AXIN2+ Pericentral Hepatocytes Have Limited Contributions to Liver Homeostasis and Regeneration

Controlling the False Discovery Rate: A Practical and Powerful Approach to Multiple Testing

Benjamini, Y., & Hochberg, Y. (1995) · Journal of the Royal Statistical Society Series B: Statistical Methodology · doi:10.1111/j.2517-6161.1995.tb02031.x · Cited by 109,482 · see citing works

limma powers differential expression analyses for RNA-sequencing and microarray studies

Ritchie, M. E., Phipson, B., Wu, D., Hu, Y., Law, C. W., Shi, W., & Smyth, G. K. (2015) · Nucleic Acids Research · doi:10.1093/nar/gkv007 · Cited by 40,458 · see citing works

A scaling normalization method for differential expression analysis of RNA-seq data

Robinson, M. D., & Oshlack, A. (2010) · Genome Biology · doi:10.1186/gb-2010-11-3-r25 · Cited by 7,876 · see citing works

Identification of stem cells in small intestine and colon by marker gene Lgr5

Barker, N., van Es, J. H., Kuipers, J., Kujala, P., van den Born, M., Cozijnsen, M., Haegebarth, A., Korving, J., Begthel, H., Peters, P. J., et al. (2007) · Nature · doi:10.1038/nature06196 · Cited by 5,687 · see citing works

Generalized lacZ expression with the ROSA26 Cre reporter strain

Soriano, P. (1999) · Nature Genetics · doi:10.1038/5007 · Cited by 5,237 · see citing works

Liver Regeneration

Michalopoulos, G. K., & DeFrances, M. C. (1997) · Science · doi:10.1126/science.276.5309.60 · Cited by 2,828 · see citing works

Wnt/β-Catenin/Tcf Signaling Induces the Transcription of Axin2, a Negative Regulator of the Signaling Pathway

Jho, E., Zhang, T., Domon–Dell, C., Joo, C., Freund, J., & Costantini, F. D. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.4.1172-1183.2002 · Cited by 1,683 · see citing works

Ensembl 2015

Cunningham, F., Amode, M. R., Barrell, D., Beal, K., Billis, K., Brent, S., Carvalho-Silva, D., Clapham, P., Coates, G., Fitzgerald, S., et al. (2015) · Nucleic Acids Research · doi:10.1093/nar/gku1010 · Cited by 1,115 · see citing works

Negative Feedback Loop of Wnt Signaling through Upregulation of Conductin/Axin2 in Colorectal and Liver Tumors

Lustig, B., Jerchow, B., Sachs, M., Weiler, S., Pietsch, T., Karsten, U. R., van de Wetering, M., Clevers, H. C., Schlag, P. M., Birchmeier, W., et al. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.4.1184-1193.2002 · Cited by 1,037 · see citing works

Camera: a competitive gene set test accounting for inter-gene correlation

Wu, D., & Smyth, G. K. (2012) · Nucleic Acids Research · doi:10.1093/nar/gks461 · Cited by 880 · see citing works

Self-renewing diploid Axin2+ cells fuel homeostatic renewal of the liver

Wang, B., Zhao, L., Fish, M., Logan, C. Y., & Nusse, R. (2015) · Nature · doi:10.1038/nature14863 · Cited by 674 · see citing works

A reproducible and well-tolerated method for 2/3 partial hepatectomy in mice

Mitchell, C., & Willenbring, H. (2008) · Nature Protocols · doi:10.1038/nprot.2008.80 · Cited by 577 · see citing works

Stem/progenitor cells in liver development, homeostasis, regeneration, and reprogramming

Miyajima, A., Tanaka, M., & Itoh, T. (2014) · Cell Stem Cell · doi:10.1016/j.stem.2014.04.010 · Cited by 570 · see citing works

Bipotential Adult Liver Progenitors Are Derived from Chronically Injured Mature Hepatocytes

Tarlow, B. D., Pelz, C., Naugler, W. E., Wakefield, L., Wilson, E. M., Finegold, M. J., & Grompe, M. (2014) · Cell Stem Cell · doi:10.1016/j.stem.2014.09.008 · Cited by 533 · see citing works

Cholangiocytes act as facultative liver stem cells during impaired hepatocyte regeneration

Raven, A., Lu, W.-Y., Man, T. Y., Ferreira-Gonzalez, S., O’Duibhir, E., Dwyer, B. J., Thomson, J. P., Meehan, R. R., Bogorad, R., Koteliansky, V., et al. (2017) · Nature · doi:10.1038/nature23015 · Cited by 533 · see citing works

Hybrid Periportal Hepatocytes Regenerate the Injured Liver without Giving Rise to Cancer

Font-Burgada, J., Shalapour, S., Ramaswamy, S., Hsueh, B., Rossell, D., Umemura, A., Taniguchi, K., Nakagawa, H., Valasek, M. A., Ye, L., et al. (2015) · Cell · doi:10.1016/j.cell.2015.07.026 · Cited by 486 · see citing works

Mutational spectrum of β-catenin, AXIN1, and AXIN2 in hepatocellular carcinomas and hepatoblastomas

Taniguchi, K., Roberts, L. R., Aderca, I., Dong, X., Qian, C., Murphy, L. M., Nagorney, D. M., Burgart, L. J., Roche, P. C., Smith, D. I., et al. (2002) · Oncogene · doi:10.1038/sj.onc.1205591 · Cited by 485 · see citing works

Robust cellular reprogramming occurs spontaneously during liver regeneration

Yanger, K., Zong, Y., Maggs, L. R., Shapira, S. N., Maddipati, R., Aiello, N. M., Thung, S. N., Wells, R. G., Greenbaum, L. E., & Stanger, B. Z. (2013) · Genes & Development · doi:10.1101/gad.207803.112 · Cited by 484 · see citing works

