Acquisition of Dynamic Function in Human Stem Cell-Derived β Cells

Cited by (406)

Items 101–200 of 406

1. Understanding generation and regeneration of pancreatic β cells from a single-cell perspective
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3. Insulin/Glucose-Responsive Cells Derived from Induced Pluripotent Stem Cells: Disease Modeling and Treatment of Diabetes
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4. Human stem cell models: lessons for pancreatic development and disease
   B. Gaertner, Andrea C. Carrano, M. Sander · 2019 · Genes & Development
5. Challenges of CRISPR/Cas-Based Cell Therapy for Type 1 Diabetes: How Not to Engineer a “Trojan Horse”
   Dmitry S. Karpov, Anastasiia O. Sosnovtseva, Svetlana V. Pylina, Asya Bastrich, Darya A. Petrova, Maxim A. Kovalev, Anastasija I. Shuvalova, Еремкина Анна Константиновна, Natalia G. Mokrysheva · 2023 · International Journal of Molecular Sciences
6. Islet Regeneration: Endogenous and Exogenous Approaches
   Fiona M. Docherty, Lori Sussel · 2021 · International Journal of Molecular Sciences
7. Overcoming the Limitations of Stem Cell-Derived Beta Cells
   Mariana V. Karimova, Inessa G. Gvazava, Ekaterina Andreevna Vorotelyak · 2022 · Biomolecules
8. Human T Cells Expressing a CD19 CAR-T Receptor Provide Insights into Mechanisms of Human CD19-Positive β Cell Destruction
   Hai-Ting Ma, J. F. Jeppesen, R. Jaenisch · 2020 · Cell Reports Medicine
9. Epigenetic Memory: Lessons From iPS Cells Derived From Human β Cells
   S. Efrat · 2021 · Frontiers in Endocrinology
10. Stem cell therapies for diabetes
    Juin Ting Chen, Nidheesh Dadheech, Eddie Han Pin Tan, Natasha Hui Jin Ng, Mickey Koh, Andrew M. James Shapiro, Adrian Kee Keong Teo · 2025 · Nature Medicine
11. Pancreatic β cell regeneration induced by clinical and preclinical agents
    Kangli Wang, Ming Tao, Tianjiao Wei, Rui Wei · 2021 · World Journal of Stem Cells
12. Process parameter development for the scaled generation of stem cell‐derived pancreatic endocrine cells
    D. Iworima, Sebastian Rieck, T. Kieffer · 2021 · Stem Cells Translational Medicine
13. The Foundation for Engineering a Pancreatic Islet Niche
    Smit N. Patel, C. Mathews, R. Chandler, C. Stabler · 2022 · Frontiers in Endocrinology
14. Stepwise differentiation of functional pancreatic β cells from human pluripotent stem cells
    Wenwen Jin, Wei Jiang · 2022 · Cell Regeneration
15. Pancreatic Extracellular Matrix/Alginate Hydrogels Provide a Supportive Microenvironment for Insulin-Producing Cells
    Dongzhi Wang, Yi Xin Zhu, Yan Hong Huang, Jiachen Zhu, Biwen Zhu, Yahong Zhao, Yuhua Lu, Zhiwei Wang, Yibing Guo · 2021 · ACS Biomaterials Science & Engineering
16. Immune checkpoint CD47 molecule engineered islets mitigate instant blood‐mediated inflammatory reaction and show improved engraftment following intraportal transplantation
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17. Engineered Biomaterials for Enhanced Function of Insulin‐Secreting β‐Cell Organoids
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18. Manufacturing clinical‐grade human induced pluripotent stem cell‐derived beta cells for diabetes treatment
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19. Methionine metabolism regulates pluripotent stem cell pluripotency and differentiation through zinc mobilization
    Erinn Zixuan Sim, Takayuki Enomoto, Nobuaki Shiraki, Nao Furuta, Soshiro Kashio, Taiho Kambe, Tomonori Tsuyama, Akihiro Arakawa, Hiroki Ozawa, Mizuho Yokoyama et al. · 2022 · Cell Reports
20. Differentiation of stem cell-derived pancreatic progenitors into insulin-secreting islet clusters in a multiwell-based static 3D culture system
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21. In vivo Environment Swiftly Restricts Human Pancreatic Progenitors Toward Mono-Hormonal Identity via a HNF1A/HNF4A Mechanism
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22. Cell Mass Increase Associated with Formation of Glucose‐Controlling β‐Cell Mass in Device‐Encapsulated Implants of hiPS‐Derived Pancreatic Endoderm
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23. Pancreas organoid models of development and regeneration.
