rudalska, R., Potapova, A., et al. (2011) · Nature · doi:10.1038/nature10599 · Cited by 1,621 · see citing works

Clearance of senescent glial cells prevents tau-dependent pathology and cognitive decline

Bussian, T. J., Aziz, A., Meyer, C. F., Swenson, B. L., van Deursen, J. M., & Baker, D. J. (2018) · Nature · doi:10.1038/s41586-018-0543-y · Cited by 1,289 · see citing works

Cas9 as a versatile tool for engineering biology

Mali, P., Esvelt, K. M., & Church, G. M. (2013) · Nature Methods · doi:10.1038/nmeth.2649 · Cited by 1,197 · see citing works

Targeting cellular senescence prevents age-related bone loss in mice

Farr, J. N., Xu, M., Weivoda, M. M., Monroe, D. G., Fraser, D. G., Onken, J. L., Negley, B. A., Sfeir, J. G., Ogrodnik, M. B., Hachfeld, C. M., et al. (2017) · Nature Medicine · doi:10.1038/nm.4385 · Cited by 1,182 · see citing works

A meta-analysis of genome-wide association studies identifies 17 new Parkinson's disease risk loci

Chang, D., Nalls, M. A., Hallgrímsdóttir, I. B., Hunkapiller, J., van der Brug, M., Cai, F., International Parkinson's Disease Genomics Consortium, 23andMe Research Team, Kerchner, G. A., Ayalon, G., et al. (2017) · Nature Genetics · doi:10.1038/ng.3955 · Cited by 1,112 · see citing works

Cellular Senescence in Aging Primates

Herbig, U., Ferreira, M., Condel, L., Carey, D., & Sedivy, J. M. (2006) · Science · doi:10.1126/science.1122446 · Cited by 1,101 · see citing works

Directed elimination of senescent cells by inhibition of BCL-W and BCL-XL

Yosef, R., Pilpel, N., Tokarsky-Amiel, R., Biran, A., Ovadya, Y., Cohen, S., Vadai, E., Dassa, L., Shahar, E., Condiotti, R., et al. (2016) · Nature Communications · doi:10.1038/ncomms11190 · Cited by 1,032 · see citing works

Fisetin is a senotherapeutic that extends health and lifespan

Yousefzadeh, M. J., Zhu, Y., McGowan, S. J., Angelini, L., Fuhrmann-Stroissnigg, H., Xu, M., Ling, Y. Y., Melos, K. I., Pirtskhalava, T., Inman, C. L., et al. (2018) · EBioMedicine · doi:10.1016/j.ebiom.2018.09.015 · Cited by 1,032 · see citing works

Cellular senescence: a translational perspective

Kirkland, J. L., & Tchkonia, T. (2017) · EBioMedicine · doi:10.1016/j.ebiom.2017.04.013 · Cited by 1,013 · see citing works

Ageing and Parkinson's disease: Why is advancing age the biggest risk factor?

Reeve, A. K., Simcox, E. M., & Turnbull, D. M. (2014) · Ageing Research Reviews · doi:10.1016/j.arr.2014.01.004 · Cited by 961 · see citing works

A crucial role for adipose tissue p53 in the regulation of insulin resistance

Minamino, T., Orimo, M., Shimizu, I., Kunieda, T., Yokoyama, M., Ito, T., Nojima, A., Nabetani, A., Oike, Y., Matsubara, H., et al. (2009) · Nature Medicine · doi:10.1038/nm.2014 · Cited by 891 · see citing works

PGC-1 α, A Potential Therapeutic Target for Early Intervention in Parkinson’s Disease

Zheng, B., Liao, Z., Locascio, J. J., Lesniak, K. A., Roderick, S. S., Watt, M. L., Eklund, A. C., Zhang‐James, Y., Kim, P. D., Hauser, M. A., et al. (2010) · Science Translational Medicine · doi:10.1126/scitranslmed.3001059 · Cited by 854 · see citing works

ngs.plot: Quick mining and visualization of next-generation sequencing data by integrating genomic databases

Shen, L., Shao, N., Liu, X., & Nestler, E. J. (2014) · BMC Genomics · doi:10.1186/1471-2164-15-284 · Cited by 852 · see citing works

Meta- and Orthogonal Integration of Influenza “OMICs” Data Defines a Role for UBR4 in Virus Budding

Tripathi, S., Pohl, M. O., Zhou, Y., Rodríguez-Frandsen, A., Wang, G., Stein, D. A., Moulton, H. M., DeJesus, P., Che, J., Mulder, L. C. F., et al. (2015) · Cell Host & Microbe · doi:10.1016/j.chom.2015.11.002 · Cited by 846 · see citing works

A Modified Method for Lead Staining of Thin Sections

Sato, T. (1968) · Journal of Electron Microscopy · doi:10.1093/oxfordjournals.jmicro.a049610 · Cited by 820 · see citing works

Interleukin-1β and interleukin-6 are elevated in the cerebrospinal fluid of Alzheimer's and de novo Parkinson's disease patients

Blum-Degena, D., Müller, T., Kuhn, W., Gerlach, M., Przuntek, H., & Riederer, P. (1995) · Neuroscience Letters · doi:10.1016/0304-3940(95)12192-7 · Cited by 801 · see citing works

Human iPSC-based modeling of late-onset disease via progerin-induced aging

Miller, J. D., Ganat, Y. M., Kishinevsky, S., Bowman, R. L., Liu, B., Tu, E. Y., Mandal, P. K., Vera, E., Shim, J.-W., Kriks, S., et al. (2013) · Cell stem cell · doi:10.1016/j.stem.2013.11.006 · Cited by 777 · see citing works

Nurr1 is essential for the induction of the dopaminergic phenotype and the survival of ventral mesencephalic late dopaminergic precursor neurons

Cárdenas, O. S., Quintana-Hau, J. D. D., Le, W., Smidt, M. P., Cox, J. J., Mayo, F. J. D., Burbach, J. P. H., & Conneely, O. M. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.7.4013 · Cited by 744 · see citing works

The senescence-associated secretory phenotype induces cellular plasticity and tissue regeneration.

