Epidermal terminal differentiation depends on B lymphocyte-induced maturation protein-1
Open accessAbstract
The cornified layer is a compacted lattice of lipid-embedded corneocytes that provides an organism's barrier to the external environment. Cornification is the final differentiative step for epidermal keratinocytes and involves dramatic cell condensation before death. Using conditional gene deletion in mice, we identified the transcriptional repressor Blimp-1 (B lymphocyte-induced maturation protein-1) as an important regulator of keratinocyte transition from the granular to the cornified layer. More than 250 genes are misregulated in conditional knockout epidermis, including those encoding transcription factors, signal transduction components, proteinases, and enzymes involved in lipid metabolism. Steady-state mRNA and ChIP analyses of a subset of these genes provide evidence that nfat5 , fos , prdm1 , and dusp16 are novel direct targets of Blimp-1. Identifying nfat5 as a target of Blimp-1 repression indicates that cornification involves suppression of normal osmotic regulation in granular cells. Consistently, conditional knockout mice have delayed barrier formation as embryos, enlarged granular layer cells and corneocytes, and a morphologically abnormal cornified layer. These studies provide insight into cornification, identifying transcriptional regulatory circuitry and indicating the importance of blocking osmotic homeostasis.
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Blimp1 functions in terminally differentiated sebocytes as well as in granular IFE cells.
“Alternatively, it has recently been suggested that Blimp1 functions in terminally differentiated sebocytes8 as well as in granular IFE cells9, 10.”
From Blimp1+ cells generate functional mouse sebaceous gland organoids in vitro (2019) · cites this paper as [10]
Terminally differentiated sebocytes and granular layer IFE keratinocytes are marked by the Blimp1 protein.
“Subsequently, it was described that terminally differentiated sebocytes8, as well as granular layer IFE keratinocytes9, 10 are marked by the Blimp1 protein.”
From Blimp1+ cells generate functional mouse sebaceous gland organoids in vitro (2019) · cites this paper as [10]
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Self-citationZNF750 is a p63 target gene that induces KLF4 to drive terminal epidermal differentiation
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BackgroundA LncRNA-MAF:MAFB transcription factor network regulates epidermal differentiation
Lopez-Pajares, V., Qu, K., Zhang, J., Webster, D. E., Barajas, B. C., Siprashvili, Z., Zarnegar, B. J., Boxer, L. D., Rios, E. J., Tao, S., et al. (2015) · Developmental Cell · doi:10.1016/j.devcel.2015.01.028 · Cited by 194 · see citing works
“Among these are TFs, including GRHL3, ZNF750, KLF4, and PRDM1, each of which plays an essential and non-redundant role in epidermal differentiation (Yu et al., 2006; Ting et al., 2005; Peyrard-Janvid et al., 2014; Birnbaum et al., 2006; Sen et al., 2012; Segre et al., 1999; Magnúsdóttir et al., 2007).”
BackgroundRepression of the DNA-binding inhibitor Id3 by Blimp-1 limits the formation of memory CD8+ T cells
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“Blimp-1 has now emerged as a key master regulator of terminal differentiation in a variety of cell types, including keratinocytes and osteoclasts, as well as T lymphocyte”
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Self-citationBlimp-1 Attenuates Th1 Differentiation by Repression of ifng , tbx21 , and bcl6 Gene Expression
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“In the epidermis it represses myc, fos, nfat5, and dusp16 (17).”
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“scribed previously for detection of Blimp-1 binding (27) and LSD1 and FLAG-”
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“Indeed, recent reports demonstrate that Blimp1 binds to a distal site within intron 2 and represses its own expression via an autoregulatory feedback loop (11, 43).”
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“…been shown to be expressed in multiple cell lineages during development and adulthood, and in many of these cases, it plays a critical role for the lineage specification or maintenance (Horsley et al. 2006, Kallies et al. 2006, Martins et al. 2006, Magnusdottir et al. 2007, Robertson et al. 2007).”
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“B-lymphocyte-induced nuclear maturation protein 1 (Blimp1), another SG marker, is expressed at the base of the gland and in post-mitotic and terminally differentiated sebocytes and was shown to mark SG progenitor cells and to support terminal differentiation of sebocytes (67, 75 – 77).”
