Tsai, Chung-Jung

Folding funnels, binding funnels, and protein function

Tsai, C., Kumar, S., Ma, B., & Nussinov, R. (1999) · Protein Science

Protein Structure and DynamicsRNA and protein synthesis mechanisms

Cited by 648

Folding and binding cascades: Dynamic landscapes and population shifts

Kumar, S., Ma, B., Tsai, C., Sinha, N., & Nussinov, R. (2000) · Protein Science

Protein Structure and DynamicsProtein Interaction Studies and Fluorescence Analysis

Cited by 595

Folding funnels and binding mechanisms

Ma, B., Kumar, S., Tsai, C.-J., & Nussinov, R. (1999) · Protein Engineering, Design and Selection

Protein Structure and DynamicsProtein Interaction Studies and Fluorescence Analysis

Cited by 594

Allostery: Absence of a change in shape does not imply that allostery is not at play

Tsai, C.-J., del Sol, A., & Nussinov, R. (2008) · Journal of Molecular Biology

Protein Structure and DynamicsReceptor Mechanisms and Signaling

Cited by 453

Allostery in Its Many Disguises: From Theory to Applications

Wodak, S. J., Paci, E., Dokholyan, N. V., Berezovsky, I. N., Horovitz, A., Li, J., Hilser, V. J., Bahar, I., Karanicolas, J., Stock, G., et al. (2019) · Structure

Protein Structure and DynamicsReceptor Mechanisms and Signaling

Cited by 404

A Unified View of “How Allostery Works”

Tsai, C.-J., & Nussinov, R. (2014) · PLoS Computational Biology

Receptor Mechanisms and SignalingProtein Structure and Dynamics

Cited by 401

Folding and binding cascades: Shifts in energy landscapes

Tsai, C.-J., Ma, B., & Nussinov, R. (1999) · Proceedings of the National Academy of Sciences

Protein Structure and DynamicsRNA and protein synthesis mechanisms

Cited by 365

Dynamic Allostery: Linkers Are Not Merely Flexible

Ma, B., Tsai, C.-J., Haliloğlu, T., & Nussinov, R. (2011) · Structure

Protein Structure and DynamicsReceptor Mechanisms and Signaling

Cited by 222

Allosteric post-translational modification codes

Nussinov, R., Tsai, C.-J., Xin, F., & Radivojac, P. (2012) · Trends in Biochemical Sciences

Protein Structure and DynamicsAdvanced Proteomics Techniques and Applications

Cited by 211

Structured disorder and conformational selection

Tsai, C., Ma, B., Sham, Y. Y., Kumar, S., & Nussinov, R. (2001) · Proteins: Structure, Function, and Bioinformatics

Protein Structure and DynamicsEnzyme Structure and Function

Cited by 202

Allostery without a conformational change? Revisiting the paradigm

Nussinov, R., & Tsai, C.-J. (2015) · Current Opinion in Structural Biology

Protein Structure and DynamicsReceptor Mechanisms and Signaling

Cited by 202

Principles of Allosteric Interactions in Cell Signaling

Nussinov, R., Tsai, C.-J., & Liu, J. (2014) · Journal of the American Chemical Society

Receptor Mechanisms and SignalingProtein Structure and Dynamics

Cited by 154

Protein–protein interaction networks: how can a hub protein bind so many different partners?

Tsai, C.-J., Ma, B., & Nussinov, R. (2009) · Trends in Biochemical Sciences

Bioinformatics and Genomic NetworksProtein Structure and Dynamics

Cited by 138

Unraveling structural mechanisms of allosteric drug action

Nussinov, R., & Tsai, C.-J. (2014) · Trends in Pharmacological Sciences

Receptor Mechanisms and SignalingNeuroscience and Neuropharmacology Research

Cited by 119

The Design of Covalent Allosteric Drugs

Nussinov, R., & Tsai, C.-J. (2015) · Annual Review of Pharmacology and Toxicology

Click Chemistry and ApplicationsChemical Synthesis and Analysis

Cited by 112

Allostery: Allosteric Cancer Drivers and Innovative Allosteric Drugs

Nussinov, R., Zhang, M., Maloney, R., Liu, Y., Tsai, C.-J., & Jang, H. (2022) · Journal of Molecular Biology

Protein Degradation and InhibitorsProtein Kinase Regulation and GTPase Signaling

Cited by 66

“Pathway drug cocktail”: targeting Ras signaling based on structural pathways

Nussinov, R., Tsai, C.-J., & Mattos, C. (2013) · Trends in Molecular Medicine

Protein Kinase Regulation and GTPase SignalingBioinformatics and Genomic Networks

Cited by 62

Allosteric Conformational Barcodes Direct Signaling in the Cell

Nussinov, R., Ma, B., Tsai, C.-J., & Csermely, P. (2013) · Structure

Protein Structure and DynamicsReceptor Mechanisms and Signaling

Cited by 55

Artificial intelligence approaches to human-microbiome protein–protein interactions

Lim, H., Cankara, F., Tsai, C.-J., Keskin, O., Nussinov, R., & Gursoy, A. (2022) · Current Opinion in Structural Biology

Machine Learning in BioinformaticsBioinformatics and Genomic Networks

Cited by 39

Dynamic Protein Allosteric Regulation and Disease

Nussinov, R., Tsai, C.-J., & Jang, H. (2019) · Advances in Experimental Medicine and Biology

Protein Structure and DynamicsReceptor Mechanisms and Signaling

Cited by 18