Ritschka, B., Storer, M., Mas, A., Heinzmann, F., Ortells, M. C., Morton, J. P., Sansom, O. J., Zender, L., & Keyes, W. M. (2017) · Genes &amp; Development · doi:10.1101/gad.290635.116 · Cited by 650 · see citing works

Postmitotic neurons develop a p21‐dependent senescence‐like phenotype driven by a DNA damage response

Jurk, D., Wang, C., Miwa, S., Maddick, M., Korolchuk, V., Tsolou, A., Gonos, E. S., Thrasivoulou, C., Jill Saffrey, M., Cameron, K., et al. (2012) · Aging Cell · doi:10.1111/j.1474-9726.2012.00870.x · Cited by 598 · see citing works

Directed Differentiation and Functional Maturation of Cortical Interneurons from Human Embryonic Stem Cells

Maroof, A. M., Keros, S., Tyson, J. A., Ying, S.-W., Ganat, Y. M., Merkle, F. T., Liu, B., Goulburn, A., Stanley, E. G., Elefanty, A. G., et al. (2013) · Cell Stem Cell · doi:10.1016/j.stem.2013.04.008 · Cited by 596 · see citing works

Accumulation of senescent cells in Mitotic tissue of aging primates

Jeyapalan, J. C., Ferreira, M., Sedivy, J. M., & Herbig, U. (2007) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2006.11.008 · Cited by 571 · see citing works

Target analysis by integration of transcriptome and ChIP-seq data with BETA

Wang, S., Sun, H., Ma, J., Zang, C., Wang, C., Wang, J., Tang, Q., Meyer, C. A., Zhang, Y., & Liu, X. S. (2013) · Nature Protocols · doi:10.1038/nprot.2013.150 · Cited by 544 · see citing works

Elevated Mitochondrial Bioenergetics and Axonal Arborization Size Are Key Contributors to the Vulnerability of Dopamine Neurons

Pacelli, C., Giguère, N., Bourque, M.-J., Lévesque, M., Slack, R. S., & Trudeau, L. (2015) · Current Biology · doi:10.1016/j.cub.2015.07.050 · Cited by 530 · see citing works

Cellular Senescence Is Induced by the Environmental Neurotoxin Paraquat and Contributes to Neuropathology Linked to Parkinson’s Disease

Chinta, S. J., Woods, G., Demaria, M., Rane, A., Zou, Y., McQuade, A., Rajagopalan, S., Limbad, C., Madden, D. T., Campisi, J., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2017.12.092 · Cited by 530 · cited 1× · see citing works

Cellular senescence in brain aging and neurodegenerative diseases: evidence and perspectives

Baker, D. J., & Petersen, R. C. (2018) · Journal of Clinical Investigation · doi:10.1172/jci95145 · Cited by 514 · see citing works

Alterations in lysosomal and proteasomal markers in Parkinson's disease: Relationship to alpha-synuclein inclusions

Chu, Y., Dodiya, H. B., Aebischer, P., Olanow, C. W., & Kordower, J. H. (2009) · Neurobiology of Disease · doi:10.1016/j.nbd.2009.05.023 · Cited by 420 · see citing works

On Cell Loss and Selective Vulnerability of Neuronal Populations in Parkinson's Disease

Giguère, N., Burke, S., & Trudeau, L. (2018) · Frontiers in Neurology · doi:10.3389/fneur.2018.00455 · Cited by 415 · see citing works

Is β-Galactosidase Staining a Marker of Senescence in Vitro and in Vivo?

Severino, J., Allen, R. G., Balin, S., Balin, A., & Cristofalo, V. J. (2000) · Experimental Cell Research · doi:10.1006/excr.2000.4875 · Cited by 370 · see citing works

Characterizing microglia activation: a spatial statistics approach to maximize information extraction

Davis, B. M., Salinas‐Navarro, M., Cordeiro, M. F., Moons, L., & Groef, L. D. (2017) · Scientific Reports · doi:10.1038/s41598-017-01747-8 · Cited by 343 · see citing works

Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor

Coppé, J.-P., Patil, C. K., Rodier, F., Sun, Y., Muñoz, D. P., Goldstein, J., Nelson, P. S., Desprez, P.-Y., & Campisi, J. (2008) · PLoS Biology · doi:10.1371/journal.pbio.0060301 · Cited by 302 · cited 1× · see citing works

Optogenetics enables functional analysis of human embryonic stem cell–derived grafts in a Parkinson's disease model

Steinbeck, J. A., Choi, S. J., Mrejeru, A., Ganat, Y. M., Deisseroth, K. A., Sulzer, D., Mosharov, E. V., & Studer, L. (2015) · Nature Biotechnology · doi:10.1038/nbt.3124 · Cited by 299 · see citing works

Abnormal Mitochondrial Morphology in Sporadic Parkinson's and Alzheimer's Disease Cybrid Cell Lines

Trimmer, P. A., Swerdlow, R. H., Parks, J. K., Keeney, P. M., Bennett, J. P., Miller, S. W., Davis, R. E., & Parker, W. D. (2000) · Experimental Neurology · doi:10.1006/exnr.2000.7333 · Cited by 296 · see citing works

Lysosomal signaling molecules regulate longevity in Caenorhabditis elegans

Folick, A., Oakley, H. D., Yu, Y., Armstrong, E. H., Kumari, M., Sanor, L., Moore, D. D., Ortlund, E. A., Zechner, R., & Wang, M. C. (2015) · Science · doi:10.1126/science.1258857 · Cited by 283 · see citing works

Combined small-molecule inhibition accelerates the derivation of functional cortical neurons from human pluripotent stem cells

Qi, Y., Zhang, X.-J., Renier, N., Wu, Z., Atkin, T., Sun, Z., Ozair, M. Z., Tchieu, J., Zimmer, B., Fattahi, F., et al. (2017) · Nature Biotechnology · doi:10.1038/nbt.3777 · Cited by 248 · see citing works

PTBP1-Mediated Alternative Splicing Regulates the Inflammatory Secretome and the Pro-tumorigenic Effects of Senescent Cells

Georgilis, A., Klotz, S., Hanley, C. J., Herranz, N., Weirich, B., Morancho, B., Leote, A. C., D'Artista, L., Gallage, S., Seehawer, M., et al. (2018) · Cancer Cell · doi:10.1016/j.ccell.2018.06.007 · Cited by 237 · see citing works

CDK inhibitors (p16/p19/p21) induce senescence and autophagy in cancer-associated fibroblasts, “fueling” tumor growth via paracrine interactions, without an increase in neo-angiogenesis

Capparelli, C., Chiavarina, B., Whitaker-Menezes, D., Pestell, T. G., Pestell, R. G., Hulit, J., Andò, S., Howell, A., Martinez-Outschoorn, U. E., Sotgia, F., et al. (2012) · Cell Cycle · doi:10.4161/cc.21884 · Cited by 221 · see citing works

Insulin-like growth factor binding proteins 4 and 7 released by senescent cells promote premature senescence in mesenchymal stem cells.

Severino, V, Alessio, N., Farina, A., Sandomenico, A., Cipollaro, M., Peluso, G., Galderisi, U., & Chambery, A. (2013) · Cell Death &amp; Disease · doi:10.1038/cddis.2013.445 · Cited by 214 · see citing works

Cellular Senescence in Postmitotic Cells: Beyond Growth Arrest

Sapieha, P., & Mallette, F. A. (2018) · Trends in Cell Biology · doi:10.1016/j.tcb.2018.03.003 · Cited by 193 · see citing works

Therapeutic interventions for aging: the case of cellular senescence

Soto-Gamez, A., & Demaria, M. (2017) · Drug Discovery Today · doi:10.1016/j.drudis.2017.01.004 · Cited by 192 · see citing works

Dysautonomia in Parkinsonism: a clinicopathological study.

Rajput, A. H., & Rozdilsky, B. (1976) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.39.11.1092 · Cited by 164 · see citing works

Cytoplasmic p21Cip1/WAF1 regulates neurite remodeling by inhibiting Rho-kinase activity

Tanaka, H., Yamashita, T., Asada, M., Mizutani, S., Yoshikawa, H., & Tohyama, M. (2002) · The Journal of Cell Biology · doi:10.1083/jcb.200202071 · Cited by 157 · see citing works

Is senescence-associated β-galactosidase a marker of neuronal senescence?

