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Cited by 151Drug Transport and Resistance MechanismsPharmacogenetics and Drug MetabolismIon Transport and Channel Regulation

The DOI matches its Crossref record; 208 of the 220 references it cites were found in a registry or an index.

Organic anion transporter (Slc22a) family members as mediators of toxicity

Sweet, Douglas H.·2005·Toxicology and Applied Pharmacology
DOI 10.1016/j.taap.2004.10.016
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Abstract

Exposure of the body to toxic organic anions is unavoidable and occurs from both intentional and unintentional sources. Many hormones, neurotransmitters, and waste products of cellular metabolism, or their metabolites, are organic anions. The same is true for a wide variety of medications, herbicides, pesticides, plant and animal toxins, and industrial chemicals and solvents. Rapid and efficient elimination of these substances is often the body's best defense for limiting both systemic exposure and the duration of their pharmacological or toxicological effects. For organic anions, active transepithelial transport across the renal proximal tubule followed by elimination via the urine is a major pathway in this detoxification process. Accordingly, a large number of organic anion transport proteins belonging to several different gene families have been identified and found to be expressed in the proximal nephron. The function of these transporters, in combination with the high volume of renal blood flow, predisposes the kidney to increased toxic susceptibility. Understanding how the kidney mediates the transport of organic anions is integral to achieving desired therapeutic outcomes in response to drug interactions and chemical exposures, to understanding the progression of some disease states, and to predicting the influence of genetic variation upon these processes. This review will focus on the organic anion transporter (OAT) family and discuss the known members, their mechanisms of action, subcellular localization, and current evidence implicating their function as a determinant of the toxicity of certain endogenous and xenobiotic agents.

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Crossref · 10.1016/j.taap.2004.10.016

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Citations

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Research works printed but not linked: 2

  1. Lacy, 1998, Evaluation of toxicity associated with chronic administration of anti-HIV nucleotide analogue adefovir dipivoxil in rats and cynomolgus monkeys, The Toxicologist, 42, 374
  2. Shimada, 1987, Indirect coupling to Na of p-aminohippurate acid uptake into rat renal basolateral membrane vesicles, Am. J. Physiol.: Renal Physiol., 253, F795

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Metadata

Authors
Sweet, D. H.
Affiliations
Medical University of South Carolina (US)
Corresponding author
Sweet, Douglas H.
ORCID
Sweet, Douglas H.
Venue
Toxicology and Applied Pharmacology
Publisher
Elsevier BV
Published
2005-05
Volume
204
Issue
3
Pages
198-215
ISSN
0041-008X (ISSN-L)
DOI
10.1016/j.taap.2004.10.016
OpenAlex
W2124824529
Cited by
150
References
220
Citations by year
2024: 2 · 2023: 3 · 2022: 5 · 2021: 4 · 2020: 8 · 2019: 3 · 2018: 2 · 2017: 2 · 2016: 3 · 2015: 3 · 2014: 9 · 2013: 6 · 2012: 12
FWCI
1.29
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Toxicology and Applied Pharmacology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacogenetics and Drug Metabolism
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion Transport and Channel Regulation
Keywords
organic anion transporters, proximal tubule, drug toxicity, xenobiotic transport, drug interactions, subcellular localization
MeSH terms
Animals, Pharmaceutical Preparations, Humans, Kidney, Toxins, Biological, Organic Anion Transporters, Drug-Related Side Effects and Adverse Reactions

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