The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Structural Basis for Phosphoinositide Substrate Recognition, Catalysis, and Membrane Interactions in Human Inositol Polyphosphate 5-Phosphatases
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“We could not detect robust hydrolysis of PtdIns-4,5-P2 by either TMEM55, though we could detect hydrolysis by SHIP2, despite the fact that this enzyme has by far the weakest activity against this substrate of the 5-phosphatases44 (Supplementary Fig. 8e).”
From TFEB regulates lysosomal positioning by modulating TMEM55B expression and JIP4 recruitment to lysosomes (2017) · cites this paper as [44]
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Phosphoinositides in cell regulation and membrane dynamics
Di Paolo, G., & De Camilli, P. (2006) · Nature · doi:10.1038/nature05185 · Cited by 2,790
Laporte, J., Hu, L. J., Kretz, C., Mandel, J.-L., Kioschis, P., Coy, J. F., Klauck, S. M., Poustka, A., & Dahl, N. (1996) · Nature Genetics · doi:10.1038/ng0696-175 · Cited by 639
SHIP2 and its involvement in various diseases
Suwa, A., Kurama, T., & Shimokawa, T. (2010) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.2010.492780 · Cited by 74
Flagged first, then by citations
Research works printed but not linked: 68
- Amoasii, 2012, Myotubularin phosphoinositide phosphatases in human diseases. Curr. Top, Microbiol. Immunol., 362, 209
- Annis, 2009, Inhibitors of the lipid phosphatase SHIP2 discovered by high-throughput affinity selection-mass spectrometry screening of combinatorial libraries, Comb. Chem. High Throughput Screen., 12, 760, 10.2174/138620709789104870 · DOI
- Astle, 2006, Regulation of phosphoinositide signaling by the inositol polyphosphate 5-phosphatases, IUBMB Life, 58, 451, 10.1080/15216540600871159 · DOI
- Astle, 2007, The inositol polyphosphate 5-phosphatases: traffic controllers, waistline watchers and tumour suppressors?, Biochem. Soc. Symp., 161, 10.1042/BSS2007c15 · DOI
- Attree, 1992, The Lowe’s oculocerebrorenal syndrome gene encodes a protein highly homologous to inositol polyphosphate-5-phosphatase, Nature, 358, 239, 10.1038/358239a0 · DOI
- Azzedine, 2003, Mutations in MTMR13, a new pseudophosphatase homologue of MTMR2 and Sbf1, in two families with an autosomal recessive demyelinating form of Charcot-Marie-Tooth disease associated with early-onset glaucoma, Am. J. Hum. Genet., 72, 1141, 10.1086/375034 · DOI
- Beernink, 2001, Two divalent metal ions in the active site of a new crystal form of human apurinic/apyrimidinic endonuclease, Ape1: implications for the catalytic mechanism, J. Mol. Biol., 307, 1023, 10.1006/jmbi.2001.4529 · DOI
- Bielas, 2009, Mutations in INPP5E, encoding inositol polyphosphate-5-phosphatase E, link phosphatidyl inositol signaling to the ciliopathies, Nat. Genet., 41, 1032, 10.1038/ng.423 · DOI
- Blunt, 2012, Targeting PI3K isoforms and SHIP in the immune system: new therapeutics for inflammation and leukemia, Curr. Opin. Pharmacol., 12, 444, 10.1016/j.coph.2012.02.015 · DOI
- Bolino, 2000, Charcot-Marie-Tooth type 4B is caused by mutations in the gene encoding myotubularin-related protein-2, Nat. Genet., 25, 17, 10.1038/75542 · DOI
- Chen, 2010, MolProbity: all-atom structure validation for macromolecular crystallography, Acta Crystallogr. D Biol. Crystallogr., 66, 12, 10.1107/S0907444909042073 · DOI · Paper page
- Chi, 2004, Comparative mechanistic and substrate specificity study of inositol polyphosphate 5-phosphatase Schizosaccharomyces pombe Synaptojanin and SHIP2, J. Biol. Chem., 279, 44987, 10.1074/jbc.M406416200 · DOI