Piechota, M. J., Sunderland, P., Wysocka, A., Nalberczak‐Skóra, M., Śliwińska, M. A., Radwańska, K., & Sikora, E. (2016) · Oncotarget · doi:10.18632/oncotarget.12752 · Cited by 156 · see citing works

Dynamic regulation of midbrain dopamine neuron activity: intrinsic, synaptic, and plasticity mechanisms

Morikawa, H., & Paladini, C. A. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2011.08.023 · Cited by 150 · see citing works

Is there a role for placental senescence in the genesis of obstetric complications and fetal growth restriction?

Sultana, Z., Maiti, K., Dedman, L., & Smith, R. (2017) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2017.11.567 · Cited by 148 · see citing works

Parkinson’s disease genetics: identifying novel risk loci, providing causal insights and improving estimates of heritable riskPreprint

Nalls, M., Blauwendraat, C., Vallerga, C., et al. (2018) · bioRxiv · doi:10.1101/388165 · Cited by 145 · see citing works

Age Changes in Size and Number of Mitochondria of Human Hepatic Cells

Tauchi, H., & Sato, T. (1968) · Journal of Gerontology · doi:10.1093/geronj/23.4.454 · Cited by 143 · see citing works

Azithromycin and Roxithromycin define a new family of “senolytic” drugs that target senescent human fibroblasts

Ozsvari, B., Nuttall, J. R., Sotgia, F., & Lisanti, M. P. (2018) · Aging · doi:10.18632/aging.101633 · Cited by 138 · see citing works

Multi-omics enrichment analysis using the GeneTrail2 web service

Stöckel, D., Kehl, T., Trampert, P., Schneider, L., Backes, C., Ludwig, N., Gerasch, A., Kaufmann, M., Gessler, M., Graf, N. M., et al. (2016) · Bioinformatics · doi:10.1093/bioinformatics/btv770 · Cited by 135 · see citing works

SnapShot: Cellular Senescence Pathways

Martínez‐Zamudio, R. I., Robinson, L. J., Roux, P., & Bischof, O. (2017) · Cell · doi:10.1016/j.cell.2017.07.049 · Cited by 129 · see citing works

Identification of neurodegenerative factors using translatome–regulatory network analysis

Brichta, L., Shin, W., Jackson-Lewis, V., Blesa, J., Yap, E.-L., Walker, Z., Zhang, J., Roussarie, J.-P., Alvarez, M. J., Califano, A., et al. (2015) · Nature Neuroscience · doi:10.1038/nn.4070 · Cited by 118 · see citing works

Are there roles for brain cell senescence in aging and neurodegenerative disorders?

Tan, F. C. C., Hutchison, E. R., Eitan, E., & Mattson, M. P. (2014) · Biogerontology · doi:10.1007/s10522-014-9532-1 · Cited by 116 · see citing works

Changes in endolysosomal enzyme activities in cerebrospinal fluid of patients with Parkinson's disease

van Dijk, K. D., Persichetti, E., Chiasserini, D., Eusebi, P., Beccari, T., Calabresi, P., Berendse, H. W., Parnetti, L., & van de Berg, W. D. J. (2013) · Movement Disorders · doi:10.1002/mds.25495 · Cited by 101 · see citing works

A Postsynaptic AMPK→p21-Activated Kinase Pathway Drives Fasting-Induced Synaptic Plasticity in AgRP Neurons

Kong, D., Dagon, Y., Campbell, J. N., Guo, Y., Yang, Z., Yi, X., Aryal, P., Wellenstein, K., Kahn, B. B., Sabatini, B. L., et al. (2016) · Neuron · doi:10.1016/j.neuron.2016.05.025 · Cited by 90 · see citing works

The genetics of Parkinson's disease

Mullin, S., & Schapira, A. H. V. (2015) · British Medical Bulletin · doi:10.1093/bmb/ldv022 · Cited by 78 · see citing works

Bcl-xL Is Essential for the Survival and Function of Differentiated Neurons in the Cortex That Control Complex Behaviors

Nakamura, A., Swahari, V., Plestant, C., Smith, I. T., McCoy, E. S., Smith, S. L., Moy, S. S., Anton, E. S., & Deshmukh, M. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.4247-15.2016 · Cited by 67 · see citing works

MicroRNA-191 triggers keratinocytes senescence by SATB1 and CDK6 downregulation

Lena, A. M., Mancini, M., Cervo, P. R. D. V., Saintigny, G., Mahé, C., Melino, G., & Candi, E. (2012) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2012.05.153 · Cited by 63 · see citing works

A novel p21 attenuator which is structurally related to sorafenib

Wettersten, H. I., Hwang, S. H., Li, C., Shiu, E. Y. C., Wecksler, A. T., Hammock, B. D., & Weiss, R. H. (2013) · Cancer Biology & Therapy · doi:10.4161/cbt.23374 · Cited by 59 · see citing works

Dopamine and α-synuclein dysfunction in Smad3 null mice

Tapia‐González, S., Giráldez‐Pérez, R. M., Cuartero, M. I., Casarejos, M. J., Mena, M. A., Wang, X., & Sánchez‐Capelo, A. (2011) · Molecular Neurodegeneration · doi:10.1186/1750-1326-6-72 · Cited by 57 · see citing works

No global loss of neocortical neurons in parkinson's disease: A quantitative stereological study

Pedersen, K. M., Marner, L., Pakkenberg, H., & Pakkenberg, B. (2004) · Movement Disorders · doi:10.1002/mds.20289 · Cited by 55 · see citing works

Long-term Neuroglial Cocultures as a Brain Aging Model: Hallmarks of Senescence, MicroRNA Expression Profiles, and Comparison With In Vivo Models

Bigagli, E., Luceri, C., Scartabelli, T., Dolara, P., Casamenti, F., Pellegrini-Giampietro, D. E., & Giovannelli, L. (2015) · The Journals of Gerontology Series A · doi:10.1093/gerona/glu231 · Cited by 54 · see citing works

FoxO1 in dopaminergic neurons regulates energy homeostasis and targets tyrosine hydroxylase

Doan, K. V., Kinyua, A. W., Yang, D. J., Ko, C. M., Moh, S. H., Shong, K. E., Kim, H., Park, S.-K., Kim, D. H., Kim, I., et al. (2016) · Nature Communications · doi:10.1038/ncomms12733 · Cited by 54 · see citing works

Cultured cerebellar granule neurons as an in vitro aging model: Topoisomerase IIβ as an additional biomarker in DNA repair and aging

Bhanu, M. U., Mandraju, R. K., Bhaskar, C., & Kondapi, A. K. (2010) · Toxicology in Vitro · doi:10.1016/j.tiv.2010.08.003 · Cited by 50 · see citing works

Transcriptional responses to loss or gain of function of the leucine-rich repeat kinase 2 (LRRK2) gene uncover biological processes modulated by LRRK2 activity