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ACTL6a Enforces the Epidermal Progenitor State by Suppressing SWI/SNF-Dependent Induction of KLF4
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“This partial rescue of the ACTL6a loss defect could be due to a number of factors, including action by transcription factors other than KLF4, such as GRHL3, PRDM1, HOPX, and others.”
InfluentialHeterogeneity and plasticity of epidermal stem cells
Schepeler, T., Page, M. E., & Jensen, K. B. (2014) · Development · doi:10.1242/dev.104588 · Cited by 120 · see citing works
“However, it was subsequently shown that Blimp1 is more widely expressed in the epidermis, including in differentiated cells of the sebaceous gland, and it has therefore been rejected as a specific marker of sebaceous gland stem cells (Magnusdottir et al., 2007; Cottle et al., 2013).”
Markers of Epidermal Stem Cell Subpopulations in Adult Mammalian SkinPreprint
Kretzschmar, K., & Watt, F. M. (2014) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a013631 · Cited by 115 · see citing works
“However, this study is controversial because BLIMP1 is expressed in terminally differentiated cells of all epidermal compartments, including the SG (Magnúsdóttir et al. 2007; Lo Celso et al. 2008; Cottle et al. 2013; Page et al. 2013).”
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“…et al. 2005, Wilm & Solnica-Krezel 2005, Horsley et al. 2006, Kallies et al. 2006, Martins Reproduction (2008) 136 503–514 et al. 2006, Magnusdottir et al. 2007, Robertson et al. 2007), and a transgenic reporter strain faithfully recapitulating its entire expression should be of…”
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“TLR9 is involved in barrier function and pattern-recognition receptors that elicit innate/adaptive immune response and inflammation, and c11orf30 is involved in epithelial immunity, growth, and/or differentiation (42, 77).”
BackgroundAn expanding job description for Blimp-1/PRDM1
Bikoff, E. K., Morgan, M. A., & Robertson, E. J. (2009) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2009.05.005 · Cited by 108 · see citing works
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“Primers were as follows: Rp 63 to 139, 5=-CTCTTACCTGCGTCTGTTTGT G-3= and 5=-CTCTCTGCTGCCCACTCATACT-3= (55); Rp 512 to 770, 5=-ATAAGGCTGCCAATAAGGTGCGTG-3= and 5=-GGATGTC CAGAGTGCCTACAATGTCT-3=; c-Myc, 5=-CGCCTGCGATGATTTA TACTC-3= and 5=-CGCCTACCATTTTCTTTTGC-3= (42); Qp, 5=-GAC CACTGAGGGAGTGTTCCACAG-3= and 5=-ACACCGTGCG…”
BackgroundInfluentialBlimp1: A conserved transcriptional repressor critical for differentiation of many tissues
John, S. A., & Garrett‐Sinha, L. A. (2008) · Experimental Cell Research · doi:10.1016/j.yexcr.2008.11.015 · Cited by 99 · see citing works
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Generating diversity: transcriptional regulation of effector and memory CD8+ T‐cell differentiation
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Activation-dependent induction of Blimp-1
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Self-citationActivation of the Hippo pathway by CTLA-4 regulates the expression of Blimp-1 in the CD8 + T cell
Thaventhiran, J. E. D., Hoffmann, A., Magiera, Ł., de la Roche, M., Lingel, H., Brunner-Weinzierl, M. C., & Fearon, D. T. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1209115109 · Cited by 86 · see citing works
“A potential role for the Hippo pathway in regulating the expression of Blimp-1 and Eomes is suggested by the independent observations that Blimp-1 and the Hippo pathway, respectively, are required for the normal differentiation of skin (27, 28) and that Yap, by interacting with the transcription factor TEA domain (TEA…”
BackgroundTelerman, S. B., Rognoni, E., Sequeira, I., Pisco, A. O., Lichtenberger, B. M., Culley, O. J., Viswanathan, P., Driskell, R. R., & Watt, F. M. (2017) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2017.06.015 · Cited by 81 · see citing works
“Epidermal deletion of Blimp1 causes multiple differentiation defects (Kretzschmar et al., 2014), including interfollicular epidermal hyperplasia (Chiang et al., 2013), sebaceous gland enlargement (Horsley et al., 2006), and impaired epidermal barrier formation (Magnúsdóttir et al., 2007).”