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24. Tissue Engineering Strategies for Improving Beta Cell Transplantation Outcome
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25. Multiplexed microfluidic platform for stem-cell derived pancreatic islet β cells
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26. Tissue engineering of decellularized pancreas scaffolds for regenerative medicine in diabetes
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27. Urocortin3: Local inducer of somatostatin release and bellwether of beta cell maturity
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28. Recent Progress of Research Regarding the Applications of Stem Cells for Treating Diabetes Mellitus
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29. Scalable generation of 3D pancreatic islet organoids from human pluripotent stem cells in suspension bioreactors
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30. Bioengineering and vascularization strategies for islet organoids: advancing toward diabetes therapy.
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31. Reconstruction of endocrine subtype-complete human pluripotent stem cell-derived islets with capacity for hypoglycemia protection in vivo
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32. Lessons from Human Islet Transplantation Inform Stem Cell-Based Approaches in the Treatment of Diabetes
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33. Monogenic Diabetes Modeling: In Vitro Pancreatic Differentiation From Human Pluripotent Stem Cells Gains Momentum
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34. LIN28B Impairs the Transition of hESC-Derived β Cells from the Juvenile to Adult State
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35. Endocrine Pancreas Development and Dysfunction Through the Lens of Single-Cell RNA-Sequencing
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36. Stem Cells as a Source of Pancreatic Cells for Production of 3D Bioprinted Bionic Pancreas in the Treatment of Type 1 Diabetes
    M. Wszoła, Daria Nitarska, P. Cywoniuk, M. Gomółka, M. Klak · 2021 · Cells
37. Islet transplantation into brown adipose tissue can delay immune rejection
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38. The progress of pluripotent stem cell-derived pancreatic β-cells regeneration for diabetic therapy
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39. Validating expression of beta cell maturation-associated genes in human pancreas development
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40. Systematic investigation of the underlying mechanisms of GLP-1 receptor agonists to prevent myocardial infarction in patients with type 2 diabetes mellitus using network pharmacology
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41. Development of electrochemical Zn2+ sensors for rapid voltammetric detection of glucose-stimulated insulin release from pancreatic β-cells
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42. Reprogramming Cells to Make Insulin
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43. Genetic deletion of Urocortin 3 does not prevent functional maturation of beta cells
    Jessica L. Huang, Sharon Chih Lin Lee, Pelle Hoek, Talitha van der Meulen, Richard Van, Mark O. Huising · 2020 · Journal of Endocrinology
44. Single-cell RNA sequencing for engineering and studying human islets
    Punn Augsornworawat, Jeffrey R. Millman · 2020 · Current Opinion in Biomedical Engineering
45. Developmentally-Inspired Biomimetic Culture Models to Produce Functional Islet-Like Cells From Pluripotent Precursors
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46. Mitogen Synergy: An Emerging Route to Boosting Human Beta Cell Proliferation
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47. Stem cell-based multi-tissue platforms to model human autoimmune diabetes
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48. Protocol development to further differentiate and transition stem cell-derived pancreatic progenitors from a monolayer into endocrine cells in suspension culture
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49. Enrichment of stem cell-derived pancreatic beta-like cells and controlled graft size through pharmacological removal of proliferating cells
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50. Islets in the body are never flat: transitioning from two-dimensional (2D) monolayer culture to three-dimensional (3D) spheroid for better efficiency in the generation of functional hPSC-derived pancreatic β cells in vitro
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51. Mitochondrial regulation in human pluripotent stem cells during reprogramming and β cell differentiation
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52. Transplantation of stem cell-derived pancreatic islet cells
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53. Scalable bioreactor-based suspension approach to generate stem cell-derived islets from healthy donor-derived iPSCs
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54. Scale up manufacturing approach for production of human induced pluripotent stem cell-derived islets using Vertical Wheel® bioreactors
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55. The functional importance of the cellular and extracellular composition of the islets of Langerhans
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56. Microwell bag culture for large-scale production of homogeneous islet-like clusters
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57. Extrahepatic transplantation of 3D cultured stem cell-derived islet organoids on microporous scaffolds
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58. Ca2+-Mediated Signaling Pathways: A Promising Target for the Successful Generation of Mature and Functional Stem Cell-Derived Pancreatic Beta Cells In Vitro
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59. Integration of Islet/Beta-Cell Transplants with Host Tissue Using Biomaterial Platforms
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60. Modeling Type 1 Diabetes Using Pluripotent Stem Cell Technology
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61. Sonic hedgehog signals hinder the transcriptional network necessary for pancreatic endoderm formation from human embryonic stem cells
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62. New advances in insulin products
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63. FGF7 enhances the expression of ACE2 in human islet organoids aggravating SARS-CoV-2 infection
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65. Mesenchymal Stem Cells: A Trump Card for the Treatment of Diabetes?
