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Cited by 401

The DOI matches its Crossref record; 52 of the 52 references it cites were found in a registry or an index.

The Extracellular Architecture of Adherens Junctions Revealed by Crystal Structures of Type I Cadherins

Open access
Harrison, Oliver J., Jin, Xiangshu, Hong, Soonjin, Bahna, Fabiana, Ahlsen, Goran, Brasch, Julia, Wu, Yinghao, Vendome, Jeremie, Felsovalyi, Klara, Hampton, Cheri M., Troyanovsky, Regina B., Ben-Shaul, Avinoam, Frank, Joachim, Troyanovsky, Sergey M., Shapiro, Lawrence, Honig, Barry·2011·Structure
DOI 10.1016/j.str.2010.11.016
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Abstract

Summary Adherens junctions, which play a central role in intercellular adhesion, comprise clusters of type I classical cadherins that bind via extracellular domains extended from opposing cell surfaces. We show that a molecular layer seen in crystal structures of E- and N-cadherin ectodomains reported here and in the C-cadherin structure corresponds to the extracellular architecture of adherens junctions. In all three ectodomain crystals, cadherins dimerize through a trans adhesive interface and are connected by a second, cis, interface. Assemblies formed by E-cadherin ectodomains coated on liposomes also appear to adopt this structure. Fluorescent imaging of junctions formed from wild-type and mutant E-cadherins in cultured cells confirm conclusions derived from structural evidence. Mutations that interfere with the trans interface ablate adhesion, whereas cis interface mutations disrupt stable junction formation. Our observations are consistent with a model for junction assembly involving strong trans and weak cis interactions localized in the ectodomain.

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Crossref · 10.1016/j.str.2010.11.016

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Metadata

Authors
Harrison, O. J., Jin, X., Hong, S., Bahna, F., Ahlsen, G., Brasch, J., Wu, Y., Vendome, J., Felsovalyi, K., Hampton, C. M., Troyanovsky, R. B., Ben-Shaul, A., Frank, J., Troyanovsky, S. M., Shapiro, L., & Honig, B.
Venue
Structure
Publisher
Elsevier BV
Published
2011-02
Volume
19
Issue
2
Pages
244-256
ISSN
0969-2126 (ISSN-L)
DOI
10.1016/j.str.2010.11.016
OpenAlex
W2138687527
Cited by
401
References
52
FWCI
19.39
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: The Extracellular Architecture of Adherens Junctions Revealed by Crystal Structures of Type I Cadherins. https://app.cochat.ai/papers/10.1016/j.str.2010.11.016
The paper
Harrison, O. J., Jin, X., Hong, S., Bahna, F., Ahlsen, G., Brasch, J., Wu, Y., Vendome, J., Felsovalyi, K., Hampton, C. M., Troyanovsky, R. B., Ben-Shaul, A., Frank, J., Troyanovsky, S. M., Shapiro, L., & Honig, B. (2011). The Extracellular Architecture of Adherens Junctions Revealed by Crystal Structures of Type I Cadherins. Structure. https://doi.org/10.1016/j.str.2010.11.016

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.