- Communi, 1996, Arginine 343 and 350 are two active residues involved in substrate binding by human Type I D-myo-inositol 1,4,5,-trisphosphate 5-phosphatase, J. Biol. Chem., 271, 11676, 10.1074/jbc.271.20.11676 · DOI
- Conduit, 2012, Inositol polyphosphate 5-phosphatases; new players in the regulation of cilia and ciliopathies, FEBS Lett., 586, 2846, 10.1016/j.febslet.2012.07.037 · DOI
- Dyson, 2005, The SH2 domain containing inositol polyphosphate 5-phosphatase-2: SHIP2, Int. J. Biochem. Cell Biol., 37, 2260, 10.1016/j.biocel.2005.05.003 · DOI
- Eberhard, 1990, Evidence that the inositol phospholipids are necessary for exocytosis. Loss of inositol phospholipids and inhibition of secretion in permeabilized cells caused by a bacterial phospholipase C and removal of ATP, Biochem. J., 268, 15, 10.1042/bj2680015 · DOI
- Erdmann, 2007, A role of the Lowe syndrome protein OCRL in early steps of the endocytic pathway, Dev. Cell, 13, 377, 10.1016/j.devcel.2007.08.004 · DOI
- Fuhler, 2012, Therapeutic potential of SH2 domain-containing inositol-5′-phosphatase 1 (SHIP1) and SHIP2 inhibition in cancer, Mol. Med., 18, 65, 10.2119/molmed.2011.00178 · DOI · Paper page
- Gamper, 2007, Regulation of ion transport proteins by membrane phosphoinositides, Nat. Rev. Neurosci., 8, 921, 10.1038/nrn2257 · DOI
- Gorman, 1997, The crystal structure of the human DNA repair endonuclease HAP1 suggests the recognition of extra-helical deoxyribose at DNA abasic sites, EMBO J., 16, 6548, 10.1093/emboj/16.21.6548 · DOI
- Gräslund, 2008, The use of systematic N- and C-terminal deletions to promote production and structural studies of recombinant proteins, Protein Expr. Purif., 58, 210, 10.1016/j.pep.2007.11.008 · DOI
- Hakim, 2012, Inositol polyphosphate phosphatases in human disease, Curr. Top. Microbiol. Immunol., 362, 247
- Hartwig, 1995, Thrombin receptor ligation and activated Rac uncap actin filament barbed ends through phosphoinositide synthesis in permeabilized human platelets, Cell, 82, 643, 10.1016/0092-8674(95)90036-5 · DOI
- Hellsten, 2001, Disrupted sperm function and fertilin beta processing in mice deficient in the inositol polyphosphate 5-phosphatase Inpp5b, Dev. Biol., 240, 641, 10.1006/dbio.2001.0476 · DOI
- Hoopes, 2005, Dent Disease with mutations in OCRL1, Am. J. Hum. Genet., 76, 260, 10.1086/427887 · DOI
- Ichihara, 2013, Rational design and synthesis of 4-substituted 2-pyridin-2-ylamides with inhibitory effects on SH2 domain-containing inositol 5′-phosphatase 2 (SHIP2), Eur. J. Med. Chem., 62, 649, 10.1016/j.ejmech.2013.01.014 · DOI
- Jänne, 1998, Functional overlap between murine Inpp5b and Ocrl1 may explain why deficiency of the murine ortholog for OCRL1 does not cause Lowe syndrome in mice, J. Clin. Invest., 101, 2042, 10.1172/JCI2414 · DOI
- Jefferson, 1996, Mutation of the conserved domains of two inositol polyphosphate 5-phosphatases, Biochemistry, 35, 7890, 10.1021/bi9602627 · DOI
- Koch, 2005, The SH2-domian-containing inositol 5-phosphatase (SHIP)-2 binds to c-Met directly via tyrosine residue 1356 and involves hepatocyte growth factor (HGF)-induced lamellipodium formation, cell scattering and cell spreading, Oncogene, 24, 3436, 10.1038/sj.onc.1208558 · DOI
- Ligresti, 2009, PIK3CA mutations in human solid tumors: role in sensitivity to various therapeutic approaches, Cell Cycle, 8, 1352, 10.4161/cc.8.9.8255 · DOI · Paper page
- Lipton, 2008, Characterization of Mg2+ binding to the DNA repair protein apurinic/apyrimidic endonuclease 1 via solid-state 25Mg NMR spectroscopy, J. Am. Chem. Soc., 130, 9332, 10.1021/ja0776881 · DOI