BackgroundMethodRapid and widespread suppression of self-renewal by microRNA-203 during epidermal differentiation
Jackson, S. J., Zhang, Z., Feng, D., Flagg, M., O’Loughlin, E., Wang, D., Stokes, N., Fuchs, E. V., & Yi, R. (2013) · Development · doi:10.1242/dev.089649 · Cited by 77 · see citing works
“, 2006) and Blimp1 (Magnúsdóttir et al., 2007) have been reported to have crucial roles in promoting epidermal differentiation, whereas E2F (Dicker et al.”
BackgroundHorn, M., Geisen, C., C̆ermák, L., Becker, B., Nakamura, S., Klein, C., Pagano, M., & Antebi, A. (2014) · Developmental Cell · doi:10.1016/j.devcel.2014.01.028 · Cited by 77 · see citing works
“…cell development have counterparts in mammals regulating skin stem cell homeostasis including blmp-1/BLIMP-1 itself, daf-12/FXR/VDR, lin-4/mir-125, let-7, lin-42/Period, and others (Cianferotti et al., 2007; Horsley et al., 2006; Janich et al., 2011; Magnúsdóttir et al., 2007; Zhang et al., 2011).”
Backgroundc-MYC-Induced Sebaceous Gland Differentiation Is Controlled by an Androgen Receptor/p53 Axis
Cottle, D. L., Kretzschmar, K., Schweiger, P. J., Quist, S. R., Gollnick, H. P., Natsuga, K., Aoyagi, S., & Watt, F. M. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.01.013 · Cited by 80 · see citing works
“c-MYC-Induced Sebaceous Gland Differentiation”
Mould, A. W., Morgan, M. A. J., Li, L., et al. (2012) · Genes & Development · doi:10.1101/gad.199828.112 · Cited by 72 · see citing works
“Interestingly, the regulator of G protein signaling family member Rgs5, a key regulator of vascular remodeling and pericyte maturation (Manzur and Ganss 2009), also shows significantly down-regulated expression.”
BackgroundA practical guide for the study of human and murine sebaceous glands in situ
Hinde, E., Haslam, I. S., Schneider, M. R., Langan, E. A., Kloepper, J. E., Schramm, C., Zouboulis, C. C., & Paus, R. (2013) · Experimental Dermatology · doi:10.1111/exd.12207 · Cited by 71 · see citing works
Chan, Y., Chiang, M.-F., Tsai, Y.-C., et al. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0901543 · Cited by 65 · see citing works
“Blimp-1 binding in vivo was detected essentially as reported (28, 30) using rabbit antiserum against Blimp-1 as described (31).”
BackgroundMethodGene deletion of inositol hexakisphosphate kinase 2 predisposes to aerodigestive tract carcinoma
Morrison, B., Haney, R. M., Lamarre, E., Drazba, J. A., Prestwich, G. D., & Lindner, D. J. (2009) · Oncogene · doi:10.1038/onc.2009.113 · Cited by 67 · see citing works
“DUSP16 dysregulation leads to abnormal keratinocyte function and skin formation (Magnusdottir et al., 2007).”
BackgroundFantauzzo, K. A., & Christiano, A. M. (2011) · Development · doi:10.1242/dev.069971 · Cited by 64 · see citing works
“…D. H. et al., Yes: DP, IRS precursors cKO: defective sebocyte differentiation (Horsley et al., 2006); defective epidermal differentiation (Magnusdottir et al., 2007); absent vibrissae (Robertson et al., 2007) Yes: absent vibrissae No Sox18 SRY boxcontaining transcription…”
BackgroundSox2 modulates the function of two distinct cell lineages in mouse skin
Lesko, M. H., Driskell, R. R., Kretzschmar, K., Goldie, S. J., & Watt, F. M. (2013) · Developmental Biology · doi:10.1016/j.ydbio.2013.08.004 · Cited by 66 · see citing works
Kretzschmar, K., Cottle, D. L., Donati, G., Chiang, M.-F., Quist, S. R., Gollnick, H. P., Natsuga, K., Lin, K.-I., & Watt, F. M. (2014) · Stem Cell Reports · doi:10.1016/j.stemcr.2014.08.007 · Cited by 65 · see citing works
Galectin-1 Promotes Immunoglobulin Production during Plasma Cell Differentiation
Tsai, C., Chiu, Y.-K., Hsu, T.-L., Lin, I., Hsieh, S.-L., & Lin, K. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.7.4570 · Cited by 60 · see citing works
“The lentiviral vector expressing either GFP alone or GFP-tagged Blimp-1 (27) was used to transduce CESS cells, an EBV-transformed human lymphoblastoid B cell line.”