Wnt/β-Catenin Signaling in Liver Development, Homeostasis, and Pathobiology

Russell, J. O., & Monga, S. P. (2018) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev-pathol-020117-044010 · Cited by 471 · see citing works

The RSPO–LGR4/5–ZNRF3/RNF43 module controls liver zonation and size

Planas-Paz, L., Orsini, V., Boulter, L., Calabrese, D., Pikiolek, M., Nigsch, F., Xie, Y., Roma, G., Donovan, A., Marti, P., et al. (2016) · Nature Cell Biology · doi:10.1038/ncb3337 · Cited by 359 · see citing works

Liver Progenitor Cells Yield Functional Hepatocytes in Response to Chronic Liver Injury in Mice

Español–Suñer, R., Carpentier, R., Van Hul, N., Legry, V., Achouri, Y., Cordi, S., Jacquemin, P., Lemaigre, F., & Leclercq, I. A. (2012) · Gastroenterology · doi:10.1053/j.gastro.2012.08.024 · Cited by 356 · see citing works

Transdifferentiation of rat hepatocytes into biliary cells after bile duct ligation and toxic biliary injury†

Michalopoulos, G. K., Barua, L., & Bowen, W. C. (2005) · Hepatology · doi:10.1002/hep.20600 · Cited by 319 · see citing works

Liver‐specific loss of β‐catenin blocks glutamine synthesis pathway activity and cytochrome p450 expression in mice†‡

Sekine, S., Lan, B. Y., Bedolli, M., Feng, S., & Hebrok, M. (2006) · Hepatology · doi:10.1002/hep.21131 · Cited by 295 · see citing works

De novo formation of the biliary system by TGFβ-mediated hepatocyte transdifferentiation

Schaub, J. R., Huppert, K. A., Kurial, S. N. T., Hsu, B. Y., Cast, A. E., Donnelly, B., Karns, R. A., Chen, F., Rezvani, M., Luu, H. Y., et al. (2018) · Nature · doi:10.1038/s41586-018-0075-5 · Cited by 289 · see citing works

Chronic Liver Injury Induces Conversion of Biliary Epithelial Cells into Hepatocytes

Deng, X., Zhang, X., Li, W., Feng, R.-X., Li, L., Yi, G.-R., Zhang, X.-N., Yin, C., Yu, H.-Y., Zhang, J.-P., et al. (2018) · Cell Stem Cell · doi:10.1016/j.stem.2018.05.022 · Cited by 289 · see citing works

Dynamic Reorganization of Chromatin Accessibility Signatures during Dedifferentiation of Secretory Precursors into Lgr5+ Intestinal Stem Cells

Jadhav, U., Saxena, M., O’Neill, N. K., Saadatpour, A., Yuan, G., Herbert, Z. T., Murata, K., & Shivdasani, R. A. (2017) · Cell stem cell · doi:10.1016/j.stem.2017.05.001 · Cited by 283 · see citing works

Beta-catenin signaling, liver regeneration and hepatocellular cancer: sorting the good from the bad

Nejak-Bowen, K. N., & Monga, S. P. S. (2011) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2010.12.010 · Cited by 260 · see citing works

Beta-catenin signaling in murine liver zonation and regeneration: A Wnt-Wnt situation!

Yang, J., Mowry, L. E., Nejak‐Bowen, K. N., Okabe, H., Diegel, C. R., Lang, R. A., Williams, B. O., & Monga, S. P. (2014) · Hepatology · doi:10.1002/hep.27082 · Cited by 244 · see citing works

Distributed hepatocytes expressing telomerase repopulate the liver in homeostasis and injury

Lin, S., Nascimento, E. M., Gajera, C. R., Chen, L., Neuhöfer, P., Garbuzov, A., Wang, S., & Artandi, S. E. (2018) · Nature · doi:10.1038/s41586-018-0004-7 · Cited by 241 · see citing works

Clonal Tracing of Sox9+ Liver Progenitors in Mouse Oval Cell Injury

Tarlow, B., Finegold, M. J., & Grompe, M. (2014) · Hepatology · doi:10.1002/hep.27084 · Cited by 220 · see citing works

Cyclebase 3.0: a multi-organism database on cell-cycle regulation and phenotypes

Santos, A., Wernersson, R., & Jensen, L. J. (2014) · Nucleic Acids Research · doi:10.1093/nar/gku1092 · Cited by 219 · see citing works

YAP, but Not RSPO-LGR4/5, Signaling in Biliary Epithelial Cells Promotes a Ductular Reaction in Response to Liver Injury

Planas-Paz, L., Sun, T., Pikiolek, M., Cochran, N. R., Bergling, S., Orsini, V., Yang, Z., Sigoillot, F., Jetzer, J., Syed, M., et al. (2019) · Cell Stem Cell · doi:10.1016/j.stem.2019.04.005 · Cited by 216 · see citing works

Apoptosis in the intestinal epithelium: Its relevance in normal and pathophysiological conditions

Ramachandran, A., Madesh, M., & Balasubramanian, K. A. (2000) · Journal of Gastroenterology and Hepatology · doi:10.1046/j.1440-1746.2000.02059.x · Cited by 211 · see citing works

Motoneurons and oligodendrocytes are sequentially generated from neural stem cells but do not appear to share common lineage-restricted progenitors in vivo

Wu, S., Wu, Y.-Y., & Capecchi, M. (2006) · Development · doi:10.1242/dev.02236 · Cited by 206 · see citing works

The Angiocrine Factor Rspondin3 Is a Key Determinant of Liver Zonation

Rocha, A. S., Vidal, V., Mertz, M., Kendall, T. J., Charlet, A., Okamoto, H., & Schedl, A. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.10.049 · Cited by 194 · see citing works

T-cell factor 4 and β-catenin chromatin occupancies pattern zonal liver metabolism in mice