- Liu, 2009, Targeting the phosphoinositide 3-kinase pathway in cancer, Nat. Rev. Drug Discov., 8, 627, 10.1038/nrd2926 · DOI
- Lomize, 2006, Positioning of proteins in membranes: a computational approach, Protein Sci., 15, 1318, 10.1110/ps.062126106 · DOI
- Lomize, 2012, OPM database and PPM web server: resources for positioning of proteins in membranes, Nucleic Acids Res., 40, D370, 10.1093/nar/gkr703 · DOI
- Maffucci, 2012, An introduction to phosphoinositides, Curr. Top. Microbiol. Immunol., 362, 1
- Mao, 2009, A PH domain within OCRL bridges clathrin-mediated membrane trafficking to phosphoinositide metabolism, EMBO J., 28, 1831, 10.1038/emboj.2009.155 · DOI
- Martin, 2001, PI(4,5)P(2) regulation of surface membrane traffic, Curr. Opin. Cell Biol., 13, 493, 10.1016/S0955-0674(00)00241-6 · DOI
- McCrea, 2009, Mutations in phosphoinositide metabolizing enzymes and human disease, Physiology (Bethesda), 24, 8, 10.1152/physiol.00035.2008 · DOI
- Michell, 2008, Inositol derivatives: evolution and functions, Nat. Rev. Mol. Cell Biol., 9, 151, 10.1038/nrm2334 · DOI
- Mills, 2012, A synthetic polyphosphoinositide headgroup surrogate in complex with SHIP2 provides a rationale for drug discovery, ACS Chem. Biol., 7, 822, 10.1021/cb200494d · DOI
- Mol, 2000, DNA-bound structures and mutants reveal abasic DNA binding by APE1 and DNA repair coordination [corrected], Nature, 403, 451, 10.1038/35000249 · DOI
- Moses, 2009, In vitro and in vivo activity of novel small-molecule inhibitors targeting the pleckstrin homology domain of protein kinase B/AKT, Cancer Res., 69, 5073, 10.1158/0008-5472.CAN-08-3839 · DOI
- Oezguen, 2007, A “moving metal mechanism” for substrate cleavage by the DNA repair endonuclease APE-1, Proteins, 68, 313, 10.1002/prot.21397 · DOI
- Oezguen, 2011, MD simulation and experimental evidence for Mg²+ binding at the B site in human AP endonuclease 1, Bioinformation, 7, 184, 10.6026/97320630007184 · DOI
- Ooms, 2009, The role of the inositol polyphosphate 5-phosphatases in cellular function and human disease, Biochem. J., 419, 29, 10.1042/BJ20081673 · DOI
- Pesesse, 1998, The SH2 domain containing inositol 5-phosphatase SHIP2 displays phosphatidylinositol 3,4,5-trisphosphate and inositol 1,3,4,5-tetrakisphosphate 5-phosphatase activity, FEBS Lett., 437, 301, 10.1016/S0014-5793(98)01255-1 · DOI
- Pirruccello, 2012, Inositol 5-phosphatases: insights from the Lowe syndrome protein OCRL, Trends Biochem. Sci., 37, 134, 10.1016/j.tibs.2012.01.002 · DOI
- Poccia, 2009, Phosphatidylinositol metabolism and membrane fusion, Biochem. J., 418, 233, 10.1042/BJ20082105 · DOI
- Prasad, 2001, SH2-containing inositol 5′-phosphatase SHIP2 associates with the p130(Cas) adapter protein and regulates cellular adhesion and spreading, Mol. Cell. Biol., 21, 1416, 10.1128/MCB.21.4.1416-1428.2001 · DOI
- Samuels, 2004, High frequency of mutations of the PIK3CA gene in human cancers, Science, 304, 554, 10.1126/science.1096502 · DOI
- Sasaoka, 2006, Lipid phosphatases as a possible therapeutic target in cases of type 2 diabetes and obesity, Pharmacol. Ther., 112, 799, 10.1016/j.pharmthera.2006.06.001 · DOI
- Schmid, 2004, Type II phosphoinositide 5-phosphatases have unique sensitivities towards fatty acid composition and head group phosphorylation, FEBS Lett., 576, 9, 10.1016/j.febslet.2004.08.052 · DOI
- Senderek, 2003, Mutation of the SBF2 gene, encoding a novel member of the myotubularin family, in Charcot-Marie-Tooth neuropathy type 4B2/11p15, Hum. Mol. Genet., 12, 349, 10.1093/hmg/ddg030 · DOI
- Sleeman, 2005, Absence of the lipid phosphatase SHIP2 confers resistance to dietary obesity, Nat. Med., 11, 199, 10.1038/nm1178 · DOI