BackgroundMethodBlimp-1/Prdm1 Alternative Promoter Usage during Mouse Development and Plasma Cell Differentiation
Morgan, M. A. J., Magnúsdóttir, E., Kuo, T. C., Tunyaplin, C., Harper, J., Arnold, S. J., Calame, K. L., Robertson, E. J., & Bikoff, E. K. (2009) · Molecular and Cellular Biology · doi:10.1128/mcb.00670-09 · Cited by 60 · see citing works
“Consistent with this idea, conserved Blimp-1 binding sites were characterized within intron 2 (48).”
BackgroundMethodInfluentialSelf-citationHou, X., Wei, Z., Zouboulis, C. C., & Ju, Q. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.909694 · Cited by 65 · see citing works
“However, further studies have shown that Blimp1 is a terminal differentiation marker in human SGs (Magnusdottir et al., 2007).”
BackgroundNawandar, D. M., Ohashi, M., Djavadian, R., et al. (2017) · Journal of Virology · doi:10.1128/jvi.02438-16 · Cited by 57 · see citing works
Nie, K., Zhang, T., Allawi, H. T., Gomez, M. F., Liu, Y., Chadburn, A., Wang, Y. L., Knowles, D. M., & Tam, W. (2010) · American Journal Of Pathology · doi:10.2353/ajpath.2010.091291 · Cited by 56 · see citing works
“It also plays a critical role in effector and memory T-cell differentiation,(1,3,5) myeloid cell development,(6) dendritic cell development,(7) and epithelial cell differentiation.(8) Inactivating mutations that result in the generation of a severely truncated nonfunctional PRDM1 are found in about 20% of the diffuse…”
BackgroundKlein, R. H., Lin, Z., Hopkin, A. S., Gordon, W., Tsoi, L. C., Liang, Y., Gudjonsson, J. E., & D, B. A. M. (2017) · PLoS Genetics · doi:10.1371/journal.pgen.1006745 · Cited by 54 · see citing works
PRDM1 silences stem cell-related genes and inhibits proliferation of human colon tumor organoids
Liu, C., Banister, C. E., Weige, C. C., Altomare, D., Richardson, J. H., Contreras, C. M., & Buckhaults, P. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1802902115 · Cited by 58 · see citing works
“In human and mouse cells PRDM1 target genes include IFN-β, KLF4, IL2, c-Fos, Dusp16, and TP53 (1, 7, 13, 20, 22).”
BackgroundInfluentialCraene, B. D., Denecker, G., Vermassen, P., Taminau, J., Mauch, C., Derore, A., Jonkers, J., Fuchs, E. V., & Berx, G. (2013) · Cell Death and Differentiation · doi:10.1038/cdd.2013.148 · Cited by 54 · see citing works
“The transcriptional repressor Blimp-1 marks the terminally differentiated region of the sebaceous gland.(26) We found that loss of Blimp-1 in the sebaceous gland is one of the earliest molecular consequences of Snail expression in the skin.”