Nikonova, E. V., Xiong, Y., Tanis, K. Q., Dawson, V. L., Vogel, R. L., Finney, E. M., Stone, D. J., Reynolds, I. J., Kern, J. T., & Dawson, T. M. (2011) · Human Molecular Genetics · doi:10.1093/hmg/ddr451 · Cited by 42 · see citing works

Alterations of p11 in brain tissue and peripheral blood leukocytes in Parkinson’s disease

Green, H., Zhang, X., Tiklová, K., Volakakis, N., Brodin, L., Berg, L., Greengard, P., Perlmann, T., & Svenningsson, P. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1621218114 · Cited by 39 · see citing works

SATB1 overexpression promotes malignant T-cell proliferation in cutaneous CD30+ lymphoproliferative disease by repressing p21

Wang, Y., Gu, X., Zhang, G., Wang, L., Wang, T., Zhao, Y., Zhang, X., Zhou, Y., Kadin, M. E., & Tu, P. (2014) · Blood · doi:10.1182/blood-2013-10-534693 · Cited by 35 · see citing works

Forkhead Box O1 (FOXO1) Protein, but Not p53, Contributes to Robust Induction of p21 Expression in Fasted Mice

Tinkum, K. L., White, L. S., Marpegán, L., Herzog, E. D., Piwnica-Worms, D. R., & Piwnica-Worms, H. M. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.494328 · Cited by 34 · see citing works

Parkin Knockout Inhibits Neuronal Development via Regulation of Proteasomal Degradation of p21

Park, M. H., Lee, H., Lee, H. L., Son, D. J., Ju, J. H., Hyun, B. K., Jung, S. H., Song, J.-K., Lee, D., Hwang, C. J., et al. (2017) · Theranostics · doi:10.7150/thno.19824 · Cited by 32 · see citing works

Developing senescence to remodel the embryo

Storer, M. A., & Keyes, W. M. (2014) · Communicative & Integrative Biology · doi:10.4161/cib.29098 · Cited by 12 · see citing works

A Natural Model of Mouse Cardiac Myocyte Senescence

Wang, Z., Rong, X., Luo, B., Qin, S., Lu, L., Zhang, X., Sun, Y., Hu, Q., & Zhang, C. (2016) · Journal of Cardiovascular Translational Research · doi:10.1007/s12265-016-9711-3 · Cited by 12 · see citing works

Telomere dysfunction in ageing and age-related diseases

Rossiello, F., Jurk, D., Passos, J. F., & d’Adda di Fagagna, F. (2022) · Nature Cell Biology · doi:10.1038/s41556-022-00842-x · Cited by 754 · see citing works

The flavonoid procyanidin C1 has senotherapeutic activity and increases lifespan in mice

Xu, Q., Fu, Q., Li, Z., Liu, H., Wang, Y., Lin, X., He, R., Zhang, X., Ju, Z., Campisi, J., et al. (2021) · Nature Metabolism · doi:10.1038/s42255-021-00491-8 · Cited by 341 · see citing works

Senolytic therapy in mild Alzheimer's disease: a phase 1 feasibility trial

Gonzales, M. M., Garbarino, V. R., Kautz, T. F., Palavicini, J. P., Lopez-Cruzan, M., Dehkordi, S. K., Mathews, J. J., Zare, H., Xu, P., Zhang, B., et al. (2023) · Nature Medicine · doi:10.1038/s41591-023-02543-w · Cited by 310 · see citing works

A Senescence-Centric View of Aging: Implications for Longevity and Disease

Borghesan, M., Hoogaars, W. M. H., Varela-Eirin, M., Talma, N., & Demaria, M. (2020) · Trends in Cell Biology · doi:10.1016/j.tcb.2020.07.002 · Cited by 267 · see citing works

Cellular senescence and Alzheimer disease: the egg and the chicken scenario

Saez-Atienzar, S., & Masliah, E. (2020) · Nature Reviews Neuroscience · doi:10.1038/s41583-020-0325-z · Cited by 257 · see citing works

Age-dependent instability of mature neuronal fate in induced neurons from Alzheimer’s patients

Mertens, J., Herdy, J. R., Traxler, L., Schafer, S. T., Schlachetzki, J. C. M., Böhnke, L., Reid, D. A., Lee, H., Zangwill, D., Fernandes, D. P., et al. (2021) · Cell Stem Cell · doi:10.1016/j.stem.2021.04.004 · Cited by 240 · see citing works

Cellular senescence at the crossroads of inflammation and Alzheimer's disease

Guerrero, A., De Strooper, B., & Arancibia-Cárcamo, I. L. (2021) · Trends in Neurosciences · doi:10.1016/j.tins.2021.06.007 · Cited by 236 · see citing works

Increased post-mitotic senescence in aged human neurons is a pathological feature of Alzheimer’s disease

Herdy, J. R., Traxler, L., Agarwal, R. K., Karbacher, L., Schlachetzki, J. C. M., Boehnke, L., Zangwill, D., Galasko, D., Glass, C. K., Mertens, J., et al. (2022) · Cell Stem Cell · doi:10.1016/j.stem.2022.11.010 · Cited by 208 · see citing works

Profiling senescent cells in human brains reveals neurons with CDKN2D/p19 and tau neuropathology

Dehkordi, S. K., Walker, J., Sah, E., Bennett, E., Atrian, F., Frost, B., Woost, B., Bennett, R. E., Orr, T. C., Zhou, Y., et al. (2021) · Nature Aging · doi:10.1038/s43587-021-00142-3 · Cited by 169 · see citing works

The role of p21 in cellular senescence and aging-related diseases

Yan, J., Chen, S., Yi, Z., Zhao, R., Zhu, J., Shuwen, D., & Wu, J. (2024) · Molecules and Cells · doi:10.1016/j.mocell.2024.100113 · Cited by 181 · see citing works

Biomarkers used in Alzheimer’s disease diagnosis, treatment, and prevention

Mahaman, Y. A. R., Embaye, K. S., Huang, F., Li, L., Zhu, F., Wang, J.-Z., Liu, R., Feng, J., & Wang, X. (2022) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101544 · Cited by 149 · see citing works

Spatiotemporal transcriptomic changes of human ovarian aging and the regulatory role of FOXP1

Wu, M., Tang, W., Chen, Y., Xue, L., Dai, J. Y., Li, Y., Zhu, X., Wu, C., Xiong, J., Zhang, J., et al. (2024) · Nature Aging · doi:10.1038/s43587-024-00607-1 · Cited by 151 · see citing works

Cellular senescence in brain aging and neurodegeneration

dos Santos, L. M., Trombetta-Lima, M., Eggen, B. J. L., & Demaria, M. (2023) · Ageing Research Reviews · doi:10.1016/j.arr.2023.102141 · Cited by 158 · see citing works

Single-cell senescence identification reveals senescence heterogeneity, trajectory, and modulators

Tao, W., Yu, Z., & Han, J.-D. J. (2024) · Cell Metabolism · doi:10.1016/j.cmet.2024.03.009 · Cited by 147 · see citing works

Autophagy lysosomal pathway dysfunction in Parkinson's disease; evidence from human genetics