Gougelet, A., Torre, C., Veber, P., Sartor, C., Bachelot, L., Denechaud, P.-D., Godard, C., Moldes, M., Burnol, A.-F., Dubuquoy, C., et al. (2014) · Hepatology · doi:10.1002/hep.26924 · Cited by 190 · see citing works

Inhibiting Glutamine-Dependent mTORC1 Activation Ameliorates Liver Cancers Driven by β-Catenin Mutations

Adebayo Michael, A. O., Ko, S., Tao, J., Moghe, A., Yang, H., Xu, M., Russell, J. O., Pradhan-Sundd, T., Liu, S., Singh, S., et al. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2019.01.002 · Cited by 155 · see citing works

Hepatocyte‐Specific β‐Catenin Deletion During Severe Liver Injury Provokes Cholangiocytes to Differentiate Into Hepatocytes

Russell, J. O., Lu, W., Okabe, H., Abrams, M. T., Oertel, M., Poddar, M., Singh, S., Forbes, S. J., & Monga, S. P. (2018) · Hepatology · doi:10.1002/hep.30270 · Cited by 137 · see citing works

Endothelial Wnts regulate β‐catenin signaling in murine liver zonation and regeneration: A sequel to the Wnt–Wnt situation

Preziosi, M., Okabe, H., Poddar, M., Singh, S., & Monga, S. P. (2018) · Hepatology Communications · doi:10.1002/hep4.1196 · Cited by 135 · see citing works

Cell proliferation and renewal of normal hepatocytes and bile duct cells in adult mouse liver

Magami, Y., Azuma, T., Inokuchi, H., Kokuno, S., Moriyasu, F., Kawai, K., & Hattori, T. (2002) · Liver International · doi:10.1034/j.1600-0676.2002.01702.x · Cited by 124 · see citing works

Tissue Repair in the Mouse Liver Following Acute Carbon Tetrachloride Depends on Injury‐Induced Wnt/β‐Catenin Signaling

Zhao, L., Jin, Y., Donahue, K., Tsui, M., Fish, M., Logan, C. Y., Wang, B., & Nusse, R. (2019) · Hepatology · doi:10.1002/hep.30563 · Cited by 111 · see citing works

Heterogeneity and stochastic growth regulation of biliary epithelial cells dictate dynamic epithelial tissue remodeling

Kamimoto, K., Kaneko, K., Kok, C., Okada, H., Miyajima, A., & Itoh, T. (2016) · eLife · doi:10.7554/elife.15034 · Cited by 104 · see citing works

Lgr5 ⁺ pericentral hepatocytes are self-maintained in normal liver regeneration and susceptible to hepatocarcinogenesis

Ang, C. H., Hsu, S. H., Guo, F., Tan, C. T., Yu, V. C., Visvader, J. E., Chow, P. K. H., & Fu, N. Y. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1908099116 · Cited by 102 · see citing works

Ablation of Foxl1-Cre–Labeled Hepatic Progenitor Cells and Their Descendants Impairs Recovery of Mice From Liver Injury

Shin, S., Upadhyay, N., Greenbaum, L. E., & Kaestner, K. H. (2014) · Gastroenterology · doi:10.1053/j.gastro.2014.09.039 · Cited by 80 · see citing works

Facultative stem cells in liver and pancreas: Fact and fancy

Yanger, K., & Stanger, B. Z. (2011) · Developmental Dynamics · doi:10.1002/dvdy.22561 · Cited by 77 · see citing works

Apoptosis in the gastric mucosa: molecular mechanisms, basic and clinical implications.

Szabó, I., & Tarnawski, A. (2000) · PubMed · Cited by 71 · see citing works

The exon quantification pipeline (EQP): a comprehensive approach to the quantification of gene, exon and junction expression from RNA-seq data

Schuierer, S., & Roma, G. (2016) · Nucleic Acids Research · doi:10.1093/nar/gkw538 · Cited by 43 · see citing works

Liver regeneration: biological and pathological mechanisms and implications

Michalopoulos, G. K., & Bhushan, B. (2021) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-020-0342-4 · Cited by 998 · see citing works

Ischemia-reperfusion injury: molecular mechanisms and therapeutic targets

Zhang, M., Liu, Q., Meng, H., Duan, H., Liu, X., Wu, J., Gao, F., Wang, S., Tan, R., & Yuan, J. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01688-x · Cited by 773 · see citing works

Liver regeneration and inflammation: from fundamental science to clinical applications

Campana, L., Esser, H., Huch, M., & Forbes, S. (2021) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-021-00373-7 · Cited by 307 · see citing works

Building consensus on definition and nomenclature of hepatic, pancreatic, and biliary organoids

Marsee, A., Roos, F. J. M., Verstegen, M. M. A., Marsee, A., Roos, F., Verstegen, M., Clevers, H., Vallier, L., Takebe, T., Huch, M., et al. (2021) · Cell Stem Cell · doi:10.1016/j.stem.2021.04.005 · Cited by 310 · see citing works

Liver homeostasis is maintained by midlobular zone 2 hepatocytes

Wei, Y., Wang, Y. G., Jia, Y., Li, L., Yoon, J., Zhang, S., Wang, Z., Zhang, Y., Zhu, M., Sharma, T., et al. (2021) · Science · doi:10.1126/science.abb1625 · Cited by 292 · see citing works

Proliferation tracing reveals regional hepatocyte generation in liver homeostasis and repair

He, L., Pu, W., Liu, X., Zhang, Z., Han, M., Li, Y., Huang, X., Han, X., Li, Y., Liu, K., et al. (2021) · Science · doi:10.1126/science.abc4346 · Cited by 261 · see citing works

The spatiotemporal program of zonal liver regeneration following acute injury

Ben-Moshe, S., Veg, T., Manco, R., Dan, S., Papinutti, D., Lifshitz, A., Kolodziejczyk, A. A., Bahar Halpern, K., Elinav, E., & Itzkovitz, S. (2022) · Cell Stem Cell · doi:10.1016/j.stem.2022.04.008 · Cited by 224 · see citing works