BackgroundMassively parallel knock-in engineering of human T cells
Dai, X., Park, J. J.-Y., Du, Y., Na, Z., Lam, S. Z., Chow, R. D.-W., Renauer, P. A., Gu, J., Shan, X., Chu, Z., et al. (2023) · Nature Biotechnology · doi:10.1038/s41587-022-01639-x · Cited by 54 · see citing works
Blimp1+ cells generate functional mouse sebaceous gland organoids in vitro
Feldman, A., Mukha, D., Maor, I. I., Sedov, E., Koren, E., Yosefzon, Y., Shlomi, T., & Fuchs, Y. (2019) · Nature Communications · doi:10.1038/s41467-019-10261-6 · Cited by 52 · see citing works
Characterization of Hair Follicle Development in Engineered Skin Substitutes
Sriwiriyanont, P., Lynch, K. A., McFarland, K. L., Supp, D. M., & Boyce, S. T. (2013) · PLoS ONE · doi:10.1371/journal.pone.0065664 · Cited by 49 · see citing works
Kongsuwan, K., Josh, P., Colgrave, M. L., Bagnall, N. H., Gough, J., Burns, B., & Pearson, R. (2010) · International Journal for Parasitology · doi:10.1016/j.ijpara.2009.10.013 · Cited by 48 · see citing works
Camilleri, M., Carlson, P., McKinzie, S., Zucchelli, M., D’Amato, M., Busciglio, I., Burton, D., & Zinsmeister, A. R. (2011) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2011.01749.x · Cited by 47 · see citing works
TGFβ signaling regulates lipogenesis in human sebaceous glands cells
McNairn, A. J., Doucet, Y., Demaude, J., Brusadelli, M. G., Gordon, C. B., Uribe‐Rivera, A., Lambert, P. F., Bouez, C., Breton, L., & Guasch, G. (2013) · BMC Dermatology · doi:10.1186/1471-5945-13-2 · Cited by 47 · see citing works
“In agreement with recent reports [16,30], Blimp1 is expressed in the inner root sheath of the hair follicle and in terminally differentiated cells of the sebaceous glands in human scalp sections from which SSG3 cells were derived (Additional file 1: Figure S1c).”
ResultHighly Rapid and Efficient Conversion of Human Fibroblasts to Keratinocyte-Like Cells
Chen, Y., Mistry, D. S., & Sen, G. L. (2013) · Journal of Investigative Dermatology · doi:10.1038/jid.2013.327 · Cited by 45 · see citing works
“…KLF4, OVOL1, ZNF750, and GRHL3) that we and others have previously published to be critical for epidermal fate determination and differentiation(Magnusdottir et al., 2007; Mills et al., 1999; Mistry et al., 2012; Nair et al., 2006; Segre et al., 1999; Sen et al., 2012; Ting et al., 2005;…”
BackgroundStem and progenitor cells in sebaceous gland development, homeostasis and pathologies
Geueke, A., & Niemann, C. (2021) · Experimental Dermatology · doi:10.1111/exd.14303 · Cited by 45 · see citing works
Boehm, D., & Ott, M. (2017) · AIDS Research and Human Retroviruses · doi:10.1089/aid.2017.0180 · Cited by 45 · see citing works
Spidale, N. A., Malhotra, N., Frascoli, M., Sylvia, K., Miu, B., Freeman, C., Stadinski, B. D., Huseby, E. S., & Kang, J. (2020) · eLife · doi:10.7554/elife.51188 · Cited by 45 · see citing works
Primoridal germ cell specification: a context-dependent cellular differentiation event
Günesdogan, U., Magnúsdóttir, E., & Surani, M. A. (2014) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2013.0543 · Cited by 43 · see citing works
Self-citationNagarajan, P., Parikh, N., Garrett‐Sinha, L. A., & Sinha, S. (2009) · PLoS ONE · doi:10.1371/journal.pone.0004179 · Cited by 40 · see citing works
“Blimp-1 is important for the final differentiation step of keratinocytes from the granular layer to the cornified layer [ 75 ].”
BackgroundChiang, M.-F., Yang, S.-Y., Lin, I.-Y., Hong, J.-B., Lin, S.-J., Ying, H.-Y., Chen, C.-M., Wu, S.-Y., Liu, F.-T., & Lin, K.-I. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1219462110 · Cited by 42 · see citing works
“However, no significant binding of Blimp-1 to the candidate cytokine/chemokine genes was detected compared with the negative control locus, snail3 (9) (Fig.”
BackgroundResultInfluentialSpecification of the germ cell lineage in mice
Saitou, M. (2009) · Frontiers in bioscience · doi:10.2741/3294 · Cited by 39 · see citing works
Élias, S., Morgan, M. A., Bikoff, E. K., & Robertson, E. J. (2017) · Nature Communications · doi:10.1038/s41467-017-01971-w · Cited by 39 · see citing works
Sybirna, A., Wong, F. C. K., & Surani, M. (2019) · Current Topics in Developmental Biology · doi:10.1016/bs.ctdb.2019.04.004 · Cited by 33 · see citing works
Sahlén, P., Spalinskas, R., Asad, S., Mahapatra, K. D., Höjer, P., Anil, A., Eisfeldt, J., Srivastava, A., Nikamo, P., Mukherjee, A., et al. (2020) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2020.09.035 · Cited by 37 · see citing works
Mould, A. W., Morgan, M. A. J., Nelson, A., Bikoff, E. K., & Robertson, E. J. (2015) · PLoS Genetics · doi:10.1371/journal.pgen.1005375 · Cited by 36 · see citing works
“Nfat5, Fos, Dusp16 and Prdm1 itself are direct targets in the skin epidermis [14].”