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66. Benefits and Hurdles of Pancreatic β-Cell Replacement
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67. Cell Replacement Therapy for Type 1 Diabetes Patients: Potential Mechanisms Leading to Stem-Cell-Derived Pancreatic β-Cell Loss upon Transplant
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68. Importance of multiple endocrine cell types in islet organoids for type 1 diabetes treatment
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69. Fas Ligand-Modified Scaffolds Protect Stem Cell Derived β-Cells by Modulating Immune Cell Numbers and Polarization
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70. Recent progress in modeling and treating diabetes using stem cell-derived islets
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71. A multimodal cross-species comparison of pancreas development
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72. Adaptive Landscape Shaped by Core Endogenous Network Coordinates Complex Early Progenitor Fate Commitments in Embryonic Pancreas
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73. Harnessing reaction-based probes to preferentially target pancreatic β-cells and β-like cells
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74. Superporous agarose scaffolds for encapsulation of adult human islets and human stem‐cell‐derived β cells for intravascular bioartificial pancreas applications
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75. Recent progress in pancreatic islet cell therapy
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76. Characterizing the degeneration of nuclear membrane and mitochondria of adipose‐derived mesenchymal stem cells from patients with type II diabetes
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77. Promises and pitfalls of beta cell–replacement therapies
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78. Stem Cell-Derived β Cells: A Versatile Research Platform to Interrogate the Genetic Basis of β Cell Dysfunction
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79. Analysis of the effects of bench-scale cell culture platforms and inoculum cell concentrations on PSC aggregate formation and culture
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80. From stem cells to pancreatic β-cells: strategies, applications, and potential treatments for diabetes
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81. Inceptor binds to and directs insulin towards lysosomal degradation in β cells
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82. Stem-cell-derived beta cells mature metabolically upon murine engraftment
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83. Silencing the G-protein coupled receptor 3-salt inducible kinase 2 pathway promotes human β cell proliferation
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84. Optimizing Generation of Stem Cell-Derived Islet Cells
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85. Cell Heterogeneity and Paracrine Interactions in Human Islet Function: A Perspective Focused in β-Cell Regeneration Strategies
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86. Cryopreservation of Stem Cell–Derived β-Like Cells Enriches for Insulin-Producing Cells With Improved Function
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87. Advancements and Innovative Strategies in Induced Pluripotent Stem Cell‐Derived Mesenchymal Stem Cell Therapy: A Comprehensive Review
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88. Human Pluripotent Stem Cells: A Unique Tool for Toxicity Testing in Pancreatic Progenitor and Endocrine Cells
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89. Automated optimization of endoderm differentiation on chip
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90. Generation of Isogenic hiPSCs with Targeted Edits at Multiple Intronic SNPs to Study the Effects of the Type 2 Diabetes Associated KCNQ1 Locus in American Indians
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91. Therapeutic Strategies Targeting Pancreatic Islet β-Cell Proliferation, Regeneration, and Replacement
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92. Forward programming of hiPSCs towards beta-like cells using Ngn3, Pdx1, and MafA
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93. An INSULIN and IAPP dual reporter enables tracking of functional maturation of stem cell-derived insulin producing cells
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94. Tracking Insulin- and Glucagon-Expressing Cells In Vitro and In Vivo Using a Double-Reporter Human Embryonic Stem Cell Line
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95. Recent advances and potential applications of human pluripotent stem cell-derived pancreatic β cells
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96. Repopulation of decellularized organ scaffolds with human pluripotent stem cell-derived pancreatic progenitor cells
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97. Informing β-cell regeneration strategies using studies of heterogeneity
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98. Enhancing the Functionality of Immunoisolated Human SC‐βeta Cell Clusters through Prior Resizing
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99. Tankyrase inhibition promotes endocrine commitment of hPSC-derived pancreatic progenitors
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100. Bioengineering of a human iPSC-derived vascularized endocrine pancreas for type 1 diabetes
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