Cited by 18

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Cork-in-Bottle Occlusion of Fluoride Ion Channels by Crystallization Chaperones

McIlwain, Benjamin C., Newstead, Simon, Stockbridge, Randy B.·2018·Structure

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Crossref · 10.1016/j.str.2018.02.004

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  • Proteins encoded by the crcB genes are electrodiffusive F− channels.

    “Electrophysiological characterization showed that the proteins encoded by the crcB genes are electrodiffusive F− channels (2, 3, 60–63), and they were renamed Fluc (Fluoride channel) in bacteria and FEX (Fluoride exporter) in eukaryotes.”

    From Membrane exporters of fluoride ion (2021) · cites this paper as [63]

  • Of the various topologies, the dual topology homodimers from B. pertussis (Fluc-Bpe) and an E. coli virulence plasmid (Fluc-Ec2) are the only ones that have been structurally characterized.

    “Of these various topologies, the dual topology homodimers, from Bordetella pertussis (Fluc-Bpe) and an E. coli virulence plasmid (Fluc-Ec2), are the only ones that have been structurally characterized(63, 73, 74).”

    From Membrane exporters of fluoride ion (2021) · cites this paper as [63]

  • Synthetic proteins that inhibit fluoride channels have been developed but have not been tested in biological systems, and no such natural regulatory mechanism has been identified.

    “Although synthetic proteins that inhibit fluoride channels have been developed123–125, they have not been tested in biological systems, and no such natural regulatory mechanism has been identified.”

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Research works printed but not linked: 16

  1. Blanc, 2004, Refinement of severely incomplete structures with maximum likelihood in BUSTER-TNT, Acta Crystallogr. D Biol. Crystallogr., 60, 2210, 10.1107/S0907444904016427 · DOI
  2. Bukowska, 2013, New concepts and aids to facilitate crystallization, Curr. Opin. Struct. Biol., 23, 409, 10.1016/j.sbi.2013.03.003 · DOI
  3. Emsley, 2010, Features and development of Coot, Acta Crystallogr. D Biol. Crystallogr., 66, 486, 10.1107/S0907444910007493 · DOI · Paper page
  4. Jiang, 2003, X-ray structure of a voltage-dependent K+ channel, Nature, 423, 33, 10.1038/nature01580 · DOI
  5. Koide, 2012, Teaching an old scaffold new tricks: monobodies constructed using alternative surfaces of the FN3 scaffold, J. Mol. Biol., 415, 393, 10.1016/j.jmb.2011.12.019 · DOI · Paper page
  6. Koide, 2009, Accelerating phage-display library selection by reversible and site-specific biotinylation, Protein Eng. Des. Sel., 22, 685, 10.1093/protein/gzp053 · DOI
  7. Last, 2016, Mechanistic signs of double-barreled structure in a fluoride ion channel, Elife, 5, 10.7554/eLife.18767 · DOI · Paper page
  8. Last, 2017, Molecular determinants of permeation in a fluoride-specific ion channel, Elife, 6, 10.7554/eLife.31259 · DOI · Paper page
  9. Lee, 2005, Structure of the KvAP voltage-dependent K+ channel and its dependence on the lipid membrane, Proc. Natl. Acad. Sci. USA, 102, 15441, 10.1073/pnas.0507651102 · DOI
  10. McCoy, 2007, Phaser crystallographic software, J. Appl. Crystallogr., 40, 658, 10.1107/S0021889807021206 · DOI · Paper page
  11. Stockbridge, 2014, Proof of dual-topology architecture of Fluc F- channels with monobody blockers, Nat. Commun., 5, 5120, 10.1038/ncomms6120 · DOI · Paper page
  12. Stockbridge, 2013, A family of fluoride-specific ion channels with dual-topology architecture, Elife, 2, e01084, 10.7554/eLife.01084 · DOI · Paper page
  13. Turman, 2015, Two-sided block of a dual-topology F- channel, Proc. Natl. Acad. Sci. USA, 112, 5697, 10.1073/pnas.1505301112 · DOI · Paper page
  14. Turman, 2017, Mechanism of single- and double-sided inhibition of dual topology fluoride channels by synthetic monobodies, J. Gen. Physiol., 149, 511, 10.1085/jgp.201611747 · DOI · Paper page
  15. Turman, 2018, Molecular interactions between a fluoride ion channel and synthetic protein blockers, Biochemistry, 10.1021/acs.biochem.7b01272 · DOI · Paper page
  16. Uysal, 2009, Crystal structure of full-length KcsA in its closed conformation, Proc. Natl. Acad. Sci. USA, 106, 6644, 10.1073/pnas.0810663106 · DOI

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Metadata

Authors
McIlwain, B. C., Newstead, S., & Stockbridge, R. B.
Venue
Structure
Publisher
Elsevier BV
Published
2018-04
Volume
26
Issue
4
Pages
635-639.e1
ISSN
0969-2126
Cited by
18
References
1
Language
en
Funders
  • Wellcome Trust (102890/Z/13/Z)
  • National Institutes of Health (R00-GM111767)
  • Alfred P. Sloan Foundation

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