Liver zonation, revisited

Paris, J., & Henderson, N. C. (2022) · Hepatology · doi:10.1002/hep.32408 · Cited by 167 · see citing works

Liver Zonation – Revisiting Old Questions With New Technologies

Cunningham, R. P., & Porat‐Shliom, N. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.732929 · Cited by 166 · see citing works

Organoids to model liver disease

Nuciforo, S., & Heim, M. H. (2021) · JHEP Reports · doi:10.1016/j.jhepr.2020.100198 · Cited by 164 · see citing works

Mapping cells through time and space with moscot

Klein, D., Palla, G., Lange, M., Klein, M., Piran, Z., Gander, M., Meng-Papaxanthos, L., Sterr, M., Saber, L., Jing, C., et al. (2025) · Nature · doi:10.1038/s41586-024-08453-2 · Cited by 202 · see citing works

Epithelial Plasticity during Liver Injury and Regeneration

Gadd, V. L., Aleksieva, N., & Forbes, S. J. (2020) · Cell Stem Cell · doi:10.1016/j.stem.2020.08.016 · Cited by 142 · see citing works

Cell Plasticity in Liver Regeneration

Li, W., Li, L., & Hui, L. (2020) · Trends in Cell Biology · doi:10.1016/j.tcb.2020.01.007 · Cited by 167 · see citing works

Multimodal decoding of human liver regeneration

Matchett, K. P., Wilson-Kanamori, J. R., Portman, J. R., Kapourani, C. A., Fercoq, F., May, S., Zajdel, E., Beltran, M., Sutherland, E. F., Mackey, J. B. G., et al. (2024) · Nature · doi:10.1038/s41586-024-07376-2 · Cited by 140 · see citing works

Bipotent transitional liver progenitor cells contribute to liver regeneration

Pu, W., Zhu, H., Zhang, M., Pikiolek, M., Ercan, C., Li, J., Huang, X., Han, X., Zhang, Z., Lv, Z., et al. (2023) · Nature Genetics · doi:10.1038/s41588-023-01335-9 · Cited by 138 · see citing works

Molecular mechanisms in liver repair and regeneration: from physiology to therapeutics

Ma, X., Huang, T., Chen, X., Li, Q., Liao, M., Fu, L., Huang, J., Yuan, K., Wang, Z., & Zeng, Y. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-02104-8 · Cited by 133 · see citing works

Cirrhosis: A Questioned Risk Factor for Hepatocellular Carcinoma

Garrido, A., & Djouder, N. (2020) · Trends in cancer · doi:10.1016/j.trecan.2020.08.005 · Cited by 122 · see citing works

Spatiotemporal Metabolic Liver Zonation and Consequences on Pathophysiology

Martini, T., Naef, F., & Tchorz, J. S. (2023) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev-pathmechdis-031521-024831 · Cited by 113 · see citing works

Maladaptive regeneration - the reawakening of developmental pathways in NASH and fibrosis

Zhu, C., Tabas, I., Schwabe, R. F., & Pajvani, U. B. (2021) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-020-00365-6 · Cited by 112 · see citing works

Cellular plasticity balances the metabolic and proliferation dynamics of a regenerating liver

Chembazhi, U. V., Bangru, S., Hernaez, M., & Kalsotra, A. (2021) · Genome Research · doi:10.1101/gr.267013.120 · Cited by 102 · see citing works

Metabolic and non-metabolic liver zonation is established non-synchronously and requires sinusoidal Wnts

Ma, R., Martínez-Ramírez, A. S., Borders, T. L., Gao, F., & Sosa-Pineda, B. (2020) · eLife · doi:10.7554/elife.46206 · Cited by 97 · see citing works

Hallmarks of stemness in mammalian tissues

Beumer, J., & Clevers, H. C. (2024) · Cell stem cell · doi:10.1016/j.stem.2023.12.006 · Cited by 91 · see citing works

ZNRF3 and RNF43 cooperate to safeguard metabolic liver zonation and hepatocyte proliferation

Sun, T., Annunziato, S., Bergling, S., Sheng, C., Orsini, V., Forcella, P., Pikiolek, M., Kancherla, V., Holwerda, S., Imanci, D., et al. (2021) · Cell Stem Cell · doi:10.1016/j.stem.2021.05.013 · Cited by 84 · see citing works

SiGra: single-cell spatial elucidation through an image-augmented graph transformer

Tang, Z., Li, Z., Hou, T., Zhang, T., Yang, B., Su, J., & Song, Q. (2023) · Nature Communications · doi:10.1038/s41467-023-41437-w · Cited by 82 · see citing works

Single-nucleus RNA-seq2 reveals functional crosstalk between liver zonation and ploidy

Richter, M. L., Deligiannis, I. K., Yin, K., Danese, A., Lleshi, E., Coupland, P., Vallejos, C. A., Matchett, K. P., Henderson, N. C., Colome-Tatche, M., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-24543-5 · Cited by 75 · see citing works

Diploid hepatocytes drive physiological liver renewal in adult humans

Heinke, P., Rost, F., Rode, J., Trus, P., Simonova, I., Lázár, E., Feddema, J., Welsch, T., Alkass, K., Salehpour, M., et al. (2022) · Cell Systems · doi:10.1016/j.cels.2022.05.001 · Cited by 73 · see citing works

Liver regeneration: Cellular origin and molecular mechanisms

Huang, R. C. C., Zhang, X., Gracia‐Sancho, J., & Xie, W. (2022) · Liver International · doi:10.1111/liv.15174 · Cited by 68 · see citing works

Wnt signaling in liver regeneration, disease, and cancer

Zou, G., & Park, J.-I. (2023) · Clinical and Molecular Hepatology · doi:10.3350/cmh.2022.0058 · Cited by 64 · see citing works

