Dynamic Allostery: Linkers Are Not Merely Flexible
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Items 101–200 of 223
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- Protein Allostery at the Solid–Liquid Interface: Endoglucanase Attachment to Cellulose Affects Glucan Clenching in the Binding CleftYu‐Chun Lin, Jordi Silvestre-Ryan, Michael E. Himmel, Michael F. Crowley, Gregg T. Beckham, Jhih‐Wei Chu · 2011 · Journal of the American Chemical Society
- Flexible connection of the N‐terminal domain in ClpB modulates substrate binding and the aggregate reactivation efficiencyTing Zhang, Elizabeth A. Ploetz, Maria Nagy, Shannon M. Doyle, Sue Wickner, Paul E. Smith, Michal Žółkiewski · 2012 · Proteins Structure Function and Bioinformatics
- A Mechanism for Localized Dynamics-driven Affinity Regulation of the Binding of von Willebrand Factor to Platelet Glycoprotein IbαGuangjian Liu, Ying Guang Fang, Jianhua Wu · 2013 · Journal of Biological Chemistry
- Structure-Based Function and Regulation of NCX Variants: Updates and ChallengesDaniel Khananshvili · 2022 · International Journal of Molecular Sciences
- Structure-Dynamic Determinants Governing a Mode of Regulatory Response and Propagation of Allosteric Signal in Splice Variants of Na+/Ca2+ Exchange (NCX) ProteinsSu Youn Lee, Ka Young Chung, Daniel Khananshvili, Moshe Giladi · 2016 · Biophysical Journal
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- Allosteric linkers in cAMP signallingMadoka Akimoto, Kody Moleschi, Stephen Boulton, Bryan VanSchouwen, Rajeevan Selvaratnam, Susan Serota Taylor, Giuseppe Melacini · 2014 · Biochemical Society Transactions
- Influence of PEGylation on Domain Dynamics of Phosphoglycerate Kinase: PEG Acts Like Entropic Spring for the ProteinKarol Ciepluch, Aurel Rădulescu, Ingo Hoffmann, Andreas Raba, Jürgen Allgaier, Dieter Richter, Ralf Biehl · 2018 · Bioconjugate Chemistry
- Unique Structure and Dynamics of the EphA5 Ligand Binding Domain Mediate Its Binding Specificity as Revealed by X-ray Crystallography, NMR and MD SimulationsHuan, Xuelu, Shi, Jiahai, Lim, Liangzhong, Mitra, Sayantan, Zhu, Wanlong, Qin, Haina, Pasquale, Elena B., Song, Jianxing · 2013 · PLoS ONE
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- Leveraging Bidirectional Nature of Allostery To Inhibit Protein–Protein Interactions (PPIs): A Case Study of PCSK9–LDLR InteractionKrishnendu Sinha, Ipsita Basu, Zacharia Shah, Salim Shah, Suman Chakrabarty · 2024 · Journal of Chemical Information and Modeling
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- Allosterism in human complement component 5a (hC5a): a damper of C5a receptor (C5aR) signalingSoumendra Rana, Amita Rani Sahoo, Bharat Kumar Majhi · 2015 · Journal of Biomolecular Structure and Dynamics
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- Identification of the Binding Site of an Allosteric Ligand Using STD‐NMR, Docking, and CORCEMA‐ST CalculationsWei Zhang, Rongbao Li, Ronald Shin, Yi‐Min Wang, Indira Padmalayam, Ling Zhai, N. Rama Krishna · 2013 · ChemMedChem
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- The properties of the linker in a mini-scaffoldin influence the catalytic efficiency of scaffoldin-mediated enzyme complexesDongdong Meng, Juan Wang, Chun You · 2019 · Enzyme and Microbial Technology