Senkevich, K. A., & Gan‐Or, Z. (2019) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2019.11.015 · Cited by 135 · see citing works

Cortical neurons develop a senescence-like phenotype promoted by dysfunctional autophagy

Moreno-Blas, D., Gorostieta-Salas, E., Pommer-Alba, A., Muciño-Hernández, G., Gerónimo-Olvera, C., Maciel-Barón, L. A., Konigsberg, M., Massieu, L., & Castro-Obregón, S. (2019) · Aging · doi:10.18632/aging.102181 · Cited by 128 · see citing works

The role of cellular senescence in neurodegenerative diseases

Wang, Y., Kuča, K., Li, Y., Nepovimová, E., Heger, Z., Valko, M., Adam, V., Wu, Q., & Jomová, K. (2024) · Archives of Toxicology · doi:10.1007/s00204-024-03768-5 · Cited by 118 · see citing works

SARS-CoV-2 infection causes dopaminergic neuron senescence

Chen, S., Kim, T. W., Yang, L., Kim, T., Nair, M., Harschnitz, O., Wang, P., Zhu, J., Koo, S. Y., Tang, X., et al. (2024) · Cell stem cell · doi:10.1016/j.stem.2023.12.012 · Cited by 124 · see citing works

Pluripotent Stem Cell Therapies for Parkinson Disease: Present Challenges and Future Opportunities

Kim, T. W., Koo, S. Y., & Studer, L. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00729 · Cited by 98 · see citing works

Cell senescence induced by toxic interaction between α-synuclein and iron precedes nigral dopaminergic neuron loss in a mouse model of Parkinson’s disease

Shen, Q., Jv, X.-H., Ma, X., Li, C., Liu, L., Jia, W., Qu, L., Chen, L., & Xie, J. (2023) · Acta Pharmacologica Sinica · doi:10.1038/s41401-023-01153-z · Cited by 88 · see citing works

Thioredoxin (Trx): A redox target and modulator of cellular senescence and aging-related diseases

Yang, B., Lin, Y., Huang, Y., Shen, Y.-Q., & Chen, Q. (2024) · Redox Biology · doi:10.1016/j.redox.2024.103032 · Cited by 90 · see citing works

Alpha-Synuclein Preformed Fibrils Induce Cellular Senescence in Parkinson’s Disease Models

Verma, D., Seo, B. A., Ghosh, A., Ma, S.-X., Hernandez-Quijada, K., Andersen, J. K., Ko, H. S., & Kim, Y. (2021) · Cells · doi:10.3390/cells10071694 · Cited by 85 · see citing works

circHIPK3 prevents cardiac senescence by acting as a scaffold to recruit ubiquitin ligase to degrade HuR

Ding, F., Lu, L., Wu, C., Pan, X., Liu, B., Zhang, Y., Wang, Y., Wu, W., Yan, B., Zhang, Y., et al. (2022) · Theranostics · doi:10.7150/thno.77630 · Cited by 81 · see citing works

Cellular senescence in the aging brain: A promising target for neurodegenerative diseases

Sahu, M. R., Rani, L., Subba, R., & Mondal, A. C. (2022) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2022.111675 · Cited by 75 · see citing works

Targeting senescent cells to attenuate cardiovascular disease progression

Song, P., Zhao, Q., & Zou, M. (2020) · Ageing Research Reviews · doi:10.1016/j.arr.2020.101072 · Cited by 76 · see citing works

Cell senescence in neuropathology: A focus on neurodegeneration and tumours

Carreno, G., Guiho, R., & Martı́nez-Barberá, J. P. (2020) · Neuropathology and Applied Neurobiology · doi:10.1111/nan.12689 · Cited by 77 · see citing works

TNF-NF-κB-p53 axis restricts in vivo survival of hPSC-derived dopamine neurons

Kim, T. W., Koo, S. Y., Rießland, M., Chaudhry, F. F., Kolisnyk, B., Cho, H., Russo, M. V., Saurat, N. G., Mehta, S., Garippa, R. J., et al. (2024) · Cell · doi:10.1016/j.cell.2024.05.030 · Cited by 79 · see citing works

The impact of neuroinflammation on neuronal integrity

Tastan, B., & Heneka, M. T. (2024) · Immunological Reviews · doi:10.1111/imr.13419 · Cited by 77 · see citing works

Neuronal senescence may drive brain aging

Herdy, J. R., Mertens, J., & Gage, F. H. (2024) · Science · doi:10.1126/science.adi3450 · Cited by 74 · see citing works

Advanced human iPSC-based preclinical model for Parkinson’s disease with optogenetic alpha-synuclein aggregation

Kim, M. S., Ra, E. A., Kweon, S. H., Seo, B. A., Ko, H. S., Oh, Y., & Lee, G. (2023) · Cell stem cell · doi:10.1016/j.stem.2023.05.015 · Cited by 71 · see citing works

Therapeutic targeting of senescent cells in the CNS

Rießland, M., Ximerakis, M., Jarjour, A. A., Zhang, B., & Orr, M. E. (2024) · Nature Reviews Drug Discovery · doi:10.1038/s41573-024-01033-z · Cited by 74 · see citing works

Ageing in the brain: mechanisms and rejuvenating strategies

Gaspar-Silva, F., Trigo, D., & Magalhães, J. (2023) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-023-04832-6 · Cited by 75 · see citing works

Senescence: A DNA damage response and its role in aging and Neurodegenerative Diseases

Shreeya, T., Ansari, M. S., Kumar, P., Saifi, M., Shati, A. A., Alfaifi, M. Y., & Elbehairi, S. E. I. (2024) · Frontiers in Aging · doi:10.3389/fragi.2023.1292053 · Cited by 67 · see citing works

Generation of caudal-type serotonin neurons and hindbrain-fate organoids from hPSCs

Valiulahi, P., Vidyawan, V., Puspita, L., Oh, Y., Juwono, V. B., Sittipo, P., Friedlander, G., Yahalomi, D., Sohn, J.-W., Lee, Y., et al. (2021) · Stem Cell Reports · doi:10.1016/j.stemcr.2021.06.006 · Cited by 55 · see citing works

Targeting senescent retinal pigment epithelial cells facilitates retinal regeneration in mouse models of age-related macular degeneration

Chae, J., Jang, H., Son, C., Park, C., Choi, H., Jin, S., Lee, H., Lee, H., Ryu, J., Kim, N., et al. (2021) · GeroScience · doi:10.1007/s11357-021-00457-4 · Cited by 63 · see citing works

Genome-wide CRISPR screen identifies neddylation as a regulator of neuronal aging and AD neurodegeneration

Saurat, N. G., Minotti, A. P., Rahman, M. T., Sikder, T., Zhang, C., Cornacchia, D., Jungverdorben, J., Ciceri, G., Betel, D., & Studer, L. (2024) · Cell stem cell · doi:10.1016/j.stem.2024.06.001 · Cited by 58 · see citing works

Metabolism navigates neural cell fate in development, aging and neurodegeneration

Traxler, L., Lagerwall, J., Eichhorner, S., Stefanoni, D., D’Alessandro, A., & Mertens, J. (2021) · Disease Models & Mechanisms · doi:10.1242/dmm.048993 · Cited by 57 · see citing works