Molecular pathways of liver regeneration: A comprehensive review

Kiseleva, Y. V., Antonyan, S. Z., Zharikova, T. S., Tupikin, K. A., Kalinin, D. V., & Zharikov, Y. O. (2021) · World Journal of Hepatology · doi:10.4254/wjh.v13.i3.270 · Cited by 62 · see citing works

Hepatocyte Injury and Hepatic Stem Cell Niche in the Progression of Non-Alcoholic Steatohepatitis

Overi, D., Carpino, G., Franchitto, A., Onori, P., & Gaudio, E. (2020) · Cells · doi:10.3390/cells9030590 · Cited by 61 · see citing works

Gene Deconvolution Reveals Aberrant Liver Regeneration and Immune Cell Infiltration in Alcohol‐Associated Hepatitis

Kim, A., Wu, X., Allende, D. S., & Nagy, L. E. (2021) · Hepatology · doi:10.1002/hep.31759 · Cited by 60 · see citing works

The interaction of Notch and Wnt signaling pathways in vertebrate regeneration

Gao, J., Fan, L., Zhao, L., & Su, Y. (2021) · Cell Regeneration · doi:10.1186/s13619-020-00072-2 · Cited by 63 · see citing works

Hepatocyte organoids and cell transplantation: What the future holds

Peng, W. C., Kraaier, L. J., & Kluiver, T. A. (2021) · Experimental & Molecular Medicine · doi:10.1038/s12276-021-00579-x · Cited by 59 · see citing works

Hepatobiliary Organoids and Their Applications for Studies of Liver Health and Disease: Are We There Yet?

Shiota, J., Samuelson, L. C., & Razumilava, N. (2021) · Hepatology · doi:10.1002/hep.31772 · Cited by 57 · see citing works

VEGF‐FGF Signaling Activates Quiescent CD63+ Liver Stem Cells to Proliferate and Differentiate

Chen, F., Zhang, K., Wang, M., He, Z., Yu, B., Wang, X., Pan, X., Luo, Y., Xu, S., Lau, J. T. Y., et al. (2024) · Advanced Science · doi:10.1002/advs.202308711 · Cited by 57 · see citing works

Stem cell-derived hepatocyte therapy using versatile biomimetic nanozyme incorporated nanofiber-reinforced decellularized extracellular matrix hydrogels for the treatment of acute liver failure

Jin, Y., Zhang, J., Xu, Y., Yi, K., Li, F., Zhou, H., Wang, H., Chan, H. F., Lao, Y.-H., Lv, S., et al. (2023) · Bioactive Materials · doi:10.1016/j.bioactmat.2023.05.001 · Cited by 55 · see citing works

Progress in human liver organoids

Sun, L., & Hui, L. (2020) · Journal of Molecular Cell Biology · doi:10.1093/jmcb/mjaa013 · Cited by 55 · see citing works

Macrophages harness hepatocyte glutamate to boost liver regeneration

Rigual, M. D. M., Angulo-Aguado, M., Zagorac, S., Álvarez-Díaz, R., Benítez-Mondéjar, M., Yi, F., Martínez-Garay, C., Santos-de-Frutos, K., Kim, E., Campos-Olivas, R., et al. (2025) · Nature · doi:10.1038/s41586-025-08778-6 · Cited by 53 · see citing works

Polyploidy control in hepatic health and disease

Sladky, V. C., Eichin, F., Reiberger, T., & Villunger, A. (2021) · Journal of Hepatology · doi:10.1016/j.jhep.2021.06.030 · Cited by 49 · see citing works

Hepatitis B Virus DNA Integration and Clonal Expansion of Hepatocytes in the Chronically Infected Liver

Mason, W. S., Jilbert, A. R., & Litwin, S. (2021) · Viruses · doi:10.3390/v13020210 · Cited by 47 · see citing works

Wnt/β-Catenin signaling pathway in hepatocellular carcinoma: pathogenic role and therapeutic target

Zhao, Z., Cui, T., Wei, F., Zhou, Z., Sun, Y., Gao, C., Xu, X., & Zhang, H. (2024) · Frontiers in Oncology · doi:10.3389/fonc.2024.1367364 · Cited by 45 · see citing works

The RSPO‐LGR4/5‐ZNRF3/RNF43 module in liver homeostasis, regeneration, and disease

Annunziato, S., Sun, T., & Tchorz, J. S. (2022) · Hepatology · doi:10.1002/hep.32328 · Cited by 45 · see citing works

Hepatic stellate cells maintain liver homeostasis through paracrine neurotrophin-3 signaling that induces hepatocyte proliferation

Trinh, V. Q.-H., Lee, T.-F., Lemoinne, S., Ray, K. C., Ybanez, M. D., Tsuchida, T., Carter, J. K., Agudo, J., Brown, B. D., Akat, K. M., et al. (2023) · Science Signaling · doi:10.1126/scisignal.adf6696 · Cited by 45 · see citing works

Wnt/-Catenin Signaling and Liver Regeneration: Circuit, Biology, and Opportunities

Hu, S., & Monga, S. P. (2021) · Gene Expression · doi:10.3727/105221621x16111780348794 · Cited by 44 · see citing works

The Role of Liver Zonation in Physiology, Regeneration, and Disease

Panday, R., Monckton, C. P., & Khetani, S. R. (2022) · Seminars in Liver Disease · doi:10.1055/s-0041-1742279 · Cited by 44 · see citing works

Role of the Hippo pathway in liver regeneration and repair: recent advances

Pibiri, M., & Simbula, G. (2022) · Inflammation and Regeneration · doi:10.1186/s41232-022-00235-5 · Cited by 46 · see citing works

Region-specific cellular and molecular basis of liver regeneration after acute pericentral injury.