Bogani, D., Morgan, M. A., Nelson, A., Costello, I., McGouran, J. F., Kessler, B. M., Robertson, E. J., & Bikoff, E. K. (2013) · Molecular and Cellular Biology · doi:10.1128/mcb.00498-13 · Cited by 35 · see citing works
“We performed ChIP-seq experiments using stably transfected ESCs strongly expressing full-length Prdm4-EGFP from the chicken beta-actin promoter in combination with a ChIP-quality anti-GFP monoclonal antibody (30) (Fig.”
BackgroundMethodVincent, S. D., Mayeuf-Louchart, A., Watanabe, Y., Brzezinski, J. A., Miyagawa‐Tomita, S., Kelly, R. G., & BUCKINGHAM, M. E. (2014) · Human Molecular Genetics · doi:10.1093/hmg/ddu232 · Cited by 35 · see citing works
“However, this function is clearly context dependent since Prdm1 is also expressed in differentiated skeletal muscle cells (23,62) or epidermis (63), where proliferation is not affected in the mutant.”
BackgroundBlimp‐1: a marker of terminal differentiation but not of sebocytic progenitor cells
Sellheyer, K., & Krahl, D. (2009) · Journal of Cutaneous Pathology · doi:10.1111/j.1600-0560.2009.01434.x · Cited by 35 · see citing works
Nagarajan, P., Chin, S. S., Wang, D., Liu, S., Sinha, S., & Garrett‐Sinha, L. A. (2010) · Journal of Cell Science · doi:10.1242/jcs.062240 · Cited by 35 · see citing works
“One study has demonstrated that Blimp1 plays an important role in regulating terminal differentiation of epidermal keratinocytes (Magnusdottir et al., 2007), although another study failed to detect alterations in the IFE of Blimp1 conditional knockout mice (Horsley et al.”
ResultDUSP16 is an epigenetically regulated determinant of JNK signalling in Burkitt's lymphoma
Lee, S., Syed, N., Taylor, J., Smith, P., Griffin, B. E., Baens, M., Bai, M., Bourantas, K. L., Stebbing, J., Naresh, K. N., et al. (2010) · British Journal of Cancer · doi:10.1038/sj.bjc.6605711 · Cited by 34 · see citing works
“DUSP16 is a direct transcriptional target of B lymphocyte-induced maturation protein, Blimp-1 (Magnusdottir et al, 2007), suggesting that it may have a role in the normal developmental physiology of B lymphocytes.”
BackgroundBlimp-1/PRDM1 Mediates Transcriptional Suppression of the NLR Gene NLRP12/Monarch-1
Lord, C. A., Savitsky, D. A., Sitcheran, R., Calame, K. L., Wright, J. R., Ting, J. P.-Y., & Williams, K. L. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0801692 · Cited by 34 · see citing works
“All previously identified Blimp-1 binding sites contain the consensus sequence (/C)AG( /C)GAAAG( /C)( /T) with the exception of the NLR gene CIITA, which contains the sequence (/C)AG (/C)GAAAT( /C)( /T) (49, 57, 58).”
BackgroundSelf-citationSevera, M., Islam, S. A., Waggoner, S. N., Jiang, Z., Kim, N. D., Ryan, G., Kurt‐Jones, E. A., Charo, I. F., Caffrey, D. R., Boyartchuk, V., et al. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1301799 · Cited by 32 · see citing works
“It also plays a central role in the differentiation and function of keratinocytes (11) and sebocytes (12) and in the tolerogenic function of DCs (13).”
BackgroundAberrant CREB1 activation in prostate cancer disrupts normal prostate luminal cell differentiation
Watson, M. J., Berger, P. L., Banerjee, K., et al. (2021) · Oncogene · doi:10.1038/s41388-021-01772-y · Cited by 31 · see citing works
“Epidermal terminal differentiation in the mouse depends on BLIMP1 protein expression in the granular layer of keratinocytes, the most differentiated corneocyte precursors [32].”