The Cellular Senescence Stress Response in Post-Mitotic Brain Cells: Cell Survival at the Expense of Tissue Degeneration

Sah, E., Krishnamurthy, S., Ahmidouch, M. Y., Gillispie, G. J., Milligan, C., & Orr, M. E. (2021) · Life · doi:10.3390/life11030229 · Cited by 54 · see citing works

Translating the Biology of Aging into New Therapeutics for Alzheimer's Disease: Senolytics

Rießland, M., & Orr, M. E. (2023) · The Journal of Prevention of Alzheimer s Disease · doi:10.14283/jpad.2023.104 · Cited by 55 · see citing works

Neuronal Senescence in the Aged Brain

Chou, S.-M., Yen, Y., Yuan, F., Zhang, S., & Chong, C. (2023) · Aging and Disease · doi:10.14336/ad.2023.0214 · Cited by 54 · see citing works

Photoinduced elimination of senescent microglia cells in vivo by chiral gold nanoparticles

Xu, Z., Qu, A., Zhang, H., Wang, W., Hao, C., Lu, M., Shi, B., Xu, L., Sun, M., Xu, C., et al. (2022) · Chemical Science · doi:10.1039/d2sc01662a · Cited by 49 · see citing works

Diverse Roles of Cellular Senescence in Skeletal Muscle Inflammation, Regeneration, and Therapeutics

Saito, Y., & Chikenji, T. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.739510 · Cited by 48 · see citing works

Pharmacological Targeting of Senescence with Senolytics as a New Therapeutic Strategy for Neurodegeneration

Richardson, M., & Richardson, D. R. (2023) · Molecular Pharmacology · doi:10.1124/molpharm.123.000803 · Cited by 48 · see citing works

Alpha-synuclein pathology is associated with astrocyte senescence in a midbrain organoid model of familial Parkinson's disease

Muwanigwa, M. N., Modamio, J., Antony, P. M. A., Gomez‐Giro, G., Krüger, R., Bolognin, S., & Schwamborn, J. C. (2024) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2024.103919 · Cited by 50 · see citing works

Neuronal cell cycle reentry events in the aging brain are more prevalent in neurodegeneration and lead to cellular senescence

Wu, D., Sun, J. K., & Chow, H. (2024) · PLoS Biology · doi:10.1371/journal.pbio.3002559 · Cited by 48 · see citing works

Activation of HERV-K(HML-2) disrupts cortical patterning and neuronal differentiation by increasing NTRK3

Nair, V. P., Liu, H., Ciceri, G., Jungverdorben, J., Frishman, G., Tchieu, J. H., Cederquist, G., Rothenaigner, I., Schorpp, K., Klepper, L., et al. (2021) · Cell stem cell · doi:10.1016/j.stem.2021.04.009 · Cited by 47 · see citing works

Aging, cellular senescence and Parkinson's disease

Ma, Y., Erb, M. L., & Moore, D. J. (2025) · Journal of Parkinson s Disease · doi:10.1177/1877718x251316552 · Cited by 45 · see citing works

Cell Cycle and Senescence Regulation by Podocyte Histone Deacetylase 1 and 2

Rangel, P. X. M., Cross, E., Liu, C., Pedigo, C. E., Tian, X., Gutiérrez-Calabrés, E., Nagata, S., Priyadarshini, A., Lerner, G., Bunda, P., et al. (2022) · Journal of the American Society of Nephrology · doi:10.1681/asn.2022050598 · Cited by 46 · see citing works

Molecular heterogeneity in the substantia nigra: A roadmap for understanding PD motor pathophysiology

Gaertner, Z. A., Azcorra, M., Dombeck, D. A., & Awatramani, R. B. (2022) · Neurobiology of Disease · doi:10.1016/j.nbd.2022.105925 · Cited by 44 · see citing works

DNA Damage Response-Associated Cell Cycle Re-Entry and Neuronal Senescence in Brain Aging and Alzheimer’s Disease

Wong, G. C., & Chow, H. (2022) · Journal of Alzheimer s Disease · doi:10.3233/jad-220203 · Cited by 40 · see citing works

Unraveling the Genetic Landscape of Neurological Disorders: Insights into Pathogenesis, Techniques for Variant Identification, and Therapeutic Approaches

Firdaus, Z., & Li, X. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25042320 · Cited by 43 · see citing works

Focus on senescence: Clinical significance and practical applications

Boccardi, V., Orr, M. E., Polidori, M. C., Ruggiero, C., & Mecocci, P. (2024) · Journal of Internal Medicine · doi:10.1111/joim.13775 · Cited by 40 · see citing works

Age-Related Midbrain Inflammation and Senescence in Parkinson’s Disease

Russo, T., & Rießland, M. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.917797 · Cited by 39 · see citing works

DNA Damage-Mediated Neurotoxicity in Parkinson’s Disease

Wang, Z., Li, Y., Pu, J., & Zhang, B. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24076313 · Cited by 39 · see citing works

GDF11 slows excitatory neuronal senescence and brain ageing by repressing p21

Wang, D.-X., Dong, Z.-J., Deng, S., Tian, Y.-M., Xiao, Y., Li, X., Ma, X.-R., Li, L., Li, P., Chang, H., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-43292-1 · Cited by 38 · see citing works

Glial senescence enhances α-synuclein pathology owing to its insufficient clearance caused by autophagy dysfunction

Hong, B., Ohtake, Y., Itokazu, T., & Yamashita, T. (2024) · Cell Death Discovery · doi:10.1038/s41420-024-01816-8 · Cited by 38 · see citing works

Molecular Mechanisms of Cellular Senescence in Neurodegenerative Diseases

Lee, H.-J., Yoon, Y.-S., & Lee, S.-J. (2023) · Journal of Molecular Biology · doi:10.1016/j.jmb.2023.168114 · Cited by 36 · see citing works

Radiation induces primary osteocyte senescence phenotype and affects osteoclastogenesis in vitro

Wang, Y., Xu, L., Wang, J., Bai, J., Zhai, J., & Zhu, G. (2021) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2021.4909 · Cited by 39 · see citing works

Human endogenous retrovirus onco-exaptation counters cancer cell senescence through calbindin

Attig, J., Pape, J., Doglio, L. E., Kazachenka, A., Ottina, E., Young, G. R., Enfield, K. S. S., Aramburu, I. V., Ng, K. W., Faulkner, N., et al. (2023) · Journal of Clinical Investigation · doi:10.1172/jci164397 · Cited by 38 · see citing works

Lessons from inducible pluripotent stem cell models on neuronal senescence in aging and neurodegeneration

de Luzy, I. R., Lee, M. K., Mobley, W. C., & Studer, L. (2024) · Nature Aging · doi:10.1038/s43587-024-00586-3 · Cited by 36 · see citing works

Cellular senescence and neurodegeneration

Holloway, K., Neherin, K., Dam, K. U., & Zhang, H. (2023) · Human Genetics · doi:10.1007/s00439-023-02565-x · Cited by 40 · see citing works