- Stenton, 2013, Characterization of AQX-1125, a small-molecule SHIP1 activator: Part 2. Efficacy studies in allergic and pulmonary inflammation models in vivo, Br. J. Pharmacol., 168, 1519, 10.1111/bph.12038 · DOI
- Stenton, 2013, Characterization of AQX-1125, a small-molecule SHIP1 activator: Part 1. Effects on inflammatory cell activation and chemotaxis in vitro and pharmacokinetic characterization in vivo, Br. J. Pharmacol., 168, 1506, 10.1111/bph.12039 · DOI
- Suwa, 2009, Discovery and functional characterization of a novel small molecule inhibitor of the intracellular phosphatase, SHIP2, Br. J. Pharmacol., 158, 879, 10.1111/j.1476-5381.2009.00358.x · DOI
- Suwa, 2010, Glucose metabolism activation by SHIP2 inhibitors via up-regulation of GLUT1 gene in L6 myotubes, Eur. J. Pharmacol., 642, 177, 10.1016/j.ejphar.2010.06.002 · DOI
- Tolias, 2000, Type Ialpha phosphatidylinositol-4-phosphate 5-kinase mediates Rac-dependent actin assembly, Curr. Biol., 10, 153, 10.1016/S0960-9822(00)00315-8 · DOI
- Tsujishita, 2001, Specificity determinants in phosphoinositide dephosphorylation: crystal structure of an archetypal inositol polyphosphate 5-phosphatase, Cell, 105, 379, 10.1016/S0092-8674(01)00326-9 · DOI
- Tsutakawa, 2013, Conserved structural chemistry for incision activity in structurally non-homologous apurinic/apyrimidinic endonuclease APE1 and endonuclease IV DNA repair enzymes, J. Biol. Chem., 288, 8445, 10.1074/jbc.M112.422774 · DOI
- Ungewickell, 2004, The inositol polyphosphate 5-phosphatase Ocrl associates with endosomes that are partially coated with clathrin, Proc. Natl. Acad. Sci. USA, 101, 13501, 10.1073/pnas.0405664101 · DOI
- Vanhaesebroeck, 1997, Phosphoinositide 3-kinases: a conserved family of signal transducers, Trends Biochem. Sci., 22, 267, 10.1016/S0968-0004(97)01061-X · DOI
- Waugh, 2012, Phosphatidylinositol 4-kinases, phosphatidylinositol 4-phosphate and cancer, Cancer Lett., 325, 125, 10.1016/j.canlet.2012.06.009 · DOI
- Whisstock, 2000, The inositol polyphosphate 5-phosphatases and the apurinic/apyrimidinic base excision repair endonucleases share a common mechanism for catalysis, J. Biol. Chem., 275, 37055, 10.1074/jbc.M006244200 · DOI
- Wisniewski, 1999, A novel SH2-containing phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase (SHIP2) is constitutively tyrosine phosphorylated and associated with src homologous and collagen gene (SHC) in chronic myelogenous leukemia progenitor cells, Blood, 93, 2707, 10.1182/blood.V93.8.2707 · DOI · Paper page
- Yin, 2008, PTEN: a new guardian of the genome, Oncogene, 27, 5443, 10.1038/onc.2008.241 · DOI
- Zhang, 2013, Novel OCRL mutations in Chinese children with Lowe syndrome, World J. Pediatr., 9, 53, 10.1007/s12519-013-0406-4 · DOI
Cited by
Sorted by citations
Willett, R., Martina, J. A., Zewe, J. P., Wills, R., Hammond, G. R. V., & Puertollano, R. (2017) · Nature Communications · doi:10.1038/s41467-017-01871-z · Cited by 201
Pedicone, C., Fernandes, S., Matera, A., Meyer, S. T., Loh, S., Ha, J.-H., Bernard, D., Chisholm, J. D., Paolicelli, R. C., & Kerr, W. G. (2022) · iScience · doi:10.1016/j.isci.2022.104170 · Cited by 26
Metadata
- Authors
- Trésaugues, L., Silvander, C., Flodin, S., Welin, M., Nyman, T., Gräslund, S., Hammarström, M., Berglund, H., & Nordlund, P.
- Venue
- Structure
- Publisher
- Elsevier BV
- Published
- 2014-05
- Volume
- 22
- Issue
- 5
- Pages
- 744-755
- ISSN
- 0969-2126
- Cited by
- 58
- References
- 3
- Language
- en
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review