Reactive Astrocytes Promote ALS-like Degeneration and Intracellular Protein Aggregation in Human Motor Neurons by Disrupting Autophagy through TGF-β1
Tripathi, Pratibha, Rodriguez-Muela, Natalia, Klim, Joseph R., de Boer, A. Sophie, Agrawal, Sahil, Sandoe, Jackson, Lopes, Claudia S., Ogliari, Karolyn Sassi, Williams, Luis A., Shear, Matthew, Rubin, Lee L., Eggan, Kevin, Zhou, Qiao·2017·Stem Cell Reports
Cited by (123)
Items 101–123 of 123
- Astrocytes in Pathogenesis of ALS Disease and Potential Translation into ClinicMichal Izrael, Shalom Guy Slutsky, Joseph Itskovitz‐Eldor, Revel Michel · 2018 · InTech eBooks
- siRNA for REST ameliorates symptoms in ALS mice and serum REST predicts disease prognosis and survival in ALS patientsNatascia Guida, Valeria Valsecchi, Serenella Anzilotti, Raffaele Dubbioso, Ornella Cuomo, Silvia Ruggiero, Gianmaria Senerchia, Valentina Virginia Iuzzolino, Xhesika Kolici, Nunzia De Iesu et al. · 2025 · Molecular Therapy
- Non-cell autonomous autophagy in amyotrophic lateral sclerosis: A new promising target?Francesca Rosso, Rocio Magdalena, Carola Torazza, Francesca Bacchetti, Marco Milanese, Angelo Poletti, Giambattista Bonanno, Riccardo Cristofani, Tiziana Bonifacino · 2025 · Neurobiology of Disease
- Evaluation of Motor Neuron Injury in ALS by Different Parameters of Diffusion Tensor ImagingYong Sang, Jingfeng Xu · 2020 · IEEE Access
- Motor Neuron DiseasesMichelle M. Dompenciel · 2021 · Springer eBooks
- The role of astrocytes with genetic mutations linked to amyotrophic lateral sclerosisDavid Brash-Arias, Gonzálo Emiliano Aranda-Abreu, Fausto Rojas-Durán, María Elena Hernández‐Aguilar, María Rebeca Toledo‐Cárdenas, César Antonio Pérez-Estudillo, Arturo Ortega, Donají Chi-Castañeda · 2023 · Neurology Perspectives
- Nanotherapeutics of Phytoantioxidants for CNS DisordersArpita Paul, Nilayan Guha, Kamaruz Zaman · 2022 · Wiley eBooks
- Heart-brain axis, gliotransmitters and peripheral neurogenesis: Emerging regenerative roles of cardiac nexus glia in health and diseaseAbirami Sekhar, Mahesh Kandasamy · 2025 · World Journal of Cardiology
- ALS: An Organism-Wide Bioenergetic Failure Due to Mitochondrial Dysfunctions?Hiroshi Mitsumoto, Hélène Blasco, Philippe Corcia, Vincenzo Silani · 2026 · Biomolecules
- Astrocyte-Neuron Interactions Contributing to Amyotrophic Lateral Sclerosis ProgressionBrigid K. Jensen · 2024 · Advances in neurobiology
- Expression of a miRNA targeting mutated SOD1 in astrocytes induces motoneuron plasticity and improves neuromuscular function in ALS miceCylia Rochat, Nathalie Bernard‐Marissal, Sylvain Pradervand, Florence Evelyne Perrin, Cédric Raoul, Patrick Aebischer, Bernard Laurent Schneider · 2021 · bioRxiv (Cold Spring Harbor Laboratory)
- TNFα hinders FGF4 efficacy to mitigate ALS astrocyte dysfunction and cGAS-STING pathway-induced innate immune reactivityErika Velásquez, Ekaterina Savchenko, Sara Marmolejo-Martínez-Artesero, Désiré Challuau, Aline Aebi, Yuriy Pomeshchik, Nuno Jorge Lamas, Mauno Vihinen, Melinda Rezeli, Bernard Laurent Schneider et al. · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
- Protective Role of Glial Heat Shock Proteins in Amyotrophic Lateral SclerosisBenjamin E. Clarke, Bernadett Kalmár, Linda Greensmith · 2019 · Heat shock proteins
- Astrocytes in neurodegenerative disordersAurélie de Rus Jacquet · 2021 · Elsevier eBooks
- Astrocytic expression of ALS-causative mutant FUS leads to TNFα-dependent neurodegeneration in vivoBrigid K. Jensen, Kevin McAvoy, Nicolette M. Heinsinger, A. Lepore, Hristelina Ilieva, A. Haeusler, D. Trotti, P. Pasinelli · 2021 · bioRxiv
- [Facioacromelic disostosis with metal retardation (author's transl)].J M Cantú, A Hernández, Z Nazará-Cazorla, C Pacheco, S Armendares · 1974 · PubMed
- Astrocytes in multiple sclerosisGavin Piester, Francisco Javier Quintana · 2024 · Elsevier eBooks
- Additional file 2 of FUS-ALS hiPSC-derived astrocytes impair human motor units through both gain-of-toxicity and loss-of-support mechanismsKatarina Stoklund Dittlau, Lisanne Terrie, Pieter Baatsen, Axelle Kerstens, Lim De Swert, Rekin’s Janky, Nikky Corthout, Pegah Masrori, Philip Van Damme, P. Hyttel et al. · 2024 · Figshare
- Additional file 1 of FUS-ALS hiPSC-derived astrocytes impair human motor units through both gain-of-toxicity and loss-of-support mechanismsKatarina Stoklund Dittlau, Lisanne Terrie, Pieter Baatsen, Axelle Kerstens, Lim De Swert, Rekin’s Janky, Nikky Corthout, Pegah Masrori, Philip Van Damme, P. Hyttel et al. · 2024 · Figshare
- Quantification multiplexe de biomarqueurs d’intérêt clinique et de leurs protéoformes par spectrométrie de masse. Application à l’analyse de cohortes médicalesArthur Viodé · 2018 · theses.fr (ABES)
- Les astrocytes réactifs, des partenaires anti-agrégants dans la maladie de Huntington : identification des mécanismes impliqués dans le dialogue neurone-astrocyteLaurene Abjean · 2019 · theses.fr (ABES)
- Étude des perturbations astrocytaires sous l’influence de l’apolipoprotéine E4 : implications et applications dans la maladie d’AlzheimerLaurie Arnaud · 2021 · theses.fr (ABES)
- Multiplex Panel Detects Glial and Inflammatory Biomarker Signatures in Sporadic and C9orf72-ALSKarthik Baskar, Christina Steffke, Sarah Bernsen, Zeynep Elmas, Jasper Hesebeck‐Brinckmann, Joachim Schuster, Thomas Meyer, Patrick Weydt, Jochen Hans Weishaupt, Dávid Brenner et al. · 2026 · Neurology Neuroimmunology & Neuroinflammation