Wang, S., Wang, X., Shan, Y., Tan, Z., Su, Y., Cao, Y., Wang, S., Dong, J., Gu, J., & Wang, Y. (2024) · Cell Stem Cell · doi:10.1016/j.stem.2024.01.013 · Cited by 40 · see citing works

Cellular origins of regenerating liver and hepatocellular carcinoma

Holczbauer, Á., Wangensteen, K. J., & Shin, S. (2021) · JHEP Reports · doi:10.1016/j.jhepr.2021.100416 · Cited by 39 · see citing works

The Canonical Wnt Pathway as a Key Regulator in Liver Development, Differentiation and Homeostatic Renewal

Wild, S. L., Elghajiji, A., Rodriguez, C. G., Weston, S. D., Burke, Z. D., & Tosh, D. (2020) · Genes · doi:10.3390/genes11101163 · Cited by 39 · see citing works

Hepatic sinusoids versus central veins: Structures, markers, angiocrines, and roles in liver regeneration and homeostasis

Mak, K. M., & Shin, D. W. (2020) · The Anatomical Record · doi:10.1002/ar.24560 · Cited by 35 · see citing works

Cell adhesion molecule KIRREL1 is a feedback regulator of Hippo signaling recruiting SAV1 to cell-cell contact sites

Paul, A., Annunziato, S., Lu, B., Sun, T., Evrova, O., Planas‐Paz, L., Orsini, V., Terracciano, L., Charlat, O., Yang, Z., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-28567-3 · Cited by 35 · see citing works

IGFBP2 expressing midlobular hepatocytes preferentially contribute to liver homeostasis and regeneration

Lin, Y.-H., Wei, Y., Zeng, Q., Wang, Y., Pagani, C. A., Li, L., Zhu, M., Wang, Z., Hsieh, M.-H., Corbitt, N., et al. (2023) · Cell Stem Cell · doi:10.1016/j.stem.2023.04.007 · Cited by 33 · see citing works

Cell fate analysis of zone 3 hepatocytes in liver injury and tumorigenesis

Kurosaki, S., Nakagawa, H., Hayata, Y., Kawamura, S., Matsushita, Y., Yamada, T., Uchino, K., Hayakawa, Y., Suzuki, N., Hata, M., et al. (2021) · JHEP Reports · doi:10.1016/j.jhepr.2021.100315 · Cited by 34 · see citing works

Lineage tracing: technology tool for exploring the development, regeneration, and disease of the digestive system

Zhang, Y., Zeng, F., Han, X., Weng, J., & Gao, Y. (2020) · Stem cell research & therapeutics · doi:10.1186/s13287-020-01941-y · Cited by 24 · see citing works

Distinct hepatocyte identities in liver homeostasis and regeneration

Chen, F., Schönberger, K., & Tchorz, J. S. (2023) · JHEP Reports · doi:10.1016/j.jhepr.2023.100779 · Cited by 30 · see citing works

Hepatocyte generation in liver homeostasis, repair, and regeneration

Pu, W., & Zhou, B. (2022) · Cell Regeneration · doi:10.1186/s13619-021-00101-8 · Cited by 25 · see citing works

Is liver regeneration key in hepatocellular carcinoma development?

Rigual, M. D. M., Sánchez, P. S., & Djouder, N. (2022) · Trends in cancer · doi:10.1016/j.trecan.2022.10.005 · Cited by 27 · see citing works

Overcoming Expressional Drop-outs in Lineage Reconstruction from Single-Cell RNA-Sequencing Data

Lu, T., Park, S., Zhu, J. J., Wang, Y., Zhan, X., Wang, X., Wang, L., Zhu, H., & Wang, T. (2021) · Cell Reports · doi:10.1016/j.celrep.2020.108589 · Cited by 26 · see citing works

Epigenetic Regulation of Cell-Fate Changes That Determine Adult Liver Regeneration After Injury

Aloia, L. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.643055 · Cited by 25 · see citing works

Mouse Models of Liver Parenchyma Injuries and Regeneration

Du, Y., Zhang, W., Qiu, H., Xiao, C., Shi, J., Reid, L. M., & He, Z. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.903740 · Cited by 27 · see citing works

WT1+ glomerular parietal epithelial progenitors promote renal proximal tubule regeneration after severe acute kidney injury

Hong, X., Nie, H., Deng, J., Liang, S., Chen, L., Li, J., Gong, S., Wang, G., Zuo, W., Hou, F. F., et al. (2023) · Theranostics · doi:10.7150/thno.79326 · Cited by 25 · see citing works

Cell transplantation-based regenerative medicine in liver diseases

Cardinale, V., Lanthier, N., Baptista, P. M., Carpino, G., Carnevale, G., Orlando, G., Angelico, R., Manzia, T. M., Schuppan, D., Pinzani, M., et al. (2023) · Stem Cell Reports · doi:10.1016/j.stemcr.2023.06.005 · Cited by 26 · see citing works

Heterogeneity of hepatocyte dynamics restores liver architecture after chemical, physical or viral damage

Ruz‐Maldonado, I., González, J. T., Zhang, H., Sun, J., Bort, A., Kabir, I., Kibbey, R. G., Suárez, Y., Greif, D. M., & Fernandez-Hernando, C. F. (2024) · Nature Communications · doi:10.1038/s41467-024-45439-0 · Cited by 26 · see citing works

Controversies Surrounding the Origin of Hepatocytes in Adult Livers and the in Vitro Generation or Propagation of Hepatocytes

Pek, N. M. Q., Liu, K. J., Nichane, M., & Ang, L. T. (2020) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2020.09.016 · Cited by 25 · see citing works

Cell and Tissue Therapy for the Treatment of Chronic Liver Disease

Bram, Y., Nguyen, D.-H. T., Gupta, V., Park, J., Richardson, C., Chandar, V., & Schwartz, R. E. (2021) · Annual Review of Biomedical Engineering · doi:10.1146/annurev-bioeng-112619-044026 · Cited by 24 · see citing works

Decoding liver fibrogenesis with single-cell technologies

Zhou, T., Musunuru, K., Lui, K. O., & Ding, Q. (2022) · Life Medicine · doi:10.1093/lifemedi/lnac040 · Cited by 21 · see citing works

