Reactive Astrocytes Promote ALS-like Degeneration and Intracellular Protein Aggregation in Human Motor Neurons by Disrupting Autophagy through TGF-β1

Tripathi, Pratibha, Rodriguez-Muela, Natalia, Klim, Joseph R., de Boer, A. Sophie, Agrawal, Sahil, Sandoe, Jackson, Lopes, Claudia S., Ogliari, Karolyn Sassi, Williams, Luis A., Shear, Matthew, Rubin, Lee L., Eggan, Kevin, Zhou, Qiao·2017·Stem Cell Reports

Cited by (123)

Items 101–123 of 123

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  2. siRNA for REST ameliorates symptoms in ALS mice and serum REST predicts disease prognosis and survival in ALS patients
    Natascia Guida, Valeria Valsecchi, Serenella Anzilotti, Raffaele Dubbioso, Ornella Cuomo, Silvia Ruggiero, Gianmaria Senerchia, Valentina Virginia Iuzzolino, Xhesika Kolici, Nunzia De Iesu et al. · 2025 · Molecular Therapy
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    Francesca Rosso, Rocio Magdalena, Carola Torazza, Francesca Bacchetti, Marco Milanese, Angelo Poletti, Giambattista Bonanno, Riccardo Cristofani, Tiziana Bonifacino · 2025 · Neurobiology of Disease
  4. Evaluation of Motor Neuron Injury in ALS by Different Parameters of Diffusion Tensor Imaging
    Yong Sang, Jingfeng Xu · 2020 · IEEE Access
  5. Motor Neuron Diseases
    Michelle M. Dompenciel · 2021 · Springer eBooks
  6. The role of astrocytes with genetic mutations linked to amyotrophic lateral sclerosis
    David Brash-Arias, Gonzálo Emiliano Aranda-Abreu, Fausto Rojas-Durán, María Elena Hernández‐Aguilar, María Rebeca Toledo‐Cárdenas, César Antonio Pérez-Estudillo, Arturo Ortega, Donají Chi-Castañeda · 2023 · Neurology Perspectives
  7. Nanotherapeutics of Phytoantioxidants for CNS Disorders
    Arpita Paul, Nilayan Guha, Kamaruz Zaman · 2022 · Wiley eBooks
  8. Heart-brain axis, gliotransmitters and peripheral neurogenesis: Emerging regenerative roles of cardiac nexus glia in health and disease
    Abirami Sekhar, Mahesh Kandasamy · 2025 · World Journal of Cardiology
  9. ALS: An Organism-Wide Bioenergetic Failure Due to Mitochondrial Dysfunctions?
    Hiroshi Mitsumoto, Hélène Blasco, Philippe Corcia, Vincenzo Silani · 2026 · Biomolecules
  10. Astrocyte-Neuron Interactions Contributing to Amyotrophic Lateral Sclerosis Progression
    Brigid K. Jensen · 2024 · Advances in neurobiology
  11. Expression of a miRNA targeting mutated SOD1 in astrocytes induces motoneuron plasticity and improves neuromuscular function in ALS mice
    Cylia Rochat, Nathalie Bernard‐Marissal, Sylvain Pradervand, Florence Evelyne Perrin, Cédric Raoul, Patrick Aebischer, Bernard Laurent Schneider · 2021 · bioRxiv (Cold Spring Harbor Laboratory)
  12. TNFα hinders FGF4 efficacy to mitigate ALS astrocyte dysfunction and cGAS-STING pathway-induced innate immune reactivity
    Erika Velásquez, Ekaterina Savchenko, Sara Marmolejo-Martínez-Artesero, Désiré Challuau, Aline Aebi, Yuriy Pomeshchik, Nuno Jorge Lamas, Mauno Vihinen, Melinda Rezeli, Bernard Laurent Schneider et al. · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
  13. Protective Role of Glial Heat Shock Proteins in Amyotrophic Lateral Sclerosis
    Benjamin E. Clarke, Bernadett Kalmár, Linda Greensmith · 2019 · Heat shock proteins
  14. Astrocytes in neurodegenerative disorders
    Aurélie de Rus Jacquet · 2021 · Elsevier eBooks
  15. Astrocytic expression of ALS-causative mutant FUS leads to TNFα-dependent neurodegeneration in vivo
    Brigid K. Jensen, Kevin McAvoy, Nicolette M. Heinsinger, A. Lepore, Hristelina Ilieva, A. Haeusler, D. Trotti, P. Pasinelli · 2021 · bioRxiv
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  17. Astrocytes in multiple sclerosis
    Gavin Piester, Francisco Javier Quintana · 2024 · Elsevier eBooks
  18. Additional file 2 of FUS-ALS hiPSC-derived astrocytes impair human motor units through both gain-of-toxicity and loss-of-support mechanisms
    Katarina Stoklund Dittlau, Lisanne Terrie, Pieter Baatsen, Axelle Kerstens, Lim De Swert, Rekin’s Janky, Nikky Corthout, Pegah Masrori, Philip Van Damme, P. Hyttel et al. · 2024 · Figshare
  19. Additional file 1 of FUS-ALS hiPSC-derived astrocytes impair human motor units through both gain-of-toxicity and loss-of-support mechanisms
    Katarina Stoklund Dittlau, Lisanne Terrie, Pieter Baatsen, Axelle Kerstens, Lim De Swert, Rekin’s Janky, Nikky Corthout, Pegah Masrori, Philip Van Damme, P. Hyttel et al. · 2024 · Figshare
  20. Quantification multiplexe de biomarqueurs d’intérêt clinique et de leurs protéoformes par spectrométrie de masse. Application à l’analyse de cohortes médicales
    Arthur Viodé · 2018 · theses.fr (ABES)
  21. Les astrocytes réactifs, des partenaires anti-agrégants dans la maladie de Huntington : identification des mécanismes impliqués dans le dialogue neurone-astrocyte
    Laurene Abjean · 2019 · theses.fr (ABES)
  22. Étude des perturbations astrocytaires sous l’influence de l’apolipoprotéine E4 : implications et applications dans la maladie d’Alzheimer
    Laurie Arnaud · 2021 · theses.fr (ABES)
  23. Multiplex Panel Detects Glial and Inflammatory Biomarker Signatures in Sporadic and C9orf72-ALS
    Karthik Baskar, Christina Steffke, Sarah Bernsen, Zeynep Elmas, Jasper Hesebeck‐Brinckmann, Joachim Schuster, Thomas Meyer, Patrick Weydt, Jochen Hans Weishaupt, Dávid Brenner et al. · 2026 · Neurology Neuroimmunology & Neuroinflammation