B lymphocyte-induced maturation protein 1 is a novel target gene of aryl hydrocarbon receptor
Ikuta, T., Ohba, M., Zouboulis, C. C., Fujii‐Kuriyama, Y., & Kawajiri, K. (2010) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2010.04.003 · Cited by 31 · see citing works
“In this report, we studied the biological functions of AhR in the skin and found a novel target gene, B lymphocyte maturation protein 1 (Blimp1), which is a transcriptional repressor that is a critical regulatorofmaturationof epidermis [15]aswell asdeterminationof cell fate in sebocytes [16].”
BackgroundBlimp-1, an Intrinsic Factor that Represses HIV-1 Proviral Transcription in Memory CD4+ T Cells
Michaels, K. K., Natarajan, M., Euler, Z., Alter, G., Viglianti, G. A., & Henderson, A. J. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1402581 · Cited by 31 · see citing works
Prdm1 Regulates Thymic Epithelial Function To Prevent Autoimmunity
Roberts, N. A., Adams, B. D., McCarthy, N. I., et al. (2017) · The Journal of Immunology · doi:10.4049/jimmunol.1600941 · Cited by 31 · see citing works
“This is consistent with Prdm1’s expression in the most differentiated layers of the skin epidermis (26).”
BackgroundSellheyer, K. (2011) · Journal of Cutaneous Pathology · doi:10.1111/j.1600-0560.2010.01671.x · Cited by 27 · see citing works
PRDM1, a Tumor‐Suppressor Gene, is Induced by Genkwadaphnin in Human Colon Cancer SW620 Cells
Kang, H., Lee, H., Jee, D. J., Shin, S., Nah, S., Yoon, S. Y., & Kim, J. W. (2015) · Journal of Cellular Biochemistry · doi:10.1002/jcb.25262 · Cited by 26 · see citing works
“JOURNAL OF CELLULAR BIOCHEMISTRY PRDM1 PRODUCTION BY GENKWADAPHNIN 177 PRDM1 expression has also been reported in epithelial cells and is the most important factor for keratinocyte differentiation [Magnusdottir et al., 2007].”
BackgroundBach1-dependent and -independent Regulation of Heme Oxygenase-1 in Keratinocytes
Okada, S., Muto, A., Ogawa, E., Nakanome, A., Katoh, Y., Ikawa, S., Aiba, S., Igarashi, K., & Okuyama, R. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.068197 · Cited by 25 · see citing works
Cangkrama, M., Ting, S. B., & Darido, C. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms140713670 · Cited by 26 · see citing works
“In mice, the transcriptional repressor Blimp-1 has been proposed to regulate sebaceous gland homeostasis via unipotent progenitor cells within the sebaceous glands of the skin.”
BackgroundInfluentialC. elegans molting requires rhythmic accumulation of the Grainyhead/LSF transcription factor GRH‐1
Meeuse, M. W. M., Hauser, Y. P., Nahar, S., Smith, A., Braun, K., Azzi, C., Rempfler, M., & Großhans, H. (2023) · The EMBO Journal · doi:10.15252/embj.2022111895 · Cited by 23 · see citing works
“…mouse orthologues of blmp-1 and nhr-23, respectively, Prdm1 and Rora, impair the proper execution of hair follicle cycles (Steinmayr et al, 1998; Magnusdottir et al, 2007; Telerman et al, 2017), while grhl1 ablation causes hair coat defects related to hair anchoring and potentially other…”
BackgroundBuettner, M. J., Lang, A., Tudor, C. S., et al. (2012) · Journal of General Virology · doi:10.1099/vir.0.038661-0 · Cited by 23 · see citing works
Tools for the genetic analysis of germ cells
Hammond, S. S., & Matin, A. (2009) · genesis · doi:10.1002/dvg.20539 · Cited by 23 · see citing works
“…stage in the mouse embryo (before E7) and subsequently its expression is found in a number of ectoderm, endoderm, and mesoderm-derived tissues of the embryo (Chang et al., 2002; Horsley et al., 2006; Magnúsdóttir et al., 2007; Ohinata et al., 2008; Robertson et al., 2007; Vincent et al., 2005).”
