Phosphoinositides in cell regulation and membrane dynamics
Abstract
Inositol phospholipids have long been known to have an important regulatory role in cell physiology. The repertoire of cellular processes known to be directly or indirectly controlled by this class of lipids has now dramatically expanded. Through interactions mediated by their headgroups, which can be reversibly phosphorylated to generate seven species, phosphoinositides play a fundamental part in controlling membrane-cytosol interfaces. These lipids mediate acute responses, but also act as constitutive signals that help define organelle identity. Their functions, besides classical signal transduction at the cell surface, include regulation of membrane traffic, the cytoskeleton, nuclear events and the permeability and transport functions of membranes.
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PLC hydrolysis of PI(4,5)P2 generates IP3 and DAG.
“Phospholipase C (PLC) leads to the generation of two second messengers, inositol(1,4,5)trisphosphate (I(1,4,5)P3), known trigger for mobilising Ca2+ from endoplasmic reticulum (ER) stores and diacylglycerol (DAG), an activator for protein kinase C (PKC).”
From Phosphatidylinositol(4,5)bisphosphate: diverse functions at the plasma membrane (2020) · cites this paper as [7]
IP3 mobilises Ca2+ from ER stores.
“Phospholipase C (PLC) leads to the generation of two second messengers, inositol(1,4,5)trisphosphate (I(1,4,5)P3), known trigger for mobilising Ca2+ from endoplasmic reticulum (ER) stores and diacylglycerol (DAG), an activator for protein kinase C (PKC).”
From Phosphatidylinositol(4,5)bisphosphate: diverse functions at the plasma membrane (2020) · cites this paper as [7]
PI(4,5)P2 is a substrate for PLC and PI3K.
“PI(4,5)P2 is a substrate for two signalling pathways.”
From Phosphatidylinositol(4,5)bisphosphate: diverse functions at the plasma membrane (2020) · cites this paper as [7]
DAG activates PKC.
“Phospholipase C (PLC) leads to the generation of two second messengers, inositol(1,4,5)trisphosphate (I(1,4,5)P3), known trigger for mobilising Ca2+ from endoplasmic reticulum (ER) stores and diacylglycerol (DAG), an activator for protein kinase C (PKC).”
From Phosphatidylinositol(4,5)bisphosphate: diverse functions at the plasma membrane (2020) · cites this paper as [7]
PI3K generates PI(3,4,5)P3, a lipid with wide-ranging functions.
“The second pathway is phosphoinositide-3-kinase (PI3K) to make PI(3,4,5)P3, a lipid with wide-ranging functions.”
From Phosphatidylinositol(4,5)bisphosphate: diverse functions at the plasma membrane (2020) · cites this paper as [7]
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- Authors
- Di Paolo, G., & De Camilli, P.
- Venue
- Nature
- Published
- 2006-10
- Volume
- 443
- Issue
- 7112
- Pages
- 651-657
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2091884933
- Cited by
- 2,790
- References
- 1
- Citations by year
- 2026: 69 · 2025: 95 · 2024: 103 · 2023: 123 · 2022: 121 · 2021: 159 · 2020: 149 · 2019: 145 · 2018: 149 · 2017: 138 · 2016: 179 · 2015: 171 · 2014: 200 · 2013: 171 · 2012: 202
- FWCI
- 9.09
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Funders
- Howard Hughes Medical Institute
- Yale University
- National Institute on Drug Abuse (P30DA018343)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Lipid Membrane Structure and Behavior
- Keywords
- phosphoinositides, inositol phospholipids, lipid signaling, membrane dynamics, membrane traffic, cytoskeleton regulation, nuclear incidents, membrane permeability, cell surface signaling
- MeSH terms
- Animals, Cell Membrane, Endocytosis, Golgi Apparatus, Humans, Phosphatidylinositols, Signal Transduction, GTP Phosphohydrolases
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