- Ubiquitin Interacting Motifs: Duality Between Structured and Disordered MotifsMatteo Lambrughi, Emiliano Maiani, Burcu Aykaç Fas, Gary S. Shaw, Birthe Brandt Kragelund, Kresten Lindorff‐Larsen, Kaare Teilum, Gaetano Invernizzi, Elena Papaleo · 2021 · Frontiers in Molecular Biosciences
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- Stiffness of the C-terminal disordered linker affects the geometry of the active site in endoglucanase Cel8ABartosz Różycki, Marek Cieplak · 2016 · Molecular BioSystems
- Oncogenic Mutations Differentially Affect Bax Monomer, Dimer, and Oligomeric Pore Formation in the MembraneMingzhen Zhang, Jie Zheng, Ruth Nussinov, Buyong Ma · 2016 · Scientific Reports
- Coarse-Grained Modeling of Multiple Pathways in Conformational Transitions of Multi-Domain ProteinsAi Shinobu, Chigusa Kobayashi, Yasuhiro Matsunaga, Yuji Sugita · 2021 · Journal of Chemical Information and Modeling
- Subdomain dynamics enable chemical chain reactions in non-ribosomal peptide synthetasesXun Sun, Jonas Alfermann, Hao Li, Maxwell B. Watkins, Yi-Tsao Chen, Thomas E. Morrell, Florian Mayerthaler, Chia-Ying Wang, Tamiki Komatsuzaki, Jhih‐Wei Chu et al. · 2023 · Nature Chemistry
- Dynamic Fluctuations Provide the Basis of a Conformational Switch Mechanism in Apo Cyclic AMP Receptor ProteinBurcu Aykaç Fas, Yusuf Tutar, Türkan Haliloǧlu · 2013 · PLoS Computational Biology
- Fine-tuning of Voltage Sensitivity of the Kv1.2 Potassium Channel by Interhelix Loop DynamicsRheanna M. Sand, Nazlee Sharmin, Carla Morgan, Warren J. Gallin · 2013 · Journal of Biological Chemistry
- Discovery of Novel Allosteric Eg5 Inhibitors Through Structure‐Based Virtual ScreeningWei Zhang, Ling Zhai, Wenyan Lü, Rebecca J. Boohaker, Indira Padmalayam, Yonghe Li · 2016 · Chemical Biology & Drug Design
- Insight into the Tumor Suppression Mechanism from the Structure of Human Polypyrimidine Splicing Factor (PSF/SFPQ) Complexed with a 30mer RNA from Murine Virus-like 30S Transcript-1Jimin Wang, Aristidis Sachpatzidis, Thomas David Christian, Ivan B. Lomakin, Alan Garen, William H. Konigsberg · 2022 · Biochemistry
- Allosteric therapies for lung cancerLing Ye, Meiling Jing, Xiangdong Wang · 2015 · Cancer and Metastasis Reviews
- MD simulations indicate Omicron P132H of SARS-CoV-2 Mpro is a potential allosteric mutant involved in modulating the dynamics of catalytic site entry loopZahoor Ahmad Bhat, Mohd Muzammil Khan, Ayyub Rehman, Jawed Iqbal, B. S. Sanjeev, Arumugam Madhumalar · 2024 · International Journal of Biological Macromolecules
- Effect of Linker Flexibility on the Catalytic Features of a Glycoside Hydrolase Family 45 Endoglucanase from Rhizopus stoloniferBin Tang, Lanfang Wei, Wenjing Tang, Li Song, Ruofei Zhou · 2015 · Applied Biochemistry and Biotechnology
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- RETRACTED ARTICLE: Advances of Predicting Allosteric Mechanisms Through Protein Contact in New Technologies and Their ApplicationSayed Haidar Abbas Raza, Ruimin Zhong, Xiaoting Yu, Gang Zhao, Xiaoqun Wei, Hongtao Lei · 2023 · Molecular Biotechnology · Retracted
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- Allostery in Biomolecular CondensatesRuth Nussinov, Clil Regev, Hyunbum Jang · 2025 · Journal of Molecular Biology
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