No Zones Left Behind: Democratic Hepatocytes Contribute to Liver Homeostasis and Repair
Open accessAbstract
Despite minimal turnover, liver cells possess immense regenerative capacity. Some studies suggest existence of a hepatocyte subset with such unique capabilities. However, in the current issue of Cell Stem Cell, three independent studies (Chen et al., 2020; Matsumoto et al., 2020, and Sun et al., 2020) demonstrate an equitable homeostatic and reparative potential of all hepatocytes, irrespective of their lobular location or ploidy status.
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Whether specialised liver stem cells maintain hepatocyte numbers during homeostasis remains controversial.
“Whether specialised liver stem cells maintain hepatocyte numbers during homeostasis remains controversial.13,77”
From Distinct hepatocyte identities in liver homeostasis and regeneration (2023) · cites this paper as [77]
The only passage retrieved from our copy is the title and publication metadata; it does not address whether specialised liver stem cells maintain hepatocyte numbers or whether that question is controversial. Searches for stem cells, homeostasis, hepatocytes, and related terms found no substantive passage. (LLM, conf=0.70)
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Self-renewing diploid Axin2+ cells fuel homeostatic renewal of the liver
Wang, B., Zhao, L., Fish, M., Logan, C. Y., & Nusse, R. (2015) · Nature · doi:10.1038/nature14863 · Cited by 674 · see citing works
Broad Distribution of Hepatocyte Proliferation in Liver Homeostasis and Regeneration
Chen, F., Jimenez, R. J., Sharma, K., Luu, H. Y., Hsu, B. Y., Ravindranathan, A., Stohr, B. A., & Willenbring, H. (2020) · Cell Stem Cell · doi:10.1016/j.stem.2019.11.001 · Cited by 236 · see citing works
The Polyploid State Plays a Tumor-Suppressive Role in the Liver
Zhang, S., Zhou, K., Luo, X., Li, L., Tu, H.-C., Sehgal, A., Nguyen, L. H., Zhang, Y., Gopal, P., Tarlow, B. D., et al. (2018) · Developmental Cell · doi:10.1016/j.devcel.2018.01.010 · Cited by 180 · see citing works
AXIN2+ Pericentral Hepatocytes Have Limited Contributions to Liver Homeostasis and Regeneration
Sun, T., Pikiolek, M., Orsini, V., Bergling, S., Holwerda, S., Morelli, L., Hoppe, P. S., Planas-Paz, L., Yang, Y., Ruffner, H., et al. (2020) · Cell Stem Cell · doi:10.1016/j.stem.2019.10.011 · Cited by 166 · see citing works
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Liver regeneration: biological and pathological mechanisms and implications
Michalopoulos, G. K., & Bhushan, B. (2021) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-020-0342-4 · Cited by 998 · see citing works
The RSPO‐LGR4/5‐ZNRF3/RNF43 module in liver homeostasis, regeneration, and disease
Annunziato, S., Sun, T., & Tchorz, J. S. (2022) · Hepatology · doi:10.1002/hep.32328 · Cited by 45 · see citing works
Distinct hepatocyte identities in liver homeostasis and regeneration
Chen, F., Schönberger, K., & Tchorz, J. S. (2023) · JHEP Reports · doi:10.1016/j.jhepr.2023.100779 · Cited by 30 · see citing works
May, S., Müller, M., Livingstone, C. R., Skalka, G. L., Walsh, P. J., Nixon, C., Hedley, A., Shaw, R., Clark, W., Vande Voorde, J., et al. (2023) · Journal of Hepatology · doi:10.1016/j.jhep.2023.01.009 · Cited by 13 · see citing works
- Authors
- Monga, S. P.
- Affiliations
- University of Pittsburgh (US)
- Corresponding author
- Monga, Satdarshan P.
- ORCID
- Monga, Satdarshan P.
- Venue
- Cell Stem Cell
- Publisher
- Elsevier BV
- Published
- 2020-01
- Volume
- 26
- Issue
- 1
- Pages
- 2-3
- ISSN
- 1875-9777 (ISSN-L)
- 1934-5909
- OpenAlex
- W2997354593
- Cited by
- 18
- References
- 4
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 3 · 2023: 3 · 2022: 2 · 2021: 3 · 2020: 4
- FWCI
- 1.78
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell stem cell (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Keywords
- hepatocytes, liver regeneration, liver homeostasis, ploidy, hepatocyte heterogeneity, liver repair, hepatocyte turnover
- MeSH terms
- Homeostasis, Humans, Liver, Liver Regeneration, Polyploidy, Hepatocytes, Cell Proliferation
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