The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Mechanosensitive Channels: What Can They Do and How Do They Do It?
Open accessAbstract
SUMMARY While mechanobiological processes employ diverse mechanisms, at their heart are force-induced perturbations in the structure and dynamics of molecules capable of triggering subsequent events. Among the best-characterized force-sensing systems are bacterial mechanosensitive channels. These channels reflect an intimate coupling of protein conformation with the mechanics of the surrounding membrane; the membrane serves as an adaptable sensor that responds to an input of applied force and converts it into an output signal, interpreted for the cell by mechanosensitive channels. The cell can exploit this information in a number of ways - ensuring cellular viability in the presence of osmotic stress and perhaps also serving as a signal transducer for membrane tension or other functions. This review focuses on the bacterial mechanosensitive channels of large (MscL) and small (MscS) conductance and their eukaryotic homologues with an emphasis on the outstanding issues surrounding the function and mechanism of this fascinating class of molecules.
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Cites
Local force and geometry sensing regulate cell functions
Vogel, V., & Sheetz, M. (2006) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1890 · Cited by 2,328 · cited 2×
“All organisms, from single-celled bacteria to multi-cellular animals and plants, must sense and respond to mechanical force in their external environment (for example, shear force, gravity, touch) and in their internal environment (including osmotic pressure and membrane deformation) for proper growth, development, an…”
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Metadata
- Authors
- Haswell, E. S., Phillips, R., & Rees, D. C.
- Venue
- Structure
- Publisher
- Elsevier BV
- Published
- 2011-10
- Volume
- 19
- Issue
- 10
- Pages
- 1356-1369
- ISSN
- 0969-2126 (ISSN-L)
- OpenAlex
- W2026702641
- Cited by
- 378
- References
- 1
- FWCI
- 8.82
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Haswell, E. S., Phillips, R., & Rees, D. C. (2011). Mechanosensitive Channels: What Can They Do and How Do They Do It? Structure. https://doi.org/10.1016/j.str.2011.09.005
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