Hepatocyte reprogramming in liver regeneration: Biological mechanisms and applications

Jiang, M., Ren, J., Belmonte, J. C. I., & Liu, G. (2023) · FEBS Journal · doi:10.1111/febs.16930 · Cited by 20 · see citing works

All routes lead to Rome: multifaceted origin of hepatocytes during liver regeneration

Gao, C., & Peng, J. (2021) · Cell Regeneration · doi:10.1186/s13619-020-00063-3 · Cited by 21 · see citing works

Hepatic Regeneration in Cirrhosis

Jindal, A., Jagdish, R. K., & Kumar, A. (2021) · Journal of Clinical and Experimental Hepatology · doi:10.1016/j.jceh.2021.08.029 · Cited by 20 · see citing works

Dual-ligand engineered exosome regulates WNT signaling activation to promote liver repair and regeneration

Yang, L., Wang, S., Qiao, Z., Liu, Y., Wang, X., Liu, L., Yang, C., Ding, J., Lei, M., Zheng, J., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-64069-8 · Cited by 18 · see citing works

Zonation, Zonation, Zonation: The Real Estate of the Liver

Yasaka, T. M., Kim, C., Meadows, V., & Monga, S. P. (2025) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev-pathmechdis-042624-091820 · Cited by 21 · see citing works

Single-cell sequencing and organoids: applications in organ development and disease

Li, T., Yin, J., Hao, Y., Gao, W., Li, Q., Feng, Q., Tao, B., Hao, M., Liu, Y., Lin, C., et al. (2025) · Molecular Biomedicine · doi:10.1186/s43556-025-00364-6 · Cited by 19 · see citing works

Liver Regeneration in Chronic Liver Injuries: Basic and Clinical Applications Focusing on Macrophages and Natural Killer Cells

Qian, Y., Shang, Z., Gao, Y., Wu, H., & Kong, X. (2022) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2022.05.014 · Cited by 18 · see citing works

Multiple Facets of Cellular Homeostasis and Regeneration of the Mammalian Liver

Huppert, S. S., & Schwartz, R. E. (2022) · Annual Review of Physiology · doi:10.1146/annurev-physiol-032822-094134 · Cited by 19 · see citing works

A latent Axin2+/Scx+ progenitor pool is the central organizer of tendon healing

Grinstein, M., Tsai, S. L., Montoro, D. T., Freedman, B. R., Dingwall, H. L., Villaseñor, S., Zou, K., Sade-Feldman, M., Tanaka, M. J., Mooney, D. J., et al. (2024) · npj Regenerative Medicine · doi:10.1038/s41536-024-00370-2 · Cited by 21 · see citing works

No Zones Left Behind: Democratic Hepatocytes Contribute to Liver Homeostasis and Repair

Monga, S. P. (2020) · Cell Stem Cell · doi:10.1016/j.stem.2019.12.002 · Cited by 18 · see citing works

Identification of a rare Gli1+ progenitor cell population contributing to liver regeneration during chronic injury

Peng, J., Li, F., Wang, J., Wang, C., Jiang, Y., Liu, B., He, J., Yuan, K., Pan, C., Lin, M., et al. (2022) · Cell Discovery · doi:10.1038/s41421-022-00474-3 · Cited by 17 · see citing works

ScRNA-seq and ST-seq in liver research

He, J., Deng, C., Krall, L., & Shan, Z. (2023) · Cell Regeneration · doi:10.1186/s13619-022-00152-5 · Cited by 17 · see citing works

PTEN-mediated AKT/β-catenin signaling enhances the proliferation and expansion of Lgr5+ hepatocytes

Han, J., Lin, K., Zhang, X., Yan, L., Liu, J., & Liu, J. (2021) · International Journal of Biological Sciences · doi:10.7150/ijbs.56091 · Cited by 16 · see citing works

Compartmentalization, cooperation, and communication: The 3Cs of Hepatocyte zonation

Porat‐Shliom, N. (2023) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2023.102292 · Cited by 16 · see citing works

Contributions of biliary epithelial cells to hepatocyte homeostasis and regeneration in zebrafish

Zhang, W., Chen, J., Ni, R., Yang, Q., Luo, L., & He, J. (2021) · iScience · doi:10.1016/j.isci.2021.102142 · Cited by 15 · see citing works

Tissue regeneration: Unraveling strategies for resolving pathological fibrosis

Li, J., Wang, S., Yuan, J., Mao, X., Wang, X., Zhang, L., Dong, Q., Chen, Z., Wang, Y., & Tang, N. (2025) · Cell stem cell · doi:10.1016/j.stem.2025.10.002 · Cited by 16 · see citing works

In Search of Zonation Markers to Identify Liver Functional Disorders

Yang, Q., Zhang, S., Ma, J., Liu, S., & Chen, S. (2020) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2020/9374896 · Cited by 15 · see citing works

Spatial-temporal proliferation of hepatocytes during pregnancy revealed by genetic lineage tracing

He, S., Guo, Z., Zhou, M., Wang, H., Zhang, Z., Shi, M., Li, X., Yang, X., & He, L. (2023) · Cell stem cell · doi:10.1016/j.stem.2023.09.002 · Cited by 15 · see citing works

Binucleated human hepatocytes arise through late cytokinetic regression during endomitosis M phase

Darmasaputra, G. S., Geerlings, C. C., Lopes, S. M. C. D. S., Clevers, H., & Galli, M. (2024) · Journal of Cell Biology · doi:10.1083/jcb.202403020 · Cited by 12 · see citing works

Lgr5 + cell fate regulation by coordination of metabolic nuclear receptors during liver repair

Qin, D., Liu, S., Lu, Y., Yan, Y. L., Zhang, J., Cao, S., Chen, M., Chen, N., Huang, W., Wang, L., et al. (2022) · Theranostics · doi:10.7150/thno.74194 · Cited by 14 · see citing works