Neural cell state shifts and fate loss in ageing and age-related diseases

Traxler, L., Lucciola, R., Herdy, J. R., Jones, J. R., Mertens, J., & Gage, F. H. (2023) · Nature Reviews Neurology · doi:10.1038/s41582-023-00815-0 · Cited by 34 · see citing works

LRRK2 Kinase Inhibitor Rejuvenates Oxidative Stress‐Induced Cellular Senescence in Neuronal Cells

Ho, D. H., Nam, D., Seo, M. K., Park, S. W., Seol, W., & Son, I. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/9969842 · Cited by 34 · see citing works

Robust derivation of transplantable dopamine neurons from human pluripotent stem cells by timed retinoic acid delivery

Alekseenko, Z., Dias, J. M. M., Adler, A. F., Kozhevnikova, M. N., van Lunteren, J. A., Nolbrant, S., Jeggari, A., Vasylovska, S., Yoshitake, T., Kehr, J., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-30777-8 · Cited by 38 · see citing works

Pharmacological inhibition of nSMase2 reduces brain exosome release and α-synuclein pathology in a Parkinson’s disease model

Zhu, C., Bilousova, T. V., Focht, S., Jun, M., Elias, C. J., Melnik, M., Chandra, S., Campagna, J. J., Cohn, W., Hatami, A., et al. (2021) · Molecular Brain · doi:10.1186/s13041-021-00776-9 · Cited by 33 · see citing works

Alzheimer’s Amyloid-β Accelerates Cell Senescence and Suppresses SIRT1 in Human Neural Stem Cells

Li, R., Li, Y., Zuo, H., Pei, G., Huang, S., & Hou, Y. (2024) · Biomolecules · doi:10.3390/biom14020189 · Cited by 32 · see citing works

Neuroglial Senescence, α-Synucleinopathy, and the Therapeutic Potential of Senolytics in Parkinson’s Disease

Miller, S., Campbell, C. E., Jimenez-Corea, H. A., Wu, G., & Logan, R. A. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.824191 · Cited by 32 · see citing works

Cellular senescence in glioma

Chojak, R., Fares, J., Petrosyan, E., & Lesniak, M. S. (2023) · Journal of Neuro-Oncology · doi:10.1007/s11060-023-04387-3 · Cited by 30 · see citing works

The SATB1‐MIR22‐GBA axis mediates glucocerebroside accumulation inducing a cellular senescence‐like phenotype in dopaminergic neurons

Russo, T., Kolisnyk, B., Aswathy, B. S., Kim, T. W., Martin, J., Plessis‐Belair, J., Ni, J., Pearson, J. A., Park, E. J., Sher, R. B., et al. (2024) · Aging Cell · doi:10.1111/acel.14077 · Cited by 29 · see citing works

Senescent cells as a target for anti-aging interventions: From senolytics to immune therapies

Fu, T., & Zhou, Z. (2025) · Journal of Translational Internal Medicine · doi:10.1515/jtim-2025-0005 · Cited by 33 · see citing works

Nano-Based Theranostic Tools for the Detection and Elimination of Senescent Cells

Adamczyk‐Grochala, J., & Lewińska, A. (2020) · Cells · doi:10.3390/cells9122659 · Cited by 31 · see citing works

Evidence of the Cellular Senescence Stress Response in Mitotically Active Brain Cells—Implications for Cancer and Neurodegeneration

Gillispie, G. J., Sah, E., Krishnamurthy, S., Ahmidouch, M. Y., Zhang, B., & Orr, M. E. (2021) · Life · doi:10.3390/life11020153 · Cited by 32 · see citing works

Accumulation of Senescent Neural Cells in Murine Lupus With Depression-Like Behavior

Saito, Y., Miyajima, M., Yamamoto, S., Sato, T., Miura, N., Fujimiya, M., & Chikenji, T. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.692321 · Cited by 31 · see citing works

SARS-CoV-2 Infection Causes Dopaminergic Neuron SenescencePreprint

Chen, S., Han, Y., Yang, L., Kim, T., Nair, M. S., Harschnitz, O., Wang, P., Zhu, J., Koo, S. Y., Tang, X., et al. (2021) · Research Square · doi:10.21203/rs.3.rs-513461/v1 · Cited by 31 · see citing works

p53-mediated ferroptosis is required for 1-methyl-4-phenylpyridinium-induced senescence of PC12 cells

Li, S., Wang, M., Wang, Y., Guo, Y., Tao, X., Wang, X., Cao, Y., Tian, S., & Li, Q. (2021) · Toxicology in Vitro · doi:10.1016/j.tiv.2021.105146 · Cited by 30 · see citing works

Rack1 is essential for corticogenesis by preventing p21-dependent senescence in neural stem cells

Zhu, Q., Chen, L., Li, Y., Huang, M.-H., Shao, J., Li, S., Cheng, J., Yang, H., Wu, Y., Zhang, J., et al. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.109639 · Cited by 27 · see citing works

Restoration of Adult Neurogenesis by Intranasal Administration of Gangliosides GD3 and GM1 in The Olfactory Bulb of A53T Alpha-Synuclein-Expressing Parkinson’s-Disease Model Mice

Fuchigami, T., Itokazu, Y., Morgan, J. C., & Yu, R. K. (2023) · Molecular Neurobiology · doi:10.1007/s12035-023-03282-2 · Cited by 26 · see citing works

Senescent brain cell types in Alzheimer's disease: Pathological mechanisms and therapeutic opportunities

Hudson, H. R., Sun, X., & Orr, M. E. (2025) · Neurotherapeutics · doi:10.1016/j.neurot.2024.e00519 · Cited by 26 · see citing works

Genome-wide analyses identify NEAT1 as genetic modifier of age at onset of amyotrophic lateral sclerosis

Li, C., Wei, Q., Hou, Y., Lin, J., Ou, R., Zhang, L., Jiang, Q., Xiao, Y., Liu, K., Chen, X., et al. (2023) · Molecular Neurodegeneration · doi:10.1186/s13024-023-00669-6 · Cited by 26 · see citing works

Lipid accumulation drives cellular senescence in dopaminergic neurons

Russo, T., & Rießland, M. (2024) · Aging · doi:10.18632/aging.206030 · Cited by 23 · see citing works

The role of cardiomyocyte senescence in cardiovascular diseases: a molecular biology update.

