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Cited by 65Hair Growth and DisordersSkin and Cellular Biology ResearchGenetic and rare skin diseases.

BLIMP1 Is Required for Postnatal Epidermal Homeostasis but Does Not Define a Sebaceous Gland Progenitor under Steady-State Conditions

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Kretzschmar, Kai, Cottle, Denny L., Donati, Giacomo, Chiang, Ming-Feng, Quist, Sven R., Gollnick, Harald P., Natsuga, Ken, Lin, Kuo-I +1 more·2014·Stem Cell Reports
DOI 10.1016/j.stemcr.2014.08.007PMC PMC4223714
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Abstract

B-lymphocyte-induced nuclear maturation protein 1 (BLIMP1) was previously reported to define a sebaceous gland (SG) progenitor population in the epidermis. However, the recent identification of multiple stem cell populations in the hair follicle junctional zone has led us to re-evaluate its function. We show, in agreement with previous studies, that BLIMP1 is expressed by postmitotic, terminally differentiated epidermal cells within the SG, interfollicular epidermis, and hair follicle. Epidermal overexpression of c-Myc results in loss of BLIMP1(+) cells, an effect modulated by androgen signaling. Epidermal-specific deletion of Blimp1 causes multiple differentiation defects in the epidermis in addition to SG enlargement. In culture, BLIMP1(+) sebocytes have no greater clonogenic potential than BLIMP1(-) sebocytes. Finally, lineage-tracing experiments reveal that, under steady-state conditions, BLIMP1-expressing cells do not divide. Thus, rather than defining a sebocyte progenitor population, BLIMP1 functions in terminally differentiated cells to maintain homeostasis in multiple epidermal compartments.

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  • Blimp1 functions in terminally differentiated sebocytes as well as in granular IFE cells.

    “Alternatively, it has recently been suggested that Blimp1 functions in terminally differentiated sebocytes8 as well as in granular IFE cells9, 10.”

    From Blimp1+ cells generate functional mouse sebaceous gland organoids in vitro (2019) · cites this paper as [8]

  • Terminally differentiated sebocytes and granular layer IFE keratinocytes are marked by the Blimp1 protein.

    “Subsequently, it was described that terminally differentiated sebocytes8, as well as granular layer IFE keratinocytes9, 10 are marked by the Blimp1 protein.”

    From Blimp1+ cells generate functional mouse sebaceous gland organoids in vitro (2019) · cites this paper as [8]

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Authors
Kretzschmar, K., Cottle, D. L., Donati, G., Chiang, M.-F., Quist, S. R., Gollnick, H. P., Natsuga, K., Lin, K.-I., & Watt, F. M.
Affiliations
  • Guy's Hospital (GB)
  • Wellcome/MRC Cambridge Stem Cell Institute (GB)
  • Genomics Research Center, Academia Sinica (TW)
  • Cancer Research UK (GB)
  • Otto-von-Guericke-Universität Magdeburg (DE)
  • Hokkaido University (JP)
Corresponding author
Watt, Fiona M.
ORCID
Venue
Stem Cell Reports
Publisher
Elsevier BV
Published
2014-10
Volume
3
Issue
4
Pages
620-633
ISSN
2213-6711 (ISSN-L)
DOI
10.1016/j.stemcr.2014.08.007
PMC
PMC4223714
OpenAlex
W2063503020
Cited by
65
References
1
Citations by year
2026: 5 · 2024: 10 · 2023: 5 · 2022: 2 · 2021: 4 · 2020: 4 · 2019: 9 · 2018: 4 · 2017: 13 · 2016: 6 · 2015: 3
FWCI
9.33
Type
journal article
Language
en
Open access
Licence
Locations
  • Stem Cell Reports (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Research Portal (King's College London) (publishedVersion, other-oa)
  • Institutional Research Information System University of Turin (University of Turin) (submittedVersion, other-oa)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • Wellcome Trust (096540)
  • Cancer Research UK
  • National Institute for Health and Care Research
  • King's College London
  • European Commission
  • Medical Research Council
Topics
  • Health Sciences › Medicine › Urology › Hair Growth and Disorders
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Skin and Cellular Biology Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and rare skin diseases.
Keywords
Blimp-1, sebaceous glands, epidermal homeostasis, sebocytes, c-Myc, androgen signaling, hair follicle, terminally differentiated cells, epidermal stem cells, lineage tracing, clonogenicity
MeSH terms
Positive Regulatory Domain I-Binding Factor 1, Epidermal Cells, Animals, Cell Differentiation, Cells, Cultured, Homeostasis, Humans, Sebaceous Glands, Transcription Factors, Keratinocytes, Cell Lineage, Cell Proliferation, Mice, Adult Stem Cells

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