Absent expansion of AXIN2+ hepatocytes and altered physiology in Axin2CreERT2 mice challenges the role of pericentral hepatocytes in homeostatic liver regeneration

May, S., Müller, M., Livingstone, C. R., Skalka, G. L., Walsh, P. J., Nixon, C., Hedley, A., Shaw, R., Clark, W., Vande Voorde, J., et al. (2023) · Journal of Hepatology · doi:10.1016/j.jhep.2023.01.009 · Cited by 13 · see citing works

Hepatocytes undergo punctuated expansion dynamics from a periportal stem cell niche in normal human liver

Passman, A. M., Haughey, M. J., Carlotti, E., Williams, M. J., Cereser, B., Lin, M., Devkumar, S., Gabriel, J. P., Gringeri, E., Cillo, U., et al. (2023) · Journal of Hepatology · doi:10.1016/j.jhep.2023.03.044 · Cited by 12 · see citing works

Cellular and Transcriptional Heterogeneity in the Intrahepatic Biliary Epithelium

Hrncir, H. R., & Gracz, A. D. (2022) · Gastro Hep Advances · doi:10.1016/j.gastha.2022.07.015 · Cited by 12 · see citing works

Liver cell therapies: cellular sources and grafting strategies

Zhang, W., Cui, Y., Du, Y., Yang, Y., Fang, T., Lu, F., Kong, W.-X., Xiao, C., Shi, J., Reid, L. M., et al. (2023) · Frontiers of Medicine · doi:10.1007/s11684-023-1002-1 · Cited by 11 · see citing works

Cellular plasticity at the nexus of development and disease

Spatz, L. B., Jin, R. U., & Mills, J. (2021) · Development · doi:10.1242/dev.197392 · Cited by 9 · see citing works

Molecular mechanisms of transcription factor mediated cell reprogramming: conversion of liver to pancreas

Wild, S. L., & Tosh, D. (2021) · Biochemical Society Transactions · doi:10.1042/bst20200219 · Cited by 11 · see citing works

Raloxifene prevents intracellular invasion of pathogenic bacteria through modulation of cell metabolic pathways

Chang, J., Kim, J. A., & Lee, W. (2022) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkac069 · Cited by 11 · see citing works

A postnatal network of co-hepato/pancreatic stem/progenitors in the biliary trees of pigs and humans

Zhang, W., Wang, X., Lanzoni, G., Wauthier, E., Simpson, S. G., Ezzell, J. A., Allen, A., Suitt, C., Krolik, J., Jhirad, A., et al. (2023) · npj Regenerative Medicine · doi:10.1038/s41536-023-00303-5 · Cited by 11 · see citing works

Multicellular dynamics of zonal liver regeneration mapped in space and time

Chen, F., & Tchorz, J. S. (2022) · Cell stem cell · doi:10.1016/j.stem.2022.05.008 · Cited by 10 · see citing works

Self-maintenance of zonal hepatocytes during adult homeostasis and their complex plasticity upon distinct liver injuries

Ang, C. H., Arandjelovic, P., Cheng, J., Yang, J., Guo, F., Yu, Y., Nelameham, S., Whitehead, L. W., Li, J., Silver, D. L., et al. (2024) · Cell Reports · doi:10.1016/j.celrep.2024.115093 · Cited by 10 · see citing works

Unveiling the power of microenvironment in liver regeneration: an in-depth overview

Hu, Y., Wang, R., An, N. A., Li, C., Wang, Q., Cao, Y., Li, C., Liu, J., & Wang, Y. (2023) · Frontiers in Genetics · doi:10.3389/fgene.2023.1332190 · Cited by 12 · see citing works

Development of a hepatic cryoinjury model to study liver regeneration

Sande-Melón, M., Bergemann, D., Fernández-Lajarín, M., González‐Rosa, J. M., & Cox, A. G. (2024) · Development · doi:10.1242/dev.203124 · Cited by 9 · see citing works

Advances in liver engineering with cell, scaffold, and vascularization

Liu, C., Wang, Y., Zhou, X., & Dong, L. (2024) · EngMedicine · doi:10.1016/j.engmed.2024.100041 · Cited by 9 · see citing works

Organ‐Specific Dedifferentiation and Epigenetic Remodeling in In Vivo Reprogramming

Jo, B., Lee, S., Eom, H., Kim, J., & Cha, H. (2025) · Aging Cell · doi:10.1111/acel.70268 · Cited by 8 · see citing works

PS-035-The role of pericentral hepatocytes in homeostatic liver regeneration: Caveats to lineage tracing from Axin2

Livingstone, C., May, S., Mueller, M., Kiourtis, C., Drake, T., Nixon, C., Sansom, O. J., & Bird, T. G. (2019) · Journal of Hepatology · doi:10.1016/s0618-8278(19)30041-6

Absent expansion of AXIN2+ hepatocytes and altered physiology in Axin2CreERT2 mice challenges the role of pericentral hepatocytes in homeostatic liver regeneration

May, S., Müller, M., Livingstone, C. R., Skalka, G. L., Walsh, P. J., Nixon, C., Hedley, A., Shaw, R., Clark, W., Vande Voorde, J., et al. (2023) · Journal of Hepatology · doi:10.1016/j.jhep.2023.01.009 · Cited by 13 · see citing works

On the origin of liver regeneration

Ray, K. (2015) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2015.147 · Cited by 4 · see citing works

The many ways to mend your liver: A critical appraisal

Alison, M. R. (2018) · International Journal of Experimental Pathology · doi:10.1111/iep.12272 · Cited by 8 · see citing works

Self-renewing diploid Axin2+ cells fuel homeostatic renewal of the liver

Wang, B., Zhao, L., Fish, M., Logan, C. Y., & Nusse, R. (2015) · Nature · doi:10.1038/nature14863 · Cited by 674 · see citing works