He, S., Yan, L., Yuan, C., Li, W., Wu, T., Chen, S., Li, N., Wu, M., & Jiang, J. (2024) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2024.176961 · Cited by 19 · see citing works

Cocaine-Induced Changes in Sperm Cdkn1a Methylation Are Associated with Cocaine Resistance in Male Offspring

Swinford-Jackson, S. E., Fant, B., Wimmer, M. E., Chan, D., Knouse, M. C., Sarmiento, M., Thomas, A. S., Huffman, P. J., Mankame, S., Worobey, S. J., et al. (2022) · Journal of Neuroscience · doi:10.1523/jneurosci.3172-20.2022 · Cited by 23 · see citing works

Structure, Function, and Molecular Landscapes of the Aging Retina

Zhu, J. D., Tarachand, S. P., Abdulwahab, Q., & Samuel, M. A. (2023) · Annual Review of Vision Science · doi:10.1146/annurev-vision-112122-020950 · Cited by 23 · see citing works

Cell-based regenerative and rejuvenation strategies for treating neurodegenerative diseases

Deng, S., Xie, H., & Xie, B. (2025) · Stem Cell Research & Therapy · doi:10.1186/s13287-025-04285-7 · Cited by 23 · see citing works

Obesity-induced neuronal senescence: Unraveling the pathophysiological links

Ghosh, P., Fontanella, R. A., Scisciola, L., Taktaz, F., Pesapane, A., Basilicata, M. G., Tortorella, G., Matacchione, G., Capuano, A., Vietri, M. T., et al. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102533 · Cited by 21 · see citing works

Defining and characterizing neuronal senescence, ‘neurescence’, as GX arrested cells

Hudson, H. R., Rießland, M., & Orr, M. E. (2024) · Trends in Neurosciences · doi:10.1016/j.tins.2024.09.006 · Cited by 20 · see citing works

Cellular senescence: A novel therapeutic target for central nervous system diseases

Lei, S.-Y., Qu, Y., Yang, Y.-Q., Liu, J., Zhang, Y.-F., Zhou, S., He, Q., Jin, H., Yang, Y., & Guo, Z. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.117311 · Cited by 19 · see citing works

Current State-of-the-Art and Unresolved Problems in Using Human Induced Pluripotent Stem Cell-Derived Dopamine Neurons for Parkinson’s Disease Drug Development

Antonov, S. A., & Novosadova, E. V. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22073381 · Cited by 19 · see citing works

Role of Satb1 and Satb2 Transcription Factors in the Glutamate Receptors Expression and Ca2+ Signaling in the Cortical Neurons In Vitro

Turovsky, E. A., Turovskaya, M. V., Fedotova, E. I., Babaev, A. A., Tarabykin, V. S., & Varlamova, E. G. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22115968 · Cited by 19 · see citing works

Multimodal single-cell analyses reveal molecular markers of neuronal senescence in human drug-resistant epilepsy

Ge, Q., Yang, J., Huang, F., Dai, X., Chen, C., Guo, J., Wang, M., Zhu, M., Shao, Y., Xia, Y., et al. (2025) · Journal of Clinical Investigation · doi:10.1172/jci188942 · Cited by 21 · see citing works

Perturbed DNA methylation by Gadd45b induces chromatin disorganization, DNA strand breaks and dopaminergic neuron death

Ravel‐Godreuil, C., Massiani-Beaudoin, O., Mailly, P., Prochiantz, A., Joshi, R. L., & Fuchs, J. (2021) · iScience · doi:10.1016/j.isci.2021.102756 · Cited by 18 · see citing works

Advanced Materials to Enhance Central Nervous System Tissue Modeling and Cell Therapy

Muckom, R. J., Sampayo, R. G., Johnson, H. J., & Schaffer, D. V. (2020) · Advanced Functional Materials · doi:10.1002/adfm.202002931 · Cited by 16 · see citing works

A hypothesis explaining Alzheimer's disease, Parkinson's disease, and dementia with Lewy bodies overlap

Lau, V. Z., Awogbindin, I. O., Frenkel, D., Whitehead, S. N., & Tremblay, M. (2025) · Alzheimer s & Dementia · doi:10.1002/alz.70363 · Cited by 15 · see citing works

Mechanical stimulation induced osteogenic differentiation of BMSCs through TWIST/E2A/p21 axis

Guo, Q., Liu, Y., Sun, R., Yang, F., Qiao, P., Zhang, R., Ling, S., Lingling, E., & Liu, H. (2020) · Bioscience Reports · doi:10.1042/bsr20193876 · Cited by 15 · see citing works

Cellular Senescence in Renal and Urinary Tract Disorders

Santin, Y., Lluel, P., Rischmann, P., Gamé, X., Mialet‐Perez, J., & Parini, A. (2020) · Cells · doi:10.3390/cells9112420 · Cited by 15 · see citing works

Nuclear alpha-synuclein accelerates cell senescence and neurodegeneration

Du, T., Li, G., Zong, Q., Luo, H., Pan, Y., & Ma, K. (2024) · Immunity & Ageing · doi:10.1186/s12979-024-00429-0 · Cited by 14 · see citing works

Enhanced neuroimaging genetics using multi-view non-negative matrix factorization with sparsity and prior knowledge

Won, J. H., Youn, J., & Park, H. (2022) · Medical Image Analysis · doi:10.1016/j.media.2022.102378 · Cited by 13 · see citing works

Effects of Dopamine on stem cells and its potential roles in the treatment of inflammatory disorders: a narrative review

Liu, G., Liu, Z., Lin, Z., Chen, P., Yan, Y.-C., Lin, Q., Hu, Y., Jiang, N., & Yu, B. (2023) · Stem Cell Research & Therapy · doi:10.1186/s13287-023-03454-w · Cited by 14 · see citing works

Dynamic neuro-immune regulation of psychiatric risk loci in human neurons

Townsley, K. G., Lee, S. H., Williams, S., Cartwright, S., Cohen, S., Sen, A., Jia, M., Young, H. E., Dobbyn, L., Deans, M., et al. (2026) · Nature Communications · doi:10.1038/s41467-026-77114-x · Cited by 13 · see citing works

Autophagy controls neuronal differentiation by regulating the WNT-DVL signaling pathway

Vidyawan, V., Puspita, L., Juwono, V. B., Deline, M., Pieknell, K., Chang, M., Lee, S., & Shim, J. (2024) · Autophagy · doi:10.1080/15548627.2024.2407707 · Cited by 12 · see citing works

The SATB1‐MIR22‐GBA axis mediates glucocerebroside accumulation inducing a cellular senescence‐like phenotype in dopaminergic neurons

Russo, T., Kolisnyk, B., Aswathy, B. S., Kim, T. W., Martin, J., Plessis‐Belair, J., Ni, J., Pearson, J. A., Park, E. J., Sher, R. B., et al. (2024) · Aging Cell · doi:10.1111/acel.14077 · Cited by 29 · see citing works

NLRP3 facilitates α-synuclein-induced dopaminergic neuronal senescence in a mouse model of Parkinson's disease through SATB1/DNA damage/p21 signaling pathway.

Chen, L.-L., Shen, Q.-Q., Sun, L., Song, Y.-X., Jia, W.-T., Qu, L., & Xie, J.-X. (2026) · Acta Pharmacologica Sinica · doi:10.1038/s41401-025-01691-8 · Cited by 3 · see citing works

Role of Cellular Senescence in Parkinson’s Disease: Potential for Disease-Modification Through Senotherapy

Rademacher, D. J., Exline, J. E., & Foecking, E. M. (2025) · Biomedicines · doi:10.3390/biomedicines13061400 · Cited by 7 · see citing works

Cellular Senescence in Parkinson’s Disease (PD)

Afzal, M. (2025) · Springer eBooks · doi:10.1007/978-981-96-8873-9_7

Implications of cellular senescence in Parkinson’s disease: Recent developments and future directions

Andersen, J. K. (2026) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2026.103173 · Cited by 4 · see citing works