BackgroundUncovering MicroRNA Regulatory Hubs that Modulate Plasma Cell Differentiation
Tsai, D.-Y., Hung, K.-H., Lin, I., Su, S., Wu, S.-Y., Chung, C., Wang, T.-C., Li, W., Shih, A. C.-C., & Lin, K. (2015) · Scientific Reports · doi:10.1038/srep17957 · Cited by 21 · see citing works
Nelson, A. C., Mould, A. W., Bikoff, E. K., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-06859-9 · Cited by 20 · see citing works
EGR3 Is a Late Epidermal Differentiation Regulator that Establishes the Skin-Specific Gene Network
Kim, K., Son, E. D., Kim, H.-J., Lee, S. H., Bae, I., & Lee, T. R. (2018) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2018.09.019 · Cited by 18 · see citing works
Alternative Splicing Regulates Prdm1/Blimp-1 DNA Binding Activities and Corepressor Interactions
Morgan, M. A., Mould, A. W., Li, L., Robertson, E. J., & Bikoff, E. K. (2012) · Molecular and Cellular Biology · doi:10.1128/mcb.00174-12 · Cited by 20 · see citing works
“DNA binding activity is therefore required to mediate a previously described autoinhibitory feedback loop via recognition of the consensus binding site located in intron 2 at the Prdm1 locus (46).”
BackgroundProtective effects of glycerol and xylitol in keratinocytes exposed to hyperosmotic stress
Szél, E., Danis, J., Sőrés, E., Tóth, D., Korponyai, C., Degovics, D., Prorok, J., Acsai, K., Dikstein, S., Kemény, L. V., et al. (2019) · Clinical Cosmetic and Investigational Dermatology · doi:10.2147/ccid.s197946 · Cited by 19 · see citing works
Mononuclear phagocyte regulation by the transcription factor Blimp‐1 in health and disease
Ulmert, I., Henriques‐Oliveira, L., Pereira, C., & Lahl, K. (2020) · Immunology · doi:10.1111/imm.13249 · Cited by 18 · see citing works
- Authors
- Magnúsdóttir, E., Kalachikov, S., Mizukoshi, K., Savitsky, D., Ishida-Yamamoto, A., Panteleyev, A. A., & Calame, K.
- Affiliations
- Columbia University (US)
- Columbia Genome Center, and
- Asahikawa Medical College Hospital (JP)
- Department of Dermatology, Asahikawa Medical College, Asahikawa 078-8510, Japan
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2007-09-18
- Volume
- 104
- Issue
- 38
- Pages
- 14988-14993
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC1986600
- OpenAlex
- W2148705591
- Semantic Scholar
- e4381d4ef6d206ca8953a70f0a5f76ffdfe8846d
- Cited by
- 152
- References
- 36
- Citations by year
- 2026: 2 · 2025: 6 · 2024: 2 · 2023: 4 · 2022: 8 · 2021: 4 · 2020: 5 · 2019: 5 · 2018: 5 · 2017: 10 · 2016: 3 · 2015: 9 · 2014: 15 · 2013: 16 · 2012: 8
- FWCI
- 5.66
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Institute of Allergy and Infectious Diseases (R01AI050659, R01 AI43576, R01-AI50659, R01AI043576)
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (P30AR044535, K01 AR02204, K01AR002204)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Skin and Cellular Biology Research
- Health Sciences › Medicine › Urology › Hair Growth and Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and rare skin diseases.
- Keywords
- Blimp-1, keratinization, keratinocytes, cornified layer, transcriptional repression, conditional knockout mice, NFAT5, FOS, DUSP16, skin barrier, osmotic balance, granular layer, corneocytes, lipid metabolism
- MeSH terms
- Positive Regulatory Domain I-Binding Factor 1, Epidermal Cells, Animals, Cell Differentiation, Embryonic Structures, Epidermis, Humans, Phenotype, Repressor Proteins, RNA, Messenger, Transcription Factors, Keratinocytes, Proto-Oncogene Proteins c-fos, Gene Deletion, Mice, Knockout, Oligonucleotide Array Sequence Analysis, NFATC Transcription Factors, Mice, Dual-Specificity Phosphatases, Mitogen-Activated Protein Kinase Phosphatases
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